Abstract: Various embodiments relate to a resonator system that can be used to monitor proteins, cells, or small molecules in a container. A resonant sensor, embedded in or on the container, can have an inductive element and a capacitive element, where the container and resonant sensor are structured such that, when a concentration of the proteins, cells, or small molecules in the container changes, dielectric permittivity and conductivity of the proteins, cells, or small molecules contributes to capacitance of the resonant sensor to affect a resonant frequency shift of the resonant sensor. Interrogating the resonant sensor can be conducted wirelessly along with wirelessly transmitting data collected from the interrogation. Additional apparatus, systems, and methods are disclosed.
Type:
Grant
Filed:
February 18, 2020
Date of Patent:
August 31, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: A method is provided for separating and/or purifying different metal oxalates by mixing the different metal oxalates in an aqueous solution comprising oxalic acid and an organic base so that at least one metal oxalate is soluble and at least another metal oxalate is not soluble. Different rare earth metal oxalates and/or transition metal oxalates can be separated.
Type:
Grant
Filed:
January 22, 2019
Date of Patent:
August 17, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: The present invention relates to a method of preparing a multiblock copolymer. This method comprises i) providing a block copolymer comprising at least one PA block and at least one PB block, where PA represents a polymer block comprising one or more units of monomer A and PB represents a polymer block comprising one or more units of monomer B, with monomers A and B being the same or different, where the block copolymer contains a chain transfer agent moiety (CTA); ii) providing a radically polymerizable monomer C; and iii) polymerizing the block copolymer with monomer C under conditions effective to achieve a number average degree of polymerization (Nn) for the multiblock copolymer of up to 100,000 without gelation.
Type:
Grant
Filed:
July 7, 2017
Date of Patent:
July 27, 2021
Assignee:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Nacu Hernandez, Eric W. Cochran, Ronald Christopher Williams, Austin Hohmann
Abstract: This work develops a novel microfluidic method to fabricate conductive graphene-based 3D micro-electronic circuits on any solid substrate including, Teflon, Delrin, silicon wafer, glass, metal or biodegradable/non-biodegradable polymer-based, 3D microstructured, flexible films. It was demonstrated that this novel method can be universally applied to many different natural or synthetic polymer-based films or any other solid substrates with proper pattern to create graphene-based conductive electronic circuits. This approach also enables fabrication of 3D circuits of flexible electronic films or solid substrates. It is a green process preventing the need for expensive and harsh postprocessing requirements for other fabrication methods such as ink-jet printing or photolithography. We reported that it is possible to fill the pattern channels with different dimensions as low as 10×10 ?m. The graphene nanoplatelet solution with a concentration of 60 mg/mL in 70% ethanol, pre-annealed at 75° C. for 3 h, provided ˜0.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
July 20, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus (“PEDV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.
Type:
Grant
Filed:
February 26, 2016
Date of Patent:
July 13, 2021
Assignees:
Zoetis Services LLC, Iowa State University Research Foundation, Inc.
Inventors:
Jianqiang Zhang, Qi Chen, Phillip Gauger, Darin Madson, John Morgan Hardham, Meggan Bandrick, Jay Gregory Calvert, James Richard Thompson, Mira Ivanova Stoeva, Walter Valdez
Abstract: In this disclosure, transition and rare earth metal-based magnetic ionic liquids (MILs) are successfully prepared in a two-step synthesis and used to extract viable bacteria from a liquid sample. The disclosed MILs are extremely hydrophobic MILs and were insoluble in aqueous solution at 0.01% (v/v). Furthermore, these MILs were miscible in a variety of polar and non-polar organic solvents. Moreover, these MILs possess low viscosity and increased magnetic susceptibility. These MILs possess unique characteristics that can have great potential uses in various chemical applications such as extraction solvents in LLE, liquid electrochromic materials (Co-based MILs), and novel reaction media for organic synthesis.
