Patents Assigned to Keio University
  • Publication number: 20250144136
    Abstract: A cell population including macrophages that are CD11b positive, F4/80 positive, CD180 positive, and CD9 positive and that are derived from a tissue selected from the group consisting of placenta, umbilical cord, and amnion with a percentage of 75% or more, the cell population having cell viability of 80% or more.
    Type: Application
    Filed: February 9, 2023
    Publication date: May 8, 2025
    Applicant: KEIO UNIVERSITY
    Inventors: Shigeki SAKAI, Kazuo KISHI
  • Publication number: 20250146070
    Abstract: The present disclosure provides a method capable of more conveniently determining at an earlier stage whether a cell population collected from a vertebrate animal adipose tissue has mesenchymal stem cells (ASCs) at high purity, a kit for determining it, etc. The present disclosure includes, for example, a method for determining whether a cell population derived from an adipose tissue collected from a vertebrate animal comprises mesenchymal stem cells (ASCs) at high purity, the method comprising detecting expression of one or more genes in the cell population.
    Type: Application
    Filed: February 14, 2023
    Publication date: May 8, 2025
    Applicant: KEIO UNIVERSITY
    Inventors: Yukako URUGA, Yumiko MATSUBARA
  • Patent number: 12285475
    Abstract: The result of orally administering saliva derived from a Crohn's disease patient or an ulcerative colitis patient to germ-free mice has revealed that Th1 cells markedly increased in the colons. Further, from the bacterial microbiota in the intestines of the mice in which such an increase in Th1 cells were observed, bacteria have been successfully isolated which caused strong Th1 cell induction in the colon upon intestinal colonization.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: April 29, 2025
    Assignee: KEIO UNIVERSITY
    Inventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori
  • Patent number: 12285862
    Abstract: A position/force controller performs a first conversion for distributing control energy to at least one of velocity or position energy and force energy, in accordance with a function to be realized, based on velocity (or position) and force information, which correspond to information relating to a position based on an operation of an actuator, and information serving as reference of control. The position/force controller calculates at least one of a velocity or position control amount and a force control amount based on at least one of the energies obtained through the distribution. The position/force controller integrates the calculated control amounts, performs a second conversion, and determines input to the actuator. The position/force controller performs a process, corresponding to increasing or decreasing performed on at least one of the velocity or position energy and the force energy together or independently, with satisfaction of a condition set for the control energy.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 29, 2025
    Assignees: KEIO UNIVERSITY, MOTION LIB, INC.
    Inventors: Kouhei Ohnishi, Takahiro Nozaki, Takahiro Mizoguchi
  • Publication number: 20250122472
    Abstract: Provided is a method of producing a gene-modified T cell population, including mixing a cell population containing T cells with beads each having bound thereto a virus containing a target gene to introduce the target gene into each of the cells of the cell population, wherein the cell population containing the T cells is cultured in a solution containing a CD3 signal activator that is present without being immobilized on a solid phase.
    Type: Application
    Filed: August 10, 2022
    Publication date: April 17, 2025
    Applicants: KEIO UNIVERSITY, JSR CORPORATION
    Inventors: Yutaka KAWAKAMI, Seiki WAKUI, Masaru UENO, Ryo AOYAMA, Hitoshi SEKINE
  • Patent number: 12270049
    Abstract: A culture medium for inducing a pluripotent stem cell into a differentiation-promoted pluripotent stem cell, the medium including a Glycogen synthase kinase 3? (GSK3?) inhibitor, a Bone morphogenic protein (BMP) signaling inhibitor, and a Transforming growth factor (TGF)-? inhibitor as active ingredients.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: April 8, 2025
    Assignee: KEIO UNIVERSITY
    Inventors: Hideyuki Okano, Wado Akamatsu, Koki Fujimori, Takuya Matsumoto, Naoko Kuzumaki, Fumihiko Kisa
  • Publication number: 20250056169
    Abstract: A bone conduction hearing-aid system includes an intracorporeal unit that is embedded under a scalp and that includes an intracorporeal vibration generator configured to generate vibration by receiving a magnetic field frequency, and an extracorporeal unit that is disposed extracorporeally, that is configured to generate the magnetic field frequency and to apply the magnetic field frequency to the intracorporeal unit, and that is configured to generate vibration by an extracorporeal vibration generator. The vibration generated by the intracorporeal unit and the vibration generated by the extracorporeal unit vibrate a skull.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 13, 2025
    Applicants: THE UNIVERSITY OF ELECTRO-COMMUNICATIONS, EHIME UNIVERSITY, KEIO UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Takuji KOIKE, Naohito HATO, Sho KANZAKI, Katsuyoshi SUZUKI
  • Publication number: 20250056171
