Abstract: Risk prediction models are trained and deployed to analyze images, such as computed tomography scans, for predicting risk of lung cancer (e.g., current or future risk of lung cancer) for one or more subjects. Individual risk prediction models are trained on nodule-specific and non-nodule specific features, including longitudinal nodule specific and longitudinal non-nodule specific features, such that each risk prediction model can predict risk of lung cancer across different time horizons. Such risk prediction models are useful for developing preventive therapies for lung cancer by enabling clinical trial enrichment.

Abstract: A phacoemulsification apparatus includes a phacoemulsification probe, an electromechanical valve, and an electromechanical mechanism. The probe having a fluid channel for exchanging fluid with a patient's eye. The electromechanical valve is coupled with the fluid channel and is configured to regulate a fluid flow through the fluid channel. The valve including a cylinder, a piston inside the cylinder, wherein the piston divides the cylinder into a first cavity that is in fluid communication with the fluid channel, and a second cavity, and one or more fluid communication links, which are formed between the first and second cavities. The piston is configured to move inside the cylinder to regulate the flow of the fluid, and the one or more fluid communication links are configured to allow the fluid to flow between the first and second cavities during motion of the piston. The electromechanical mechanism is configured to move the piston.

Abstract: A system includes a needle, an actuator assembly and a generator. The needle is configured to be vibrated so as to emulsify a lens of an eye. The actuator assembly, includes a first actuator, a second actuator and a third actuator, which are distributed around a longitudinal axis of the needle and are configured to vibrate along the longitudinal axis in response to a first driving signal, a second driving signal and a third driving signal, respectively. The generator is configured to generate the first driving signal, the second driving signal and the third driving signal, so as to vibrate the needle in accordance with a predefined pattern.

Abstract: A press for shaping an absorbent tampon blank into a shaped tampon pledget includes a central cavity arranged and configured to accommodate an absorbent tampon blank having a front portion and a back portion. The main longitudinal axis of the press passes in the middle of the central cavity and a plurality of penetrating dies are arranged radially around the said main longitudinal axis. Each penetrating die has a pressing face on at least a fragment of its side facing the central cavity. The said press comprises at least one cam to actuate the plurality of penetrating dies. Furthermore, the plurality of penetrating dies comprises at least one penetrating die having a pressing face with a first shaped longitudinal profile, and least one penetrating die having a pressing face with a second shaped longitudinal profile.

Abstract: A doming tool for manufacturing absorbent tampon includes a plurality of stations made of devices for shaping a tampon pledget tip, and a hollow mandrel engaging with the stations. The stations are supported by at least one mounting plate.

Abstract: A system and method for provided a phacoemulsification surgery handpiece including a convertible sleeve for phacoemulsification surgery and irrigation/aspiration procedures. In a retracted state, the sleeve is in a desired relationship with the exposed portion of a phaco tip of the handpiece to support normal phacoemulsification surgery. In an extended state, the sleeve features a distally placed aspiration hole located forward from the distal end of a phaco tip to allow typical irrigation/aspiration procedures. A distal tip segment of the hand piece is overmoldedby polyimide materials having a split feature to allow egress of a phaco tip.

Abstract: The present invention comprises a heel insert for use with a phacoemulsification foot pedal that may shift a surgeon's foot forward on the treadle of a foot pedal to reduce the force required to actuate the foot pedal. The present invention may be easily attachable and removable and may provide a less complicated and alternative foot position for surgeons preferring different treadle mechanics.

Abstract: The present disclosure relates to leave-on light oil hair compositions that comprise a blend of non-cyclic silicone and non-silicone ingredients. The leave-on light oil hair compositions, which do not contain D4, D5 or D6 silicones, are particularly useful in methods for imparting durable resistance to breaking, frizz control, shine and/or volume definition with a soft feel to hair.

