Abstract: A method of creating a virtual asset based on an existing real-world asset is disclosed. The method includes digitally sequencing the existing real-world asset to create a digital sequence of the real-world asset; tokenizing the digital sequence of the real-world asset to create a tokenized digital sequence; associating the tokenized digital sequence with the real-world asset; and creating a title of ownership of the tokenized digital sequence.

Abstract: Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element; accessing a computer-readable reconstruction of the being's anatomy; accessing a computer-readable reconstruction of an implant; detecting a location of a pointer tool comprising a trackable element with the detector, where the pointer tool is associated with a location of an anatomical feature of interest; accessing at least one computer-readable reconstruction of a trace, the trace corresponding to a geometry of the anatomical feature of interest; and superimposing the at least one updatable, computer-readable trace on the second computer-readable reconstruction of the implant.

Abstract: A device may receive images of a patient, and may perform segmentation of surfaces on the images to create a 3D model. The device may identify normal tissue regions and atrial fibrosis (AF) regions in the 3D model, and may divide the 3D model into the normal tissue regions and the AF regions. The device may assign first cell and tissue properties to the normal tissue regions, and may assign second cell and tissue properties to the AF regions. The device may perform simulations on the normal tissue regions and the AD regions, based on the first and second cell and tissue properties, to generate simulation results, and may extract first features from the simulation results. The device may extract second features from the images, and may process the first and second features, with a model, to select a feature that is predictive of atrial fibrillation recurrence.

Abstract: A bifunctional linker of Formula 1 wherein in Formula I, at least one of R1 to R4 is —COOR5 and R5 is —C0-C10alkyl(C2-C10alkynyl) or —C0-C10alkyl-C2-C10alkenyl(C2-C10alkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

Abstract: A device may receive an X-ray image captured by a C-arm CBCT device at a particular position defined by a six-degree of freedom pose relative to an anatomy, and may process the X-ray image, with a machine learning model, to determine a predicted quality of next possible X-ray images provided by the C-arm CBCT device. The device may utilize the machine learning model, to identify a particular X-ray image, of the next possible X-ray images, with a greatest predicted quality and to update the six-degree of freedom pose based on the particular X-ray image. The device may provide, to the C-arm CBCT device, data that identifies the updated six-degree of freedom pose to cause the C-arm CBCT device to adjust to a new position based on the updated six-degree of freedom pose.

Abstract: Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.

Abstract: A user device may receive video associated with a patient, wherein the video depicts physiological activity involving the patient. The user device may receive profile information associated with the patient. The user device may obtain, from the video, image data using an image processing model. The user device may analyze the image data to generate a patient signature associated with the image data, wherein the patient signature is representative of the physiological activity. The user device may access a reference data structure that includes a plurality of reference signatures. The user device may identify that the patient signature is associated with a reference signature of the plurality of reference signatures, wherein the reference signature is associated with a health condition. The user device may perform an action associated with the health condition and the patient.

Abstract: A device may include an image capturing component to obtain images of an environment of a user, and a light projection system. The light projection system may include a laser source and an optical imager. The device may process, in real-time, images captured by the image capturing component to derive signals for controlling the laser source, provide the signals to the laser source to enable the laser source to generate a laser beam pattern, cause the optical imager to raster scan the laser beam pattern to an absorptive element. The absorptive element may be disposed on or in the user, and positioned proximate to a region-of interest, of the user, that includes neuronal cells. The laser beam pattern may cause the absorptive element to produce acoustic energy that cause depolarization of the neuronal cells. The sensory stimulation may enable the user to visually and/or auditorily perceive the environment.

Abstract: An embodiment in accordance with the present invention provides a handheld cryoprobe for use in percutaneous cryotherapy of tumorous masses. It includes a probe attached to a CO2 gas dispensing backend. The probe has specifically optimized parameters designed for use with CO2 gas and is made out of a partially hollowed and threaded aluminum rod providing maximum heat exchange. The system backend regulates flow of compressed CO2 gas while throttling and cooling the gas coolant to the cytotoxically low temperatures necessary for targeted tumor cell death. Additionally, the incoming initial stream of CO2 gas is throttled by the Joule-Thomson nozzle on the backend. The low temperature exhaust gas is then used to pre-cool all subsequent incoming gas, resulting in an even lower temperature at the probe tip, which provides a positive feedback loop, continually decreasing the gas's temperature. The temperature drop is caused by the Joule-Thomson effect.

