Patents Assigned to International Minerals & Chemical Corp.
  • Patent number: 5158758
    Abstract: A method for production of high specific surface area silica gel by hydrolysis of silicon tetrahalide, wherein a solution of silicon tetrahalide in a non-reactive solvent such as alcohol is mixed with water to produce silica gel having a high surface area and narrow pore diameter distribution especially suited for use as normal phase packing material in high performance chromatography columns. The water contains fluoride ions if the halide is chloride. Reverse phase packing material can be prepared by reacting the normal phase silica gel with organochlorosilanes to prepare bonded reverse phase material for use in high performance liquid chromotagraphy systems.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: October 27, 1992
    Assignee: International Minerals & Chemical Corp.
    Inventors: Paul C. Chieng, Deborah J. Brame, Alexander H. T. Chu
  • Patent number: 5104796
    Abstract: A high titer fermentation process using transformed Escherichia coli cells carrying a plasmid containing DNA which codes for Somatomedin C is disclosed. Titers of about 900-1000 mg/L have been obtained using the method of the present invention; about two times the titer of prior art processes.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: April 14, 1992
    Assignee: International Minerals & Chemical Corp.
    Inventors: Paula M. Keith, Wendy Cain
  • Patent number: 5101018
    Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight containing proteins by directly adding amine or quaternary ammonium compounds to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: March 31, 1992
    Assignee: International Minerals & Chemical Corp.
    Inventors: Vikram P. Mehrotra, Ray E. Barker
  • Patent number: 5049495
    Abstract: High titers of polyether antibiotics are obtained in a fermentation broth by inoculating a nutrient fermentation broth with a microorganism capable of producing a polyether antibiotic. Growth of the microorganism is established in the broth by incubating the inoculated broth at a physiologically acceptable temperature until pH of the broth begins to rise upon establishment of growth of the microorganism. A free fatty acid then is fed into the broth to achieve and maintain a free fatty acid concentration in the broth of about 0.1% by weight or greater but less than a level at which the free fatty acid is toxic to the microorganism. The free fatty acid is fed into the broth during the remainder of fermentation at about a rate at which the free fatty acid is consumed by the microorganism, to product high titers of the polyether antibiotic.
    Type: Grant
    Filed: May 29, 1986
    Date of Patent: September 17, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Guido M. Miescher
  • Patent number: 5047339
    Abstract: An aqueous medium having dispersed therein hydrophobic, polyether antibiotic-containing droplets, is mixed to cause the droplets to collide with each other and coalesce to form agglomerates which are separable from the medium.
    Type: Grant
    Filed: April 21, 1986
    Date of Patent: September 10, 1991
    Assignee: International Minerals & Chemical Corp
    Inventor: Vikram P. Mehrotra
  • Patent number: 5047338
    Abstract: A polyether and antibiotic material is prepared by forming discrete polyether antibiotic-containing agglomerates which are separable from an aqueous medium, by producing a polyether antibiotic through cultivation of a polyether antibiotic-producing microorganism in a generally aqueous nutrient-containing fermentation broth under conditions wherein at the end of fermentation, a lipid is present in the broth in a sufficient amount to form discrete agglomerates with polyether and antibiotic in the fermentation broth, whereupon the applomerates are separated from the broth.
    Type: Grant
    Filed: May 29, 1986
    Date of Patent: September 10, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Guido M. Miescher
  • Patent number: 5043333
    Abstract: A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.
    Type: Grant
    Filed: October 21, 1988
    Date of Patent: August 27, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Jerome L. Martin
  • Patent number: 5041610
    Abstract: Ring-opened resorcyclic acid lactone derivatives of the formla ##STR1## wherein X is ethylene or ethenylene; Y and Z, which may be the same or different, are methylene, hydroxymethylene or carbonyl; R.sub.1 is hydrogen or lower alkyl of from 1 to about 6 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, hydroxyl, halogen, nitro, amino or a radical selected from the group consisting of --R', --OR', --COOR' and --OCOR' wherein R' is lower alkyl of from 1 to about 6 carbon atoms, lower cycloalkyl of from 3 to about 8 carbon atom, alkenyl of from 2 to about 6 carbon atoms, substituted or unsubstituted aryl of from 6 to about 8 carbon atoms, or substituted or unsubstituted aralkyl wherein the alkyl portion contains from 1 to about 6 carbon atoms and the aryl portion contains from 6 to about 8 carbon atoms. These compounds are useful as growth-promotants in food-producing animals.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: August 20, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Keith A. Drengler
  • Patent number: 5041374
    Abstract: Polyether antibiotic material is liberated from agglomerates containing a lipid material and the polyether antibiotic material by separating the polyether antibiotic from the lipid through formation of an acid salt of the lipid and a desired acid salt of the polyether antibiotic. The agglomerates can be formed during fermentation or produced by adding lipids afterwards.