Abstract: Apparatus, including a tube having proximal and distal ends and an internal lumen. The distal end may bend up to 270°, and the tube may be inserted into an eye. A planar resilient strip, having proximal and distal ends, is inserted into the internal lumen, and the strip distal end is fixed to the tube distal end. A coil spring is fixed to the strip proximal end so that a coil spring symmetry axis is coplanar with the strip. A camera, mounted with the strip distal end, images the eye interior. A wire is fixed to the strip distal end, so that a predetermined force on the wire causes the tube distal end to bend by a preset angle. A magnetometer at the tube proximal end is configured, when a nonvarying magnetic field traverses it, to provide a signal that, when taken with the preset angle, indicates a camera orientation.

Abstract: A wrench assembly for attachment and removal of a tip to a handpiece of a surgical system includes a core and a shell including a central portion that defines a central bore. In various embodiments, the core includes an outer portion fixedly coupled to the shell and an inner portion configured for insertion into the central bore. The inner portion is removably coupled to the outer portion by a separation mechanism configured to facilitate separation of the inner portion from the outer portion at a predetermined torque.

Abstract: A surgical imaging system, including a first imaging device configured to generate a real-time visual image of a first field of view of a patient, and a second imaging device configured to generate a real-time thermal image of the first field of view. The system also includes a retaining structure, configured to be positioned in proximity to an eye of an operator, and a semitransparent screen configured to be mounted on the structure. The system additionally includes a processor configured to receive the images, and upon receiving an indication from the operator, to present, on the screen, the real-time visual image, or the real-time thermal image or the real-time thermal image overlaid on the real-time visual image, focused to a point in proximity to a near point of the eye while the operator can view, through the screen, a second field of view different from the first field of view.

Abstract: A location pad includes two or more field-generators, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of a patient organ, for measuring a position of a medical instrument in the ROI. The frame is coupled with tissue that is at least partially surrounding the organ and is configured to fix the two or more field-generators at respective positions surrounding the ROI.

Abstract: A location pad includes two or more field-generators, one or more tracking elements, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of an organ of a patient, for measuring a position of a medical instrument in the ROI. The one or more tracking elements are for registering the location pad with the organ. The frame is coupled with tissue that is at least partially surrounding the organ, and the frame is configured to fix (i) the two or more field-generators at respective positions surrounding at least a portion of the ROI, and (ii) the one or more tracking elements at one or more respective predefined positions on the frame.

Abstract: This invention relates to methods and compositions for inhibiting the transmission of enveloped viruses, which entails applying a composition containing a high molecular weight hydrophobically-modified polymer to an infectable or ingestible surface that may contain viruses and wherein said anti-viral composition comprises less than about 9% by weight of surfactant having an HLB greater than about 12.

Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g.

Abstract: The present invention relates to improved contact lens packages and methods of use and manufacture/assembly. A contact lens package may include a cavity that houses a contact lens, packaging solution, and an absorbent member. In one aspect, the absorbent member may be configured for transitioning between an expanded state and a compressed state, and the absorbent member may be in the compressed state when the package is in an unopened state.

Abstract: Provided are imidazolium zwitterion polymerizable compounds and their applications in ophthalmic devices and packaging solutions. The zwitterionic polymerizable compounds are of formula I: wherein R1, R2, R3, L1, L2, and Pg are as described herein.

Abstract: In one embodiment, a phacoemulsification apparatus includes actuators configured to vibrate responsively to respective driving signals, a needle including an aspiration channel, and configured to be vibrated by the actuators so as to emulsify a lens of an eye, a generator configured to generate at least one of the driving signals responsively to a vibration pattern selected for the needle, the needle being configured to vibrate in accordance with the selected vibration pattern, and a sensor configured to sense a level of vacuum in the aspiration channel, wherein the generator is configured to alter at least one of the driving signals to transition vibration of the needle from a first vibration pattern selected from the group consisting of a longitudinal vibration pattern and a first helical vibration pattern, to a second vibration pattern of a second helical vibration pattern, responsively to a decrease in the sensed level of vacuum.