Abstract: A microtome system has a cryomicrotome with a sectioning device in which is provided a preparation holder and a knife edge that are guided past one another inside a working space during a sectioning operation, in order to produce thin sections of a preparation retained in the preparation holder. A micromanipulator is operable outside the working space. With the micromanipulator, a tool for retention of a specimen support is positioned proximate the knife edge during a sectioning operation in order to receive the sections that are produced, preferably for substantially stationary retention of the specimen support.

Abstract: A Dewar vessel (1) for automated cryosubstitution or low-temperature substitution is disclosed. The invention further discloses an apparatus (10) for automated liquid transfer for cryosubstitution or low-temperature substitution. The apparatus (10) encompasses a container (50) that encompasses at least one specimen holder (2) and at least one reservoir holder (20); and wherein a movable transfer container (35) for automated exchange of at least one liquid (42) between the at least one specimen holder (2) and the at least one reservoir holder (20) is provided.

Abstract: The device (1) for fast tissue processing for histological examination consists of a housing (2) that is covered by a transparent hood (70). A baseplate (3) divides the device (1) into an upper part (4a) and a lower part (4b). Several process chambers that are served by a transport mechanism (6) with holders (40) for tissue specimens are provided for on the baseplate (3). At least one reservoir (74) is provided for in the lower part (4b) of the device, which has a flow connection to at least one process chamber. An operating panel (76) allows the user to enter the appropriate data.

Abstract: A transport container (40) for slides (4) for immunological labeling of thin tissue sections (2a) is disclosed. The transport container (40) is embodied in the form of a trough which comprises a peripheral delimiting wall (49) that is closed off by a base (50). There is embodied in the interior of the trough on the delimiting wall (49) at least one peripheral step (57) on which the slide rests and is spaced away from the base (50) of the transport container (40).

Abstract: An apparatus (1) for tissue preparation for the tissue embedding, having a transport plate (15) defining a circumferential edge (15c). At the circumferential edge (15c) several recesses (16) are formed, each of which comprises a plurality of several circular cut outs (16a) being arranged so that it has an opening into the direction of the circumferential edge (15c). The transport plate (15) is surrounded by a housing (5) which defines an inner upper side (8a) on which a heating and cooling device (3) is provided.

Abstract: An apparatus (1) for processing specimens (15), comprising an observation device (2), a specimen holder (3) for receiving the specimen (15) to be processed, and a tool holder (6), the tool holder (6) being pivotable in a plane normal to its longitudinal axis (L?) by means of a pivot arm (22), and being rotatable about its longitudinal axis (L?); furthermore a drive system for selectable execution of the pivoting of the pivot arm (22) is provided.

Abstract: An apparatus (1) for processing specimens (15), comprises an observation device (2) for observing a specimen (15), a specimen holder (3) for receiving the specimen (15) to be processed, and a tool holder (6), which is suitable for the reception of tools (5) for different processing steps.

Abstract: In an apparatus for microwave-assisted preparation of specimens with a microwave generator (1), a microwave chamber for receiving specimens (5) to be processed, and a container arrangement (11) for a number of containers (9) for liquids, the microwave chamber is realized as a waveguide (2) that comprises a first opening (7a) for introduction of a specimen (5) and a second opening (8a), preferably arranged at the bottom, through which a liquid container (9) is reversibly introduced into the microwave chamber while the specimen (5) is held stationary, until the liquid container thus introduced into the microwave chamber, and the liquid contained therein, surround the specimen (5).

Abstract: An apparatus and a method for immunological labeling of thin tissue sections are disclosed. The treatment fluid is applied in the form of liquid droplets onto at least one slide, the arrangement of liquid droplets corresponding to the arrangement of the thin tissue sections on the carrier plate. Each slide is retained in a transport container, the transport container being embodied in the form of a trough which comprises a peripheral delimiting wall that is closed off by a base. The base of one transport containers constitutes the cover of a transport container arranged beneath it. The transport containers are stacked in a first and a second station.

Abstract: In an apparatus for microwave-assisted preparation of specimens, the microwave chamber for reception of specimens to be processed is embodied as a waveguide (3), in particular as a monomode waveguide, and is equipped with at least one opening (3a) for introduction of the at least one specimen (11) into the waveguide. A cooling circuit comprises a cooling means (8) adapted to cool the fluid (12), which fluid surrounds the at least one specimen and is separated from the cooling liquid of the cooling circuit, in the region of the at least one specimen (11) inside the waveguide. The opening (3a) can be sealed in microwave-tight fashion, by means of a closure means (7), during operation of the apparatus.

