Patents Assigned to Kyowa Hakko Kogyo Co., Ltd.
  • Recombinant antibody against human insulin-like growth factor
    Publication number: 20060240015
    Abstract: It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions. The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.
    Type: Application
    Filed: September 24, 2004
    Publication date: October 26, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Kenya Shitara, Kazuyasu Nakamura, Yuji Ohki
  • Method of removing off-flavor from foods and deodorizer
    Patent number: 7125575
    Abstract: The present invention provides an effective method of removing off-flavor from foods such as seafood, meat products and vegetables, which comprises causing a polymer of phenol compounds having a styrene structure and/or a reaction mixture produced by conducting an oxidation reaction of the phenol compounds having a styrene structure in the presence of oxygen to be present in the food. Also provided is a deodorizer comprising a polymer of phenol compounds having a styrene structure.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: October 24, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazutaka Uno, Chiaki Saitoh, Makoto Egi, Shoji Ago
  • Composition improved in the solubility or oral absorbability
    Patent number: 7125565
    Abstract: An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: October 24, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jun Sugishita, Makoto Kigoshi, Setsuko Yano, Hideki Morita, Yasuki Kato
  • Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia
    Patent number: 7122173
    Abstract: The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: October 17, 2006
    Assignees: Kyowa Hakko Kogyo Co., Ltd., University of Pittsburgh
    Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa, William C. de Groat, Naoki Yoshimura, Adrian Sculptoreanu
  • Novel polynucleotides
    Publication number: 20060228712
    Abstract: Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
    Type: Application
    Filed: March 22, 2004
    Publication date: October 12, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Satoshi Nakagawa, Hiroshi Mizoguchi, Seiko Ando, Mikiro Hayashi, Keiko Ochiai, Haruhiko Yokoi, Naoko Tateishi, Akihiro Senoh, Masato Ikeda, Akio Ozaki
  • Scored tablet
    Publication number: 20060228409
    Abstract: An object of the present invention is to provide a dividable tablet that is easily and accurately divided without any particular limitation on dividing method thereof and has superior strength.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 12, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Junichi Miyabe, Kouji Murai, Tomohiko Goto, Yasuhiko Ueno
  • Process for producing glycoprotein composition
    Publication number: 20060223147
    Abstract: The present invention relates to a cell into which an RNA capable of suppressing the function of an enzyme catalyzing a reaction which converts GDP-mannose into GDP-4-keto,6-deoxy-GDP-mannose is introduced; a process for producing a glycoprotein using the cell; a cell into which an RNA capable of suppressing the function of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ?-bond in the complex type N-glycoside-linked sugar chain, and an RNA capable of suppressing the function of an enzyme relating to synthesis of an intracellular sugar nucleotide, GDP-fucose, or an RNA capable of suppressing the function of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are introduced; a process for producing a glycoprotein composition using the cell; and the like.
    Type: Application
    Filed: August 4, 2005
    Publication date: October 5, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.,
    Inventors: Harue Nishiya, Mitsuo Satoh, Katsuhiro Mori
  • Method of treating brain ischemia
    Patent number: 7115614
    Abstract: The present invention relates to a method of treating brain ischemia in which a xanthine derivative represented by formula (I): or a pharmaceutically acceptable salt thereof, as an active ingredient, is administered.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: October 3, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Junichi Shimada, Masako Kurokawa, Ken Ikeda, Fumio Suzuki, Yoshihisa Kuwana
  • Drug for nerve regeneration
    Publication number: 20060217368
    Abstract: An object of the present invention is to provide a nerve regenerating drug, an agent for the promotion of neuropoiesis of a neural stem cell, a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis, and a method of the manufacture of the neuron. In order to achieve the object, the invention provides a nerve regenerating drug comprising a substance that inhibits the activity of glycogen synthase kinase-3, as an active ingredient; an agent for the promotion of neuropoiesis of a neural stem cell comprising the substance as an active ingredient; a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis; and a method of the manufacture of the neuron.
    Type: Application
    Filed: April 16, 2004
    Publication date: September 28, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsuyoshi Morishita, Kazuhiro Sakurada, Keiko Suzuki, Shun-ichi Ikeda
  • Processes for producing pyrazoloacridone derivative and synthetic intermediate thereof
    Publication number: 20060217554
    Abstract: (wherein R represents lower alkyl; R1 represents a hydrogen atom, —CH2X or —OC(?O)R3; and R2 represents a hydrogen atom, nitro, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkylthio or substituted or unsubstituted aryl) The present invention provides a simple industrial process for producing pyrazoloacridone derivatives having an antitumor activity, 1-(2-carboxyphenyl)indazole derivatives, which are useful as synthetic intermediates thereof, or the like; and the like.
