Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.

Abstract: Estriol is administered to ruminants in dosages from about 0.01-4.0 mg/ruminant/day to promote growth and increase feed utilization efficiency.

Abstract: Crystallization of trimethylolethane from supersaturated aqueous solutions is inhibited in the presence of effective amounts of methanol and formic acid as crystallization inhibitors.

Abstract: The Resorcylic Acid Lactone (RAL) derivatives zearalenone, zearalanone, zearalene, zearalane, zearalenol, zearalanol, and dideoxyzearalane are administered to vertebrates to non-specifically stimulate the immune system.

Abstract: Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological PH, and choline salts.

Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.

Abstract: Guanidine hydrochloride (GCl) is used to remove excess sodium dodecyl sulfate (SDS) from SDS-solubilized protein solutions, and particularly from SDS-solubilized inclusion body solutions, GCl is added to the solution containing SDS to induce the formation of a GCl-SDS complex (GDS) which, when allowed to precipitate, can easily be removed by centrifugation, filtration, or other suitable means.

Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [X.sup.3, Y.sup.8, Z.sup.25, Nle.sup.27 ]-hGRF(1-A)--B, wherein X, Y, and Z are selected from the group consisting of Asn and Asp, A has a value from 29-44, and B is NH.sub.2 or OH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).

Abstract: A high-density fermentation process for high yield production of swine growth hormone by transformant E. coli is described. The process employs transformant strains of E. coli containing an expression vector coding for swine growth hormone under the control of a bacteriophage lambda promoter-operator and an expression vector coding for the cI857 temperature-sensitive repressor protein. In the initial growth period, the level of dissolved oxygen in the fermentation medium is maintained at about 20% to 60% saturation and the temperature of the medium is kept between 26.degree. C. and 30.degree. C. Production of swine growth hormone is then induced by raising the temperature of the medium to about 42.degree. C. The temperature is then reduced to about 40.degree. C. to optimize cell growth for the remainder of the induction period, during which the level of dissolved oxygen in the medium is maintained at about 10% to 40% saturation.

Abstract: This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device (or system). A buffered solution of purified recombinant growth hormone is dialyzed against a buffered solution until the salt level is reduced to less than 5% and then lyophilized.

Abstract: A method for controlling helmintic parasites in animals which comprises administering alone or in combination at least one Resorcylic Acid Lactone (RAL) compound selected from the group consisting of zearalenone, zearalanone, zearalene, zearalane, zearalenol, zearalanol, and dideoxyzearalane to the animal. The RAL compounds are administered to animals infected with or susceptible to infection by helmintic parasites to control the parasite population.

Abstract: Two different ionic forms of somatomedin C (pI 6.4-7.0 and pI 8.3-8.6) are separated and isolated by applying an aqueous solution of somatomedin C to a strong cation-exchange column, eluting the somatomedin C from the column by applying a salt concentration gradient at constant pH and recovering the two ionic forms in different eluant fractions.

Abstract: Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.

Abstract: Purification and solubilization of proteins produced in transformant microorganisms as insoluble, biologically inactive inclusion bodies is effected by solubilizing the inclusion bodies in SDS; treating the SDS-protein solution with urea; removing the SDS and purifying the protein by chromatography on an anion-exchange resin having cationic groups attached to a polysaccharide support; and dialyzing the solution obtained from the anion-exchange resin to remove urea, thereby allowing the protein to fold into its native conformation. The solution thus obtained can be activated by removing soluble protein aggregates via ultrafiltration or chromatography on a weak anion-exchange column.

Abstract: A high density fermentation process for high yield production of bovine growth hormone by transformant E. coli is described. The process employs transformant strains of E. coli containing an expression vector coding for bovine growth hormone under the control of a bacteriophage lambda promoter-operator and a plasmid containing the .lambda.cI857 gene which codes for the temperature-sensitive repressor protein. In the initial growth period, the level of dissolved oxygen in the fermentation medium is maintained at about 20% to 60% saturation and the temperature of the medium is kept at 26.degree.-30.degree. C. Production of bovine growth hormone is then induced by raising the temperature of the medium to at least about 42.degree. C. The temperature is then reduced to about 38.degree. C. to 41.degree. C. to optimize cell growth for the remainder of the induction period, during which the level of dissolved oxygen in the medium is maintained at about 10% to 40% saturation.

Abstract: A method is disclosed for increasing the fluosilicic acid (FSA) recovered from a wet process phosphoric acid manufacturing process. The filtrate obtained by washing a filter cake is pumped to a stripper and reacted with H.sub.2 SO.sub.4 to converting the dissolved FSA to gaseous SiF.sub.4. A defoamer is added to the acid-filtrate mixture to reduce the foam produced by the reaction and increase the amount of gaseous SiF.sub.4 recovered from the reaction. The gaseous SiF.sub.4 is recovered from the acid-filtrate reaction mixture and converted to FSA for commercial use.

Abstract: A growth promoting and feed efficiency-enhancing amount of a lysocellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof is administered to a food-producing animal selected from the group consisting of ruminants, swine and poultry in a process for promoting growth and enhancing feed efficiency of such a food-producing animal.

Abstract: A mixture comprising a dispersion of a water-diffusible solid in a solution of a non-aqueous solvent and a substantially water-insoluble polymer is formed. The non-aqueous solvent is removed from the mixture to substantially dry the mixture, and the substantially dry mixture is comminuted to form particles. A plurality of the particles are formed under pressure to produce a pellet suitable for use as a sustained release implant device.

Abstract: An anti-corrosion coating and pigment therefore, the latter comprising the combination of condensed aluminum phosphate with a comminuted zeolite or silica and process for the preparation thereof.

Abstract: 6' carbonate esters of zearalanol and its derivatives are used to promote growth in ruminants. The compounds have the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R is an alkyl group or a Br or Cl substituted alkyl group having from 1-12 carbon atoms.