Abstract: A medical heat exchanger includes a thin tube bundle 2 in which a plurality of heat transfer thin tubes 1 for letting heat medium liquid flow therethrough are arranged and stacked, seal members 3a to 3c sealing the thin tube bundle while allowing both ends of the heat transfer thin tubes to be exposed and forming a blood channel 5 which allows blood to flow therethrough so that the blood comes into contact with each outer surface of the heat transfer thin tubes; a housing 4 containing the seal members and the thin tube bundle and provided with an inlet port 8 and an outlet port 9 of the blood positioned respectively at both ends of the blood channel; and a pair of heat transfer thin tube headers 6, 7 forming flow chambers 14a, 14b, 15a, 15b that respectively surround both ends of the thin tube bundle and having an inlet port 6a and an outlet port 7a of the heat medium liquid.

Abstract: A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.

Abstract: A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

Abstract: A connector (1) that can be connected to a first container and a second container (20) to transfer a liquid between the first container and the second container (20) includes a first connecting portion (3) that is engageable with the first container and a second connecting portion (4) that is engageable with the second container (20). The second connecting portion (4) is integrally provided with an engagement portion that is engageable with the second container (20) and a needle-like portion (7) for piercing into the second container (20). Thus, it is possible to prevent a container from falling off during liquid transfer. Also, since the needle-like portion (7) is integral with the second connecting portion (4), connection to the second container (20) is facilitated.

Abstract: The present invention provides a separation container capable of preventing contamination with unnecessary components and efficiently separating a separation subject.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A device for measuring oral cavity pressure includes the following: a pressure measuring probe 1 having a configuration in which a balloon 4 made of an elastic material is supported by a balloon base 5; a communicating member having an inner bore that communicates with the inside of the balloon via the balloon base to transmit the air pressure in the balloon; and a pressure detecting unit 8 that is connected to the rear end of the communicating member and detects the transmitted air pressure. The balloon includes a pressure receiving portion 4a that forms a cavity and a balloon tubular portion 4b that communicates with the inside of the pressure receiving portion, and the balloon is joined to the front end portion of the balloon base with the balloon tubular portion. The balloon base has a rib 5c that protrudes outward along the outer circumferential direction of the front end portion on the balloon side.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord blood hematopoietic stem cells and the acceleration of the proliferation of the same as desired.

Abstract: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord blood hematopoietic stem cells and the acceleration of the proliferation of the same as desired.

Abstract: The present invention is a peritoneal function testing method characterized by using a ratio MTACun/MTACc calculated using MTACun and MTACc as an index for a peritoneal function test, where MTACun is an overall mass transfer-area coefficient for urea nitrogen and MTACc is an overall mass transfer-area coefficient for creatinine. The use of MTACun/c of the present invention in this way enables examination of the future peritoneal function of a patient (a mechanism of deterioration in peritoneal function). To be specific, MTACun and MTACc can be obtained by computing Pyle-Popovich model. In addition, the peritoneal function testing method may further calculate a permeability coefficient for cell pores (LPSC) and an overall permeability coefficient (LPS) from Three-Pore Theory model while obtaining a ratio LPSC/LPS calculated using the LPSC and the LPS, and may use the LPSC/LPS ratio and the MTACun/MTACc ratio as indexes for the peritoneal function test.

Abstract: A peritoneal function testing method uses a ratio of MTACun/MTACc, calculated using MTACun and MTACc, as an index for a peritoneal function test, wherein MTACun is an overall mass transfer-area coefficient for urea nitrogen and MTACun is an overall mass transfer-area coefficient for creatinine. The use of MTACun/MTACc enables examination of the future peritoneal function of a patient (a mechanism of deterioration in peritoneal function). To be specific, MTACun and MTACc can be obtained by computing a Pyle-Popovich model. In addition, the peritoneal function testing method further calculates a permeability coefficient for cell pores (LpSC) and an overall permeability coefficient (LPS) from a Three-Pore Theory model while obtaining a ratio of LPSC/LPS calculated using the LPSC and the LPS. The LPSC/LPS ratio and the MTACun/MTACc ratio can be used as indexes for the peritoneal function test.

Abstract: A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.

Abstract: It is intended to provide an apparatus for separating and storing blood components which facilitates the preparation of serum.

Abstract: A conduit tube (90) that communicates with an intracardiac blood inflow port (50) and a liquid medicine injection port (72) and allows blood from the intracardiac blood inflow port and a liquid medicine from the liquid medicine injection port to flow into a cardiotomy section (2) is inserted from above downward in the cardiotomy section 2. A blood flow channel (93) for the flow of blood and a liquid medicine flow channel (95) for the flow of a liquid medicine are formed independently of each other in the conduit tube. With respect to the vertical direction, the lower end of a blood conduit tube portion (94) that forms the blood flow channel is located at a lower position than the lower end of a liquid medicine conduit tube portion (96) that forms the liquid medicine flow channel. This prevents the generation of negative pressure in the liquid medicine flow channel due to the flow of blood. It also reduces the resistance to the inflow of a liquid medicine into the cardiotomy section.

Abstract: A cylindrical body (30) that is inserted into a drug solution container (70), a connection port (15) to which a syringe (40) is connected, and a connector (50) that is connected to a port (110) of an infusion bag (100) communicate with a cavity (11) of a delivery device main body (10). A first check valve (21) that functions to permit the flow of drug solution toward the cavity from the drug solution flow path and restrict the flow of drug solution in the opposite direction is provided on a flow path between a drug solution flow path (31) of the cylindrical body and the cavity. A second check valve (22) that functions to permit the flow of drug solution toward the connector from the cavity and restrict the flow of drug solution in the opposite direction is provided on a flow path between the connector and the cavity. Drawing a plunger (45) of the syringe in and out enables a drug solution (72) contained in the drug solution container to be efficiently transferred to the infusion bag.

Abstract: An impeller 22 includes a rotating shaft 7 supported rotatably by an upper bearing 9 and a lower bearing 20 at upper and lower ends, a plurality of vanes 6, an arm 18 coupling an inner circumferential side of the vanes to the rotating shaft, an annular coupling portion 8 coupled to an outer circumferential side of each vane, and a driven magnet portion 12 placed in a lower portion of the annular coupling portion. A drive magnet portion 16 provided at a rotor 13 and a driven magnet portion 12 are opposed to each other with a bottom wall of the housing interposed therebetween, and rotation of the rotor is transmitted to the impeller through magnetic coupling. A blockade member 23 is placed below the vanes and blocks a space in a region spreading between the rotating shaft and the annular coupling portion while leaving an opening 14 at least around the rotating shaft.