Abstract: Disclosed herein are systems and methods of nano-engineered optical metasurfaces and materials able to generate higher efficiency flat optics and controlled surface emission via photothermally reconfigurable optical metasurfaces based on optical phase change materials (PCMs). Through localized control of the material dispersion, devices can operate at higher amplitudes and phase control for greater efficiency across larger operational bandwidth in the optical and infrared (IR) spectral regions.

Abstract: The present disclosure relates to methods and compositions for generating both patient-specific and universal donor banked HLA-defined therapeutic progenitors in clinical grade, current good manufacturing practice (cGMP)-compliant conditions from a new class of tankyrase inhibitor-regulated naive human induced pluripotent stem cells (TIRN-hiPSCs).

Abstract: An embodiment in accordance with the present invention provides a system that uses simple standardized patient information routinely collected at triage to distribute patients amongst triage levels based on critical and time-sensitive outcomes. The present invention estimates the probability of electronic medical record (EMR) recorded events for patients at triage. Predictions are made for patients based upon clinical information routinely collected at triage which include demographics (age and gender), vital signs (temperature, heart rate, systolic blood pressure, respiratory rate, and oxygen saturation), complaint(s), medical/surgical history, chronic conditions, and mode of arrival. Vital signs are categorized as normal or gradations of abnormal.

Abstract: A multisegmented robot includes a first robot segment comprising a first layer of active material at least one of integral with, attached to or formed on a first layer of passive material; a second robot segment spaced apart from the first robot segment, the second robot segment including a second layer of active material at least one of integral with, attached to or formed on a second layer of passive material; and a tether connecting the first and second robot segments.

Abstract: Systems, methods, and apparatus for segmenting internal structures depicted in an image. In one aspect, a method includes receiving data representing image data that depicts internal structures of a subject, providing an input data structure to a machine learning model, wherein the input data structure comprises fields structuring data that represents the received data representing the image data that depicts internal structures of the subject, wherein the machine learning model is a multi-stage deep convolutional network that has been trained to segment internal structures depicted by one or more images, receiving output data generated by the machine learning model based on the machine learning model's processing of the input data structure, and processing the output data to generate rendering data that, when rendered, a computer, causes the computer to output, for display, data that visually distinguishes between different internal structures depicted by the image data.

Abstract: A method includes receiving one or more radiological images of an anatomy of a patient. The method also includes identifying a boundary of different tissue types in the anatomy of the patient based at least partially upon the one or more radiological images. The method also includes identifying one or more regions within the boundary. The one or more regions include a lung region. The method also includes identifying healthy tissue and COVID-19 tissue in the lung region. The method also includes quantifying an extent of the COVID-19 tissue in the lung region by comparing an amount of the COVID-19 tissue in the lung region to an amount of the healthy tissue in the lung region. The method also includes classifying the extent of the COVID-19 tissue in the lung region into one or more of a plurality of COVID-19 classes.

Abstract: A device may include an image capturing component to obtain images of an environment of a user, and a light projection system. The light projection system may include a laser source and an optical imager. The device may process, in real-time, images captured by the image capturing component to derive signals for controlling the laser source, provide the signals to the laser source to enable the laser source to generate a laser beam pattern, cause the optical imager to raster scan the laser beam pattern to an absorptive element. The absorptive element may be disposed on or in the user, and positioned proximate to a region-of interest, of the user, that includes neuronal cells. The laser beam pattern may cause the absorptive element to produce acoustic energy that cause depolarization of the neuronal cells. The sensory stimulation may enable the user to visually and/or auditorily perceive the environment.

Abstract: An anion exchange resin includes a cross-linked polymer having a plurality of pseudo +2 point charges including dicationic groups. The dicationic groups include a first cationic group and a second cationic group, and a distance between the first cationic group and the second cationic group is from about 1 Angstrom to about 10 Angstroms.

Abstract: An anatomy visualization device may include a display, an optical sensor, and processing circuitry. The processing circuitry may be configured to capture, via the optical sensor, body registration points on a body of an individual, receive external anatomical measurements of the body, apply the external anatomical measurements to a body shape model, and determine an organ placement prediction for the body based on the application of external anatomical measurements to the body shape model. The organ placement prediction may include organ position information, organ size information, and organ shape information for a plurality of organs. The processing circuitry may also align the organ placement prediction with the body registration points and render, on the display, the organ placement prediction in alignment with the body registration points as an augmented reality object on the body.

