Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

Abstract: Described herein are methods for identification/discovery of protein biomarkers for chronic kidney disease (CKD) and diagnosing and/or prognosing and/or predicting progression of and/or treating chronic kidney disease (CKD).

Abstract: The present invention is directed to a system to improve the safety of robotically assisted minimally invasive surgery. The system includes an endoscope holder, an accelerometer, and a controller. The accelerometer is configured to track motion of the patient's head and transmit that information to the controller. The controller is configured to operate the endoscope holder. When the accelerometer detects patient head movement, the controller then retracts the endoscope, via the endoscope holder. The system of the present invention can be used for endoscopic surgery for otolaryngology and neurosurgery. It can also be used for other surgical situations with similar requirements and constraints.

Abstract: Methods for identifying compounds in the treatment of muscular dystrophies, include the use of disease relevant cells derived from a patient. Compounds identified by these methods are useful in the treatment of muscular dystrophy.

Abstract: A method for adjusting laser control parameters of a laser additive manufacturing system for construction of a part is provided. The method may include performing a laser scan of a building surface, and detecting spectral and intensity response information indicative of at least a temperature at the building surface. The method may also include correlating the spectral and intensity response information with spatial positioning of the laser during the laser scan to generate spatially-correlated spectral and intensity response information.

Abstract: A device may receive, from an imaging device, a two-dimensional image of a patient being operated on by a user, where the two-dimensional image captures a portion of the patient, and where the portion of the patient is provided between a focal point of an imaging source of the imaging device and a detector plane of the imaging device. The device may translate the two-dimensional image along a frustum of the imaging source, and may generate one or more images in a three-dimensional space based on translating the two-dimensional image along the frustum of the imaging source. The device may provide the one or more images in the three-dimensional space to an augmented reality device associated with the user.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria.

Abstract: An audio analysis platform may receive a portion of an audio input, wherein the audio input corresponds to audio associated with a plurality of speakers. The audio analysis platform may process, using a neural network, the portion of the audio input to determine voice activity of the plurality of speakers during the portion of the audio input, wherein the neural network is trained using reference audio data and reference diarization data corresponding to the reference audio data. The audio analysis platform may determine, based on the neural network being used to process the portion of the audio input, a diarization output associated with the portion of the audio input, wherein the diarization output indicates individual voice activity of the plurality of speakers. The audio analysis platform may provide the diarization output to indicate the individual voice activity of the plurality of speakers during the portion of the audio input.

Abstract: Disclosed are delivery compositions and methods of making and using these compositions. The delivery compositions comprise a collection of polysaccharide degradable dextran nanopolymers comprising one or more amines having 25% or less cross linking. The polysaccharide degradable dextran nanopolymers may be sphere shaped with a radius in the range of 5 nm to 100 nm.

Abstract: The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Abstract: The present invention relates to novel compositions and methods to produce 3D organ equivalents of the brain (i.e. “mini-brains”). The invention also relates to methods of using human induced pluripotent stem cells, a combination of growth and other soluble factors and gyratory shaking. Cells from healthy or diseased donors or animals can be used to allow testing different genetic backgrounds. The model can be further enhanced by using genetically modified cells, adding micro-glia or their precursors or indicator cells (e.g. with reporter genes or tracers) as well as adding endothelial cells to form a blood-brain-barrier.

Abstract: Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or TOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.

Abstract: In one aspect, methods and compositions are provided for treating a subject suffering from or susceptible to prenatal opioid exposure. In a further aspect, methods and compositions are provided for treating a subject suffering from or susceptible traumatic brain injury, intracranial hemorrhage, acquired hydrocephalus, demyelinating diseases including multiple sclerosis, neurological symptoms from systemic lupus erythematosus, and neurodegenerative diseases. In an additional aspect, methods and compositions are provided for treating subject having a COVID-19 infection, exhibiting symptoms of a COVID-19 infection, having suspected exposure to COVID-19, or suspected of suffering from long COVID or post-acute sequelae of COVID-19 (PASC).

Abstract: A method for determining a model characterizing an output from a photon-counting detector (PCD) used in a computed tomography (CT) system is provided. The PCD has a plurality of pixels. The method includes constructing a PCD output model that has a plurality of model parameters including a first model parameter set. The first model parameter set is dependent on an incident count rate on the PCD, and dependent on a pixel position in the PCD. The method also includes receiving calibration data acquired by scanning a plurality of combinations of basis materials, under a plurality of incident count rates. The method further includes estimating the plurality of model parameters based on the received calibration data.

Abstract: Methods of recycling target elements include dissolving and/or alloying a metallic component, including one or more target elements, with liquid gallium to provide a gallium melt and exposing the gallium melt with a liquid medium to form an intermediate liquid. The liquid medium is different than the gallium melt. The method also includes adjusting a pH value of the liquid medium to a first target pH and/or adjusting an applied electrical potential value to the intermediate liquid to a first target applied electrical potential, where at least a first portion of an initial total quantity of a first target element is present in a soluble form in the liquid medium. The method further includes isolating the liquid medium from the intermediate liquid to provide a first leachate, and separating the first target element from the first leachate.

Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

Abstract: The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject.