Patents Assigned to IRONWOOD PHARMACEUTICALS
-
Publication number: 20160031903Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG
-
Publication number: 20160015644Abstract: Disclosed herein are novel compositions and methods for controlling the release of bile acid sequestrant to the stomach in order to treat or prevent upper GI tract disorders or disorders of the throat. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant dispersed in a polymeric matrix. The bite acid sequestrant composition may be administered alone or in combination with at least one proton pump inhibitor, and optionally one or more agents chosen from antacids, histamine H2-receptor antagonists, ?-aminobutyric acid-? (GABA-B) agonists, prodrugs of GABA-B agonists, acid pump antagonists, protease inhibitors and GC-C agonists.Type: ApplicationFiled: January 14, 2014Publication date: January 21, 2016Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Vasu SETHURAMAN, David Bruce HEDDEN, Kristen Marie LESKOW
-
Patent number: 9205094Abstract: Compositions comprising a therapeutically effective amount of at least one bile acid sequestrant are disclosed for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. Exemplary bile acid sequestrants include colesevelam, colesevelam hydrochloride, colestipol, sevelamer and combinations thereof. The disclosed methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor.Type: GrantFiled: December 21, 2007Date of Patent: December 8, 2015Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventor: Mark G. Currie
-
Publication number: 20150342954Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: August 12, 2015Publication date: December 3, 2015Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Charles KIM, Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, G-Yoon Jamie IM, Timothy Claude BARDEN, Rajesh R. IYENGAR, Daniel P. ZIMMER, Angelika FRETZEN, Paul Allan RENHOWE
-
Patent number: 9139564Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: December 26, 2012Date of Patent: September 22, 2015Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: Charles Kim, Takashi Nakai, Joel Moore, Nicholas Robert Perl, G-yoon Jamie Im, Timothy Claude Barden, Rajesh R. Iyengar, Daniel P. Zimmer, Angelika Fretzen, Paul Allan Renhowe
-
Publication number: 20150250795Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: April 28, 2015Publication date: September 10, 2015Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE
-
Publication number: 20150232461Abstract: The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.Type: ApplicationFiled: September 19, 2013Publication date: August 20, 2015Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Taakshi NAKAI, Nicholas Robert PERL, Joel MOORE
-
Publication number: 20150175599Abstract: The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.Type: ApplicationFiled: December 22, 2011Publication date: June 25, 2015Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Colleen Hudson, Timothy C. Barden, James Jia, Ara Mermerian, Bo Peng, Jane Yang, Xiang Y. Yu, Kevin Sprott, Angelika Fretzen
-
Patent number: 9061030Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: November 2, 2011Date of Patent: June 23, 2015Assignee: IRONWOOD PHARMACEUTICALS, INC.Inventors: Charles Kim, Takashi Nakai, Thomas Wai-Ho Lee, Joel Moore, Nicholas Robert Perl, Jason Rohde
-
Patent number: 9024069Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.Type: GrantFiled: November 8, 2013Date of Patent: May 5, 2015Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Jeffrey Segal, Nisha Perez, Timothy Claude Barden
-
Publication number: 20150094272Abstract: The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.Type: ApplicationFiled: August 17, 2012Publication date: April 2, 2015Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Marco Kessler, Angelika Fretzen, Hong Zhao, Robert Solinga, Vladimir Volchenok
-
Patent number: 8946158Abstract: The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.Type: GrantFiled: March 14, 2013Date of Patent: February 3, 2015Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Angelika Fretzen, Marco Kessler, Daniel Zimmer
-
Publication number: 20150030697Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.Type: ApplicationFiled: May 11, 2012Publication date: January 29, 2015Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler
-
Publication number: 20150018353Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: December 26, 2012Publication date: January 15, 2015Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Charles Kim, Takashi Nakai, Joel Moore, Nicholas Robert Perl, G-yoon Jamie Im, Timothy Claude Barden, Rajesh R. Iyengar, Daniel P. Zimmer, Angelika Fretzen, Paul Allan Renhowe
-
Publication number: 20140349948Abstract: The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.Type: ApplicationFiled: December 23, 2013Publication date: November 27, 2014Applicants: Forest Laboratories Holdings Limited, Ironwood Pharmaceuticals, Inc.Inventors: Jeffrey Johnston, Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Bernard Joseph Lavins, Mahendra Dedhiya, Harvey Schneier
-
Publication number: 20140348942Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.Type: ApplicationFiled: June 8, 2012Publication date: November 27, 2014Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kassler, Brian M. Cali
-
Publication number: 20140342996Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.Type: ApplicationFiled: June 8, 2012Publication date: November 20, 2014Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler, Brian M. Cali
-
Patent number: 8884020Abstract: Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.Type: GrantFiled: August 7, 2007Date of Patent: November 11, 2014Assignee: Ironwood Pharmaceuticals, Inc.Inventors: John Jeffrey Talley, Kevin Sprott, James Philip Pearson, G. Todd Milne, Wayne Schairer, Jane Yang, Charles Kim, Timothy Barden, Regina Lundrigan, Ara Mermerian, Mark G. Currie
-
Publication number: 20140329765Abstract: Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.Type: ApplicationFiled: December 16, 2013Publication date: November 6, 2014Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Mark G. Currie, Shalina Mahajan-Miklos, Li Jing Sun
-
Publication number: 20140323448Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: April 29, 2014Publication date: October 30, 2014Applicant: Ironwood Pharmaceuticals Inc.Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE, Rajesh R. IYENGAR, Ara MERMERIAN, Angelika FRETZEN