Patents Assigned to Kernforschungszentrum Karlsruhe GmbH
  • Patent number: 5885575
    Abstract: The inventon relates to antibodies that react with a variant epilope in the extracellular region of a variant CD44 polypeptide, wherein the variant epitope has the amino acid sequence:I S S T I S T T P R A P D H T K Q N Q D W T Q W N P S H S N P EV L L Q T T T R M T D V D R N G T T A Y E G N W N P E A H P P LI H H E H H E E E E T P H S T S T I O A T P S S T T E E T A T QK E Q W F G N R W H E G Y R Q T P R E D S H S T T G T A A A S AH T S H P M Q G R T T P S P E D S S W T D F F N P I S H P M G RG H Q A G R R (residues 53-219 of SEQ ID NO:4). Methods of using the antibodies to identify variant epitopes also are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 23, 1999
    Assignees: Kernforschungszentrum Karlsruhe GmbH, Universitaet Karlsruhe, Deutsches Krebsforschungszentrum
    Inventors: Peter Herrlich, Helmut Ponta, Ursula Guenthert, Siegfried Matzku, Achim Wenzel
  • Patent number: 5795519
    Abstract: In a process of making a microstructured plastic mold from which structures can be formed galvanically a compound layer including an electrically conductive and an insulating layer portion is provided and is heated, and impressed into the insulating layer portion is a tool which has microstructured bodies disposed thereon of a height corresponding at least to the thickness of the insulating layer portion and with rough front surfaces having points and ridges adapted to penetrate the electrically insulating layer thereby to expose the electrically insulating layer at the bottom of the cavities formed by microstructured bodies.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: August 18, 1998
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Walter Bacher, Peter Bley, Michael Harmening
  • Patent number: 5760178
    Abstract: A monoclonal antibody (MAb1.1ASML) directed against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, was used to identify and isolate a complementary DNA (cDNA) clone capable of encoding for a glycoprotein with partial homology to CD44, a presumed adhesion molecule. This clone, which was subsequently designated pMeta-1, contains an additional extracellular domain of 162 amino acids inserted into the CD44 protein between amino acid positions 223 and 247 (by analogy to human and murine CD44). This new variant was expressed only in the metastasizing cell lines of two rat tumors, the pancreatic carcinoma BSp73 and the mammary adenocarcinoma 13762NF; it was not expressed in non-metastasizing tumor cell lines nor in normal rat tissues. Overexpression of pMeta-1 in the nonmetastasizing BSp73AS cell line suffices to establish full metastatic behavior. The variant-specific rat CD44 sequence was used to isolate a cDNA clone encoding for a human homologue as well.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 2, 1998
    Assignees: Kernforschungszentrum Karlsruhe GmbH, Universitaet Karlsruhe, Krebsforschungszentrum
    Inventors: Peter Herrlich, Helmut Ponta, Ursula Guenthert, Siegfried Matzku, Achim Wenzel
  • Patent number: 5759616
    Abstract: In a process for producing microstructure components on a substrate which carries electronic microcircuits cooperating functionally with the microstructure components, a first layer of a plastic material which connects with the substrate is applied to the substrate and a second layer of a plastic material which includes a separating agent but which firmly connects with the first layer is applied to the first layer and a molding tool is then impressed into the second layer to form the desired microstructures or to form cavities into the plastic material, which, upon removal of the molding tool, are filled with a metal to form the desired microstructures on the substrate upon removal of the plastic material.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: June 2, 1998
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Andreas Michel, Michael Harmening, Walter Bacher, Peter Bley, Robert Ruprecht, Alexander Both
  • Patent number: 5676983
    Abstract: For a process of making a microstructured plastic mold from which structures can be formed galvanically, a compound layer, including an electrically conductive and an insulating layer portion, is provided and is heated and impressed into the insulating layer portion, a tool is provided which has microstructured bodies disposed thereon of a height corresponding at least to the thickness of the insulating layer portion and with rough from surfaces having points and ridges adapted to penetrate the electrically insulating layer thereby to expose the electrically insulating layer at the bottom of the cavities formed by microstructured bodies.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: October 14, 1997
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Walter Bacher, Peter Bley, Michael Harmening
  • Patent number: 5674177
    Abstract: In a vascular implant for the prevention or elimination of vascular restrictions a tubular body to be inserted into a body vessel includes at least a first nuclide species which has a half life in the range of 7 hours to 7 days and a second nuclide species which has a half life of more than 100 days. Instead of providing a second nuclide species, the first nuclide species may also decay into the second nuclide species thereby providing a high initial radioactivity for a relatively short period and a relatively low radioactivity over a relatively long period.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: October 7, 1997
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Christoph Hehrlein, Peter Fehsenfeld
  • Patent number: 5635645
    Abstract: In a method of compressing data obtained from ultrasonic propagation-time measurements made at a given pulse-repetition rate over a broad surface by an inspection probe which slides through the pipe in order to detect corrosion and other abnormalities in the pipe, the particular physical characteristics of the pipe are taken into consideration whereby a high data-compression factor and, for the subsequent analysis, reliable reproduction of the actual conditions in the pipe are achieved.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: June 3, 1997
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Josef G. Ottes, Helmut Stripf
  • Patent number: 5576593
