Patents Assigned to Johns Hopkins University
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Publication number: 20230412386Abstract: Disclosed herein are system, method, and computer program product embodiments for providing machine-to-machine (M2M) trust using a distributed ledger. This trust may apply to the Internet of Things (IoT) and/or smart cities contexts. To provide M2M trust, a first computing node may generate a trust score for a second computing node. The trust score may comprise four subcomponents: an identification score, an experience score, a recommendation score, and a context score. These subcomponents may be assigned different weights based on different applications. The multifaceted approach to identifying trust for a particular node provides a flexible framework to provide trust between computing nodes in a network. Additionally, the trusts scores may be published to an immutable distributed ledger and used by other computing nodes to determine updated trust scores as additional interactions between computing nodes occur.Type: ApplicationFiled: May 5, 2023Publication date: December 21, 2023Applicant: The Johns Hopkins UniversityInventors: Ali Tekeoglu, Cameron R. Hickert, Joseph M. Maurio, Tamim I. Sookoor
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Publication number: 20230404473Abstract: Provided herein are systems and methods for monitoring and treatment of an injury. The system includes a control device, an implantable device and/or a wearable device, the implantable device configured to be implanted into a body, the implantable device having a sensing device for sensing a condition of the injury and a treatment device configured to apply a treatment to the injury based on the sensed conditions of the injury. Signals of the sensed condition are sent to the control device, and the control device controls the treatment device of the implantable device to apply treatment for the injury. When a wearable device is included, the wearable device may be configured to sense another condition related to the injury and send signal indicative thereof to the control device.Type: ApplicationFiled: October 6, 2021Publication date: December 21, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Nicholas THEODORE, Amir MANBACHI
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Publication number: 20230412970Abstract: An acoustic transducer includes a first layer including an elastomer, An acoustic impedance of the first layer substantially matches an acoustic impedance of a medium that the transducer is configured to monitor. The transducer also includes a second layer including an electrode. The transducer also includes a third layer including a polymer. The second layer is positioned at least partially between the first layer and the third layer.Type: ApplicationFiled: October 8, 2021Publication date: December 21, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: James Edward WEST, Valerie RENNOLL, Adebayo Ayoola EISAPE, II, Ian MCLANE, Mounya ELHILALI
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Patent number: 11844798Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.Type: GrantFiled: December 22, 2020Date of Patent: December 19, 2023Assignees: The Board of Trustees of the University of Illinois, Vanquish Oncology, Inc., The Johns Hopkins UniversityInventors: Paul J. Hergenrother, Rachel C. Botham, Timothy M. Fan, Mark J. Gilbert, Michael K. Handley, Avadhut Joshi, Gregory J. Riggins, Theodore M. Tarasow
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Patent number: 11845994Abstract: Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade.Type: GrantFiled: April 8, 2021Date of Patent: December 19, 2023Assignees: The Johns Hopkins University, University of TorinoInventors: Victor E. Velculescu, Eniko Papp, Vilmos Adleff, Andrea Bertotti, Livio Trusolino
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Publication number: 20230402584Abstract: Disclosed herein is a battery anode compound including a metal oxide and a metal. Also disclosed herein is a method of providing a battery anode compound comprising synthesizing AlNb11O29 and combining AlNb11O29 and a metal. A Li-ion battery anode compound is also disclosed that includes a slurry comprising up to 70% AlNb11O29, up to 70% Li4Ti5O12, and up to 70% of a metal, wherein the metal is any one of Sb or Sn.Type: ApplicationFiled: June 13, 2023Publication date: December 14, 2023Applicant: The Johns Hopkins UniversityInventors: Jesse S. Ko, Konstantinos Gerasopoulos, Matthew W. Logan
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Publication number: 20230399698Abstract: The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.Type: ApplicationFiled: June 9, 2023Publication date: December 14, 2023Applicants: The Regents of the University of California, The Johns Hopkins UniversityInventors: Charles Y. CHIU, Jerome BOUQUET, Mark J. SOLOSKI, John N. AUCOTT
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Patent number: 11841363Abstract: The present invention describes methods of identifying drugs for the treatment or prevention of diabetes by measuring the activity of the human zinc transporter ZnT8 and pharmaceutical compositions.Type: GrantFiled: April 28, 2021Date of Patent: December 12, 2023Assignee: The Johns Hopkins UniversityInventor: Dax Fu
