Abstract: An anatomy visualization device may include a display, an optical sensor, and processing circuitry. The processing circuitry may be configured to capture, via the optical sensor, body registration points on a body of an individual, receive external anatomical measurements of the body, apply the external anatomical measurements to a body shape model, and determine an organ placement prediction for the body based on the application of external anatomical measurements to the body shape model. The organ placement prediction may include organ position information, organ size information, and organ shape information for a plurality of organs. The processing circuitry may also align the organ placement prediction with the body registration points and render, on the display, the organ placement prediction in alignment with the body registration points as an augmented reality object on the body.

Abstract: An anion exchange resin includes a cross-linked polymer having a plurality of pseudo +2 point charges including dicationic groups. The dicationic groups include a first cationic group and a second cationic group, and a distance between the first cationic group and the second cationic group is from about 1 Angstrom to about 10 Angstroms.

Abstract: A Flettner rotor that employs localized suction over its surface improves performance and fuel efficiency. Simulations and analysis show that such a method can significantly improve the performance of the Flettner rotor. Improvements in rotor performance enable reduction in fuel costs and greenhouse gas emission by ships or other modes of transport. Improvements in rotor performance can also reduce noise for applications such as drones or other devices having rotors.

Abstract: An electrostatic probe for positioning an insect specimen is disclosed herein. The electrostatic probe may include an ion generator, a handling end, and a controller. The controller may be configured to: activate the ion generator to produce a electrostatic field at the handling end, wherein the electrostatic field is to attract a specimen to the handling end or hold the insect specimen at the handling end, and discharge the electrostatic field to cause the insect specimen to be released from the handling end.

Abstract: Disclosed herein are systems and methods of making flexible fiber batteries. The fiber batteries are amenable for deployment in textiles, for example, wearable fabrics. The fiber battery can be used to provide power to wearable electronic devices. The fiber battery disclosed herein can be a sub-millimeter (mm) diameter active battery stack having a coating that provides a fiber having a diameter of up to 1 mm that can be woven, stitched, knitted, or otherwise incorporated into a fabric.

Abstract: Methods, systems, apparatus, and computer programs, for processing images through multiple neural networks that are trained to detect a pancreatic ductal adenocarcinoma. In one aspect, a method includes actions of obtaining a first image that depicts a first volume of voxels, performing coarse segmentation of the first image using a first neural network trained (i) to process images having the first volume of voxels and (ii) to produce first output data, determining a region of interest of the first image based on the coarse segmentation, performing multi-stage fine segmentation on a plurality of other images that are each based on the region of interest of the first image to generate output data for each stage of the multi-stage fine segmentation, and determining based on the first output data and the output data of each stage of the multi-stage fine segmentation, whether the first image depicts a tumor.

Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NANPNVDPNANPNVD (SEQ ID NO:2) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria. Alternatively, the immunogen may be administered to an individual having or at risk of having Plasmodium falciparum blood stage parasitemia. In some cases, the immunogen can be administered in combination with another therapeutic agent for treating malaria of Plasmodium falciparum blood stage parasitemia.

Abstract: A device for electrically connecting with and holding organoids includes a substrate and a multielectrode array (MEA) attached to said substrate. The MEA includes an electrical bus attached to the substrate, and a plurality of leaflets each having a first end pivotably connected to the electrical bus while remaining portions thereof are free to move relative to the substrate while remaining connected and pivoting at each first end. Each leaflet of the plurality of leaflets includes an electrical wire embedded therein that extends from each respective leaflet into the electrical bus. The MEA has a size that is suitable to electrically connect to and hold an organoid that is between 250 ?m to 2 cm while at least one leaflet of the plurality of leaflets is pivoted up away from the substrate so as to securely hold the organoid in place and form a three-dimensional electrical connection with the organoid.

Abstract: A rapid material development process for a powder bed fusion additive manufacturing (PBF AM) process generally utilizes a computational fluid dynamics (CFD) simulation to facilitate selection of a simulated parameter set, which can then be used in a design of experiments (DOE) to generate an orthogonal parameter space to predict an ideal parameter set. The orthogonal parameter space defined by the DOE can then be used to generate a multitude of reduced volume build samples using PBF AM with varying laser or electron beam parameters and/or feedstock chemistries. The reduced volume build samples are mechanically characterized using high throughput techniques and analyzed to provide an optimal parameter set for a 3D article or a validation sample, which provides an increased understanding of the parameters and their independent and confounding effects on defects and microstructure.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: Imaging and radiotherapeutics agents targeting fibroblast-activation protein-? (FAP-?) and their use in imaging and treating FAP-? related diseases and disorders are disclosed.

