Patents Assigned to Instrumentation Laboratory
  • Automated system for continuously and automatically calibrating electrochemical sensors
    Patent number: 8721852
    Abstract: An electrochemical sensor system that continuously monitors and calibrates the sensors included in the system. The invention also includes a method for determining failure patterns of a sensor and incorporating into an electrochemical sensor system the ability to recognize the failure pattern and initiate remedial action.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: May 13, 2014
    Assignee: Instrumentation Laboratory Company
    Inventors: Sohrab Mansouri, Kevin Fallon, Patti Eames
  • System and method of increasing sample throughput by estimation of a sensor endpoint
    Patent number: 8560251
    Abstract: Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: October 15, 2013
    Assignee: Instrumentation Laboratory Company
    Inventors: Sohrab Mansouri, Jose Maria Cervera
  • Composite membrane containing a cross-linked enzyme matrix for a biosensor
    Patent number: 8426192
    Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: April 23, 2013
    Assignee: Instrumentation Laboratory Company
    Inventors: Prasad Pamidi, Sohrab Mansouri, Melanie Shin, Vasile Cosofret, Clarke Xu
  • Kit for protein S functional assay
    Patent number: 8334108
    Abstract: The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma sample is diluted with protein S deficient plasma, followed by the addition of purified or recombinant tissue factor (pTF or rTF), purified natural or synthetic phospholipid (pPL or sPL) and activated protein C (APC) or protein C activator (PCA). The clotting time is then measured and compared to a standard curve or a normal control.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: December 18, 2012
    Assignee: Instrumentation Laboratory Company
    Inventors: Yong Dai, Biqing Ye, Kui Chen, Pau Bruguera, Daniel Lawson, Shamay Tang
  • Hemoglobin based bilirubin reference material
    Patent number: 8304244
    Abstract: What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and hemoglobin fractions, and, optionally, diagnostic for other blood analytes by sensor means.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: November 6, 2012
    Assignee: Instrumentation Laboratory Company
    Inventors: Michael Pistorino, Prasad Pamidi
  • Automated system for continuously and automatically calibrating electrochemical sensors
    Patent number: 8128801
    Abstract: An electrochemical sensor system that continuously monitors and calibrates the sensors included in the system. The invention also includes a method for determining failure patterns of a sensor and incorporating into an electrochemical sensor system the ability to recognize the failure pattern and initiate remedial action.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: March 6, 2012
    Assignee: Instrumentation Laboratory Company
    Inventors: Sohrab Mansouri, Kevin Fallon, Patti Eames
  • Hemoglobin based bilirubin reference material
    Patent number: 8119407
    Abstract: What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and hemoglobin fractions, and, optionally, diagnostic for other blood analytes by sensor means.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: February 21, 2012
    Assignee: Instrumentation Laboratory Company
    Inventors: Michael Pistorino, Prasad Pamidi
  • METHOD AND SYSTEM FOR MANAGING PATIENT DATA
    Publication number: 20110295091
    Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.