    Abstract: A bone conduction hearing-aid unit embedded under a scalp. The bone conduction hearing-aid unit includes a vibration generator configured to generate vibration, and an anchor. A magnetic field frequency is applied to the vibration generator from the outside of the scalp to generate vibration. The vibration is transmitted to a skull via the anchor.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 13, 2025
    Applicants: The University of Electro-Communications, Ehime University, KEIO UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Takuji KOIKE, Naohito HATO, Sho KANZAKI, Katsuyoshi SUZUKI
  • Publication number: 20250056170
    Abstract: A bone conduction hearing-aid unit that is entirely embedded under a scalp. The bone conduction hearing-aid unit includes a vibration generating device configured to generate vibration, and an anchor fixed to a skull and configured to transmit the vibration to the skull. The vibration generating device is detachably fixed to the anchor.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 13, 2025
    Applicants: The University of Electro-Communications, Ehime University, Keio University, Nihon Kohden Corporation
    Inventors: Takuji KOIKE, Naohito HATO, Sho KANZAKI, Katsuyoshi SUZUKI
  • Patent number: 12222724
    Abstract: A mobile body control device includes: an observation trajectory acquisition unit that acquires, a trajectory along which the subject walks; a basic trajectory acquisition unit that acquires, a basic trajectory that matches the observation trajectory; a subject predicted trajectory acquisition unit that acquires a trajectory along which the subject walks after the current time point based on the specific basic trajectory; a prediction reliability calculation unit that calculates a prediction reliability based on uncertainty added along the subject predicted trajectory; a target trajectory acquisition unit that acquires, a trajectory formed by a target position of a mobile body set ahead of the subject in a traveling direction of the subject; and a control-command-sequence-generating unit that generates a control command sequence using an evaluation function that uses as input the subject predicted trajectory, prediction reliability, target trajectory, and a control trajectory.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: February 11, 2025
    Assignees: AISIN CORPORATION, KEIO UNIVERSITY
    Inventors: Kazuhiro Kuno, Yutaka Watanabe, Masaki Takahashi, Ayanori Yorozu, Shunichi Sekiguchi
  • Publication number: 20250043347
    Abstract: Disclosed is a method for evaluating cell differentiation state, including inducing pluripotent stem cells to differentiate into mesodermal cells in a liquid medium by a first differentiation treatment for inducing pluripotent stem cells to differentiate into mesodermal cells and a second differentiation treatment for inducing the mesodermal cells to differentiate into cardiomyocytes; collecting a supernatant of the liquid medium comprising cells induced to differentiate by the second differentiation treatment; and measuring miRNA-3p in miR-1/133a cluster in the supernatant, where the miRNA-3p is at least one selected from a group consisting of miR-1-3p and miR-133a-3p, and the measured value of miRNA-3p is an index of differentiation into cardiomyocytes.
    Type: Application
    Filed: August 2, 2024
    Publication date: February 6, 2025
    Applicants: KEIO UNIVERSITY, HEARTSEED INC., SYSMEX CORPORATION
    Inventors: Shugo TOHYAMA, Otoya SEKINE, Sayaka KANAAMI, Kanako MASUMOTO, Yuki AIHARA
  • Publication number: 20250033189
    Abstract: An object of the present invention is to provide further assistance in addition to assistance by tactile force transmission. An information presentation system includes a master device to which an operation by an operator is input and a slave device that operates in accordance with the operation input to the master device. Furthermore, the information presentation system includes a tactile force transmission unit, a calculation unit, and a presentation unit. The tactile force transmission unit controls tactile force transmission in the master device and the slave device. The calculation unit calculates physical characteristics of a substance in contact with the slave device on the basis of an external force input from the environment to the slave device while the slave device maintains a predetermined motion state. The presentation unit presents the physical characteristics of the substance calculated by the calculation unit.
    Type: Application
    Filed: October 10, 2022
    Publication date: January 30, 2025
    Applicants: KEIO UNIVERSITY, MOTION LIB, INC., TERUMO KABUSHIKI KAISHA
    Inventors: Kouhei OHNISHI, Takahiro MIZOGUCHI, Shin MAKI, Yoshiyuki HABU, Toshihiro FUJII
  • Publication number: 20250010034
    Abstract: An object of the present invention is to make control for friction compensation executed in a master-slave system more appropriate. A control system includes a master device, a slave device, and a control device. Furthermore, the control device includes a friction compensation control unit and a tactile force transmission unit. The friction compensation control unit calculates a force for assisting an operation in the master device with respect to friction generated in the slave device on the basis of a moving average of velocity of a movable portion in the slave device. The tactile force transmission unit assists the operation in the master device with a force calculated by the friction compensation control unit and controls tactile force transmission in the master device and the slave device.