Abstract: Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies. Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with PCR employing a single primer pair. Using this approach, samples containing as little as 4% trisomy 21 DNA could be readily distinguished from euploid samples.

Abstract: An analyzing platform may obtain a first image of a liquid in a receptacle. The analyzing platform may analyze the first image to determine a first set of visual characteristics concerning the liquid. The analyzing platform may obtain a second image of a rectal sample in the liquid in the receptacle, wherein the rectal sample originated from a bowel of a subject. The analyzing platform may analyze the second image to determine a second set of visual characteristics concerning the rectal sample. The analyzing platform may determine, based on the first set of visual characteristics and the second set of visual characteristics, rectal sample information. The analyzing platform may cause one or more actions to be performed based on the rectal sample information.

Abstract: Provided herein are methods for increasing the therapeutic efficiency of oncolytic bacterial therapeutics. Bacterial oncolytic therapies, especially the ones targeting tumor hypoxia such as C. novyi-NT, often encounter incomplete tumor clearance in less hypoxic tumoral areas and severe inflammatory reactions. In this study, we explored immune-modulating preconditioning to suppress the host neutrophils and significantly enhanced the antitumor efficacy of C. novyi-NT in animal models, including an orthotopic brain tumor model in rabbits. The optimized preconditioning agent, hydroxyurea, is clinically approved and C. novyi-NT has demonstrated manageable safety and promising antitumor responses in clinical trials. Thus, the proposed preconditioning of neutrophil suppression is readily translatable to patients undergoing C. novyi-NT trials or other oncolytic biologic therapies and could improve outcome.

Abstract: A method for constructing a multifunctional antenna structure configured to generate a plurality of radiation patterns includes determining a desired source field associated with the plurality of radiation patterns, and receiving feed locations for a waveguide to an antenna aperture surface. The method may further include placing a metasurface resonator at a first resonator location that exhibits a minimum error relative to the desired source field and satisfies a maximum error threshold relative to the desired source field. The metasurface resonator may be determined based on the feed locations and a plurality of degrees of freedom for the first resonator location. The method may also include discarding a second resonator location in response to determining that no metasurface resonator at the second resonator location satisfies the maximum error threshold. The plurality of degrees of freedom may include metasurface resonator geometries that exhibit different polarizabilities defined in a candidate library.

Abstract: A computer-implemented method for training and using a neural network to predict a coherence function includes: training a neural network by mapping a plurality of different sets of training input samples to respective coherence function truths to generate a trained neural network; receiving an operational input sample; inputting the operational input sample into the trained neural network; obtaining, from the trained neural network, a coherence function mapped to the operational input sample in response to the inputting the operational input sample into the trained neural network; and executing a computer-based instruction based on obtaining the coherence function. The coherence function may be used to differentiate solid masses from fluid-filled masses.

Abstract: A LUS robotic surgical system is trainable by a surgeon to automatically move a LUS probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2D ultrasound image slices captured by the LUS probe according to stored instructions are processable into a 3D ultrasound computer model of an anatomic structure, which may be displayed as a 3D or 2D overlay to a camera view or in a PIP as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. Virtual fixtures are definable so as to assist the surgeon in accurately guiding a tool to a target on the displayed ultrasound image.

Abstract: A system for performing private information retrieval may include a data requesting computer that is configured to receive a query string, homomorphically encrypt the query string to generate an encrypted query, transmit the encrypted query to a data repository computer, and receive resultant encrypted datasets. The data repository computer may be configured to access a database comprising a plurality of datasets, receive the encrypted query, and perform a search of the plurality of datasets to identify the resultant encrypted datasets that include data that matches the encrypted query for provision to the data requesting computer. The search may be performed such that encryption of the encrypted query is maintained while performing computational operations of the search.

Abstract: Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.

Abstract: A radiator (RAD) enhanced geothermal system (EGS) may comprise a radiator vane heat exchanger (RVHE). The RVHE may be configured to be located in a plane defined by an injector well and a production well that is defined by a principal stress direction (S1) of a plurality of principal stress directions and a maximum horizontal stress component (SHmax). The RVHE may include one or more stacked laterals oriented along SHmax. Each stacked lateral, of the one or more stacked laterals, may include one or more vertical branches oriented along S1. The RVHE may be configured to extract energy from a non-hydrothermal source of energy.