Patents Assigned to IRONWOOD PHARMACEUTICALS
  • Publication number: 20140323397
    Abstract: The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
    Type: Application
    Filed: May 11, 2012
    Publication date: October 30, 2014
    Applicant: Ironwood Pharmaceuticals, inc
    Inventors: Mark G. Currie, Daniel P. Zimmer, Marco Kessler
  • Publication number: 20140296163
    Abstract: Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
    Type: Application
    Filed: September 11, 2013
    Publication date: October 2, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Mark G. Currie, Shalina Mahajan-Miklos, Li Jing Sun
  • Publication number: 20140287034
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 25, 2014
    Applicants: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings Limited
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Publication number: 20140256634
    Abstract: Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler, Brian Cali
  • Patent number: 8802628
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: August 12, 2014
    Assignees: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings, Ltd.
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Patent number: 8779090
    Abstract: Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: July 15, 2014
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Daniel Zimmer, Angelika Fretzen, Mark Currie, G. Todd Milne
  • Publication number: 20140187795
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I).
    Type: Application
    Filed: June 17, 2011
    Publication date: July 3, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: James Jia, Regina Graul, Wayne C Schairer, Vishnu Karnati, Ray Forslund
  • Publication number: 20140179607
    Abstract: The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
    Type: Application
    Filed: November 9, 2010
    Publication date: June 26, 2014
    Applicant: IRONWOOD PHARMACEUTICALS, INC
    Inventors: Mark G. Currie, Angelika Fretzen, Marco Kessler, Daniel P. Zimmer
  • Publication number: 20140162963
    Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.
    Type: Application
    Filed: September 9, 2011
    Publication date: June 12, 2014
    Applicants: Forest Laboratories Holdings Limited, Ironwood Pharmaceuticals, Inc.
    Inventors: Jeffrey Johnston, Bernard Joseph Lavins, Harvey Schneier
  • Patent number: 8748442
    Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: June 10, 2014
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles Kim, Takashi Nakai, Thomas Wai-Ho Lee, Joel Moore, Nicholas Robert Perl, Jason Rohde, Rajesh R Iyengar, Ara Mermerian, Angelika Fretzen
  • Patent number: 8748573
    Abstract: The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: June 10, 2014
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Patent number: 8735360
    Abstract: Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: May 27, 2014
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Mark G. Currie, Daniel P. Zimmer, Angelika Fretzen, Marco Kessler, Brian Cali
  • Publication number: 20140135295
    Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 15, 2014
    Applicant: IRONWOOD PHARMACEUTICALS
    Inventors: Jeffrey Segal, Nisha Perez, Timothy Claude Barden
  • Publication number: 20140105851
    Abstract: Disclosed herein are novel compositions and methods for treating or preventing GI tract disorders and/or GERD-related respiratory disorders as well as protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, ?-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 17, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventor: Mark G. CURRIE
  • Publication number: 20140088071
    Abstract: Compounds of Formula (IA) and Formula (IB) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: November 2, 2011
    Publication date: March 27, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi Nakai, Thomas Wai-Ho Lee, Charles Kim, Joel Moore, Nicholas Robert Perl, Jason Rohde
  • Patent number: 8674115
    Abstract: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: March 18, 2014
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Ara Mermerian, Bo Peng, Colleen Hudson, Charles Kim, Joel Moore, Jason Rohde, Kevin Sprott, Regina Graul, Takashi Nakai, James Jia, Wilmin Bartolini
  • Publication number: 20140024593
    Abstract: The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 23, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventor: Ironwood Pharmaceuticals, Inc.
  • Publication number: 20140005128
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: August 11, 2011
    Publication date: January 2, 2014
    Applicants: Forest Laboratories Holdings Limited, Ironwood Pharmaceuticals, Inc
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Publication number: 20130338063
    Abstract: Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
    Type: Application
    Filed: March 22, 2012
    Publication date: December 19, 2013
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Mark G. Currie, Shalina Mahajan-Miklos, Li Jing Sun
  • Publication number: 20130259830
    Abstract: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 3, 2013
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Timothy Barden, Colleen Hudson, James Jia, Charles Kim, Regina Graul, Ara Mermerian, Joel Moore, Kevin Sprott, Yueh-tyng Chien