Abstract: The present invention relates to a composition comprising 4-hexylresorcinol(4-HR) as an active ingredient for prevention or treatment of a bone disease, and a formulation thereof. The composition comprising 4-hexylresorcinol (4-HR) as an active ingredient, or an ointment thereof was found to improve bone thickness, density, and strength and control bone remodeling by promoting the differentiation of osteoblasts and suppressing the proliferation and differentiation of osteoclasts in osteoporosis-induced animal models. Thus, the composition or ointment comprising 4-hexylresorcinol (4-HR) as an active ingredient can be provided as a therapeutic agent for bone diseases including bone fracture, osteoarthritis, rheumatoid arthritis, and osteoporosis.

Abstract: An optical coherence tomography (OCT) apparatus includes a light source unit to generate light, a coupler unit to generate coupled light using reference light and measurement light generated by splitting the light, split the coupled light into n coupled and split lights and irradiate the n coupled and split lights, wherein n is a natural number greater than or equal to 2, a detection unit to irradiate the incident n coupled and split lights to n spectroscopes respectively and sequentially scan each light separated from each of the spectroscopes by wavelength range, and an image generation unit to generate a 2-dimensional single image using a result of the scanning by the detection unit. Accordingly, it is possible to improve the OCT image acquisition rate by distributing the scan time for a plurality of split lights using a plurality of array detectors.

Abstract: Provided are a programmed cell death protein 1 (PD-1)-decorated nanocage and use thereof. The PD-1-decorated nanocage (PdNC) of the present disclosure may block PD-1 and programmed cell death-ligand (PD-L) signaling and may induce anti-tumor immunity activation at two immune checkpoints of tumor microenvironment (TME) (effector phase) and tumor-draining lymph node (TDLN) (innate phase), thereby increasing the adaptability of PD-1 and PD-L blockade-based therapy. Accordingly, it may be applied to various kinds of cancer therapies.

Abstract: The present invention relates to a composition for preventing or treating cancer, the composition containing IL-2 surface expression-extracellular vesicles as an active ingredient. According to the present invention, immune cells, in which useful cytokines have been expressed on the cell surface, and extracellular vesicles, preferably small extracellular vesicles (sEV), which are derived from the immune cells and have useful cytokines expressed on the surface were prepared using a lentiviral vector containing a cytokine-linker-a PDGF receptor transmembrane domain, and it was found that the extracellular vesicles increased proliferation and activity of cytotoxic T cells thereby increasing anti-cancer immune efficacy. Thus, the extracellular vesicles having the efficacy can be usefully utilized as a pharmaceutical composition for preventing or treating cancer, a pharmaceutical composition for co-administration with an anticancer drug, or a composition for delivering a drug or a physiologically active material.

Abstract: The present invention relates to a composition comprising amniotic epithelial cell-derived exosomes as an active ingredient for prevention or treatment of ocular diseases and, more specifically, to a pharmaceutical composition for prevention or treatment of ocular diseases and a health functional food composition for prevention or alleviation of ocular diseases, each composition comprising amniotic epithelial cell-derived exosomes as an active ingredient. The amniotic epithelial cell-derived exosomes have ability to heal wounds on ocular tissues, recover the lacrimal gland destroyed by ocular diseases to induce lacrimation, and reduce the secretion of various inflammatory cytokines, thereby further effectively preventing or treating ocular diseases.

Abstract: Provided is a laser projection apparatus, a control method thereof, and a laser guidance system including the laser projection apparatus. The laser projection apparatus for projecting planned operation information of an insertion location and an insertion angle on a C-arm image photographed using a C-arm fluoroscopy device directly onto an affected part includes a line laser module configured to generate a line laser and to form a plane by rotating around an origin, a matching unit configured to calculate a coordinate representing the insertion location in a C-arm coordinate system based on C-arm fluoroscopy, calculate an insertional vector according to the coordinate representing the insertion location and the insertion angle, and calculate a vector perpendicular to the plane formed by the line laser in the C-arm coordinate system according to the insertional vector, and a control unit configured to control the line laser module based on the vector perpendicular to the plane.

Abstract: The present disclosure relates to magnetic resonance imaging technology for simultaneously measuring a plurality of magnetic resonance imaging parameters.

Abstract: Provided is a laser surgical guidance system including a C-arm fluoroscopy (hereinafter, C-arm) to identify a patient's condition and support a surgical plan and a laser targeting projector to project a line of the surgical plan directly onto an affected part through a line projection module which generates a laser. The laser surgical guidance system may generate a particular laser pattern from the line projection module, transmit the particular laser pattern outputted from the line projection module through a calibration tool including a collimator having a particular orientation, calculate an extrinsic parameter of the calibration tool in a projection image having passed through the calibration tool, and convert coordinates of the C-arm image into the line projection module coordinates using the extrinsic parameter.

Abstract: The present invention relates to a gadolinium-based compound of a Chemical Formula 1, a method for producing the same, and an MRI contrast agent containing the same. [Chemical Formula 1] [structural formula] In chemical formula 1, A and Linker represent linking groups, and RB represents a Rose Bengal-derived part.

Abstract: A pharmaceutical composition containing a tyrosine kinase activity inhibitor as an active ingredient may increase the expression of sodium iodide symporter in thyroid cancer cells, thereby promoting iodine uptake and killing thyroid cancer cells. Thus, the composition may he useful for the treatment of thyroid cancer.

