Abstract: A controlled release implant composition which includes a core comprising a macromolecular drug and a water insoluble polymer and a homogeneous outer polymeric membrane formed by coating said core with an organic solution of a water insoluble polymer and a water soluble pore-forming agent.

Abstract: A device for the release of a diffusible solid in a fluid medium which comprises a disc which comprises a substantially uniform mixture of said diffusible solid and a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid. The surfaces of said disc are coated with a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid, with the exception of one or more apertures which extend through the disc and expose a portion of the mixture of diffusible solid and polymer to the fluid medium when the device is immersed therein. The aperture or apertures are placed in said disc such that as said fluid medium enters the disc through said aperture or apertures, the ratio of surfce area of diffusible solid exposed to the fluid medium to the length of the path through which the exposed solid must diffuse to exit the disc remains substantially constant.

Abstract: Quinoxalinedione compounds are effective coccidiostats when administered to animals. The compounds are conveniently incorporated into standard animal feeds. The compounds are particularly effective for controlling coccidiosis in poultry.

Abstract: The invention relates to acaricidal compositions for the control of ectoparasites of domesticated, warm blooded animals. Methods for application of the composition disclosed are also taught.

Abstract: An improved process is described for recovering proteins from insoluble inclusion bodies produced in transformant microorganisms. Sidestream precipitates isolated from chromatography effluent are resolubilized in a denaturing agent and the resolubilized proteins are renatured either by direct dialysis into denaturant-free buffer or by dialysis into a weaker denaturing agent followed by dialysis into denaturant-free buffer.

Abstract: Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as cattle, sheep, swine and poultry. Soluble manganese salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired manganese antibiotic complex. This biomass, in a dried form, can be given orally to animals such as cattle, sheep, swine and poultry.The subject manganese complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lysocellin, etc.); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen-containing divalent pyrrole ethers (A-23187, etc.); glycolic monovalent monoglycoside polyethers (etheromycin, etc.

Abstract: A method of decolorizing wet process phosphoric acid containing organic color-imparting impurities is provided. The process includes treating the acid with a strong oxidant at a temperature in the range of about 50.degree. to about 150.degree. C. by slowly adding the oxidant to the acid over a period of time of at least about 3 hours. The oxidized acid then is contacted with a regenerable activated carbon, preferably in a packed column, in order to adsorb the oxidized color-imparting impurities.

Abstract: A process for separating and removing substantial amounts of magnesium and other ion impurities from wet process phosphoric acid of 35-45% P.sub.2 O.sub.5 content is provided. The process steps comprise: (a) heating the acid while maintaining the acid at a concentration of 35-45% P.sub.2 O.sub.5 by the addition of water for a time sufficient to effect removal of silicon as fluosilicic acid and/or silicon tetrafluoride, thereby forming a stripped acid; (b) precipitating ralstonite from the heated stripped acid; and (c) separating the precipitated ralstonite from the acid.

Abstract: A method of removing aluminum, magnesium, iron and other impurities from wet process phosphoric acid is provided. The method comprises partially ammoniating the acid and reacting the acid with a fluoride ion donating compound to precipitate aluminum- and magnesium-containing ralstonite and ammonium fluorosilicate which can be easily separated from the acid thereby producing a partially ammoniated wet process phosphoric acid of reduced impurities content.

Abstract: A novel tolylthioisoxazole compound is disclosed having activity against the pinworms S. obvelata and A. tetraptera. A process for making these compounds and a method of administering it to infested animals is also disclosed.

Abstract: An improved process for stabilizing wet process phosphoric acid is described in which the acid is treated with pressurized carbon dioxide and then is aged so as to enhance the rate of post-precipitation.

Abstract: A low cost implant device suitable for manufacture by high speed injection molding techniques is described. The implant device can be fabricated and assembled using only two parts, a plunger assembly and a plunger assembly housing. The plunger assembly housing is provided with a socket-like chamber for receiving a disposable flanged cartridge containing a solid medicament in pellet form. The cartridge also can be made by injection molding. The device is used for subcutaneously implanting the solid pellet medicament in an animal.

Abstract: Hydrogen fluoride is produced by the electrodialysis of an alkali metal fluoride salt solution or an ammonium fluoride solution in an electrodialysis cell having an anode compartment and a cathode compartment spaced from one another by an inner electrodialysis compartment bounded by spaced cation exchange membranes.

Abstract: A method of enhancing the growth rate of animals comprises passively immunizing them with growth-enhancing amounts of anti-somatostatin antibodies.

Abstract: Novel dihydroisoxazole compounds are disclosed having activity against parasitic worms and showing little or no toxicity to the host animal. These compounds are 3-chloro-4-dialkylaminophthaloylamino-4,5-dihydroisoxazoles and 3-dialkylamino-4-dialkylaminophthaloylamino-4,5-dihydroisoxazoles. A process for making these compounds and a method of administering them to infested animals is also disclosed.

Abstract: A process for stripping hexavalent uranium from an organic solution using phosphoric acid containing ferrous ion wherein the ferrous ion is provided by electrolytic reduction of ferric ion with minimal production of hydrogen.

Abstract: The amount of carbonate mineral impurities is reduced in aqueous phosphate rock slurry by (a) conditioning the slurry with an effective amount of CO.sub.2, (b) adding an effective amount of an anionic collector to the slurry and (c) subjecting the slurry to a froth flotation process whereby the carbonate mineral impurities are concentrated in the froth. The CO.sub.2 acts to depress flotation of phosphate minerals relative to the carbonate mineral impurities.

Abstract: Certain novel bipyridine substituted compounds, their metal complexes (Cu, Fe and Ni) which are effective to improve feed efficiency and promote growth in food-producing animals, particularly ruminants. The compounds are described by the general formula ##STR1## including the cupric, nickelous and ferrous salts thereof.

Abstract: An improved process for the production of potassium sulfate crystals by the reaction of saturated solution of potassium chloride with langbeinite in the solid phase at a temperature of from 45.degree.-55.degree. C., thereby forming potassium sulfate crystals and magnesium chloride solution comprising the step of conducting the reaction in the presence of a growth enhancer comprising monosulfonated or monosulfated surfactant and a neutralized disulfonated surfactant in a weight ratio of from about 0.14 to 0.69.

Abstract: An otherwise unusable western sandstone uranium ore is blended with uranium-containing phosphate rock. The mixture is then digested with sulfuric acid to produce a wet process phosphoric acid solution containing higher levels of uranium. Recovery of the uranium values from this solution can be effected by various known processes such as solvent extraction.