    Abstract: In an apparatus for accelerating electrically charged particles from a pulsed plasma reservoir of high particle density in a dielectric tubular chamber which extends from the reservoir and is surrounded by at least two electrodes of which one is disposed at the wall of the reservoir, the dielectric tubular chamber is partially evacuated to a sufficiently low pressure p such that the product of the gas pressure p and the inner diameter d of the tubular chamber is low enough to avoid parasitic discharges in the residual gas charge, and a voltage is applied to the electrodes such that the particles are drawn into the dielectric tubular chamber with high flow density and are accelerated therein thereby forming a charged particle beam whereby the residual gas charge in the dielectric tubular chamber is ionized along the inside wall of the tubular chamber and polarized such that the wall of the dielectric tubular chamber becomes repulsive for the charged particle beam and its axis becomes attractive whereby the cha
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: November 19, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Christoph Schultheiss, Martin Konijnenberg, Markus Schwall
  • Patent number: 5556371
    Abstract: In a device for transanal resectate extraction which includes a rectoscope sleeve with a proximal tubular end portion, a connecting piece sealingly mounted onto said tubular proximate end portion for closing the rectoscope sleeve and including a bore axially extending therethrough and a resectate extractor having a tubular portion extending through the bore so as to be axially movable but position-lockable therein. The tubular portion of the extractor has a protector portion at its distal end with an axial passage in alignment with the tubular extractor portion for receiving grasping pincers inserted through the tubular extractor portion. The protector portion has an outer diameter smaller than the inner diameter of the rectoscope sleeve so that it can be retracted into the sleeve.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: September 17, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Heinrich Schulken, Karl Schlipf
  • Patent number: 5531228
    Abstract: In a detector system for direct internal dosimetry of persons which comprises at least three gamma radiation detectors mounted on a support structure including a seat-like structure on which a person is supported in a seated position, the support structure has a first one of the detectors mounted thereon such that its central axis is directed toward the lungs of the person, a second detector mounted into the seat-like structure such that its central axis is directed upwardly toward the center of the digestive tract and a third detector arranged so that it is disposed above and its unshielded face is directed downwardly toward the legs of the person being checked for determining gamma ray emission from the whole body of said person.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: July 2, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventor: Hans Doerfel
  • Patent number: 5522823
    Abstract: A clip for use in surgery which comprises a lower and an upper portion interconnected by a flexible bridge portion wherein the lower clip portion has at its free end a pin with pointed end extending toward the upper clip portion and the upper clip portion has at its free end a rounded protector nose and has, adjacent thereto, an opening adapted to receive and engage the pin when the upper and lower clip portions are pressed together and the bridge portion is deformable at two points essentially at right angles such that, upon final deformation of the bridge portion, with the clip closed the lower and upper clip portions extend essentially parallel and are, at the bridge portion closer together than they are by simply closing the clip before the final deformation of the bridge portion.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: June 4, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Bertram Kuntz, Karl Schlipf, Heinrich Schulken
  • Patent number: 5512161
    Abstract: In a process for galvanically forming structured plate-like bodies, wherein a layer of a plastic material is structured at one side and structure bodies with plane front surfaces are formed thereon so as to rise from a contiguous electrically conductive base, the front surfaces of the structure bodies are provided with isolated spangles of electrically conductive material which are electrically insulated from each other and sized and spaced such that a line across a front surface intersects at least one of the spangles and the structure base--used as a cathode--and the structured bodies are then galvanically covered with a metal to form the structured plate on the layer of plastic material.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: April 30, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Heinz Dinglreiter, Helmut Kalb, Richard Rapp
  • Patent number: 5513006
    Abstract: In a photo-thermal sensor for determining the concentration of a compound in a sample which includes an excitation light source generating a first light beam of a wave length which is well absorbed by the compound to be determined, a modulator and an optical lens system disposed in the first light beam such that the first light beam is constricted at the location of the sample through which it is directed, a probe light source generating a second light beam extending at a right angle to the first light beam, a beam divider arranged at the intersection of the first and second light beams whereby part of the first light beam is deflected at one side of the beam divider and the second light beam passes through the beam divider such that both beams incide on the sample anti a photo-sensitive detector arranged in the light beam path behind the sample, a diaphragm is arranged in the beam path directly after the sample and an expansion lens adapted to expand the second light beam at the location of the sample to a d
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: April 30, 1996
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Torsten Schulz, Werner Faubel
  • Patent number: 5506119
    Abstract: The presence of certain extracellular regions ("ECR") from human and rat variants of the CD44 membrane glycoprotein have been found to be associated with metastasis ability in tumor cells. Isolated polynucleotides encoding the ECRs permit expression of the ECR polypeptide, which in turn can be used as an antigen to obtain monoclonal antibodies that recognize the ECR polypeptide. The anti-ECR monoclonal antibodies have the ability to prevent metastasis by tumor cells that would otherwise metastasize and spread.
