Abstract: An object is to provide a technique of forming CpG oligonucleotides and hydrophobized polysaccharides into complexes. This object is achieved by a complex comprising a modified CpG oligonucleotide containing a hydrophobic group A having a sterol skeleton, and a modified polysaccharide containing a hydrophobic group B.

Abstract: This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3? inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.

Abstract: Disclosed is a method for detecting regulatory dendritic cells, the method comprising step a: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step b: identifying regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Also disclosed is a method for producing a cell population enriched for regulatory dendritic cells, the method comprising step 1: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step 2: obtaining a cell population enriched for regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Further disclosed is a cell population enriched for regulatory dendritic cells obtained by the method.

Abstract: This invention provides methods for specifically testing ulcerative colitis and primary sclerosing cholangitis. The first aspect of the invention provides a method for testing ulcerative colitis comprising a step of detection comprising detecting, as an indicator of ulcerative colitis, an antibody immunologically reacting with integrin ?V?6 and/or an antibody immunologically reacting with integrin ?V?3 in a specimen. The second aspect of the invention provides a method for testing primary sclerosing cholangitis comprising a step of detection comprising detecting, as an indicator of primary sclerosing cholangitis, an antibody immunologically reacting with integrin ?V?6 and/or an antibody immunologically reacting with integrin ?V?3 in a specimen.

Abstract: The present invention provides a variant of a T-cell receptor containing a combination of two polypeptides containing a constant region of a T cell receptor chain selected from the group consisting of ? chain, ? chain, ? chain and ? chain, wherein the polypeptide does not contain a complementarity determining region (CDR) of the T cell receptor chain, a complementarity determining region (CDR) of the ? chain, and a complementarity determining region (CDR) of the ? chain.

Abstract: A method for manufacturing a surface emitting laser made of a group-III nitride semiconductor by an MOVPE method includes: (a) growing a first cladding layer of a first conductive type on a substrate; (b) growing a first optical guide layer of the first conductive type on the first cladding layer; (c) forming holes having a two-dimensional periodicity in a plane parallel to the first optical guide layer, in the first optical guide layer by etching; (d) supplying a gas containing a group-III material and a nitrogen source and performing growth to form recessed portions having a facet of a predetermined plane direction above openings of the holes, thereby closing the openings of the holes; and (e) planarizing the recessed portions by mass transport, after the openings of the holes have been closed, wherein after the planarizing at least one side surface of the holes is a {10-10} facet.

Abstract: A marker for judging the efficacy of therapy with a PD-1 signal inhibitor-containing drug before or at an early stage of the therapy is provided.

Abstract: A composite including a plurality of block copolymer chains dispersed in a base polymer, the block copolymer chains including a polymer block (A) and a polymer block (B) having lower affinity for the base polymer than that of the polymer block (A), wherein each of the block copolymer chains has the polymer block (A) at two or more locations of the block copolymer chain, and in at least some of the block copolymer chains, the polymer blocks (A) are at least partially located in the base polymer and the polymer blocks (B) are at least partially exposed from the base polymer.

Abstract: An optical device (10) includes a first substrate (11) and a second substrate (12) facing each other, a liquid crystal component (13) between the first substrate (11) and the second substrate (12), a first electrode (18) and a second electrode (19) located on the first substrate (11) on the second substrate (12) side, and a first alignment layer (14) that is located on the first substrate (11) on the second substrate (12) side and controls the alignment state of liquid crystal molecules in the liquid crystal component (13), wherein an interface between the liquid crystal component (13) and the first alignment layer (14) forms a non-glide weak anchoring interface (17).

Abstract: Provided is a communication device in which: a wireless network is formed of at least one sub-tree including a sub-root station; the sub-root station collects request wireless resource allocation information which a child station included in the sub-tree has; request wireless resource allocation information of the sub-root station itself is added to the collected request wireless resource allocation information, and the resultant information is reported to a parent station, the parent station notifies the sub-root station of wireless resource information available in the entire sub-tree; and the sub-root station allocates wireless resources to the sub-root station itself and the child station based on the wireless resource information notification.

