Abstract: A robotic system to assist a surgeon during ankle fracture procedures includes an imaging system configured to be at least one of mounted on or arranged adjacent to a robotic device. The system includes a passive arm, a separate actuatable section, and a controller configured to communicate with the actuatable section. The passive arm is structured to be placed on a side of a patient's leg fixed to a platform and the passive arm comprises a fastening mechanism structured to be attached to a tibia of the patient's leg. The actuatable section is structured to be placed on a side of said patient's leg fixed to the platform and the actuatable section comprises a fastening mechanism structured to be attached to a fibula of the patient's leg.

Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3? untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3? UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm.

Abstract: A computer-implemented method includes: receipt and accession of magnetic field data from a constellation of satellites providing global coverage over the Earth in a time span less than one day; inter-calibrating the magnetic field data from all satellites to a common standard; quantifying the global magnetic disturbance and selecting quiescent intervals at least as short as one day for evaluation of Earth's internally-generated field; calculating global maps of the mean vector magnetic field for each quiet interval from the average of all satellite measurements in angular bins; converting the time sequence of global maps of the mean fields to time series of angular harmonic coefficients via direct convolution; applying spectral and regression analysis to the harmonic coefficient time series to identify and remove artifacts in the signals; reconstructing a continuous time and spatial representation of the magnetic field continuous in time and angular position globally.

Abstract: Coating compositions include a binder that has a first polymeric material that does not undergo ultraviolet (UV) degradation and/or does not absorb UV radiation/light. The coating compositions may further include at least a first UV-reflective pigment dispersed throughout the binder. The coating compositions may be provided in a cured form as a solid coating layer that may overly at least a portion of a substrate.

Abstract: An antenna assembly may include a shape change antenna configured to transmit an electromagnetic wave or receive an electromagnetic wave. The shape change antenna may have an antenna shape and may be formed of a conductive shape memory material that physically moves in response to changes in a non-geometric characteristic. The antenna assembly may also include a shape change stimulator configured to change the non-geometric characteristic of the shape change antenna to cause the antenna shape to physically change between a first geometry and a second geometry.

Abstract: The present disclosure provides methods for sorting retinal cells for use in cellular component transfer therapy, sorted populations of retinal cells generated by such methods, and compositions comprising such sorted populations of retinal cells. The present disclosure also provides uses of sorted populations of retinal s and compositions comprising thereof for preventing and/or treating inherited retinal degenerative diseases.

Abstract: A surgical instrument may include a multi-lumen catheter configured to be inserted within the tissue. The multi-lumen catheter may include a first lumen that may enable a flow of a fluid, a second lumen that may receive a navigation probe that may facilitate an ability to locate the region of interest within the tissue, and an expandable membrane that may be situated toward a distal end of the first lumen to form an expandable cavity. The expandable cavity may be configured to expand or contract based on the flow of the fluid through the first lumen. The surgical instrument may include a fluid line, coupled to the first lumen, that may supply the fluid to the first lumen to enable the expandable cavity to expand or withdraw the fluid from the first lumen to enable the expandable cavity to contract.

Abstract: A device may obtain imaging data. The imaging data that is obtained depicts one or more body parts of a patient. A voltage sensitive dye may be applied to stain nerve tissue associated with the one or more body parts of the patient. The voltage sensitive dye may be activated by neuromodulation applied to stimulate the nerve tissue. The imaging data may capture a fluorescence of the nerve tissue based on the voltage sensitive dye being activated by neuromodulation. The device may provide the imaging data for display.

Abstract: We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% (95% CI, 84% to 99%) of 47 patients. The fractions of patients with detectable tumor DNA in early- and late-stage disease were 100% (n=10) and 95% (n=37), respectively. Saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in the saliva and plasma is a valuable biomarker for detection of HNSCC.

Abstract: Poly(ADP-ribose) (PAR) is a protein implicated in numerous neurodegenerative disease states including Parkinson's disease (PD). To date, no routine laboratory test has been developed to diagnosis, assess or monitor patients suffering from PD. Disclosed herein a novel method to assess the PAR concentration in the cerebral spinal fluid (CSF) of a patient and correlate that concentration to the medical condition of a patient with PD. Also disclosed is the use of PAR as a biomarker for PD.

