Abstract: In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.

Abstract: A control system includes a master device, a slave device, and a control device. Furthermore, the control device includes a tactile force transmission unit and a mode setting unit. The tactile force transmission unit controls tactile force transmission in the master device and the slave device. The mode setting unit changes an amplification factor of force transmitted from the slave device to the master device in a specific section in which a moving element of the slave device moves on the basis of a physical quantity in the moving element of the slave device.

Abstract: A data generation device includes: a parameter generator; and a reaction force data generator. The parameter generator generates value data based on a signal having a correlation with a driving force. The parameter generator generates velocity data based on a signal representing a response of a member driven by the driving force. The reaction force data generator generates data of a reaction force received by the member from a predetermined object based on the value data and the velocity data.

Abstract: The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.

Abstract: A position/force control system includes a worn unit and a control unit. The worn unit is configured to be worn on a body of a user, and provides force tactile sensation by an actuator. The control unit acquires data of a position of the worn unit in a space, based on data of space in which a touching object exists. The worn unit includes a control unit that acquires the data of the position from the control unit and controls driving of the actuator based on impedance and contour information of the touching object in the space, and the data of the position, thereby providing force tactile sensation.

Abstract: The present inventors have found that the content ratios of isoalloLCA, 3-oxoLCA, alloLCA, and 3-oxoalloLCA in the feces of centenarians are higher than those of younger ones, and have also identified gut microbiomes peculiar to centenarians involved in the production of these bile acids. Furthermore, it has been found that these bile acids, enzymes involved in the production thereof, and bacteria producing the enzymes reduce the risk of infection with pathogens, prostate cancer, and the like, and are involved in longevity.

Abstract: In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.

Abstract: A cell preparation for treating brain tumors used in combination with a prodrug that is converted to 5-fluorouracil by cytosine deaminase, wherein the cell preparation comprises neural stem cells derived from pluripotent stem cells having a cytosine deaminase gene and a uracil phosphoribosyltransferase gene is provided to establish new means for treating brain tumors.

Abstract: An operational data management system includes an operational data acquisition unit, a tag assigner, and a database management unit. The operational data acquisition unit acquires, as operational data, time-series control parameters used to transmit force tactile sensation between devices. The tag assigner assigns, as identification information, information related to operation content implemented by the operational data to the operational data acquired by the operational data acquisition unit. The database management unit accumulates a plurality of pieces of operational data assigned identification information by the tag assigner, and manages the operational data so that desired operational data is searchable from the accumulated plurality of pieces of operational data based on the identification information.

Abstract: Provided is an endoscope holder capable of turning or swinging an endoscope inserted into a body with the endoscope fixed at a predetermined insertion position. An endoscope holder (1) includes a holder main body (3) having an insertion hole (2), gripping members (7a) and (7b) configured to pinch an endoscope E inserted into the insertion hole (2), first elastic members (12a) and (12b) configured to urge in a direction in which the gripping members (7a) and (7b) are separated from each other, a pressing member (13) configure to press the gripping member (7a) toward the gripping member (7b), a switching mechanism (17) configured to hold or release a pressing state, rollers (10) provided in gripping members (7a) and (7b), and a second elastic member (15) configured to swingably support the gripping member (7b).

Abstract: An electroencephalogram decision system determines, when finding electroencephalogram information representing an electroencephalogram obtained by an electrode unit placed on a region of interest that forms part of a subject's head satisfying a predetermined condition, that a target electroencephalogram, which is an electroencephalogram with a characteristic variation, should have been produced. The predetermined condition is selected from of detection conditions including a first type of condition and a second type of condition. The first type of condition specifies that a decision should be made, based on a component falling within a single frequency band included in the electroencephalogram represented by the electroencephalogram information, whether or not the target electroencephalogram has been produced.

Abstract: A method for predicting a depressive state using a wearable device. Each data type of biological data for several days from plurality of subjects is converted into data in predetermined time unit (S201). Next, quantiles of the distribution of obtained sample data are determined for each subject and each data type (S202). The standard deviation of distribution of the obtained sample data is calculated for each subject and each data type (S203). The Pearson correlation coefficient is calculated for each combination of data types for each subject (S204). Next, a prediction model for the classification problem of whether subject is in a depressive state is trained by machine leaning (S206), wherein quantiles, standard deviations, and Pearson correlation coefficients extracted from the biological data are features used for an input vector, and an evaluation of existence or non-existence of a depressive state by an expert is a label used as teacher data.

Abstract: A light intensity measurement system includes a light source unit configured to emit coherent light to aqueous humor of a subject eye, a polarization control unit that is arranged between the light source unit and the subject eye, and configured to control a polarization state of the coherent light, and a measurement unit configured to measure light intensity of scattered light in the aqueous humor of the coherent light. With this configuration, a light intensity measurement system that can non-invasively measure the concentration of substances contained in aqueous humor of a subject eye is provided.

Abstract: A culture method includes culturing a spheroid of a human neural cell-like cell in the presence of a tau protein aggregate and culturing a culture product in a culture medium containing 5 ?g/mL or greater of a lipid, in which the lipid is one or more selected from the group consisting of a glycerolipid, a glycerophospholipid, and a sphingolipid. The culture method includes culturing a spheroid of a human neural cell-like cell in the presence of a tau protein aggregate and culturing a culture product in a culture medium containing a neurotrophic factor.

Abstract: The present invention is to provide a means for promoting muscle regeneration from muscle damage. According to the present invention, the muscle regeneration from muscle damage is promoted by using a compound having histamine H receptor agonist activity (except for histamine) or a salt thereof is used as an active ingredient.

Abstract: A neurite outgrowth promotion kit containing a ?-secretase inhibitor or a GADD45G expression vector, in which the neurite outgrowth promotion kit is used for significantly promoting neurite outgrowth of nerve cells as compared with a control, by acting on a neurosphere to induce differentiation of the neurosphere into nerve cells; a method for producing a neurosphere for treatment of spinal cord injury, which includes a step of using the above-described neurite outgrowth promotion kit on a neurosphere derived from a pluripotent stem cell; a neurosphere for treatment of spinal cord injury; and a method for selecting a neurosphere for treatment of spinal cord injury and a method for screening a neurite outgrowth-promoting agent.

Abstract: An object of the present disclosure is to provide an actuator that can be used for a multi-degree-of-freedom manipulator and can solve at least a part of a problem of reduction in backdrivability of a gear. Provided are an electric motor and an actuator. The electric motor comprises a stator and a rotor, wherein the electric motor comprises a first link in which a link part is provided in the stator and a second link in which a link part is provided in the rotor.

Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.

Abstract: To treat brain dysfunctions, brain diseases or tumors, the present invention provides a cell preparation comprising neural stem cells differentiated from pluripotent stem cells into which a suicide gene has been introduced.

Abstract: A function management system according is communicatively connected to a client system and includes a request receiving unit and a function assignment unit. The request receiving unit receives an execution request for one process of a plurality of processes based on the control parameters for transmitting force tactile sensation. The function assignment unit identifies the functions required to execute the one process, and assigns each of the identified functions to either the client system or the function management system by which the function is to be implemented.