Abstract: An aspiration device to be used with an irrigation-aspiration handpiece may comprise a curved body having a radius of curvature based on a human equatorial lens diameter, an interface adapted to attach the curved body to a first end of an aspiration lumen in the irrigation-aspiration handpiece, and multiple aspiration ports formed in the curved body. The multiple aspiration ports may be adapted to draw material into the aspiration lumen when a suction source is used to apply vacuum pressure at a second of the aspiration lumen while the aspiration lumen is attached to the aspiration device. The multiple aspiration ports may be arranged to distribute the vacuum pressure over an aggregate surface area of the multiple aspiration ports while the suction source applies the vacuum pressure.

Abstract: Featured is a vertebral body manipulation instrument or vertebral body manipulation device being configured and arranged to allow correction of vertebral translation. Such a vertebral body manipulation device embodies one or more identical modules that are configured as needed for correcting the deformity. Such a vertebral body manipulation device also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are known to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a vertebral body manipulation device.

Abstract: The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ?95% of them contain the identical mutation.

Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.

Abstract: Metal oxides and method for forming the method oxides are provided. The disclosed functional metal oxides are single crystalline or polycrystalline metal oxides, such as, for example, SrVO3, and have dimensions, phase purity, and crystalline quality previously unachievable. The disclosed methods include a combination of a gas atmosphere, vacuum sintering, and laser-based directional solidification of a seed rod in contact with a feed rod that is scalable for production quantities.

Abstract: A health alert device includes a physiological sensor and processing circuitry. The physiological sensor captures physiological data, including heart rate and blood oxygen data, of a detainee. The processing circuitry repeatedly receives the physiological data, calculates a health metric parameter based on a combination of the physiological data, determines a health metric baseline based on a series of health metric parameters determined over a baseline determination duration, determines first and second risk alert thresholds based on the health metric baseline, determines a health metric delta based on newly received physiological data and the health metric baseline, and transmits first and second risk alert communications to an alert device to cause the alert device to display first and second risk alerts on an alert device display in response to the health metric delta exceeding the first and second risk alert thresholds, respectively.

Abstract: Methods and apparatuses are provided for performing surgery and other interventional procedures on human and non-human animals with a semi-autonomous and/or fully autonomous robotic system. The methods and apparatuses include a system for controlling magnetic fields to dynamically detect the location of magnetizable tools and to manipulate said tools in order to obtain a favorable therapeutic or diagnostic outcome.

Abstract: The present inventors have uncovered the nature of heterotopic ossification HO progression as an excessive activation of TGF-? in recruitment of MSCs for osteogenesis in coupling with type H vessel formation. Systemic injection of TGF-? neutralizing antibody using the methods of the present invention, effectively attenuated HO progression in multiple different HO animal models. The present invention provides methods for prophylaxis and treatment of HO and also rare genetic diseases such as fibrodysplasia ossificans progressive (FOP) (also known as myositis ossificans progressive) and progressive osseous heteroplasia (POH). by inhibition of TGF-?.

Abstract: The present disclosure relates generally to controlling a volume of fluid within a portion of a patient's body. For example, the present disclosure can relate to the addition or removal of cerebral spinal fluid (CSF) from a portion of the patient's brain. The amount of fluid can be controlled by a system that includes a dual chamber probe and a volume control. One channel can include a drain element to drain the fluid from the portion of a patient's body. The other channel can include a volume changing element to facilitate the drainage of the fluid by changing a volume of the portion of the patient's body. The volume changing element can be coupled to a volume control, which can control the change of the volume of the portion of the patient's body (e.g., based on passive oscillation or active oscillation).

Abstract: Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off-target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

Abstract: The present invention relates to compositions and methods for treating neurodegenerative conditions using GLP-1r agonists. In certain embodiments, long-acting GLP-1r agonists have neuroprotective and disease modifying effects on the central nervous system.