Patents Assigned to Kyowa Hakko Kogyo Co., Ltd.
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166303
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166302
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the liker an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166301
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166304
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Lipid metabolism improving agent
    Publication number: 20070167512
    Abstract: An object of the present invention is to provide a lipid metabolism improving agent, or to provide foods and drinks, food and drink additives, and feeds or feed additives for improving lipid metabolism. In order to achieve such an object, the present invention provides a lipid metabolism improving agent comprising hydroxyproline, a hydroxyproline derivative or a pharmaceutically acceptable salt thereof or foods and drinks, food and drink additives, feeds or feed additives for improvement of lipid metabolism comprising the same.
    Type: Application
    Filed: March 26, 2004
    Publication date: July 19, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toshikazu Kamiya, Akio Shirai
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166300
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Agents for treating migraine
    Publication number: 20070161663
    Abstract: (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 28, 2005
    Publication date: July 12, 2007
    Applicant: Kyowa Hakko Kogyo CO., Ltd.
    Inventors: Megumi Takeuchi, Makoto Takayama, Shiro Shirakura, Hiroshi Kase
  • Polypeptide
    Patent number: 7241605
    Abstract: According to the present invention, there can be provided a novel polypeptide having ?1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said recombinant vector, a process for producing type 1 sugar chain-containing sugar chains and complex carbohydrates by use of said polypeptide or said transformant, an antibody recognizing said polypeptide, a method for detecting or quantifying said polypeptide by use of said antibody, a method for screening a substance correlated with said polypeptide, a method for diagnosis or treatment of cancers in the digestive system by use of said DNA or said antibody, and a method for treatment of cancers in the digestive system by use of a substance obtained by said screening method.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: July 10, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hisashi Narimatsu, Soichiro Isshiki, Akira Togayachi, Katsutoshi Sasaki
  • Anti-fibroblast growth factor-8 monoclonal antibody
    Patent number: 7241568
    Abstract: A method for preventing or treating a disease, comprising administering to human or animal in need of such prevention or treatment an effective amount of a monoclonal antibody which specifically binds to FGF-8 and inhibits FGF-8 activity.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: July 10, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Nobuo Hanai, Motoo Yamasaki, Akiko Furuya, Akira Tanaka, Kenya Shitara, Naoki Shimada, Kazuyasu Nakamura, Maiko Hirota
  • Hsp90 family protein inhibitors
    Publication number: 20070155813
    Abstract: wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
    Type: Application
    Filed: December 24, 2004
    Publication date: July 5, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yushi Kitamura, Shinji Nara, Hiroshi Nakagawa, Rieko Nakatsu, Takayuki Nakashima, Shiro Soga, Jiro Kajita, Yukimasa Shiotsu, Yutaka Kanda
  • ?1,3-galactosyltransferase and DNA encoding the same
    Patent number: 7238100
    Abstract: The present invention provides a protein having a ?1,3-galactosyltransferase activity derived from a microorganism; a DNA encoding the protein; a recombinant DNA containing the DNA and a vector; a transformant obtained by introducing the recombinant DNA into a host cell; a method for producing a protein having a ?1,3-galactosyltransferase activity using the transformant; and a method for producing a galactose-containing carbohydrate using the transformant.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: July 3, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Katsuhide Miyake, Masaki Watanabe, Shinji Iijima
  • Process for producing trans-4-hydroxy-L-proline
    Patent number: 7238501
    Abstract: The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium, Amycolatopsis or Streptomyces and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. In addition, the present invention is directed to a process for producing trans-4-hydroxy-L-proline, wherein the L-proline biosynthesis activity of the host cell of the transformant is reinforced.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: July 3, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Akio Ozaki, Hideo Mori, Takeshi Shibasaki, Katsuhiko Ando, Shigeru Chiba
  • Pulsating vibration air generation apparatus
    Patent number: 7237571
    Abstract: A pulsating vibration air generation apparatus capable of sharply and quickly controlling air flow in turning on and off operation, thereby generating a pulsating vibration air with sharp and hardly attenuated peak and valley, and capable of operation without occurrence of so much mechanical vibration. The pulsating vibration air generation apparatus is comprised of a main body having a tubular hollow space R2 with which two air communication ports are associated, and a rotary body situated for rotation in the tubular hollow space R2 and which has a peripheral side surface S4c so as to slide on the inner surface S2c forming the tubular hollow space R2.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: July 3, 2007
