Abstract: The present invention relates to a novel peptide exhibiting an effect of releasing myelopoiesis stem cells into blood and an osteoporosis therapeutic effect and use thereof and, in particularly, to a novel peptide consisting of an amino acid sequence of SEQ. ID.NO:1 which has effects of releasing hematopoietic stem cells into a bloodstream and decreasing osteoclast cells in bone narrow, and a pharmaceutical composition comprising the novel peptide as an active ingredient for preventing or treating neutropenia, anemia or osteoporosis. Because of side effects, the peptide of the present invention not only increases level of leukocytes, red blood cells and platelets in blood, but also alleviates a decrease in bone density, and therefore, can be very usefully used for the development of a prophylactic or therapeutic agent for neutropenia, anemia or osteoporosis.

Abstract: A structure construction apparatus according to one embodiment comprises: a frame unit provided on the ground on which a structure is to be constructed; a formwork unit which is mounted on the frame unit, and which maintains structural materials in a form to be constructed; and a compacting unit disposed to be adjacent to the formwork unit so as to compact the structural materials provided in the formwork unit, wherein the formwork unit and the compacting unit are moved by means of the frame unit so that the structure can be automatically constructed.

Abstract: The present invention pertains to a novel liposome-based contrast agent that is for suppressing absorption in the reticuloendothelial system and for tumor-specific delivery of a radiolabeled substance. More specifically, the present invention pertains to: a liposome contrast agent containing a lipid and a compound of chemical formula 1, which is a radiolabeled substance, the liposome contrast agent being characterized in that the lipid is composed of (a) cholesterol, (b) 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and (c) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N [methoxy(polyethylene glycol)-2000] (DSPE-PEG2000); and a cancer diagnostic composition containing the liposome contrast agent as an active ingredient.

Abstract: The present invention relates to: a fusion peptide comprising a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide; and a use thereof and, more specifically, to: a fusion peptide in which a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide are sequentially linked; a composition for preventing or treating thrombotic disorders, containing the same as an active ingredient; a method for treating thrombotic disorders; and a therapeutic use. According to the present invention, CLT-sFt-?Pn DCNC as a novel plasmin-based thrombolytic nanocage has: an effect of targeting a site at which thrombus is present; a low sensitivity to inhibitors present in the circulatory system; pharmacological activity strongly destroying both arterial and venous thrombi; and no side effects of bleeding, and thus can be very useful in developing an agent for preventing or treating thrombotic disorders.

Abstract: The present invention relates to a method for treating degenerative neurological disorders in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising an acid sphingomyelinase (ASM) activity inhibitor or expression inhibitor as an active ingredient.

Abstract: A smart screw according to an embodiment may comprise: a screw main body which penetrates an artificial joint including a shell disposed on a hip joint of an object and a liner disposed on the inner surface of the shell and is then inserted into the hip joint; a transducer including a coupling layer that senses a sound wave signal reflected from the liner, a piezo-electric layer formed to determine a frequency of the sound wave signal, and a sound absorbing layer for absorbing the sound wave signal; and a processing module for generating a sound wave signal toward the liner and receiving the sound wave signal sensed by the coupling layer, measuring the thickness of the liner on the basis of the received sound wave signal, and transferring data about the measured thickness of the liner to the outside.

Abstract: The present invention relates to a composition for preventing or treating Parkinson's disease comprising AEG-1 (S298D) as an active ingredient, and in the present invention, a point mutation was introduced into AEG-1 to induce a constitutively active form of AEG-1 (S298D), to construct AAV-AEG-1 (S298D), and to apply an animal model for Parkinson's disease, and accordingly, it was confirmed that it exhibits a protective effect on brain tissue by preserving dopaminergic neurons and dopamine nerve fibers and thus AEG-1 is useful as a composition for preventing or treating Parkinson's disease, a health food composition for preventing or improving Parkinson's disease, etc.

Abstract: Provided is a method for setting an edge blur according to a brightness value including a first step for providing a plurality of target sheets on each of which a reference pattern for detecting a reference line and a grid pattern for detecting an edge position are provided, and in which changes in brightness values included in the grid patterns are different from each other, a second step for capturing images of the target sheets to obtain target sheet images, a third step for analyzing a reference pattern for each corresponding target sheet to estimate the reference line, and analyzing the grid pattern to extract an edge profile provided in the grid pattern, a fourth step for calculating a gradient of a brightness difference between adjacent pixels on the basis of the edge profile, and acquiring a background edge blur parameter and a foreground edge blur parameter on the basis of the gradient according to brightness contrast present in the image, and a fifth step for generating background edge blur predicti

Abstract: The present invention relates to a method for preparing a solid-state photonic crystal IPN composite functionalized with an enzyme, a photonic crystal IPN composite prepared by the method, and a biosensor using the photonic crystal IPN composite. The method of the present invention includes (1) mixing a nonreactive chiral dopant with a reactive nematic mesogen, curing the mixture, and removing the chiral dopant while maintaining a helical structure, to form a solid-state helical photonic crystal structure, (2) infiltrating a PAA hydrogel into the internal space of the photonic crystal structure, followed by curing to form an IPN-structured composite, and (3) immobilizing an enzyme in the IPN-structured composite. The PAA hydrogel is infiltrated into the solid-state helical photonic crystal structure and the enzyme is immobilized such that a pH change caused by the enzymatic reaction induces shrinkage and expansion of the PAA hydrogel, leading to a color change.

