Patents Assigned to Kowa Company, Ltd.
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Publication number: 20220162206Abstract: To provide a novel compound or a salt thereof or a solvate thereof, having a CSF-1R inhibitory activity and exhibiting antitumor effect. An azaindole derivative of formula (I): wherein A represents a C6-10 aryl ring, an aromatic heterocycle, or an unsaturated heterocycle, and A optionally has one substituent or more same or different substituents; and R represents a C1-3 alkyl group or a saturated heterocyclic group, or a salt thereof or a solvate thereof.Type: ApplicationFiled: March 30, 2020Publication date: May 26, 2022Applicant: KOWA COMPANY, LTD.Inventors: Gen WATANABE, Toshiharu MORIMOTO, Akira IWATA, Hirotaka SASAKI, Takahisa OGAMINO, Kosuke USUDA, Ayumu OKUDA, Hiroyuki ISHIWATA, Yuichiro TABUNOKI, Keigo NISHII
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Publication number: 20220151996Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.Type: ApplicationFiled: February 2, 2022Publication date: May 19, 2022Applicant: KOWA COMPANY, LTD.Inventors: Shin SUGIMOTO, Akito MINAMIZONO
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Patent number: 11328417Abstract: A non-transitory computer-readable medium stores a program capable of improving the accuracy of detection of a target object. The program causes a computer to execute operations including, acquiring data in which a physical quantity is associated with each unit area acquired by dividing a given space; setting a detection region in a time space of three or more dimensions in the space or the time space; setting a control region at a position surrounding a gap with the gap surrounding the detection region disposed in a space having the same dimensions as those of the detection region; and determined whether or not one or more unit areas included in the detection region are predetermined areas on the basis of comparison between physical quantities of one or more unit areas included in the detection region and the control region that are set.Type: GrantFiled: October 29, 2018Date of Patent: May 10, 2022Assignee: KOWA COMPANY, LTD.Inventor: Katsumi Yabusaki
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Publication number: 20220133714Abstract: The present invention provide an agent for modulating expression of extracellular matrix by corneal endothelial cells. The present invention pertains to an agent for modulating expression of extracellular matrix by corneal endothelial cells containing, 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof.Type: ApplicationFiled: February 27, 2020Publication date: May 5, 2022Applicants: KOWA COMPANY, LTD.Inventors: Friedrich E. KRUSE, Ursula SCHLOTZER-SCHREHARDT
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Publication number: 20220127768Abstract: An object of the present invention is to develop and provide a fiber-reinforced composite material having a bagworm silk thread(s) as a reinforcing fiber and being isotropic in terms of elastic modulus and strength. A fiber-reinforced composite material having nonwoven fabric(s) including bagworm silk thread as a reinforcing fiber is also provided.Type: ApplicationFiled: March 13, 2020Publication date: April 28, 2022Applicants: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION, KOWA COMPANY, LTD.Inventors: Taiyo YOSHIOKA, Tsunenori KAMEDA, Akimune ASANUMA, Norhiko FUKUOKA
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Patent number: 11298340Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.Type: GrantFiled: June 29, 2018Date of Patent: April 12, 2022Assignee: KOWA COMPANY, LTD.Inventors: Shin Sugimoto, Akito Minamizono
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Publication number: 20220096443Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) and (B-7): (B-1) an alkylcellulose and a salt thereof; and a (meth)acrylic acid-based polymer.Type: ApplicationFiled: December 27, 2019Publication date: March 31, 2022Applicant: KOWA COMPANY, LTD.Inventors: Shin SUGIMOTO, Akito MINAMIZONO, Chisa NISHIDA
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Patent number: 11266308Abstract: Provided are a method and a device for evaluating a tear fluid to objectively evaluate and determine the severity of dry eye or the like. Color information is acquired in a predetermined region of a tear fluid interference fringe image, a numerical value representing a color diversity is calculated from the color information acquired, and the numerical value representing the color diversity thus calculated is used as an index for evaluating a tear fluid state.Type: GrantFiled: May 29, 2017Date of Patent: March 8, 2022Assignee: Kowa Company, Ltd.Inventor: Katsumi Yabusaki
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Publication number: 20220054458Abstract: Provided is a technique for suppressing the composition changes between pemafibrate, a salt thereof or a solvate thereof and an alkylcellulose species. A pharmaceutical preparation is provided by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) an alkylcellulose species.Type: ApplicationFiled: December 27, 2019Publication date: February 24, 2022Applicant: KOWA COMPANY, LTD.Inventor: Chisa NISHIDA
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Publication number: 20220022434Abstract: An object of the present invention is to develop: a method of efficiently producing a long bagworm silk thread containing no contaminant while preventing a change in the spinning direction and the runaway of the bagworm from a rail, and alleviating a burden on the bagworm; and an apparatus for implementing the thread-producing method. Provided is an apparatus for producing a bagworm silk thread, having a movable rail having a width smaller than the maximum width between the right and left legs of a bagworm and configured to move in the longitudinal direction and to be able to hold with the legs of the bagworm; and a fixator configured to fix a bagworm, wherein the fixator is placed at a position such that the fixed bagworm can hold the movable rail.Type: ApplicationFiled: December 4, 2019Publication date: January 27, 2022Applicants: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION, KOWA COMPANY, LTD.Inventors: Taiyo YOSHIOKA, Tsunenori KAMEDA, Takahiro KITAMURA, Akimune ASANUMA
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Publication number: 20220000786Abstract: Provided is a technique for suppressing the composition changes between pemafibrate, a salt thereof or a solvate thereof and (meth)acrylic acid-based polymers. A pharmaceutical preparation is provided by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a (meth)acrylic acid-based polymer.Type: ApplicationFiled: December 27, 2019Publication date: January 6, 2022Applicant: KOWA COMPANY, LTD.Inventor: Chisa NISHIDA