    Type: Grant
    Filed: November 9, 1992
    Date of Patent: April 9, 1996
    Assignees: Kernforschungszentrum Karlsruhe GmbH, Universitaet Karlsruhe, Deutsches Krebsforschungszentrum
    Inventors: Peter Herrlich, Helmut Ponta, Ursula Guenthert, Siegfried Matzku, Achim Wenzel
  • Patent number: 5497661
    Abstract: A delay time measurement method for ultrasound of the type wherein a testing head transmits an excitation pulse that is as close as possible to the shape of a shock wave and traverses a pretravel path until it reaches the object to be examined which has a front wall and a rear wall, with at least one reflected pulse being generated at its front wall as well as at its rear wall. To improve the above-mentioned type method so that delay time measurements for thickness determinations and abnormalities can be performed reliably even on rough surfaces and if reflected pulses are missing or falsified, a time window is determined for the recording of reflected pulses that follow the excitation pulse, within which window all successive reflected pulses are digitized.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: March 12, 1996
    Assignees: Kernforschungszentrum Karlsruhe GmbH, Pipetronix GmbH
    Inventors: Helmut Stripf, Thomas Kuhner, Armin Herth
  • Patent number: 5462640
    Abstract: An etching solution for etching away a metal layer from a substrate includes a hydrogen-containing compound that dissolves the metal layer while developing hydrogen; and a nitrosubstituted organic compound having a nitro group which is easily hydratable and which has at least a 1/3 nitro group equivalent per mole of the hydrogen developed by reaction between the hydrogen-containing compound and the metal layer until the metal layer is dissolved completely. A method for etching employs the etching solution into which the substrate is immersed. The process of preventing the release of hydrogen gas during the etching away of a metal layer from a substrate is taught and includes employing an etching solution containing one of an acid or a highly basic metal hydroxide; and adding to the etching solution an organic nitro compound which is soluble in water and which is easily hydratable.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: October 31, 1995
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Walter Stark, Robert Ruprecht
  • Patent number: 5389103
    Abstract: In a surgical stitching apparatus for endoscopically performing sutures of tissue or vessels having a drive mechanism including concentric tubes with an operating handle structure at one end and a stitching head mounted at the distal end thereof, the stitching head includes a stationary and a movable mouthpiece each with clamping structures for engaging the tips of a needle each comprising movable and stationary halves with the movable half on the stationary mouthpiece being operatively connected to one of the concentric tubes and the movable mouthpiece being connected to another of the concentric tubes which is hand-operable by a movable handle on the operating handle structure, and the one concentric tube is operable by a pedal switch-controlled mechanism mounted on the operating handle structure for foot operation of the clamping structure on the stationary mouthpiece.
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: February 14, 1995
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Andreas Melzer, Gerhard Buess, Rainer Trapp, Klaus-Peter Brhel
  • Patent number: 5369981
    Abstract: The invention relates to a process for the continuous determination of the dust content of flowing media with the isokinetic flow sampling with the separation of the dust or aerosols by cake filtration on a filter and the measurement of the pressure drop at the filter to determine its degree of clogging. To this end the time cycle of the quantity of dust separated on the filter is determined by the measurement of the pressure loss at the filter of an isokinetically operating sampling system. To find the dust load, this quantity of dust is related to the partial quantity of gas extracted isokinetically during the period concerned.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: December 6, 1994
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Albert Merz, Roland Walter, Ernst Becker, Thomas Brielmaier
  • Patent number: 5277056
    Abstract: Process for the continuous monitoring of waste gas from an incinerator plant, which contains volatile mercury halides and optionally metallic mercury in the form of vapor, with respect to the entire mercury content, of the waste gas taking a continuous test gas stream from the waste gas, cooling the test gas stream to form a condensate which contains a reducing agent, continuously passing the test gas stream into contact with the condensate to reduce the mercury halides contained in the test gas stream to metallic mercury by the reducing agent contained in the condensate, and subsequently determining the entire metallic mercury content by analysis of the test gas stream.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: January 11, 1994
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Hartmut Braun, Andreas Gerig
  • Patent number: 5266962
    Abstract: A mode converter for converting transverse electric modes into hybrid modes of type EH.sub.mn and including a circular waveguide provided with corrugations extending in a circumferential (azimuth) direction that become deeper toward its end and are continued in a subsequent helically outlined aperture antenna with constant depth. The emitted radiation is circularly polarized and, by the use of suitable reflectors for the emitted radiation, may be cause to be linearly polarized. The emitted radiation no longer has any sidelobes in the far field and its characteristic has a Gaussian profile over the azimuth angle.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: November 30, 1993
    Assignee: Kernforschungszentrum Karlsruhe GmbH
    Inventors: Arnold Mobius, Manfred Thumm