Type:
Grant
Filed:
April 11, 2018
Date of Patent:
June 29, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: Apparatus, systems, and methods for enhancing solid propellant performance include seeding combusting energetic material, including solid propellant, with microwave energy at a controlled power and duration.
Type:
Grant
Filed:
March 7, 2017
Date of Patent:
June 22, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: An integrated dual-modality microfluidic sensor chip and methods for using the same. In one form, the sensor comprises a patterned periodic array of nanoposts coated with a noble metal and graphene oxide (GO) to detect target biomarker molecules in a limited sample volume. The device generates both electrochemical and surface plasmon resonance (SPR) signals from a single sensing area of the metal-GO nanoposts. The metal-GO nanoposts are functionalized with specific receptor molecules, serving as a spatially well-defined nanostructured working electrode for electrochemical sensing, as well as a nanostructured plasmonic crystal for SPR-based sensing via the excitation of surface plasmon polaritons.
Type:
Grant
Filed:
January 21, 2019
Date of Patent:
June 1, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Parainfluenza Virus Type 1 (“PPIV-1”), including novel genotypes thereof, all of which are useful in the preparation of immunogenic compositions and vaccines for treating and preventing disease in swine.
Type:
Grant
Filed:
August 30, 2019
Date of Patent:
May 25, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Phillip Gauger, Jie Yeun Park, Karen M. Harmon, Jianqiang Zhang, Pablo Pineyro
Abstract: Systems, methods, and apparatus for meta-materials which are stretchable and tunable using an array of liquid conductor meta-atoms encased in one or more layers of elastomer. Fabrication techniques allow effective manufacture of the metamaterial in a number of form factors for a number of applications, including but not limited to fabrics or wraps around three-dimensional shapes.
Type:
Grant
Filed:
June 30, 2017
Date of Patent:
May 18, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Liang Dong, Peng Liu, Siming Yang, Jiming Song
Abstract: Embodiments of the present disclosure describe an efficient O(n log n) method that implements the Inverse Chirp Z-Transform (ICZT). This transform is the inverse of the well-known forward Chirp Z-Transform (CZT), which generalizes the fast Fourier transform (FFT) by allowing the sampling points to fall on a logarithmic spiral contour instead of the unit circle. Thus, the ICZT can be viewed as a generalization of the inverse fast Fourier transform (IFFT).
Type:
Application
Filed:
January 23, 2020
Publication date:
May 13, 2021
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: The present invention describes novel pharmaceutical compositions and methods for treatment of diseases, disorders, or conditions characterized by recurrent seizures, particularly, epilepsy. According to the invention, compounds which inhibit the activity or expression of non-receptor Fyn tyrosine kinase can prevent activation epileptic pathophysiology and provide protection from and treatment of epilepsy. Particularly preferred is the class of small molecule Fyn kinase inhibitors such as sacaratinib and its prodrugs, derivatives, analogs and the like.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
May 11, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Thimmasettappa Thippeswamy, Anumantha G. Kanthasamy
Abstract: Various embodiments disclosed relate to visually transparent UV-absorbing coatings including ZnO nanoparticles. The coating includes ZnO nanoparticles, hydroxy(C1-C10)alkyl cellulose, a dispersant, and less than about 5 wt % water.
Type:
Grant
Filed:
December 16, 2019
Date of Patent:
April 13, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: Certain embodiments herein relate to educational knee joint models with synthetic medial and lateral menisci disposed thereon. In certain implementations, one of the synthetic menisci has specific type of tear formed therein. Other embodiments relate to educational knee joint treatment platforms having a base, an attachment wall, a coupling component, and a retention strap.