Abstract: A main object of the present invention is to provide an anode current collector that is capable of inhibiting the reaction with liquid electrolyte. The present invention achieves the object by providing an anode current collector to be used for a fluoride ion battery; and the anode current collector being a simple substance of Fe, Mg, or Ti, or an alloy containing one or more of these metal elements.

Abstract: An object of the invention is to provide a modified T-cell receptor (TCR) which does not cause the antigen responsiveness and which is capable of holding CD3 subunits on a cell membrane and causing the CD3 subunits to function. The invention is an invention related to a modified TCR comprising a first polypeptide and a second polypeptide, wherein the first polypeptide is a polypeptide which comprises a constant region of human TCR? or a fragment of the constant region and which does not comprise a variable region of human TCR?, and the second polypeptide is a polypeptide which comprises a constant region of human TCR? or a fragment of the constant region and which does not comprise a variable region of human TCR?.

Abstract: The present invention provides a method for inducing differentiation of pluripotent stem cells into neural precursor cells, comprising culturing the pluripotent stem cells in the presence of a small, molecule BMP inhibitor, and induced neural precursor cells prepared by this method.

Abstract: The present invention provides: a lubricin-localized cartilage-like tissue characterized in that, when in an arbitrary cross section passing a first center of mass of a cartilage-like tissue derived from pluripotent stem cells or a center-of-mass region, which is a portion inside a concentric sphere being centered at the first center of mass and having a diameter of [first major diameter×0.2], the expression level of lubricin per unit area contained in a central region, which is a portion inside a concentric circle being centered at a second center of mass that is the center of mass of the cross section and having a diameter of [major diameter of cross section (second major diameter)×(0.4 to 0.9)] is referred to as the central lubricin level and the expression level of lubricin per unit area contained in the non-central region is referred to as the non-central lubricin level.

Abstract: A method for producing a hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from the genus Clostridium in the soil and using fatty acid as a substrate is provided by the present invention. In addition, a novel rare fatty acid with utility value which is obtained by the production method is also provided.

Abstract: According to one embodiment, a structure evaluation system according to an embodiment includes a plurality of sensors, a position locator, and an evaluator. The plurality of sensors detect elastic waves. The position locator locates positions of elastic wave sources by using the elastic waves among the plurality of elastic waves respectively detected by the plurality of sensors having an amplitude exceeding a threshold value determined according to positions of the sources of the plurality of elastic waves and the positions of the plurality of disposed sensors. The evaluator evaluates a deteriorated state of the structure on the basis of results of the position locating of the elastic wave sources which is performed by the position locator.

Abstract: Provided are a RUNX inhibitor which binds to a RUNX-binding sequence on DNA and thus inhibits the binding of a RUNX family member to the sequence; an antitumor agent comprising the RUNX inhibitor; and an antiallergic agent comprising the RUNX inhibitor.

Abstract: The present invention provides a means excellent in efficiency of introduction of a nucleic acid, a protein, a complex thereof, or the like into cells, in particular a method using a solution for transduction.

Abstract: An object of the present invention is to provide a method for producing T cells or NK cells, a culture medium for culturing T cells or NK cells, a method for culturing T cells or NK cells, a method for maintaining the undifferentiated state of undifferentiated T cells, and a growth promoter for T cells or NK cells, which are capable of efficiently proliferating T cells or NK cells and maintaining the state of the cells (for example, undifferentiated property). The present invention relates to a method for producing T cells or NK cells including culturing T cells or NK cells in a culture medium containing a bisbenzylisoquinoline alkaloid represented by formula (X-1) or formula (X-2) or a compound resulting from cleavage of one ether bond thereof or a pharmaceutically acceptable salt thereof, and the like.

Abstract: Provided is a molecular assembly (for example, a polymeric micelle nanoparticle) which is capable of efficiently encapsulating a fat-soluble drug. A molecular assembly comprising: an amphiphilic block polymer A1 comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit; a hydrophobic polymer A2 having a lactic acid unit; a fatty acid triglyceride; and a fat-soluble drug. Examples of the fat-soluble drug include miriplatin.