Abstract: A non-cellular dental tissue regeneration promoting kit is provided that makes effective dental tissue regeneration possible without transplantation of autologous or allogeneic stem cells or components derived from stem cells. The kit comprises: a pretreatment agent comprising a serine protease; and a non-cellular root canal filling material, the non-cellular root canal filling material comprising: a regeneration promoting compound including at least one of a CCR3 antagonist, a CCL11 neutralizing antibody, and an ALK5 inhibitor; and an extracellular matrix. The kit is preferably used for middle-aged or elderly individuals.

Abstract: The present invention provides a novel copolymer available for a drug delivery technique. More particularly, a novel copolymer for a drug delivery carrier targeting a tumor is provided. The present invention relates to a copolymer comprising structural units represented by the following formulas (A), (B), and (C): wherein R1, R2, and R3 are the same or different and represent a hydrogen atom or a C1-3 alkyl group, R4 represents a C1-3 alkyl group, R5 represents a hydrogen atom, a C1-18 alkyl group, a 3- to 8-membered cycloalkyl group optionally having a substituent, an adamantyl group, a C6-18 aryl group optionally having a substituent, or a 5- to 10-membered heteroaryl group optionally having a substituent, X1, X2, and X3 are the same or different and represent an oxygen atom, a sulfur atom, or N—R7, R6 represents a hydrogen atom, a leaving group, or a linker, R7 represents a hydrogen atom or a C1-3 alkyl group, m represents an integer of 1 to 100, and n represents an integer of 0 to 3.

Abstract: According to one or more embodiments of the disclosure, a lens barrel includes an operation member and a knob. The operation member is disposed to be rotatable in a circumferential direction with respect to a lens barrel body. The knob is restricting and fixing rotation of the operation member in the circumferential direction. The lens barrel further includes a knob falling-off prevention member capable of switching between a first state of making the knob detachable from the lens barrel body and a second state of making the knob non-detachable from the lens barrel body.

Abstract: Developed and provided is a method of collecting a large amount of high-quality bagworm silk threads having no contaminant from bagworm nests in a convenient manner and at low cost. The habit of bagworms is utilized to allow a bagworm to build a nest using solvent-soluble substances or thermally meltable substances as nest materials, followed by dissolving or melting the nest materials to separate the nest material from the bagworm silk threads, whereby only pure bagworm silk threads constituting the bagworm nest can be obtained.

Abstract: An object of the present invention is to develop: a method of efficiently producing a long bagworm silk thread containing no contaminant while preventing a change in the spinning direction and the runaway of the bagworm from a rail, and alleviating a burden on the bagworm; and an apparatus for implementing the thread-producing method. Provided is an apparatus for producing a bagworm silk thread, having a movable rail having a width smaller than the maximum width between the right and left legs of a bagworm and configured to move in the longitudinal direction and to be able to hold with the legs of the bagworm; and a fixator configured to fix a bagworm, wherein the fixator is placed at a position such that the fixed bagworm can hold the movable rail.

Abstract: A simple and efficient breeding method for the bagworm moth is provided, as well as a device for performing the method. Also developed and provided is a method of easily collecting eggs from a bagworm moth, an egg collection device for bagworm moths composed of a tubular container. A bagworm moth breeding method and egg collection method performed using the device are also described.

Abstract: To provide a medicament for safely treating a patient in need of treatment with pemafibrate, a salt thereof, or a solvate of any of these (hereinafter also referred to as pemafibrate therapy). A medicament for treating a patient in need of pemafibrate therapy, the medicament comprising the step of avoiding or suspending concomitant use of pemafibrate, a salt thereof, or a solvate of any of these as an active ingredient in order to suppress an increase in plasma concentration of pemafibrate when the treatment is combined with a medicament containing an OATP1B inhibitor, or the step of reducing the dose of pemafibrate, a salt thereof, or a solvate of any of these.

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and one or more selected from the group consisting of a metal oxide, a dihydric alcohol, an ester species and a silicic acid compound and which has excellent storage stability. The pharmaceutical composition includes the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) to (B-4): (B-1) a metal oxide; (B-2) a dihydric alcohol; (B-3) an ester species; and (B-4) a silicic acid compound, with component (A) and component (B) being substantially in non-contact with each other.

Abstract: In order to obtain an inspection image without blown-out highlights generated due to specular reflection or the like or blocked-up shadows generated at a position to which light hardly reaches, an image processing device includes a plurality of light sources that irradiates an object with light and a control circuit that controls light emission of the plurality of light sources, a camera that photographs the object, and a processor that controls switching of a light emission pattern of the plurality of light sources and controls photographing execution timing of the camera, controls the plurality of light sources to emit light with a plurality of light emission patterns, performs photographing at timings during at least two or more patterns among the plurality of light emission patterns to obtain a plurality of intermediate images, and generates one final image based on the plurality of obtained intermediate images.

Abstract: An imaging device according to the present invention includes an illumination unit 20 containing a light source 21 for emitting illumination light 2, and a lens group 22 for irradiating an imaging object 1 with the illumination light 2 emitted from the light source 21, and an imaging unit 10 for imaging the imaging object 1. A part of the illumination light 2 is shielded by a light shielding component 40.

Abstract: Provided is a novel inhalant as a therapeutic agent for COVID-19. The present invention relates to an inhalant containing cepharanthine.

Abstract: A medical examination device having a grip portion that is grippable by an operator in such a manner as to be sandwiched between a thumb and at least one of four fingers including an index finger, a middle finger, a ring finger, and a little finger on an index finger side of one hand, to examine a subject by performing operation in a state where the grip portion is gripped with the one hand, includes a finger hook portion provided on the grip portion to be hooked on any of the fingers located on the index finger side when the grip portion is gripped by the operator with the one hand.

Abstract: In classifying images by machine learning, provided are an image classification method, device, and program for classifying the image from which the feature difference is hardly detected, in particular, classifying the interference fringe image of tear fluid layer by the dry eye types. The method includes a step of acquiring a feature value from an interference fringe image of tear fluid layer for learning, a step of constructing a model for classifying an image from the feature value acquired from the interference fringe image of tear fluid layer for learning, a step of acquiring the feature value from an interference fringe image of tear fluid layer for testing, and a step of performing classification processing for classifying the interference fringe image of tear fluid layer for testing by types of dry eye using the model and the feature value acquired from the interference fringe image of tear fluid layer.

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition contains pemafibrate, a salt thereof or a solvate thereof in an amount of 0.017 to 4.2 mass % in terms of a free form of pemafibrate with respect to the total mass of the pharmaceutical composition.

Abstract: A movement control method and a spinning position control method for a bagworm is provided, in which a bagworm is led to a predetermined position and allowed to spin a foothold silk thread at the predetermined position. A behavior control method in which a light is radiated to a bagworm to lead the bagworm toward a direction from which the light is radiated, and a spinning position control method in which a light is radiated to a bagworm at a spinning position on a surface of a base material to allow the bagworm to spin at the position are also provided.

Abstract: An object of the present invention is to develop and provide a fiber-reinforced composite material having an “elongation” feature in addition to a high strength and a high elastic modulus. Further, an object of the present invention is to address problems of brittleness and peeling in the conventional fiber-reinforced composite materials. A fiber-reinforced composite material containing the bagworm silk thread as reinforcing fibers is provided.

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.