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Patent number: 11839360Abstract: The present disclosure relates generally to fluorescent imaging devices, systems, and methods for an endoscopic procedure, and in particular, indocyanine green (ICG) fluorescence. In some embodiments, a device for fluorescent imaging during an endoscopic procedure may include an attachment connectable to a distal end of an endoscope. The attachment may include a first filter alignable with a light source of the endoscope, and a second filter alignable with an imaging device of the endoscope. The first filter may be positionable such that in a first position the first filter is aligned with the light source, and in a second position the first filter is out of alignment with the light source. The second filter may be positionable such that in a first position the second filter is aligned with the imaging device, and in a second position the second filter is out of alignment with the imaging device.Type: GrantFiled: January 4, 2019Date of Patent: December 12, 2023Assignees: Boston Scientific Scimed, Inc., The Johns Hopkins UniversityInventors: Sritam P. Rout, Marc Chelala, Maria F. Torres, Kyle R. Cowdrick, Amir Hossein Soltanianzadeh, David M. Gullotti, Pankaj J. Pasricha, Nicholas J. Durr, Ryan V. Wales
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Publication number: 20230390587Abstract: An x-ray irradiation system includes a first x-ray tube constructed and arranged to be able to irradiate an object with at least a portion of a first x-ray beam emitted from the first x-ray tube, and a second x-ray tube constructed and arranged to be able to irradiate the object with at least a portion of a second x-ray beam emitted from said second x-ray tube simultaneously with said first x-ray beam. The first and second x-ray tubes are arranged such that the first and second x-ray beams are incident on, and intersect within, the object at respective first and second oblique angles to define a target volume such that a dose rate is substantially uniform as prescribed within said target volume.Type: ApplicationFiled: October 15, 2021Publication date: December 7, 2023Applicant: The Johns Hopkins UniversityInventors: John Wai-Chiu WONG, Mohammad REZAEE, Iulian IORDACHITA
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Publication number: 20230394670Abstract: Fully automated computer-implemented deep learning techniques of contrast-enhanced cardiac MRI segmentation are provided. The techniques may include providing cardiac MRI data to a first computer-implemented deep learning network trained in order to identify a left ventricle region of interest to generate left ventricle region-of-interest-identified cardiac MRI data. The techniques may also include providing the left ventricle region-of-interest-identified cardiac MRI data to a second computer-implemented deep learning network trained in order to identify myocardium to generate myocardium-identified cardiac MRI data. The techniques may further include providing the myocardium-identified cardiac MRI data to at least one third computer-implemented deep learning network trained to conform data to geometrical anatomical constraints in order to generate anatomical-conforming myocardium-identified cardiac MRI data.Type: ApplicationFiled: October 19, 2021Publication date: December 7, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Natalia A. TRAYANOVA, Haley Gilbert ABRAMSON, Dan POPESCU, Mauro MAGGIONI, Katherine C. WU
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Patent number: 11832969Abstract: An embodiment according to the present invention includes a method for a machine-learning based approach to the formation of ultrasound and photoacoustic images. The machine-learning approach is used to reduce or remove artifacts to create a new type of high-contrast, high-resolution, artifact-free image. The method of the present invention uses convolutional neural networks (CNNs) to determine target locations to replace the geometry-based beamforming that is currently used. The approach is extendable to any application where beamforming is required, such as radar or seismography.Type: GrantFiled: December 22, 2017Date of Patent: December 5, 2023Assignee: The Johns Hopkins UniversityInventors: Muyinatu Bell, Austin Reiter
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Patent number: 11834401Abstract: Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition.Type: GrantFiled: July 6, 2020Date of Patent: December 5, 2023Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Douglas Robinson, Alexandra Surcel, Win Pin Ng, Caren L. Freel Meyers
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Patent number: 11828741Abstract: A sensor includes a first sensing element electronically sensitive to an analyte and to an interfering stimulus. The first sensing element provides a first electrical signal in response to a presence of the analyte and/or the interfering stimulus. The sensor also includes a second sensing element electronically sensitive to the analyte and to the interfering stimulus. The second sensing element provides a second electrical signal in response to the presence of the analyte and/or the interfering stimulus. A conductive link electrically connects the first sensing mechanism and the second sensing mechanism. An electrical property is measured within the sensor that is indicative of a concentration of the analyte based on the first electrical signal and the second electrical signal.Type: GrantFiled: May 30, 2019Date of Patent: November 28, 2023Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Howard Edan Katz, Yingli Chu, Hui Li, Tushita Mukhopadhyaya, Justine Wagner, Huidong Fan
