Patents Assigned to Kyowa Hakko Kogyo Co., Ltd.
  • Methods of treating patients suffering from movement disorders
    Publication number: 20060178379
    Abstract: The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor.
    Type: Application
    Filed: January 6, 2006
    Publication date: August 10, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Hiroshi Kase, Akihisa Mori, Yutaka Waki, Yutaka Ohsawa, Akira Karasawa, Yoshihisa Kuwana
  • Remedy for diabetes
    Publication number: 20060173066
    Abstract: An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for treating diabetes mellitus or improving insulin diabetes. In order to achieve such an object, the present invention provides a therapeutic agent for diabetes mellitus and insulin resistance improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for treatment of diabetes mellitus or improvement of insulin resistance comprising the same.
    Type: Application
    Filed: March 19, 2004
    Publication date: August 3, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toshikazu Kamiya, Akio Shirai, Miho Takada, Fumiko Ogino
  • Therapeutic and/or preventive agent for chronic skin disease
    Publication number: 20060173028
    Abstract: The present invention provides a therapeutic and/or preventive agent for chronic skin diseases which comprises 7-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-4-methoxy-spiro[1,3-benzodioxol-2,1?-cyclopentane] or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: March 17, 2004
    Publication date: August 3, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Daisuke Harada, Shigehiro Masaki, Haruhiko Manabe
  • Tablet and process for producing the same
    Publication number: 20060172005
    Abstract: An object of the present invention relates to a tablet which comprises an active ingredient and a cyclodextrin or a cyclodextrin derivative and rapidly disintegrates in the oral cavity, etc. The present invention provides a tablet in which 70% by mass or more of the components of the tablet is a cyclodextrin or a cyclodextrin derivative and a method for manufacturing a tablet comprising the steps of: mixing constituent components of the tablet which comprises as constituent components an active ingredient and a cyclodextrin or a cyclodextrin derivative and in which 70% by mass or more of the total constituent components of the tablet is the cyclodextrin or the cyclodextrin derivative; and subsequently tableting the resultant mixture.
    Type: Application
    Filed: July 8, 2004
    Publication date: August 3, 2006
    Applicant: Kyowa Hakko Kogyo Co.,Ltd.
    Inventors: Takahiro Hara, Masao Kimura, Yasushi Sakai
  • Tablet containing water-absorbing amino acid
    Publication number: 20060159759
    Abstract: The present invention provides a tablet which comprises a water-absorbent amino acid and a coating agent which is soluble in ethanol and hardly soluble in water. The tablet of the present invention is useful as amino acid preparations for sports, dieting, or pharmaceuticals, and also useful as nutritional supplements, pharmaceuticals and the like in order to supply nutritious of amino acids effective to human health maintenance, or enhance physiological activity of human tissues.
    Type: Application
    Filed: March 5, 2004
    Publication date: July 20, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Motohiro Ohta, Kiyoshi Morimoto, Muneko Kuboyama, Hirokazu Yoshimoto, Hideo Kawabe
  • Medicinal composition
    Publication number: 20060160887
    Abstract: The present invention provides a pharmaceutical composition which is useful in the treatment for overactive bladder and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-d ihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an anticholinergic agent.
    Type: Application
    Filed: July 16, 2004
    Publication date: July 20, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsuyoshi Yamagata, Shiro Shirakura
  • Glucose-6-phosphate dehydrogenase
    Patent number: 7078204
    Abstract: The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as “G6PD”) derived from a bacterium belonging to the genus Corynebacterium, a DNA encoding the enzyme, a recombinant DNA comprising the DNA, a transformant comprising the recombinant DNA, a transformant comprising the DNA on its chromosome, and a process for producing L-amino acid or G6PD which comprises culturing the transformant. According to the present invention, a modified G6PD and a DNA encoding the G6PD are obtained, and the productivity of L-amino acid by a microorganism can be improved by using the modified G6PD.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 18, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Haruhiko Yokoi, Seiko Ando, Keiko Ochiai, Yoshiyuki Yonetani, Shin-ichi Hashimoto
  • Process for producing HMG-CoA reductase inhibitors
    Publication number: 20060154348
    Abstract: The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
    Type: Application
    Filed: February 13, 2006
    Publication date: July 13, 2006
    Applicant: KYOWA HAKKO KOGYO CO. LTD
    Inventors: Hirofumi Endo, Yoshiyuki Yonetani, Hiroshi Mizoguchi, Shin-ichi Hashimoto, Akio Ozaki
  • Methods of treating patients suffering from movement disorders
    Publication number: 20060148827
    Abstract: The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor.