    Type: Application
    Filed: April 23, 2004
    Publication date: September 28, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Nobuaki Tsubakihara, Takeshi Katsuhira, Masahiko Kinugawa, Nobuyuki Kato
  • Insulin-like growth factor binding protein
    Publication number: 20060216739
    Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
    Type: Application
    Filed: March 30, 2006
    Publication date: September 28, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
  • Process for producing cis-3-hydroxy-L-proline
    Patent number: 7112432
    Abstract: An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of L-proline and to act on free L-proline in the presence of 2-ketoglutaric acid and divalent iron ions to produce cis-3-hydroxy-L-proline. The gene is inserted into a vector and the resulting recombinant DNA is used to create a transformant. L-proline-3-hydroxylase is produced by culturing the transformant in a medium.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: September 26, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Akio Ozaki, Hideo Mori, Takeshi Shibasaki, Katsuhiko Ando, Keiko Ochiai, Shigeru Chiba, Yoichi Uosaki
  • Antitussives
    Publication number: 20060205756
    Abstract: An antitussive which comprises, as an active ingredient, a tricyclic compound represented by Formula (I) [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, X1—X2—X3 represents CR5?CR6—CR7?CR8 (wherein R5, R6, R7 and R8 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, Y represents —CH2S— or the like, and R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like] or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 31, 2004
    Publication date: September 14, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Ichiro Miki, Hidee Ishii
  • Microcrystal
    Publication number: 20060205745
    Abstract: Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.
    Type: Application
    Filed: May 7, 2004
    Publication date: September 14, 2006
    Applicant: Kyowa Hakko Kogyo Co,. Ltd.
    Inventors: Kazutoshi Kuroda, Noboru Aoki, Toshiro Ochiai, Akihiro Uchida, Yasuhiro Ishikawa, Makoto Kigoshi, Eiji Hayakawa
  • medical composition
    Publication number: 20060199789
    Abstract: The present invention provides a pharmaceutical composition, which comprises 7-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-4-methoxy-spiro[1,3-benzodioxol-2,1?-cyclopentane] or a pharmaceutically acceptable salt thereof and a steroid agent; an agent for treating and/or preventing a pulmonary disease; the agent which comprises 7-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-4-methoxy-spiro[1,3-benzodioxol-2,1?-cyclopentane] or a pharmaceutically acceptable salt thereof and a steroid agent which are simultaneously or separately with an interval and the like.
    Type: Application
    Filed: March 31, 2004
    Publication date: September 7, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Motoya Mie, Haruhiko Manabe
  • Pyrimidine derivatives
    Publication number: 20060194811
    Abstract: A pyrimidine derivative represented by Formula (I) wherein Ar represents substituted or unsubstituted aryl, R1 represents —NR2R3 and wherein R2 represents a hydrogen atom or substituted or unsubstituted lower alkyl and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, A represents a single bond, Formula (III) wherein m1 is 0 to 2, n1 is 0 to 4, a1 is from 0 to a substitutable number, R5 represents substituted or unsubstituted lower alkyl, and each R5 may be the same or different when a1 is 2 or more), and Q represents —NR6R7 (wherein R6 and R7 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted heteroalicyclic group, a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted piperidin-4-ylamino, or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 20, 2004
    Publication date: August 31, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Etsuo Ohshima, Motoki Miyama, Koji Yanagawa, Seiji Aratake, Ichiro Miki, Katsuya Kobayashi
  • Preventive or remedy for arthritis
    Publication number: 20060193962
    Abstract: An object of the present invention is to provide a preventing agent or a treating agent for arthritis or to provide foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis. In order to achieve the above object, the present invention provides a preventing or treating agent for arthritis or foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis comprising plant belonging to the genus Hydrangea or an extract of the plant and amino sugar or a salt thereof and/or glycosaminoglycan or a salt thereof as active ingredients.
    Type: Application
    Filed: April 9, 2004
    Publication date: August 31, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toshikazu Kamiya, Ryusuke Nakagiri
  • Diagnostic and therapeutic agents for rheumatoid arthritis
    Publication number: 20060188501
    Abstract: The present invention provides a therapeutic agent for rheumatoid arthritis which inhibits the growth of synoviocytes mediated by c-erbB-2 by clarifying the participation of c-erbB-2 in the growth of synoviocytes in rheumatoid arthritis patients and inhibiting the activation or expression of c-erbB-2.
    Type: Application
    Filed: February 24, 2006
    Publication date: August 24, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoshimi Homma, Koichiro Sato
  • Crystals of oxidized glutathione and process for producing the same
    Patent number: 7094870
    Abstract: The present invention provides crystals of glutathione oxidized n hydrate (wherein n is an integer or a fraction of not less than 0 and less than 8) useful, for example, as final products of, as raw materials for, or as intermediates of health foods, pharmaceuticals, cosmetics or the like, and a process for producing crystals of glutathione oxidized, which comprises a step of crystallizing glutathione oxidized from a mixture of an aqueous solution containing glutathione oxidized and a water-miscible organic solvent and which is suitable for large-scale synthesis or industrialization.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: August 22, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsuyoshi Shimose, Hideki Murata
  • ?-1,3-fucosyltransferase
    Patent number: 7094530
    Abstract: The invention provides a novel species of ?-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the ?-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the ?-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The ?-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: August 22, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Katsutoshi Sasaki, Kazumi Miura, Nobuo Hanai, Tatsunari Nishi