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Patent number: 11215904Abstract: A waterproof wall 60 is provided to be interposed between an end face 31 of a base end section of a waterproof lens unit 20 and a mount face 13 of a camera body 10, thereby shutting off the front surface of the camera body 10 from a space in front of the front surface of the camera body 10 by the waterproof wall 60.Type: GrantFiled: February 8, 2019Date of Patent: January 4, 2022Assignee: KOWA COMPANY, LTD.Inventor: Shuichi Tominaga
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Patent number: 11200699Abstract: Provided are an analysis evaluation method and device, and a computer program for the state of a subject surface in a still image. The method includes: a step of acquiring color information of each pixel in a predetermined region in a still image, a step of calculating a numerical value indicating a diversity of color from the acquired color information, a step of calculating an average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. Herein, the coefficient of variation is used as an index for evaluating the surface state of an object.Type: GrantFiled: April 27, 2018Date of Patent: December 14, 2021Assignee: KOWA COMPANY, LTD.Inventor: Katsumi Yabusaki
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Publication number: 20210372007Abstract: Developed and provided is a method of collecting a large amount of high-quality bagworm silk threads having no contaminant from bagworm nests in a convenient manner and at low cost. The habit of bagworms is utilized to allow a bagworm to build a nest using solvent-soluble substances or thermally meltable substances as nest materials, followed by dissolving or melting the nest materials to separate the nest material from the bagworm silk threads, whereby only pure bagworm silk threads constituting the bagworm nest can be obtained.Type: ApplicationFiled: December 18, 2018Publication date: December 2, 2021Applicants: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION, KOWA COMPANY, LTD.Inventors: Taiyo YOSHIOKA, Tsunenori KAMEDA, Akimune ASANUMA, Hironori SASSA
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Patent number: 11166948Abstract: The present invention addresses the problem of providing a therapeutic agent for abdominal aortic aneurysms, with which pharmacotherapy is possible. The present invention provides a therapeutic agent for an aortic aneurysm comprising, as an active component, (?)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these.Type: GrantFiled: September 13, 2018Date of Patent: November 9, 2021Assignees: National University Corporation Hamamatsu University School of Medicine, Kowa Company, Ltd.Inventors: Naoki Unno, Hiroki Tanaka, Tatsuro Yata, Keisuke Inoue, Yuichi Makinose, Noboru Kaneta
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Publication number: 20210290598Abstract: Provided is a medicament useful for cardiovascular diseases. An agent for prevention and/or treatment of a cardiovascular diseases, comprising a combination of pemafibrate or a salt thereof and an HMG-CoA reductase inhibitor.Type: ApplicationFiled: May 7, 2019Publication date: September 23, 2021Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, KOWA COMPANY, LTD.Inventors: Hiroshi ITO, Kazufumi NAKAMURA, Masatoki YOSHIDA, Keisuke INOUE
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Patent number: 11107214Abstract: A method and device for evaluating the dynamics of a tear fluid layer to objectively and accurately evaluate breakdown of the tear fluid layer, which is a core mechanism of dry eye, are provided. The method includes a step of acquiring color information of each pixel in a predetermined region of a tear fluid layer interference fringe image, which is a moving image or a plurality of static images, a step of calculating a numerical value indicating the diversity of color from the acquired color information, a step of calculating the average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. The coefficient of variation is used as an index for evaluating the dynamics of the tear fluid layer.Type: GrantFiled: April 27, 2018Date of Patent: August 31, 2021Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, KOWA COMPANY, LTD.Inventors: Norihiko Yokoi, Katsumi Yabusaki
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Publication number: 20210215705Abstract: An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.Type: ApplicationFiled: March 26, 2021Publication date: July 15, 2021Applicants: KOWA COMPANY, LTD.Inventors: Tsutomu Takeuchi, Keiko Yoshimoto
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Publication number: 20210172089Abstract: A bagworm silk thread spun on a base material was conventionally difficult to be collected, and thus, cannot be utilized. An object of the present invention is to develop and provide a method in which such a bagworm silk thread is peeled off from a base material with a weak force without being damaged and is collected as a thread bundle. Provided is a method for producing a thread bundle of a bagworm silk thread, including: applying, to a bagworm silk thread spun on the surface of a base material, a wetting liquid which presents a liquid form at least in the range of 20° C. or more and less than 30° C. and does not damage, denature, or dissolve the silk thread; and then separating the bagworm silk thread from the base material.Type: ApplicationFiled: August 27, 2019Publication date: June 10, 2021Applicants: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION, KOWA COMPANY, LTD.Inventors: Taiyo YOSHIOKA, Tsunenori KAMEDA, Akimune ASANUMA, Norihiko FUKUOKA
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Publication number: 20210161115Abstract: Provided is a method developed for producing a thread bundle with high efficiency in terms of spun thread collection and without causing mechanical damage to a foothold silk thread spun by a bagworm onto a base material. After a bagworm is placed along with a solvent-soluble base material and allowed to spin the foothold silk thread onto the surface of the base material, the base material is dissolved with a solvent to separate the foothold silk thread therefrom.Type: ApplicationFiled: April 16, 2019Publication date: June 3, 2021Applicants: National Agriculture and Food Research Organization, Kowa Company, Ltd.Inventors: Taiyo YOSHIOKA, Tsunenori KAMEDA, Akimune ASANUMA, Keitaro HATTORI, Norihiko FUKUOKA