    Type: Application
    Filed: October 10, 2022
    Publication date: January 9, 2025
    Applicants: KEIO UNIVERSITY, MOTION LIB, INC., TERUMO KABUSHIKI KAISHA
    Inventors: Kouhei OHNISHI, Takahiro MIZOGUCHI, Kazuhiro YAMADA, Yoshiyuki HABU, Shin MAKI, Toshihiro FUJII
  • Patent number: 12188928
    Abstract: [Problem to be solved by the invention] The purpose of the present invention is to provide a competitive immunochromatographic analysis method and immunochromatographic sensor using said analysis method capable of intuitively displaying a molecular concentration of a substance to be measured and facilitating visual judgement of the molecular concentration.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: January 7, 2025
    Assignees: Techno Medica Co., Ltd., Keio University
    Inventors: Kazushi Misawa, Daniel Citterio, Hiroki Yamazaki, Tomohiro Yamamoto
  • Publication number: 20250002526
    Abstract: Provided is a pharmaceutical composition effective for anti-cancer immunostimulating therapies.
    Type: Application
    Filed: October 21, 2022
    Publication date: January 2, 2025
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, RIKEN, KEIO UNIVERSITY
    Inventors: Yoshinori FUKUI, Takehito URUNO, Teruki HONMA, Daisuke TAKAYA, Motomu KANAI, Kounosuke OISAKI, Takaya TOGO, Yuki SUGIURA
  • Publication number: 20250003971
    Abstract: There are many options in cancer evaluation and treatment, and it is desired to ascertain the characteristics and conditions of individual patients and improve treatment efficacy and cost performance. Provided is a method for providing information pertaining to a cancer in a subject using an indicator based on the amount of D-amino acid in a biological sample from the subject, wherein the information is selected from the group consisting of: a verification result of the validity of a test or diagnosis result of the cancer in the subject; a classification of the degree of progression of the cancer in the subject; a result of a prognosis prediction for the cancer in the subject; and information for selecting a treatment means for the cancer in the subject. Also provided is a system for providing information pertaining to a cancer in a subject.
    Type: Application
    Filed: September 5, 2022
    Publication date: January 2, 2025
    Applicants: KAGAMI INC., KEIO UNIVERSITY
    Inventors: Tomohisa SUJINO, Takanori KANAI, Kai TSUGARU, Jumpei SASABE, Masashi MITA
  • Patent number: 12184204
    Abstract: A vibration-driven energy harvesting device includes a vibration-driven energy harvesting element that generates power according to vibrations of an electrode; an output unit that, when connected to a load resistor, extracts power generated by the vibration-driven energy harvesting element; a judgment unit that judges whether or not a power value of the power is greater than a predetermined threshold value; a determination unit that determines an input impedance of the output unit based on a judgment result obtained by the judgment unit; and an adjustment unit that adjusts the input impedance of the output unit according to a determination made by the determination unit.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: December 31, 2024
    Assignees: Saginomiya Seisakusho, Inc., Keio University
    Inventors: Hiroyuki Mitsuya, Hisayuki Ashizawa, Song-Ju Kim, Masashi Aono
  • Publication number: 20240415464
    Abstract: A feature amount extractor extracts a feature amount representing the feature of a brain wave from the brain wave of a subject, the brain wave being measured when a magnetic stimulation is applied to the brain of the subject. A mental disorder determiner determines whether or not the subject has a predetermined mental disorder on the basis of a feature amount variation that is a differential value between a feature amount extracted from a brain wave measured immediately before the magnetic stimulation and a feature amount extracted from a brain wave measured immediately after the magnetic stimulation.
    Type: Application
    Filed: October 31, 2023
    Publication date: December 19, 2024
    Applicants: KEIO UNIVERSITY, TEIJIN PHARMA LIMITED
    Inventors: Yoshihiro NODA, Kento Sakaue
  • Publication number: 20240408170
    Abstract: A composition for decomposition of trypsin or TMPRSS2 containing, as an active ingredient, bacteria that have 00502 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00502 protein and having a trypsin-binding ability; or bacteria that have 00509 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00509 protein and having a trypsin-binding ability.
    Type: Application
    Filed: January 18, 2022
    Publication date: December 12, 2024
    Applicants: Riken, Keio University
    Inventors: Youxian Li, Eiichiro Watanabe, Yusuke Kawashima, Zhujun Wang, Osamu Ohara, Kenya Honda, Koji Atarashi
  • Publication number: 20240390404
    Abstract: An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT) as an active ingredient. Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof: [In the formulas, each of formula (III) and formula (IV) represents an ?-anomer or a ?-anomer; each of R1, R3, and R4 is —OH or —OAc; R2 is a halogen atom, —OH, or —OAc; and R5 is —CH3, —C?CH, —C?CCH3, or —CH2C?CH.
    Type: Application
    Filed: August 5, 2024
    Publication date: November 28, 2024
    Applicants: KEIO UNIVERSITY, THE KITASATO INSTITUTE
    Inventors: Kazuhiko KATAYAMA, Akira FUJIMOTO, Kei HAGA, Reiko TODAKA, Toshiro SATO