Abstract: An electrostatic probe for positioning an insect specimen is disclosed herein. The electrostatic probe may include an ion generator, a handling end, and a controller. The controller may be configured to: activate the ion generator to produce a electrostatic field at the handling end, wherein the electrostatic field is to attract a specimen to the handling end or hold the insect specimen at the handling end, and discharge the electrostatic field to cause the insect specimen to be released from the handling end.

Abstract: A Flettner rotor that employs localized suction over its surface improves performance and fuel efficiency. Simulations and analysis show that such a method can significantly improve the performance of the Flettner rotor. Improvements in rotor performance enable reduction in fuel costs and greenhouse gas emission by ships or other modes of transport. Improvements in rotor performance can also reduce noise for applications such as drones or other devices having rotors.

Abstract: Disclosed herein are systems and methods of making flexible fiber batteries. The fiber batteries are amenable for deployment in textiles, for example, wearable fabrics. The fiber battery can be used to provide power to wearable electronic devices. The fiber battery disclosed herein can be a sub-millimeter (mm) diameter active battery stack having a coating that provides a fiber having a diameter of up to 1 mm that can be woven, stitched, knitted, or otherwise incorporated into a fabric.

Abstract: An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NANPNVDPNANPNVD (SEQ ID NO:2) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria. Alternatively, the immunogen may be administered to an individual having or at risk of having Plasmodium falciparum blood stage parasitemia. In some cases, the immunogen can be administered in combination with another therapeutic agent for treating malaria of Plasmodium falciparum blood stage parasitemia.

Abstract: Methods, systems, apparatus, and computer programs, for processing images through multiple neural networks that are trained to detect a pancreatic ductal adenocarcinoma. In one aspect, a method includes actions of obtaining a first image that depicts a first volume of voxels, performing coarse segmentation of the first image using a first neural network trained (i) to process images having the first volume of voxels and (ii) to produce first output data, determining a region of interest of the first image based on the coarse segmentation, performing multi-stage fine segmentation on a plurality of other images that are each based on the region of interest of the first image to generate output data for each stage of the multi-stage fine segmentation, and determining based on the first output data and the output data of each stage of the multi-stage fine segmentation, whether the first image depicts a tumor.

Abstract: A device for electrically connecting with and holding organoids includes a substrate and a multielectrode array (MEA) attached to said substrate. The MEA includes an electrical bus attached to the substrate, and a plurality of leaflets each having a first end pivotably connected to the electrical bus while remaining portions thereof are free to move relative to the substrate while remaining connected and pivoting at each first end. Each leaflet of the plurality of leaflets includes an electrical wire embedded therein that extends from each respective leaflet into the electrical bus. The MEA has a size that is suitable to electrically connect to and hold an organoid that is between 250 ?m to 2 cm while at least one leaflet of the plurality of leaflets is pivoted up away from the substrate so as to securely hold the organoid in place and form a three-dimensional electrical connection with the organoid.

Abstract: Imaging and radiotherapeutics agents targeting fibroblast-activation protein-? (FAP-?) and their use in imaging and treating FAP-? related diseases and disorders are disclosed.

Abstract: Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies. Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with PCR employing a single primer pair. Using this approach, samples containing as little as 4% trisomy 21 DNA could be readily distinguished from euploid samples.

Abstract: An analyzing platform may obtain a first image of a liquid in a receptacle. The analyzing platform may analyze the first image to determine a first set of visual characteristics concerning the liquid. The analyzing platform may obtain a second image of a rectal sample in the liquid in the receptacle, wherein the rectal sample originated from a bowel of a subject. The analyzing platform may analyze the second image to determine a second set of visual characteristics concerning the rectal sample. The analyzing platform may determine, based on the first set of visual characteristics and the second set of visual characteristics, rectal sample information. The analyzing platform may cause one or more actions to be performed based on the rectal sample information.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: A rapid material development process for a powder bed fusion additive manufacturing (PBF AM) process generally utilizes a computational fluid dynamics (CFD) simulation to facilitate selection of a simulated parameter set, which can then be used in a design of experiments (DOE) to generate an orthogonal parameter space to predict an ideal parameter set. The orthogonal parameter space defined by the DOE can then be used to generate a multitude of reduced volume build samples using PBF AM with varying laser or electron beam parameters and/or feedstock chemistries. The reduced volume build samples are mechanically characterized using high throughput techniques and analyzed to provide an optimal parameter set for a 3D article or a validation sample, which provides an increased understanding of the parameters and their independent and confounding effects on defects and microstructure.