Abstract: A sensor for measuring ocean water salinity is described. The sensor may include a measurement clock circuit, a control clock circuit, and a comparator circuit. The measurement clock circuit, having an output that varies with salinity of a fluid, may have a first circuit architecture that includes a capacitive gap assembly that permits a fluid to flow into a gap between two electrodes of the capacitive gap assembly. The control clock circuit, having an output that does not vary with salinity of the fluid, may have a second circuit architecture comprising a capacitor. The comparator circuit may be configured to compare the controlled clock output to the measured clock output over a duration of time to determine a salinity measurement of the fluid.

Abstract: In some aspects, a device may receive measurement data associated with a measurement subject. The device may determine an adsorption isotherm for the measurement subject based on the measurement data. The device may determine a thermodynamic adsorption capacity of the measurement subject based on the adsorption isotherm. The device may determine a surface area value associated with the measurement subject based on the thermodynamic adsorption capacity. The device may provide an output based on the adsorption capacity or the surface area value associated with the measurement subject.

Abstract: A method of creating a virtual asset based on an existing real-world asset is disclosed. The method includes digitally sequencing the existing real-world asset to create a digital sequence of the real-world asset; tokenizing the digital sequence of the real-world asset to create a tokenized digital sequence; associating the tokenized digital sequence with the real-world asset; and creating a title of ownership of the tokenized digital sequence.

Abstract: Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element; accessing a computer-readable reconstruction of the being's anatomy; accessing a computer-readable reconstruction of an implant; detecting a location of a pointer tool comprising a trackable element with the detector, where the pointer tool is associated with a location of an anatomical feature of interest; accessing at least one computer-readable reconstruction of a trace, the trace corresponding to a geometry of the anatomical feature of interest; and superimposing the at least one updatable, computer-readable trace on the second computer-readable reconstruction of the implant.

Abstract: Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.

Abstract: A bifunctional linker of Formula 1 wherein in Formula I, at least one of R1 to R4 is —COOR5 and R5 is —C0-C10alkyl(C2-C10alkynyl) or —C0-C10alkyl-C2-C10alkenyl(C2-C10alkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

Abstract: A device may receive an X-ray image captured by a C-arm CBCT device at a particular position defined by a six-degree of freedom pose relative to an anatomy, and may process the X-ray image, with a machine learning model, to determine a predicted quality of next possible X-ray images provided by the C-arm CBCT device. The device may utilize the machine learning model, to identify a particular X-ray image, of the next possible X-ray images, with a greatest predicted quality and to update the six-degree of freedom pose based on the particular X-ray image. The device may provide, to the C-arm CBCT device, data that identifies the updated six-degree of freedom pose to cause the C-arm CBCT device to adjust to a new position based on the updated six-degree of freedom pose.

Abstract: A device may receive images of a patient, and may perform segmentation of surfaces on the images to create a 3D model. The device may identify normal tissue regions and atrial fibrosis (AF) regions in the 3D model, and may divide the 3D model into the normal tissue regions and the AF regions. The device may assign first cell and tissue properties to the normal tissue regions, and may assign second cell and tissue properties to the AF regions. The device may perform simulations on the normal tissue regions and the AD regions, based on the first and second cell and tissue properties, to generate simulation results, and may extract first features from the simulation results. The device may extract second features from the images, and may process the first and second features, with a model, to select a feature that is predictive of atrial fibrillation recurrence.

Abstract: A user device may receive video associated with a patient, wherein the video depicts physiological activity involving the patient. The user device may receive profile information associated with the patient. The user device may obtain, from the video, image data using an image processing model. The user device may analyze the image data to generate a patient signature associated with the image data, wherein the patient signature is representative of the physiological activity. The user device may access a reference data structure that includes a plurality of reference signatures. The user device may identify that the patient signature is associated with a reference signature of the plurality of reference signatures, wherein the reference signature is associated with a health condition. The user device may perform an action associated with the health condition and the patient.

Abstract: A device may include an image capturing component to obtain images of an environment of a user, and a light projection system. The light projection system may include a laser source and an optical imager. The device may process, in real-time, images captured by the image capturing component to derive signals for controlling the laser source, provide the signals to the laser source to enable the laser source to generate a laser beam pattern, cause the optical imager to raster scan the laser beam pattern to an absorptive element. The absorptive element may be disposed on or in the user, and positioned proximate to a region-of interest, of the user, that includes neuronal cells. The laser beam pattern may cause the absorptive element to produce acoustic energy that cause depolarization of the neuronal cells. The sensory stimulation may enable the user to visually and/or auditorily perceive the environment.