Abstract: An object of the present invention is to provide ASO that can effectively suppress a formation of RNA foci spontaneously occurring in neurons having SCA36 mutation, without inducing the cleavage of NOP56 pre-mRNA. The present invention provides an oligonucleotide comprising a nucleotide sequence in which one or more nucleotide sequences represented by SEQ ID NO: 2 are consecutively connected and is complementary to pre-mRNA of NOP56 gene, wherein a structure formed by the hybridization of the oligonucleotide to the pre-mRNA is resistant to RNaseH.

Abstract: The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive cells in a ratio of at least 30% and cells that are insulin-positive and NKX6.1-negative in a ratio of more than 15%.

Abstract: An electroacoustic transducer includes: a diaphragm; a magnetic circuit having a magnetic gap; a frame that holds the diaphragm and the magnetic circuit; a voice coil having one end portion positioned within the magnetic gap and the other end portion coupled to the diaphragm; and a low friction material that is disposed in a sliding portion formed by the voice coil and the magnetic circuit, and includes polymer compounds swollen with liquid.

Abstract: A learning-type real space information generation system uses sensor data that can be efficiently uploaded from an information terminal device to a server, and which is capable of generating highly accurate real space information. A plurality of information terminal devices and a server are connected via in a communicable state via a network. The control unit of each information terminal device controls a transmission unit, based on the importance of elements configuring real space information, the importance being determined by an importance determination unit of the server such that sensor data corresponding to an element configuring the real space information and having high importance is preferentially transmitted. The generation unit of the server uses a feature model to generate real space information, based on elements configuring real space information and having high importance extracted by an extraction unit from the most recent sensor data received by a reception unit.

Abstract: A clearance narrowing material containing a brush-shaped polymer chain aggregate formed of multiple polymer chains immobilized on a substrate. The invention provides a clearance narrowing material which can effectively prevent fluid leakage through a clearance and which does not disturb relative movement of members to form a clearance, and can realize an article in which fluid leakage through a clearance can be effectively prevented and the members to form a clearance can move smoothly.

Abstract: A cell culture chip includes a plate having a first surface, a first opening formed inside the plate and having one end exposed on the first surface, a second opening formed inside the plate and at a location different from the first opening and having one end exposed on the first surface, a hollow connecting section communicating with the other end of the first opening and the other end of the second opening, and a water repellent section with water repellent treatment being provided at least in the vicinity of the first opening or the second opening on the first surface of the plate.

Abstract: A mucosal vaccine composition for preventing bovine mastitis, comprising: an antigen derived from Staphylococcus aureus; and a nanogel comprising a polysaccharide having a cationic functional group and a hydrophobic functional group in side chains. By administering the composition to cattle, it is possible to enhance the titer of an antibody against Staphylococcus aureus immediately after the contact with the bacteria in the udder, and prevent the bovine mastitis.

Abstract: A surface emitting laser element formed of a group III nitride semiconductor, comprising: a first clad layer of a first conductivity type; a first guide layer of the first conductivity type having a photonic crystal layer formed on the first clad layer including voids disposed having two-dimensional periodicity in a surface parallel to the layer and a first embedding layer formed on the photonic crystal layer; a second embedding layer formed on the first embedding layer by crystal growth; an active layer formed on the second embedding layer; a second guide layer formed on the active layer; and a second clad layer of a second conductivity type formed on the second guide layer, the second conductivity type being a conductivity type opposite to the first conductivity type. The first embedding layer has a surface including pits disposed at surface positions corresponding to the voids.

Abstract: The present invention provides a radiolabeled compound represented by the following formula (1), which is a radioactive imidazothiadiazole derivative compound having an affinity for CA-IX, or a salt thereof. wherein n is an integer of 1 to 4, and L represents a radionuclide or a mono- to tetravalent group containing a radionuclide.