Abstract: The present application relates to an allulose-containing composition for promoting excretion of vegetable lipids from the body and a food comprising the composition of the present application and vegetable lipids.

Abstract: The present invention relates to a peptide bound to CD44v6 and uses for inhibiting cancer metastasis using the same, and the peptide of the present invention specifically binds to CD44v6 and inhibits it, thereby inhibiting cancer cell migration and metastasis. The peptides of the present invention selected two peptides (v6Pep-1 and v6Pep-2) that bind well to cells with high expression of human CD44v6 protein using phage peptide display technology and it was confirmed that it interferes with the binding between c-Met and CD44v6 to inhibit cancer cell migration. The peptide of the present invention is relatively stable in serum and shows a high potential as an anticancer treatment agent that suppresses metastasis due to the progression and migration of cancer in the future.

Abstract: The present invention relates to a bacteriophage-derived recombinant protein having antimicrobial activity against gram-negative bacteria, and the bacteriophage-derived recombinant protein LysSS exhibits killing activity to gram-negative bacteria and thus can prevent or treat infectious diseases caused by bacteria, and can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like, wherein the LysSS uses peptidoglycan, which is a component of the cell wall of bacteria, as a substrate, and exhibits bacterial killing ability due to peptidoglycan degradation and the peptidoglycan exists only in bacteria and not in humans or animals.

Abstract: The present invention relates to the use of the recombinant antibacterial protein Ablysin for effectively killing multidrug-resistant pathogenic bacteria. The recombinant protein Ablysin of the present invention exhibits apoptosis against antibiotic-resistant Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecium to prevent or treat infectious diseases caused by these bacteria and thus it can be widely used in antibiotics, disinfectants, food additives, feed additives, and the like. In particular, the Ablysin uses peptidoglycan, which is a component of the cell wall of bacteria, as a substrate, and exhibits bacterial killing ability due to peptidoglycan degradation.

Abstract: A method and a device for registering three-dimensional data are disclosed.

Abstract: A medical inserting apparatus includes a screw nail which is inserted into a human body, a driver which inserts the screw nail into the human body, a current generator disposed in the driver to generate a predetermined current, a current meter disposed in the driver to measure the current, and a conductor element disposed in the screw nail and the driver along a lengthwise direction including an exposed portion to outside, wherein the conductor element includes a forward conductor element connected to the current generator to allow the current generated by the current generator to flow into the human body, and a reverse conductor element having one end electrically connected to the forward conductor element and the other end connected to the current generator, and including a variable resistor and the current meter installed to allow the current generated by the current generator to flow to the current meter by current division with resistance of the human body.

Abstract: A screw anchor assembly used in pedicle screw fixation is provided. The screw anchor assembly includes a screw having screw threads defined on a circumferential surface, and a screw anchor having a first end and a second end, an accommodating part defined by anchor screw threads on an inner surface of the screw anchor and having one end to receive the screw, and a locking step extended in a circumferential direction from the first end of the screw anchor. The accommodating part flexibly extends when the screw is screw-coupled to the screw anchor.

Abstract: Provided is a composition for preventing, improving or treating obesity, which includes a Platycodon grandiflorum extract as an active ingredient and a method for preparing the extract with an improved anti-obesity effect. The extract shows an effect of inhibiting increases in body weight and fat mass caused by a high-fat diet for normalization, an increase in fasting blood glucose and a decrease in energy expenditure in a diet-induced obesity mouse model. Further, compared to an extract prepared by a conventional extraction method, the Platycodon grandiflorum extract shows a more excellent effect of inhibiting increases in body weight and fat mass, fasting blood glucose, and blood lipid and adipokine contents in experiments, resulting in an excellent anti-obesity effect. Therefore, the Platycodon grandiflorum extract prepared is expected to be useful for preventing obesity and treating obesity-related complications that can be caused by an increase in fat mass as well as obesity.

Abstract: A geometrical error measurement method for a feed drive system includes entering coordinate values of four vertices of a virtual regular tetrahedron, mounting a position indicator to an end of a main shaft of a feed drive system, mounting three center mounts at three respective vertices of the four vertices except for the remaining vertex at which the main shaft is positioned while moving the main shaft of the feed drive system sequentially from one vertex to another according to the entered coordinate values, measuring distances between each of the four vertices indicated by the three center mounts and the position indicator with a double ballbar, and calculating a geometrical error from the measured distances.

Abstract: An automatic hair implanter is capable of continuously performing hair transplantation work by applying a structure of a conventional manual hair implanter. The automatic hair implanter (hair transplantation device) comprises a rotating magazine therein, and several needle modules are stored in the magazine. Two pushrods, which are positioned on a rear portion of the device and capable of translational motion, play a role of pushing a needle and a shaft, which constitute a needle module, forward. The needle and the shaft may be moved backward by a spring positioned inside the magazine.

Abstract: A hearing aid having a bellows vibration body is disclosed. The hearing aid comprises: an external unit having a microphone for converting an external voice into an electrical signal; an internal unit which can be implanted under the skin and is for communicating with the external unit; a bellows vibration body which can be connected to the auditory ossicles and comprises a non-magnetic body; and an audio transmission tube for transmitting an acoustic signal, which is output from the internal unit, to the bellows vibration body, wherein the bellows vibration body vibrates in accordance with the acoustic signal transmitted by means of the audio transmission tube and thus transmits the vibration to the auditory ossicles.