    Type: Application
    Filed: May 16, 2011
    Publication date: December 1, 2011
    Applicant: INSTRUMENTATION LABORATORY COMPANY
    Inventors: Anwar A. Azer, Ramon E. Benet
  • Method and system for managing patient data
    Patent number: 7972279
    Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: July 5, 2011
    Assignee: Instrumentation Laboratory Company
    Inventors: Anwar A. Azer, Ramon E. Benet
  • Method and system for managing patient data
    Patent number: 7972280
    Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: July 5, 2011
    Assignee: Instrumentation Laboratory Company
    Inventors: Anwar A. Azer, Ramon E. Benet
  • Adaptor for sample vial
    Patent number: 7858037
    Abstract: The invention relates generally to a sample vial adaptor for interfacing a sample vial with the sample port of a diagnostic instrument, in particular a sample vial containing a patient body fluid sample with the sample port and sample pathway of a multi-use diagnostic instrument. Embodiments of the sample vial adaptor according to the invention generally include a short exterior vent tube having one end in communication with a chamber having a vent, an interior collection tube that is longer than the short exterior vent tube, axially positioned in the lumen of the short exterior vent tube and extending to a capillary outlet that is located on the portion of the inner collection tube that is outside of the short exterior vent tube and outside the vented chamber.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: December 28, 2010
    Assignee: Instrumentation Laboratory Company
    Inventor: James Edward Flaherty
  • Reagent cartridge mixing tube
    Patent number: 7731414
    Abstract: Embodiments of the invention relate to a clinical instrument analyzer system for the automated analysis of patient samples. In one embodiment, the analyzer may be used to analyze bodily fluid samples, such as blood, plasma, serum, urine or cerebrospinal fluid, for example. Embodiments of the invention relate to an apparatus and method for suspending magnetic particles accumulated on the floor of a mixing tube and depositing the magnetic particles in bodily fluid samples.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: June 8, 2010
    Assignee: Instrumentation Laboratory Company
    Inventors: Kathleen Vincent, Mark Talmer, Gerhardt P. Schroeder
  • Multi-analyte reference solutions
    Patent number: 7732210
    Abstract: The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: June 8, 2010
    Assignee: Instrumentation Laboratory Company
    Inventors: Dennis Robert Conlon, Sohrab Mansouri, Giannantonio Vago
  • CROSS-LINKED ENZYME MATRIX AND USES THEREOF
    Publication number: 20100133101
    Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 3, 2010
    Applicant: INSTRUMENTATION LABORATORY COMPANY
    Inventors: Prasad Pamidi, Sohrab Mansouri, Melanie Shin, Vasile Cosofret, Clarke Xu
  • Composite membrane containing a cross-linked enzyme matrix for a biosensor
    Patent number: 7632672
    Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: December 15, 2009
    Assignee: Instrumentation Laboratory Co.
    Inventors: Prasad Pamidi, Sohrab Mansouri, Melanie Shin, Vasile Cosofret, Clarke Xu
  • METHOD AND SYSTEM FOR MANAGING PATIENT DATA
    Publication number: 20090306542
    Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.
    Type: Application
    Filed: August 13, 2009
    Publication date: December 10, 2009
    Applicant: Instrumentation Laboratory Company
    Inventors: Anwar A. Azer, Ramon E. Benet
  • Immunoassay probe
    Patent number: 7514270
    Abstract: An analytical instrument for the immobilization of antigens to be detected in an immunoassay using mangetizable beads. The instrument includes a probe containing magnetizable particles and a plurality of magnetic devices for applying a magnetic field gradient to the particles in the probe reservoir. The probe is movable between the plurality of magnetic devices and at least one of the probe positions may be used to immobilize the magnetic particles in the fluid medium and at least another position may be used to resuspend the particles in a fluid medium.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: April 7, 2009
    Assignee: Instrumentation Laboratory Company
    Inventors: Eugene K. Achter, Hartmut Richard Schroeder, Stephen S. Trotta
  • Protein S functional assay
    Patent number: 7468257
    Abstract: The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma sample is diluted with protein S deficient plasma, followed by the addition of purified or recombinant tissue factor (pTF or rTF), purified natural or synthetic phospholipid (pPL or sPL) and activated protein C (APC) or protein C activator (PCA). The clotting time is then measured and compared to a standard curve or a normal control.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: December 23, 2008
    Assignee: Instrumentation Laboratory Corporation
    Inventors: Yong Dai, Biqing Ye, Kui Chen, Pau Bruguera, Daniel E Lawson, Shamay Tang
  • Analytical instruments, biosensors and methods thereof
    Patent number: 7455760
    Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: November 25, 2008
    Assignee: Instrumentation Laboratory Company
    Inventors: Sohrab Mansouri, Vasile Cosofret, Clarke Xu
  • Multi-analyte reference solutions
    Patent number: 7422903
    Abstract: The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: September 9, 2008
    Assignee: Instrumentation Laboratory Company
    Inventors: Dennis Robert Conlon, Sohrab Mansouri, Giannantonio Vago