Patents Assigned to Keio University
  • Publication number: 20220142561
    Abstract: An estimation method according to the disclosure for estimating a parameter related to skin function, the estimation method includes an image acquisition step for acquiring a skin image in which unevenness of a skin surface is captured; an extraction step for extracting a feature vector based on topological information on the skin image from the skin image acquired in the image acquisition step; an estimation step for estimating the parameter related to skin function based on the feature vector extracted in the extraction step, using an estimation model constructed based on past actual measurement data in which feature vectors are associated with the parameter related to skin function; and a presentation step for presenting the parameter related to skin function estimated in the estimation step.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 12, 2022
    Applicants: KEIO UNIVERSITY, KOSE Corporation
    Inventors: Hiroshi KAWASAKI, Eiryo KAWAKAMI, Keita KOSEKI, Tamotsu EBIHARA, Masayuki AMAGAI, Eiji NARU, Makoto MIZUNO, Miki ITO, Toru ATSUGI, Yukako KIMURA
  • Publication number: 20220133813
    Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.
    Type: Application
    Filed: February 8, 2019
    Publication date: May 5, 2022
    Applicant: Keio University
    Inventors: Kenya Honda, Takeshi Tanoue, Yutaka Kawakami, Koji Atarashi, Satoru Morita, Ashwin Nicholas Skelly
  • Publication number: 20220134542
    Abstract: A position/force controller performs a first conversion for distributing control energy to at least one of velocity or position energy and force energy, in accordance with a function to be realized, based on velocity (or position) and force information, which correspond to information relating to a position based on an operation of an actuator, and information serving as reference of control. The position/force controller calculates at least one of a velocity or position control amount and a force control amount based on at least one of the energies obtained through the distribution. The position/force controller integrates the calculated control amounts, performs a second conversion, and determines input to the actuator. The position/force controller performs a process, corresponding to increasing or decreasing performed on at least one of the velocity or position energy and the force energy together or independently, with satisfaction of a condition set for the control energy.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicants: KEIO UNIVERSITY, Motion Lib, Inc.
    Inventors: Kouhei OHNISHI, Takahiro NOZAKI, Takahiro MIZOGUCHI
  • Publication number: 20220125858
    Abstract: The present invention provides an antibacterial composition against drug-resistant bacteria or pro-inflammatory bacteria containing an intestinal bacterium as an active ingredient, or a pharmaceutical composition for treating, ameliorating, or preventing an infectious disease or an inflammatory disease.
    Type: Application
    Filed: March 5, 2020
    Publication date: April 28, 2022
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Keiko YASUMA, Koji ATARASHI, Seiko NARUSHIMA, Munehiro FURUICHI, Takaaki KAWAGUCHI
  • Publication number: 20220082564
    Abstract: A marker may determine sensitivity to an anti-cancer agent early after the start of treatment with the anti-cancer agent. The anti-cancer agent may include oxaliplatin or a salt thereof, fluorouracil or a salt thereof, and levofolinate or a salt thereof, the marker including one or more molecules selected from the group consisting of 2AMAD, 2ABA, 2CYPR, 5OPRO, 6AHXA, ADEN, ASP, BETNC, CARB, CSSG, DOPM, GGLCY, GSSG, HYPT, METSF, N6MDA, NOMTR, PHEP, PRO, and RIB5P.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 17, 2022
    Inventors: Shinji SUGIMOTO, Yusuke TANIGAWARA, Mitsuhisa MATSUO, Hiroyuki TAKAHASHI
  • Patent number: 11272833
    Abstract: A treatment-instrument insertion aid (10) for aiding insertion of a treatment instrument into a body includes an inner tube (20) having flexibility into which the treatment instrument is insertable, and an outer tube (30) having flexibility into which the inner tube (20) is insertable. Both end portions (20B) of the inner tube (20) are formed of a hard material, and an intermediate portion (20A) between both the end portions (20B) is formed of a soft material.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 15, 2022
