Abstract: A method, a computer program and a device for evaluating a tear fluid layer non-invasively. The method, computer program, and device include a step of detecting a time when color information in a predetermined region in a tear fluid layer interference fringe image changes by a threshold value or more as an eyelid opening time, a step of extracting an image at the time when the predetermined time has passed from the eyelid opening time as an extracted image from the tear fluid interference fringe images, a determination value calculation step of calculating a determination value from the color information in a pixel in a local region by scanning a predetermined target region, a step of detecting a corresponding pixel by comparing the calculated determination value and a threshold value, and an evaluation step of evaluating tear fluid layer breakdown by comparing the detected pixel and a threshold value.

Abstract: An object of the present invention is to develop: a method of efficiently producing a long bagworm silk thread containing no contaminant while preventing a change in the spinning direction and the runaway of the bagworm from a rail, and alleviating a burden on the bagworm; and an apparatus for implementing the thread-producing method. Provided is an apparatus for producing a bagworm silk thread, having a movable rail having a width smaller than the maximum width between the right and left legs of a bagworm and configured to move in the longitudinal direction and to be able to hold with the legs of the bagworm; and a fixator configured to fix a bagworm, wherein the fixator is placed at a position such that the fixed bagworm can hold the movable rail.

Abstract: An object of the present invention is to develop: a method of efficiently producing a long bagworm silk thread without slack of reeling during collection while preventing a change in the spinning direction and the runaway of the bagworm from a rail, and alleviating a burden on the bagworm; and an apparatus for implementing the thread-producing method. Provided is an apparatus for producing a bagworm silk thread, including: a movable loop-shaped rail configured to move in the longitudinal direction and to be held by the legs of a bagworm; a fixator configured to fix the bagworm; and an adhesion controller configured to store an adhesion control solution for washing away or removing a gummy component from the bagworm silk thread spun on the movable loop-shaped rail, wherein the apparatus makes it possible to cumulate the bagworm silk thread spun on the movable loop-shaped rail.

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) to (B-6): (B-1) a cellulose ether species; (B-2) a starch species; (B-3) a povidone species; (B-4) a silicic acid compound; (B-5) a polyhydric alcohol; and (B-6) an alkyl sulfate ester.

Abstract: An example apparatus comprising an image acquisition unit configured to acquire a plurality of images having temporal or spatial continuity; a channel assignment unit configured to assign a channel different from each other to at least a part of gradation information on a color and/or gradation information on brightness that can be acquired from each image of the plurality of images based on a predetermined rule; a composite image generation unit configured to generate one composite image in which gradation information on at least a part of each image can be identified by the channel by extracting and combining gradation information to which the channel is assigned from each of the plurality of images; and an inference unit configured to analyze the composite image and to infer the plurality of images.

Abstract: There is provided a toric intraocular lens which improves the visibility of a toric axis. The toric intraocular lens is a toric intraocular lens including a lens body provided with an astigmatic axis. A mark indicating the astigmatic axis is formed at an optical surface of an outer rim portion of the lens body, and a length in a radial direction of the lens body and a length in a circumferential direction of the lens body of external dimensions of the mark are different from each other in top view of the optical surface.

Abstract: The finger supporter is disclosed. The finger supporter includes: a first anchor portion 2 that is formed at an upper end 10a of a tubular fabric and causes the tubular fabric to be fastened to a forearm wrist portion of a wearer; a second anchor portion 3 that is formed to continue two points of a circling portion on the other end side of the tubular fabric and forms the circling portion into two opening portions 12a and 12b with different sizes; and a first support portion 4 that couples the second anchor portion 3 and the first anchor portion 2 and supports any one finger inserted into the smaller opening portion 12a from among five fingers.

Abstract: An ophthalmic image of an evaluation target is acquired, a plurality of subsection images is extracted from the ophthalmic image, a state of a subject's eye is predicted for each of the subsection images based on a learned model in which learning has been performed in advance regarding extracting a plurality of subsection images from an ophthalmic image for learning, and predicting a state of a subject's eye for the each of subsection image by machine learning using correct answer data related to a state of each subsection image, and the subsection image is extracted from the ophthalmic image so as to have an image size corresponding to a state of a subject's eye of an evaluation target.