Abstract: A semiconductor film containing silicon that is evenly doped in the semiconductor film with an enhanced semiconductor property and a method of the semiconductor film using a dopant material containing a complex compound that contains at least silicon and a halogen. The complex compound further contains a hydrocarbon group that is optionally substituted or heterocyclic group that is optionally substituted. A semiconductor film containing Si doped into the semiconductor film as a dopant to a depth that is at least 0.3 ?m or deeper from a surface of the semiconductor film is obtained by forming the semiconductor film in that the dopant material is doped, the semiconductor film is 100 ?m or less in film thickness with carrier density that is 1×1020/cm3 or less and electron mobility that is 1 cm2/Vs or more.

Abstract: A multiplexing optical system includes a light source, a lens and a lens array. The light source includes a plurality of light emitting elements of surface emitting lasers. The lens is configured to change and condense optical paths of laser light beams emitted from the light emitting elements. The lens array includes a plurality of lens regions arrayed so as to correspond to respective optical paths of the laser light beams changed by the lens, and is configured to condense the laser light beams by the lens regions to form a multiplexed beam.

Abstract: The present invention provides a silicon carbide fiber reinforced silicon carbide composite material, which is a composite material of SiC fibers and SiC ceramics with improved toughness and can be produced with high yield by relatively simple steps without complex steps such as a step of oxidation-resistant coating or an advanced interface control step. The silicon carbide composite material comprises a multiphase matrix and silicon carbide fibers disposed in the matrix, the matrix containing a silicon carbide phase and a phase that includes a substance of low reactivity with respect to silicon carbide. It can be obtained by steps suitable for mass production and ensures greatly improved fracture toughness while maintaining the excellent properties of SiC ceramics.

Abstract: An infusion set (1) includes: a first flow path (10a) having a first connector (11a) and a downstream connector (19); a first open/close valve (12a), a first liquid surface sensor (13a), a second liquid surface sensor (13b), a drip chamber (14), and a variable valve (17) that are provided in this order on the first flow path from the first connector side toward the downstream connector side; a droplet sensor (15) with which the drip chamber is provided; a second flow path (10b) having a second connector (11b); and a second open/close valve (12b) provided on the second flow path. The second flow path is in communication with a portion of the first flow path between the first liquid surface sensor and the second liquid surface sensor. The controller is configured to control the first and second open/close valves and the variable valves based on signals from the first and second liquid surface sensors and the droplet sensor.

Abstract: Provided is a model parameter learning device and the like capable of learning model parameters such that the influence of a noise in input data can be suppressed. A model parameter learning device (1) alternately carries out first learning processing for learning model parameters W1, b1, W2 and b2 such that an error between data Xout and data Xorg is minimized, and second learning processing for learning model parameters W1, b1, Wm, bm, Wq and bq such that a loss function LAE is minimized.

Abstract: The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A.

Abstract: Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.

Abstract: The present invention provides a conjugate comprising an antibody or antibody fragment targeting an exosome surface antigen, and an inhibitor of a gene or an expression product thereof, wherein the antibody or antibody fragment and the inhibitor of a gene or an expression product thereof are covalently bonded either directly or via a linker, or are non-covalently bonded.

Abstract: The present invention provides a plate-shaped cartilage comprising a plurality of pluripotent stem cell-derived cartilaginous particles integrated with one another; and a method for producing the plate-shaped cartilage, comprising step 1: producing pluripotent stem cell-derived cartilaginous particles, and step 2: culturing the cartilaginous particles under culture conditions that allow adjacent cartilaginous particles to be in contact with one another, wherein the number of the cartilaginous particles is that required to form the plate-shaped cartilage.

Abstract: The invention provides a microfluidic device comprising at least one cell culture chamber, the at least one cell culture chamber being connected to at least two openings, the device being configured to supply at least one physiologically active substance from at least one of the openings to the at least one cell culture chamber in such a manner as to form a concentration gradient or concentration gradients in the at least one cell culture chamber when cells and a hydrogel are introduced into the at least one cell culture chamber to culture the cells in a 3D-gel medium.

Abstract: The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.