Abstract: Disclosed herein is a composition for enhancing skin elasticity or improving skin wrinkles. In one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, activates skin primary cilia and inhibits the expression of MMP-1 to enhance skin elasticity and improve skin wrinkles. In addition, in one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, is a safe material and has the advantage that it can be treated in the living body in various forms such as cosmetics and food.

Abstract: The present invention relates to extracellular vesicles derived from ginger (Zingiber officinale) and a use thereof, and provides: extracellular vesicles which are derived from ginger and have anticancer activity, a pharmaceutical composition and a health functional food composition which is for preventing or treating cancer and contains the extracellular vesicles as an active ingredient. The ginger-derived extracellular vesicles can penetrate into cancer cells, have excellent anticancer activity, such as inhibiting the proliferation, infiltration and migration of cancer cells, and thus may be provided as an effective anticancer composition.

Abstract: The present disclosure relates to an optoelectronic device based on a dual micro-cavity structure, and more particularly, to a technology that simultaneously realizes the high Q factors of the three primary colors in an optoelectronic device based on a dual micro-cavity structure. The optoelectronic device according to one embodiment of the present disclosure is applied to a self-emissive device, and includes a first reflector layer, an active cavity layer formed on the first reflector layer, a second reflector layer formed on the active cavity layer, an external cavity layer formed on the second reflector layer, a third reflector layer formed on the external cavity layer, and a passivation layer formed on the third reflector layer, wherein a first micro-cavity corresponding to the first and second reflector layers and a second micro-cavity corresponding to the second and third reflector layers may be generated.

Abstract: The present invention relates to a composition for hair regeneration comprising a macrophage-derived extracellular vesicle mimetics, and since macrophage-derived extracellular vesicle mimetics are well absorbed into dermal papilla cells, have an excellent effect in promoting the proliferation of dermal papilla cells, as well as having an activity to increase the level of hair-induced proteins, it is excellent in the effects of proliferation of dermal papilla cells and hair increase and thus a composition comprising macrophage-derived extracellular vesicle mimetics can be provided for hair regeneration.

Abstract: The present invention relates to a amyotrophic lateral sclerosis (ALS) diagnostic composition using acid sphingomyelinase (ASM), and a method for detecting diagnostic markers and, more specifically, to a method and a composition for detecting markers for ALS, the method comprising the steps of: (a) providing a sample of a subject; (b) measuring the ASM expression level or the enzyme activation level in the sample; (c) determining that a subject, of which the ASM expression level or the enzyme activation level is increased compared to that of a normal person, has ALS. According to the investigation of the present inventors, the activity of ASM, among lipids and enzymes related to the sphingolipid metabolism, is specifically increased in a sample of an ALS patient compared to that of a normal person. ASM can be used as a marker for diagnosing ALS, thereby enabling the development of a novel and effective diagnostic reagent.

Abstract: The present invention relates to a use of an endothelin receptor inhibitor for inhibiting exosome secretion or inhibiting PD-L1 expression. It was confirmed that the endothelin receptor inhibitor inhibits endothelin receptors, which are currently known as a target for anticancer drug development, to not only inhibit the secretion of cancer cell-derived exosomes, but also reduce the expression of PD-L1 in cells, and is thus effective for cancer treatment when used in combination with existing anticancer drugs or when used alone in the form of a drug. Accordingly, the present invention can be used in novel modes of anticancer drug development using drugs exhibiting immune-checkpoint inhibition effects and exosome secretion inhibition effects.

Abstract: The present invention relates to a composition for material delivery, including exosome mimetics derived from red blood cells, and a use thereof and the composition for material delivery according to an exemplary embodiment of the present invention includes exosome mimetics derived from red blood cells, which are capable of being loaded with a drug, a radioactive material, or a fluorescent material, and thus may be usefully utilized for a drug delivery use, a cell labeling use, a contrast medium, or the like, and when the composition for material delivery according to an exemplary embodiment of the present invention is used, treatment and diagnosis may be simultaneously performed.

Abstract: The present invention relates to a device and a method for acquiring multi-luminosity images, wherein images having multiple luminosities in visible-ray and infrared wavelength domains can be captured and synthesized by using optical filter transmittance adjustment and infrared lighting strength adjustment.

Abstract: A three terminal neuromorphic synaptic device and a method for manufacturing the same are provided. The three terminal neuromorphic synaptic device includes a substrate, source/drain electrodes provided on the substrate, a channel region electrically connected between the source electrode and the drain electrode, an ion transfer layer provided on the channel region, a gate electrode provided on the ion transfer layer, and a voltage application unit to apply a gate voltage to the gate electrode. The ion transfer layer includes an electrolyte material to transfer an active ion of the gate electrode between the gate electrode and the channel region, in response to the gate voltage applied to the gate electrode. The voltage application unit adjusts a resistance and a conductance of the channel region by changing an amount of active ions accumulated in the channel region, depending on the number of times that the gate voltage is applied.

Abstract: A dental liner and a manufacturing method therefor are disclosed. The dental liner is a dental liner for coupling feldspar porcelain and zirconia and includes: silicon dioxide; aluminum oxide; 1,4-butanediol for maintaining the moisture of the dental liner and preventing the generation of layers; and a zirconia powder for coupling the dental liner and zirconia by strengthening chemical bonding of the dental liner and zirconia.