    Type: Grant
    Filed: May 29, 1986
    Date of Patent: August 20, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventors: Alexander H. T. Chu, Robert J. Urban
  • Patent number: 5030433
    Abstract: A method of producing pure and dense amorphous fused synthetic silica. Silica of desired purity is wet pelletized or agglomerated to form particles having an average particle size of between about 5 and 2500 microns. These particles are calcined to volatilize impurities and increase density to at least about 0.9 g/cm.sup.3. Calcined particles are classified by size or reduced in size if desired or needed by grinding in such a way that the purity of the product is maintained.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: July 9, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Vikram P. Mehrotra
  • Patent number: 5028407
    Abstract: A method of producing a high purity silica powder which can be fused to form transparent, bubble-free particles. An ammonium fluosilicate solution is purified preliminarily by removing colloidal-sized silica onto which impurities in the solution have been adsorbed. The high purity powder is produced by ammoniation of an unsaturated aqueous solution of ammonium fluosilicate. Silica powder produced is filtered, washed, and dried before fusion. Additional pre-fusion treatments such as washing, hydrothermal leaching, calcination, and a combination thereof, may be utilized to ensure that the concentration of volatile material is low.
    Type: Grant
    Filed: January 25, 1990
    Date of Patent: July 2, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventors: Paul C. Chieng, Vikram P. Mehrotra, Chin-Liang Chou
  • Patent number: 4992440
    Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: February 12, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventors: Kurt G. R. Sundelin, Joseph P. Salanitro, Susan Stackhouse
  • Patent number: 4938956
    Abstract: The known immunostimulants FK-565 and IL-2 are administered to animals in conjunction to synergistically stimulate the immune system.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: July 3, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventors: David K. Howard, Ellen R. Clough, Anthony F. Abruzzini, Paula Myers-Keith
  • Patent number: 4933364
    Abstract: A process for promoting growth and feed efficiency in food producing mammals is provided by administering to such mammals, growth promoting amounts of a zinc complex of a polyether antibiotic selected from the group consisting of monensin, nigericin, salinomycin, narasin, noborotomycin A and B, SY-1, grisorixin, X-206, lonomycin, laidlomycin, mutalomycin, alborixin, lasalocid and lysocellin.Zinc complexes of this type are prepared by adding soluble zinc salt to a fermentation beer containing a polyether antibiotic to thereby form an insoluble, recoverable biomass containing the desired growth-promoting zinc complex for use in the process herein.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: June 12, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventors: Richard E. Ivy, David R. Bright, Robert D. Williams
  • Patent number: 4904689
    Abstract: A process for promoting growth and feed efficiency in food producing animals is provided by administering to such animals, growth promoting amounts of certain forms of lysocellin, including the free acid and physiologically-acceptable salts thereof.Metal complexes of lysocellin can be prepared by adding the appropriate soluble metal salts to a fermentation beer containing lysocellin to thereby form an insoluble, recoverable biomass containing the desired growth-promoting metal salt complex of lysocellin for use in the process herein.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: February 27, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventors: Jerome L. Martin, David R. Bright, Robert D. Williams, Vernon V. Young
  • Patent number: 4904473
    Abstract: A pelletized feed supplement is supplied which effectively increases productivity of animals fed high acid producing diets. The pelletized feed supplement can also be used to neutralize stomach acid of humans and to maintain a proper electrolyte balance. A method is taught of producing the pelletized feed supplement which results in a buffering agent which is dissolved gradually, and has a high buffering capacity.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: February 27, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventors: Brian R. Schricker, Vikram P. Mehrotra
  • Patent number: 4898733
    Abstract: A device for the continuous administration of a beneficial agent to a living being at a substantially steady rate which comprises:(a) a body fluid-contacting layer which comprises a dispersion of an agent which is substantially soluble in the body fluid and a solid matrix material, said matrix material comprising a polymer which is substantially insoluble in said body fluid, and(b) a non-body fluid-contacting layer which comprises said beneficial agent,wherein said body fluid-contacting layer is compression molded to said non-body fluid contacting layer.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: February 6, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventors: Randolph B. DePrince, Ravi Viswanathan
  • Patent number: 4892960
    Abstract: Crystalline lysocellin compositions, and method of making them. These compounds are useful for promoting growth and feed efficiency in food producing mammals by administering growth promoting amounts of the compounds to such mammals. In particular, the crystalline free acid and the crystalline zinc, copper and manganese of lysocellin can be made according to the disclosed methods.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: January 9, 1990
    Assignee: International Minerals & Chemical Corp.
    Inventor: Vernon V. Young
  • Patent number: 4888416
    Abstract: A method for preparing a dried protein product, such that the bioactivity and potential for solubility of the protein are substantially maintained when said product is administered to a living being and contacted with body fluids of said being, which comprises:(a) forming an aqueous solution comprising a mixture of said protein and an ionic detergent and(b) drying said protein-detergent mixture, wherein a sufficient amount of detergent is mixed with said protein in step (a) to substantially fully coat said protein.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: December 19, 1989
    Assignee: International Minerals & Chemical Corp.
    Inventors: Alvin M. Janski, Susan M. Drengler
  • Patent number: RE33699
    Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [X.sup.3, Y.sup.8, Z.sup.25, Nle.sup.27 ]-hGRF(1-A)--B, wherein X, Y and Z are selected from the group consisting of Asn and Asp, A has a value from 29-44, and B is NH.sub.2 or OH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: September 24, 1991
    Assignee: International Minerals & Chemical Corp.
    Inventor: Keith A. Drengler