    Assignees: Kyowa Hakko Kogyo Co., Ltd., Kabushikikaisha Matsui Seisakusho
    Inventors: Kiyoshi Morimoto, Hirokazu Yoshimoto, Yasushi Watanabe, Kazue Murata
  • Method of treating atopic dermatitis using antibody against human interleukin-5 receptor alpha chain
    Patent number: 7238354
    Abstract: The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor ? chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor ? chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: July 3, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masamichi Koike, Akiko Furuya, Kazuyasu Nakamura, Akihiro Iida, Hideharu Anazawa, Nobuo Hanai, Kiyoshi Takatsu
  • Recombinant antibody composition
    Publication number: 20070148165
    Abstract: The present invention relates to a recombinant antibody composition having higher complement-dependent cytotoxic activity than a human IgG1 antibody and a human IgG3 antibody, wherein a polypeptide comprising a CH2 domain in the Fc region of a human IgG1 antibody is replaced by a polypeptide comprising an amino acid sequence which corresponds to the same position of a human IgG3 antibody indicated by the EU index as in Kabat, et al.; a DNA encoding the antibody molecule or a heavy chain constant region of the antibody molecule contained in the recombinant antibody composition; a transformant obtainable by introducing the recombinant vector into a host cell; a process for producing the recombinant antibody composition using the transformant; and a medicament comprising the recombinant antibody composition as an active ingredient.
    Type: Application
    Filed: July 24, 2006
    Publication date: June 28, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Kenya Shitara, Rinpei Niwa, Akito Natsume
  • Prophylatic and/or therapeutic agents for chronic musculoskeletal pain
    Publication number: 20070149555
    Abstract: A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R1, R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the following formula (II); and X1 and X2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 30, 2005
    Publication date: June 28, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd
    Inventors: Hiroshi Kase, Isami Takahashi, Shunji Kunori, Minoru Kobayashi, Shizuo Shiozaki, Shiro Shirakura
  • Process for producing ?1,4-galactosyltransferase and galactose-containing complex sugar
    Patent number: 7232674
    Abstract: The present invention can provide a process for producing a protein having ?1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having ?1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella and a process for producing a galactose-containing complex carbohydrate using a transformant capable of producing a protein having ?1,4-galactosyltransferase activity derived from a microorganism.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: June 19, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tetsuo Endo, Satoshi Koizumi
  • Proliferative glomerulonephritis-related gene
    Publication number: 20070128186
    Abstract: A gene which is useful in searching for a therapeutic agent which restores tissue that suffered damage in a renal disease, a polypeptide encoded by the gene and an antibody which recognizes the polypeptide, are provided. A gene whose expression level changes depending on progression and recovery of the pathology in a proliferative glomerulonephritis model animal is obtained, and a polypeptide encoded by the gene and an antibody which recognizes the polypeptide are produced. These gene, polypeptide and antibody can be used in the search for an agent for restoring kidney tissue that suffered damage and an agent for diagnosing kidney disorder.
    Type: Application
    Filed: November 30, 2006
    Publication date: June 7, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Kyoko Takeuchi, Susumu Sekine, Yasuhiro Kikuchi, Kazuhiro Sakurada
  • Pyrazoloacrydone derivative-containing solution
    Publication number: 20070123554
    Abstract: [wherein R1a, R1b, R1c, and R1d may be the same or different and each represent a hydrogen atom, lower alkyl, —(CH2)p—X (wherein p represents an integer of 1 to 6, X represents hydroxy, lower alkoxy, or —NR2aR2b), or —CH[(CH2)nOH]2 (wherein n represents an integer of 1 to 5)] The present invention provides an aqueous solution having a pH of 3.5 or less and containing a pyrazoloacrydone derivative or a pharmaceutically acceptable salt thereof represented by, for example, above general formula (I).
    Type: Application
    Filed: February 4, 2005
    Publication date: May 31, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yuji Ueno, Yasuhiko Ueno
  • FF-ATPase and DNA encoding the same
    Patent number: 7223581
    Abstract: Provided are a protein complex having the F0F1-ATPase activity; a DNA encoding the protein complex; a method for producing the protein complex, using the DNA; and a method for producing nucleoside 5?-triphosphate using the protein. The present invention further provides a recombinant DNA with the DNA inserted therein; a transformant carrying the recombinant DNA; and a method for producing a protein complex, using the transformant.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: May 29, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fusao Tomita, Atsushi Yokota