    Inventors: Norihito Wada, Takuya Miyazaki, Yoshihiko Himura
  • Publication number: 20220062315
    Abstract: An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising, as an active ingredient, a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT). Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof. [In the formulas, each of formula (III) and formula (IV) represents an ?-anomer or a ?-anomer; each of R4, R3, and R4 is —OH or -OAc; R2 is a halogen atom, —OH, or -OAc; and R5 is —CH3, —C?CH, —C?CCH3, or —CH2C?CH.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 3, 2022
    Inventors: Kazuhiko KATAYAMA, Akira FUJIMOTO, Kei HAGA, Reiko TODAKA, Toshiro SATO
  • Patent number: 11241200
    Abstract: According to one embodiment, an X-ray computed tomography apparatus includes a gantry body, a column, and fixing equipment. The gantry body includes a bore to form a field of view, and also includes an X-ray tube and an X-ray detector. The column supports the gantry body so that the gantry body is vertically movable with a central axis of the bore extending vertically to a floor face. The fixing equipment fixes a subject holder so that the subject holder is located on a passage of the bore and partially in the bore in a phase of attaching a subject to the subject holder.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: February 8, 2022
    Inventors: Keisuke Oishi, Katsumi Gotanda, Masahiro Jinzaki, Takeo Nagura, Naomichi Ogihara
  • Publication number: 20220033911
    Abstract: Provided are a method for determining prognosis of endometrial cancer, a method for determining endometrial cancer patient compatible to preservation therapy, and a method for determining risk of endometrial cancer. The methods comprise detecting DNA methylation level at a target CpG site in a genomic DNA derived from an endometrial cell, endometrial cancer cell or tissue containing the cell. Prognosis of endometrial cancer, compatibility to preservation therapy, or risk of endometrial cancer of a subject is determined on the basis of the detected DNA methylation level.
    Type: Application
    Filed: December 5, 2019
    Publication date: February 3, 2022
    Inventors: Yae KANAI, Eri ARAI, Daisuke AOKI, Nobuyuki SUSUMU, Wataru YAMAGAMI, Takeshi MAKABE
  • Publication number: 20220034900
    Abstract: An analysis method includes: acquiring data corresponding to a mass spectrum obtained by subjecting a sample containing a microorganism to mass spectrometry; and acquiring information on Group A Streptococcus of emm type 1, based on the presence or absence, or magnitude of a peak in a first range of m/z of 10930 or more to 10945 or less in the mass spectrum.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 3, 2022
    Inventors: Miyuki MOROZUMI, Megumi SAKUMA, Koretsugu OGATA, Keisuke SHIMA, Shinji FUNATSU
  • Publication number: 20220023355
    Abstract: In the present invention, the influence by flora of the skin on dermatitis is examined by analyzing Tmem79-knockout model mice, and a bacterium having a suppressive effect on dermatitis is identified, and the present invention relates to a pharmaceutical composition derived from such a bacterium, containing as active components one or more substances selected from: (a) a bacterial cell of an ampicillin-sensitive bacterium, or a constituent component of the bacterium; (b) a culture supernatant of an ampicillin-sensitive bacterium, or a purified product from the culture supernatant; (c) an extract of an ampicillin-sensitive bacterium; and (d) a metabolite of an ampicillin-sensitive bacterium.
    Type: Application
    Filed: February 3, 2020
    Publication date: January 27, 2022
    Inventors: Yoshihiro Ito, Kenya Honda, Masayuki Amagai, Eiryo Kawakami
  • Publication number: 20220010271
    Abstract: A method for producing a brain organoid is provided, including a step of culturing a neuroectoderm marker-positive cell aggregate in a medium containing an extracellular matrix with a concentration of more than 10% by volume.