Type:
Grant
Filed:
April 12, 2018
Date of Patent:
April 6, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: Metal-support interaction offers electronic, geometrical and compositional effects to tune and maneuver catalytically active sites. Here we report the first example of a reactive metal support interaction (RMSI) between Pt and various MXenes, which are two-dimensional (2D) metal carbides, nitrides, or carbonitrides. The invention thus provides intermetallic Pt/MXene nanoparticle catalysts comprising platinum and MXene moieties. Pt3Ti and Pt3Nb intermetallic nanoparticle catalysts were prepared by RMSI of Pt nanoparticles supported on Ti3C2 and Nb2C MXenes. The intermetallic structures were verified by XAS, ARSTEM, and XPS. Experimental analysis showed that the extent of alloy formation is temperature dependent. Kinetics analysis revealed that in contrast to Pt/Al2O3, Pt supported by Nb2CTx exhibits weaker CO adsorption and the alloy-MXene interface shows enhanced ability of H2O dissociation for a water gas shift (WGS) reaction at 300° C.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
April 6, 2021
Assignees:
Iowa State University Research Foundation, Inc., Purdue Research Foundation
Abstract: The present invention relates to a compound having the structure of formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.
Type:
Grant
Filed:
July 7, 2017
Date of Patent:
April 6, 2021
Assignee:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Eric W. Cochran, Nacu Hernandez, Michael Forrester, Austin Hohmann
Abstract: The present invention relates to an asphalt product. The asphalt product includes an asphalt binder and a bio-oil blend comprising a mixture of a non-hydrogenated bio-oil and a partially hydrogenated bio-oil, where the bio-oil blend is mixed with the asphalt binder to form an asphalt product having a shear stiffness of 0.20 kPa to 11,000 kPa at a temperature ranging from 25° C. to 85° C. and/or a viscosity of 0.15 Pa·s to 1.50 Pa·s at a temperature ranging from 120° C. to 165° C. The present invention further relates to methods of producing an asphalt product and methods of applying an asphalt product to a surface.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
March 30, 2021
Assignee:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Ronald Christopher Williams, Joseph Herbert Podolsky, Nacu Hernandez, Eric W. Cochran
Abstract: The present invention relates to relates to a method of optimizing a plastic composition formed from a plurality of resin feedstocks. A plurality of resin feedstocks are provided. The plurality of resin feedstocks are blended to form the plastic composition. One or more properties of the plastic composition, including radiation absorption, radiation transmission, gas evolution, radiation fluorescence, or melting properties, are measured. The ratio of the plurality of resin feedstocks being blended into the plastic composition is adjusted, based on said measuring, to form an optimized plastic composition. A system for performing the method is also disclosed.
Type:
Grant
Filed:
April 19, 2019
Date of Patent:
March 23, 2021
Assignees:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., CAL POLY CORPORATION
Inventors:
Keith Vorst, John Wyatt Brown, Jeffrey E. Danes, Greg Curtzwiler
Abstract: A microfluidic device comprising one or more fluidic microchannels and one or more arrays of wireless bipolar electrodes is disclosed. The disclosed microfluidic device can be used to separate cells, especially rare cells, from its biological matrix. The disclosed device can isolate cells in a high-throughput fashion and without any modification or labelling to the cells. Cells isolated using the disclosed devices does not lose their vitality.
Type:
Grant
Filed:
October 25, 2017
Date of Patent:
March 23, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: The present invention relates to a thermoplastic copolymer, block copolymer, and statistical copolymer comprising plural acrylated polyol monomeric units having different degrees of acrylation of hydroxyl groups. The acrylated polyol monomeric units have an average degree of acrylation greater than 1 and less than the number of the hydroxyl groups of the polyol. The present invention also relates to a method of making the thermoplastic copolymer, block copolymer, and statistical copolymer, and using them in various applications, such as asphalt rubber modifiers, adhesives, or an additive in a fracking fluid for oil fracking.
Type:
Grant
Filed:
December 7, 2018
Date of Patent:
March 16, 2021
Assignee:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
Eric W. Cochran, R. Christopher Williams, Nacu Hernandez, Elvira Joana Ferreira Peralta, Michael John Forrester