Patents Assigned to IRONWOOD PHARMACEUTICALS
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Patent number: 9725453Abstract: The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.Type: GrantFiled: September 18, 2014Date of Patent: August 8, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Matthew Gregory Bursavich, Andrew J. McRiner, Amy Ripka, Gideon Shapiro
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Patent number: 9708371Abstract: The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.Type: GrantFiled: August 17, 2012Date of Patent: July 18, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Marco Kessler, Angelika Fretzen, Hong Zhao, Robert Solinga, Vladimir Volchenok
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Patent number: 9657012Abstract: The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.Type: GrantFiled: December 22, 2011Date of Patent: May 23, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Colleen Hudson, Timothy C. Barden, James Jia, Ara Mermerian, Bo Peng, Jane Yang, Xiang Y. Yu, Kevin Sprott, Angelika Fretzen
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Publication number: 20170137439Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: January 16, 2017Publication date: May 18, 2017Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
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Publication number: 20170136019Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: January 16, 2017Publication date: May 18, 2017Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
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Patent number: 9650417Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.Type: GrantFiled: May 11, 2012Date of Patent: May 16, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler
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Publication number: 20170112845Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: May 31, 2016Publication date: April 27, 2017Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE
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Patent number: 9617305Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.Type: GrantFiled: June 8, 2012Date of Patent: April 11, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler, Brian M. Cali
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Publication number: 20170065586Abstract: The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.Type: ApplicationFiled: September 15, 2016Publication date: March 9, 2017Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Takashi NAKAI, Nicholas Robert PERL, Joel MOORE
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Patent number: 9586937Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: July 21, 2016Date of Patent: March 7, 2017Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
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Patent number: 9540380Abstract: The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.Type: GrantFiled: July 17, 2014Date of Patent: January 10, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Richard Chesworth, Gerhard Koenig, Amy Ripka, Gideon Shapiro
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Publication number: 20160375022Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: August 24, 2016Publication date: December 29, 2016Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
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Patent number: 9527887Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.Type: GrantFiled: June 8, 2012Date of Patent: December 27, 2016Assignee: Ironwood Pharmaceutical, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler, Brian M. Cali
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Patent number: 9487508Abstract: The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.Type: GrantFiled: September 19, 2013Date of Patent: November 8, 2016Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: Takashi Nakai, Nicholas Robert Perl, Joel Moore
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Patent number: 9481689Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: March 14, 2014Date of Patent: November 1, 2016Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
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Publication number: 20160213739Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.Type: ApplicationFiled: May 11, 2012Publication date: July 28, 2016Applicant: Ironwood Pharmaceuticals, IncInventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler
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Publication number: 20160175307Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: February 26, 2016Publication date: June 23, 2016Applicant: Ironwood Pharmaceuticals, Inc.Inventors: G-Yoon Jamie IM, Rajesh IYENGAR, Joel MOORE, Angelika FRETZEN
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Patent number: 9309235Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: September 18, 2013Date of Patent: April 12, 2016Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: G-Yoon Jamie Im, Rajesh Iyengar, Joel Moore, Angelika Fretzen
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Patent number: 9303066Abstract: The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.Type: GrantFiled: May 11, 2012Date of Patent: April 5, 2016Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Marco Kessler
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Publication number: 20160051577Abstract: Disclosed herein are novel compositions and methods for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, ?-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.Type: ApplicationFiled: November 3, 2015Publication date: February 25, 2016Applicant: Ironwood Pharmaceuticals, Inc.Inventor: Mark CURRIE