    Type: Application
    Filed: October 10, 2019
    Publication date: January 13, 2022
    Applicants: JSR Corporation, KEIO UNIVERSITY
    Inventors: Hayato HIRAMINE, Mitsuru ISHIKAWA, Hideyuki OKANO
  • Patent number: 11220418
    Abstract: Weighing and filling apparatus for controlling filling device based on a container weight. A linear actuator for driving a drive shaft coupled to container support unit is included, a weight measuring unit determines the container weight from a detected height of the drive shaft detected by a height detecting unit and a drive signal of the linear actuator at the detected height. A first acceleration signal is calculated from a specified height of the container support unit set in advance and the height detected by the height detecting unit, a second acceleration signal is calculated from the container weight and an expected weight expected to be applied to the container support unit. The container support unit is kept at the specified height by a drive signal calculated from the first and second acceleration signals.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: January 11, 2022
    Inventors: Takahiro Nozaki, Kouhei Ohnishi, Toshiaki Naka, Masato Ohta, Takaharu Kikura
  • Publication number: 20210404009
    Abstract: A method for determining a risk of urothelial carcinoma may be based on the methylation level of DNA. A method for determining a risk of canceration of a urothelial tissue may involve detecting the DNA methylation level of a CpG site of at least one gene selected from TENM3, HOXC4, TLR1, CPVL and PRDM16 in genomic DNA preferably derived from a urothelial cell or a tissue containing the urothelial cell; and determining a risk of canceration of the urothelial tissue from the detected DNA methylation level.
    Type: Application
    Filed: March 19, 2019
    Publication date: December 30, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Yae KANAI, Eri ARAI
  • Publication number: 20210393634
    Abstract: The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.
    Type: Application
    Filed: May 10, 2019
    Publication date: December 23, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Tsutomu Takeuchi, Katsuya Suzuki, Keiko Yoshimoto
  • Publication number: 20210395692
    Abstract: In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being stable and highly efficient. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by attenuating differentiation resistance of a pluripotent stem cell to generate a pluripotent stem cell that actively proceeds to a differentiated cell type has been found, and thus the present invention has been completed.
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Minoru Ko, Tomohiko Akiyama
  • Patent number: 11193107
    Abstract: The invention provides a method for producing a substrate for supporting cells, including a humidification step of humidifying the periphery of a non-fluorine resin based substrate, and a UV irradiation step of irradiating the substrate with UV in an oxygen and/or ozone containing atmosphere during and/or after the humidification step. The invention also provides a substrate for supporting cells, which is a non-fluorine resin based substrate. The substrate has a cell supporting surface for supporting cells, containing a component capable of generating C7H5O+ molecules by beam irradiation of a time-of-flight secondary ion mass spectrometer, such that cells are supported on the cell-supporting surface.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: December 7, 2021
    Assignees: Ebara Jitsugyo Co., Ltd., Keio University
    Inventors: Shuichi Takahashi, Michio Ohira, Hideo Nakata, Shogo Miyata, Shugo Tohyama, Jun Fujita, Keiichi Fukuda
  • Publication number: 20210369785
    Abstract: A cell preparation for treating brain tumors used in combination with a prodrug that is converted to 5-fluorouracil by cytosine deaminase, wherein the cell preparation comprises neural stem cells derived from pluripotent stem cells having a cytosine deaminase gene and a uracil phosphoribosyltransferase gene is provided to establish new means for treating brain tumors.
    Type: Application
    Filed: November 19, 2018
    Publication date: December 2, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Masahiro TODA, Hideyuki OKANO, Hiroyuki MIYOSHI, Ryota TAMURA
  • Patent number: 11167018
    Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: November 9, 2021
    Assignees: Keio University, The University of Tokyo
    Inventors: Kenya Honda, Takeshi Tanoue, Masahira Hattori, Yutaka Kawakami
  • Publication number: 20210334336
    Abstract: A function generation apparatus includes a function setter, a data string selector, and a matrix generator. The function setter sets a target function in an apparatus to be controlled. The data string selector selects, from among data strings indicating a plurality of combinations of parameters that can be reflected in control in the apparatus to be controlled, data strings according to the function set by the function setter. The matrix generator generates a transformation matrix according to the target function using the data strings selected by the data string selector as elements.
    Type: Application
    Filed: September 2, 2019
    Publication date: October 28, 2021
    Applicants: KEIO UNIVERSITY, Motion Lib, Inc.
    Inventors: Kouhei OHNISHI, Takahiro MIZOGUCHI