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Patent number: 11826280Abstract: Lacrimal canalicular delivery systems (LCDS) and their methods of use for the delivery of implants at a specific location into the canaliculus of a subject generally include a lumen, a guide wire, and an implant. The guide wire and implant are within the lumen. When pressure is applied to the guide wire, the guide wire pushes the implant out of the lumen into a specific location into the canaliculus of a subject.Type: GrantFiled: July 15, 2019Date of Patent: November 28, 2023Assignee: The Johns Hopkins UniversityInventors: Bradley P. Barnett, Albert S. Jun
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Patent number: 11827663Abstract: Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.Type: GrantFiled: December 18, 2020Date of Patent: November 28, 2023Assignee: The Johns Hopkins UniversityInventors: Kevin J. Yarema, Christopher T. Saeui, Alfredo Quinones-Hinojosa, Sagar Ramesh Shah
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Patent number: 11829503Abstract: A term-based encrypted retrieval privacy (TERP) data retrieval system performs data retrieval from a data repository server. The system includes a client processor included with a data requesting client and a server processor included with the data repository server. The client processor determines a vector forest that is shared with the data repository server, which includes forest vectors assigned with a respective vector ID, and generates a query including an encrypted ciphertext table that cross-references the vector IDs with a corresponding ciphertext entry. The server processor receives the query, and selects a given document from the data repository server that has assigned thereto at least one nearest neighbor vector among the forest vectors. The server processor compares a nearest neighbor vector ID of the nearest neighbor vector to the vector IDs included in the encrypted ciphertext table, and generates an encoded search result based on the encrypted ciphertext entries.Type: GrantFiled: September 29, 2020Date of Patent: November 28, 2023Assignee: The Johns Hopkins UniversityInventors: Russell A. Fink, David R. Zaret, Paul McNamee
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Publication number: 20230378573Abstract: Disclosed herein is an electronic device encapsulation including a non-permeable coating and at least one pair of leads coupled to an electronic device protruding from the non-permeable coating. Also disclosed herein is a method of encapsulating an electronic device including attaching at least a pair of electric leads to the device, coating the device and a portion of each lead with a non-permeable coating, and curing the non-permeable coating. Further disclosed is an encapsulated system including a device, at least one pair of leads coupled to the device configured to extend from the device and attach to an exterior system, and a non-permeable coating configured to provide a vapor barrier surrounding the device and to provide an exposed portion of the pair of leads.Type: ApplicationFiled: May 23, 2023Publication date: November 23, 2023Applicant: The Johns Hopkins UniversityInventors: Nicholas G. Pavlopoulos, Jason E. Tiffany, Spencer A. Langevin
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Publication number: 20230371901Abstract: Provided herein are medical devices, systems, and methods for monitoring and treating injuries, diseases, or other conditions in patients. The medical devices include body structures that comprise an imaging array, a stimulation array, and an electrode array. The medical devices are implantable in patients in some embodiments.Type: ApplicationFiled: October 6, 2021Publication date: November 23, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Amir MANBACHI, Nicholas THEODORE, George L. COLES, Ana M. AINECHI, Sandeep KAMBHAMPATI
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Publication number: 20230372685Abstract: An implant includes a cannula. The cannula defines an axial drainage bore and a plurality of radial openings providing a path of fluid communication between an exterior of the cannula and the axial drainage bore to drain fluid. The implant also includes a first sensor positioned at least partially in the cannula. The first sensor is configured to measure a biomarker in the fluid. The implant also includes a second sensor positioned at least partially in the cannula. The second sensor is configured to measure a pressure of the fluid. The implant also includes a third sensor positioned at least partially in the cannula. The third sensor is configured to measure a temperature of the fluid.Type: ApplicationFiled: October 6, 2021Publication date: November 23, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Amir MANBACHI, Nicholas THEODORE, George L. COLES, Jeffrey Maxwell KALTER, Steven Michael BABIN, Francesco Vincenzo Gualtiero TENORE, Austin James DEVINNEY, Paul Robert SCHUSTER