    Type: Application
    Filed: January 6, 2006
    Publication date: July 6, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Hiroshi Kase, Akihisa Mori, Yutaka Waki, Yutaka Ohsawa, Akira Karasawa, Yoshihisa Kuwana
  • Medicinal composition
    Publication number: 20060148885
    Abstract: The present invention provides a pharmaceutical composition which is useful in the treatment for bladder irritative symptoms accompanied by benign prostatic hyperplasia and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an ?1-adrenoceptor antagonist.
    Type: Application
    Filed: July 16, 2004
    Publication date: July 6, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsuyoshi Yamagata, Shiro Shirakura
  • Insulin-like growth factor-binding protein
    Patent number: 7071160
    Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 4, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
  • Medicinal preparations
    Patent number: 7067618
    Abstract: The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The preparation is capable of improving the in vivo durability of various compounds and releasing the compounds in response to changes in pH, and thus is useful for causing the compounds to act specifically on target parts.
    Type: Grant
    Filed: December 24, 1999
    Date of Patent: June 27, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yasuki Kato, Hiroko Kusano, Yuji Kawaguchi, Kunio Ito
  • Method for producing histidine by fermentation with
    Patent number: 7067289
    Abstract: The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-glutamine, L-lysine, L-histidine, L-arginine, L-aspartic acid and L-glutamic acid and useful as medicament, chemical agent, food material and feed additive at high industrial efficiency, the method comprising culturing a microorganism having an ability to produce the amino acid and having resistance to an aminoquinoline derivative in a medium, producing and accumulating the amino acid in the present invention in the culture, and recovering the amino acid from the culture.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: June 27, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kuniki Kino, Tetsuya Abe
  • Method of stabilizing diarylvinylene compound
    Publication number: 20060134192
    Abstract: (wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like.
    Type: Application
    Filed: September 29, 2004
    Publication date: June 22, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Akihiro Uchida, Yasuhiro Ishikawa, Yasuhiko Ueno, Kiichiro Kaji, Masaharu Aimoto, Naoki Kaneko
  • Process for purifying antibody
    Patent number: 7064191
    Abstract: The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by the process; and a method for diagnosing or preventing various diseases, which comprises using a substance having an affinity to a carbohydrate binding to an antibody.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: June 20, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toyohide Shinkawa, Kazuhisa Uchida, Motoo Yamasaki, Emi Hosaka, Kenya Shitara
  • Sustained improver of muscular fatigue
    Publication number: 20060127492
    Abstract: A long-acting improver of muscular fatigue characterized by comprising 4 kinds of amino acids made up of leucine, isoleucine, valine and glutamine, and a whey protein component (whey protein and/or decomposition product of whey protein). At least one of a whey protein isolate (WPI), a whey protein concentrate (WPC), ?-lactoglobulin, and ?-lactalbumin is used as the whey protein. Novel food or drink, and pharmaceuticals which exhibit sustained recovery effects on muscular fatigue are provided.
    Type: Application
    Filed: December 2, 2003
    Publication date: June 15, 2006
    Applicants: MEIJI DAIRIES CORPORATION, KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Hiroshi Tsuchita, Masato Saito, Toshikazu Kamiya, Miho Komatsu
  • Antiepileptic agent
    Publication number: 20060122198
    Abstract: An antiepileptic agent which contains either a xanthine derivative represented by the formula (I): (I) (wherein R1, R2, and R3 are the same or different and each represents hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; R4 represents cycloalkyl, —(CH2)n.R5, or the formula (II); (II) and X1 and X2 are the same or different and each represents oxygen or sulfur) or a pharmacologically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: June 25, 2004
    Publication date: June 8, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Shunji Ichikawa, Chiemi Takashima, Hironori Imma, Junichi Shimada
  • Anti-human VEGF receptor FLT-1 monoclonal antibody
    Patent number: 7052693
    Abstract: The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: May 30, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenya Shitara, Mikito Ito, Nobuo Hanai, Yoko Kawada, Kazuyasu Nakamura, Masabumi Shibuya
  • Phosphodiesterase inhibitor
    Publication number: 20060111368
    Abstract: [wherein n represents an integer of from 1 to 4, R1 represents substituted or unsubstituted lower alkyl, —C(?Y)R9 or the like, R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group or the like, and R4 represents halogen or the like.]A phosphodiesterase 10A inhibitor which comprises a quinoline derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient is provided.
    Type: Application
    Filed: June 26, 2003
    Publication date: May 25, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Naoto Osakada, Motoko Haruoka, Ken Ikeda, Shinichiro Toki, Hiromasa Miyaji, Junichi Shimada
  • Process for producing HMG-CoA reductase inhibitor
    Patent number: 7049111
    Abstract: The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: May 23, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Endo, Yoshiyuki Yonetani, Hiroshi Mizoguchi, Shin-ichi Hashimoto, Akio Ozaki