Abstract: Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off-target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

Abstract: The present invention relates to compositions and methods for treating neurodegenerative conditions using GLP-1r agonists. In certain embodiments, long-acting GLP-1r agonists have neuroprotective and disease modifying effects on the central nervous system.

Abstract: The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and compositions for treating disorders associated with Resistin. In a specific embodiment, the present invention provides an antibody that binds human Resistin.

Abstract: A method of additive manufacturing. The method comprises: i) positioning porous particles on a substrate, the porous particles having an average porosity and comprising at least one material chosen from metals and metalloids; ii) heating at least a portion of the porous particles to a reaction temperature; and iii) exposing the porous particles to a reactant gas to form a layer comprising a non-oxide ceramic. A method of making porous particles is also disclosed.

Abstract: Described are methods for treating or preventing a neurological disease in a subject. The methods include administering a suppressor of hemichannel permeability to a subject having or prone of getting a neurological disease. The methods include the treatment and prevention of amyotrophic lateral sclerosis (ALS).

Abstract: Described are methods for treating or preventing IBS in subjects by administering molybdenum or a salt thereof to subjects having or prone of getting IBS. The molybdenum has been shown to treat or prevent IBS in subjects administered this agent when compared to reference subjects not administered molybdenum.

Abstract: The present disclosure provides compositions and methods including modular material controllers that combine amplification with logic, translation of input signals, and response tuning to directly and precisely program dramatic material size changes. In particular, the present disclosure provides locked gels having a polymer with a nucleic acid cross link and a nucleic acid lock in a locked conformation preventing the locked gel from reacting with other nucleic acid sequences and methods of unlocking the locked gels by adding a nucleic acid key to the locked gel or by changing an inactive nucleic acid key into an active nucleic acid key with a trigger.

Abstract: The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. Refractory coatings can be formed from refractory metal, metal oxide, or metal/metal oxide composite refractory coating precursor of the 9 refractory metals encompassed by groups 4-6 and periods 4-6 of the periodic table; non-metallic elements (e.g. Si & B) and their oxides (i.e. SiO2 & B2O3) are also pertinent. The conversion of the refractory coating precursor to refractory carbide, nitride or boride is achieved via carburization, nitridization, or boridization in the presence of carbon-containing (e.g. CH4), nitrogen containing (e.g. NH3), and boron-containing (e.g. B2H6) gaseous species. Any known technique of applying the refractory coating precursor can be used.

Abstract: A battery housing may include a primary vent channel, auxiliary vent channels, and receptacles for receiving cells. Each receptacle may have sidewalls that operate as barriers to cell venting events occurring in other receptacles, an auxiliary vent channel opening to a respective auxiliary vent channel, and a primary vent channel opening to the primary vent channel. Each primary vent channel opening may be aligned with a position of a vent valve of a cell disposed within a respective receptacle such that internal substances expelled from the vent valve or a rupture at the vent valve in an associated vent direction are directed into the primary vent channel. Each auxiliary vent channel opening is not aligned with a respective primary vent channel opening and a respective position of a vent valve.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for detecting and treating prostate cancer. In a specific embodiment, a method for identifying a patient as having aggressive prostate cancer comprising the step of detecting overexpression relative to a control of epithelial cell adhesion molecule (EpCAM), H4 clustered histone 5 (H4C5), and tetratricopeptide repeat domain 3 (TTC3) in a urine sample obtained from the patient. In a more specific embodiment, the detecting step comprises detecting protein or ribonucleic acid (RNA) level of EPCAM, H4C5 and TTC3. In another specific embodiment, the method further comprises detecting overexpression relative to a control of one or more of messenger ribonucleic acid (mRNA), circulating RNA (circRNA), extracellular DNA and long non-coding RNA (lncRNA). The method can further comprise detecting metabolites.

Abstract: A minimally invasive magnetic vocal fold manipulator system and method is disclosed. Namely, a magnetic vocal fold manipulator system is provided that includes a magnetics-based thyroid cartilage implant, a magnetics-based arytenoid cartilage implant, and an implant introducer device. Additionally, a method is provided of using the minimally invasive magnetic vocal fold manipulator system for performing lateralization and/or medialization of the vocal cord.

Abstract: Self-adaptive systems, uses of the systems, and methods for adapting one or more properties of a material are disclosed.

Abstract: Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“RGUI”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first RGUI to be displayed on a display of the mobile device based on the determining.

Abstract: The present invention has developed methods and compositions utilizing the cell surface CD107a (LAMP-1) as a marker that divides bone-forming and fat-forming progenitor/stem cells within human adipose tissue. The present invention is able to partition stromal progenitors for improved bone and soft tissue engineering and therapies.

Abstract: A device for magnetic resonance artifact correction includes an array of shim coils sequentially arranged to receive a current, such that a first force arising from an interaction of a magnetic field with the current in one shim coil is balanced by a second force on the array arising from interactions of the magnetic field with the current in other shim coils when the array is operated within an imaging volume of a magnetic resonance system. The device includes a frame of non-ferromagnetic material, to provide selectable positioning of the array, and a signal processor to use a measurement of a magnetic field inhomogeneity within a region of the imaging volume, to determine a current for the shim coils and coordinates for positioning the array within the imaging volume, such that applying the current to the array at the coordinates generates a correction field to reduce the magnetic field inhomogeneity.

Abstract: A submersible vehicle may include a propulsion assembly, a pressure vessel, and a floodable actuator vessel. A bulkhead may seal a pressure shell of the pressure vessel to prevent fluid intrusion into an interior cargo compartment of the pressure shell when the submersible vehicle is submersed into a fluid. The floodable actuator vessel may be coupled to the pressure vessel and may include a floodable shell and a plurality of actuators. The floodable shell may include a plurality of flood openings configured to permit fluid intrusion into an interior flood space of the floodable shell when the submersible vehicle is submersed into a fluid. Each actuator may be disposed within the interior flood space and affixed to an interior surface of the floodable shell at an actuator opening through which an external fin is actuated to maneuver the submersible vehicle in coordination with the propulsion assembly.

Abstract: A microcapsule includes an oxime-based polymerization product of two or more monomers and a payload. The payload may be encapsulated within the microcapsule. The oxime-based polymerization products may include an oxime-based monomer and an isocyanate-based monomer. Methods of making such microcapsules and methods of delivering a payload to a target using such microcapsules are provided.

Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

Abstract: Provided herein are methods of determining a cognitive load of a sensorized device user in certain aspects. Provided herein are also methods of adjusting an interface between a user and a sensorized device in some aspects. Related devices, systems, and computer program products are also provided.

Abstract: An insect trap analysis system may detect an insect specimen on a trap mechanism of an insect trap. The insect trap analysis system may control, based on detecting the insect specimen on the trap mechanism, one or more mechanical devices to: adjust a position of the insect specimen relative to a position of an image capture device associated with the insect trap, or adjust the position of the image capture device relative to the position of the insect specimen. The insect trap analysis system may cause, while controlling the one or more mechanical devices to adjust the position of the image capture device or the position of the insect specimen, the image capture device to capture a plurality of images of the insect specimen from a plurality of different angles relative to the insect specimen, and may perform an action associated with the plurality of images.