Abstract: Provided are a method, a computer program and a device for noninvasively evaluating a state of a tear fluid and a tear fluid amount of a tear meniscus. Included are a binarization step of binarizing a tear meniscus image, obtained by capturing at least a part of a tear meniscus of a subject, using a predetermined threshold value; an extraction step of extracting a high luminance region indicating a tear meniscus part from the binarized image; and an evaluation step of evaluating a tear fluid state on the basis of the high luminance region.

Abstract: The present invention relates to pharmacological interventions with pemafibrate for moderate or severe hypertriglyceridemia.

Abstract: To provide an appropriate method of treatment with pemafibrate for a liver cirrhosis patient. The present invention relates to the use of pemafibrate in a liver cirrhosis patient. More particularly, the present invention relates to a regimen for administering a reduced dose of pemafibrate to a liver cirrhosis patient in need of treatment with pemafibrate than to persons with normal liver function.

Abstract: Provided is a novel technique for improving storage stability of a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and a cellulose species. A pharmaceutical preparation obtained by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a cellulose species.

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided containing the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a disaccharide species.

Abstract: In order to obtain an inspection image without blown-out highlights generated due to specular reflection or the like or blocked-up shadows generated at a position to which light hardly reaches, an image processing device includes a plurality of light sources that irradiates an object with light and a control circuit that controls light emission of the plurality of light sources, a camera that photographs the object, and a processor that controls switching of a light emission pattern of the plurality of light sources and controls photographing execution timing of the camera, controls the plurality of light sources to emit light with a plurality of light emission patterns, performs photographing at timings during at least two or more patterns among the plurality of light emission patterns to obtain a plurality of intermediate images, and generates one final image based on the plurality of obtained intermediate images.

Abstract: Provided is a gene expression reinforcement system for a recombinant bagworm fibroin H chain protein. The system includes a gene encoding a modified recombinant bagworm fibroin H chain protein in which either the N-terminal domain or the C-terminal domain constituting the recombinant bagworm fibroin H chain protein has been partially or entirely deleted.

Abstract: A first communication unit 11 repeatedly transmits the same data signal as a transmitted data signal to a second communication unit 23 at shorter time intervals than an acknowledgement time in which an ACK signal is returned from the second communication unit 23 without any failure. As a result, even when the transmitted data signal is garbled in the middle of a transmission path due to noise, the second communication unit 23 can rapidly receive the repeatedly transmitted same data signal.

Abstract: A method for dynamically evaluating a tear fluid layer using an interference fringe image of the tear fluid layer composed of a plurality of consecutive frames, and includes: an image creation step of creating at least one break detection image of a first break detection image, a second break detection image, a third break detection image, and a fourth break detection image, which are images for detecting a breaking site of the tear fluid layer; a determination step of determining whether the break detection image created by the image creation step corresponds to a predetermined breakup pattern; a tally step of tallying the determination results determined by the determination step; and an evaluation step of evaluating, on the basis of a tallied result by the tally step, a breakup pattern of the interference fringe image of the tear fluid layer.

Abstract: To realize a toric ophthalmic lens including an edge that makes it possible to design a lens contributing to secondary cataract prevention without deteriorating a degree of freedom of lens design. The toric ophthalmic lens is a toric ophthalmic lens in which, in a top view of an optical portion, a substantially flat portion having a substantially fixed edge thickness of the optical portion is provided to overlap a steep meridian of a toric surface of the optical portion.

Abstract: The present invention addresses the problem of providing a therapeutic agent for an abdominal aortic aneurysm, the therapeutic agent making drug therapy possible. The present invention provides a therapeutic agent for aortic aneurysm, the therapeutic agent having as active ingredients: (?)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these; and a statin.

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent storage stability. The pharmaceutical composition is provided to contain pemafibrate, a salt thereof or a solvate thereof, wherein a pH value of a solution produced by dissolving or dispersing the pharmaceutical composition in water is 7 or more.