Abstract: The invention concerns an apparatus for preparing monolayers of cells. The apparatus comprises a container (6) for a cryosubstitution system and an insert (1) for the container, the insert (1) having a surface (1a) and a plurality of orifices (3). An SCS (2) together with a cellular monolayer (20) is insertable into each of the orifices (3). The SCS (2) is thus arranged perpendicular to the surface (1a) of the insert (1).

Abstract: An apparatus (1) for tissue preparation for the tissue embedding, having a transport plate (15) that is surrounded by a housing (5). The housing defines an inner upper side (8a), a heating and cooling device (3), that is provided on the inner upper side (8a) of the housing (5) and a mechanic module (24) for turning the transport plate (15) and for raising and lowering the transport plate (15). The mechanic module (24) comprises a first motor (42) exclusively for turning the transport plate (15) around an axle (18) and a second motor (44) exclusively for raising and lowering the transport plate (15) in the direction of the axle (18).

Abstract: An apparatus for handling biopsy specimens comprises a transfer part, a slide displaceable in a groove of said transfer part, preparation plates for the reception of biopsy specimens, and a shifter part that serves to introduce the biopsy specimens into the preparation plates. The empty preparation plates are positioned at a predetermined point in the groove of the transfer part, and the shifter part is placed onto the transfer part above the preparation plates. The biopsy specimens are then introduced into the specimen well of a preparation plate by manually actuated instruments or by means of a stream of fluid. The filled preparation plate is displaced back in the groove of the transfer part using the slide, and is transferred into a specimen holder prepared for it.

Abstract: A device 1 and a method for trimming samples 38 are disclosed. The device 1 encompasses a knife holder 9 and a sample holder 7, the knife holder 9 carrying at least one trimming knife 36. A first motor 60 and a second motor 61 are provided, which move the knife holder 9 in an X-Y plane. Also provided is a control unit 15 that controls the motion of the knife holder 9. The first and the second motor 60, 61 are each equipped with a measurement means 62, 63 that measures the position of the knife holder 9 in the X direction (X) and Y direction (Y).

Abstract: The invention relates to a device and a method for carrying out in an optimized and automated manner immunological marking techniques for thin-sectioned tissue (2b). A support plate (1) which can be automatically moved by means of a computer-controlled conveying device (20) and on which several thin sections of tissue (2b) are placed on small metal screens (2) is immersed like a die into a liquid that is composed of a washing or marking solution (6) and is placed in several recesses (5) within an object support (4). The object support can also be automatically moved.

Abstract: A container (2) for tissue preparation for the tissue embedding, having a base body (4), that is formed out cylindrical shaped side wall (5), a floor (6) and several bridges (50). The bridges (50) subdivide the container (2) in several sub-containers (52). The side wall (5) has a plurality of slit shaped openings (12), that extend essentially over the total height of the side wall (5).

Abstract: A Dewar vessel (1) for automated cryosubstitution or low-temperature substitution is disclosed. The invention further discloses an apparatus (10) for automated liquid transfer for cryosubstitution or low-temperature substitution. The apparatus (10) encompasses a container (50) that encompasses at least one specimen holder (2) and at least one reservoir holder (20); and wherein a movable transfer container (35) for automated exchange of at least one liquid (42) between the at least one specimen holder (2) and the at least one reservoir holder (20) is provided.

Abstract: An apparatus (1) for tissue preparation for the tissue embedding, having a transport plate (15) defining a circumferential edge (15c). At the circumferential edge (15c) several recesses (16) are formed, each of which comprises a plurality of several circular cut outs (16a) being arranged so that it has an opening into the direction of the circumferential edge (15c). The transport plate (15) is surrounded by a housing (5) which defines an inner upper side (8a) on which a heating and cooling device (3) is provided.

Abstract: An apparatus and a method for immunological labeling of thin tissue sections are disclosed. The treatment fluid is applied in the form of liquid droplets onto at least one slide, the arrangement of liquid droplets corresponding to the arrangement of the thin tissue sections on the carrier plate. Each slide is retained in a transport container, the transport container being embodied in the form of a trough which comprises a peripheral delimiting wall that is closed off by a base. The base of one transport containers constitutes the cover of a transport container arranged beneath it. The transport containers are stacked in a first and a second station.

Abstract: An apparatus for cryosubstitution or low-temperature substitution is disclosed. The apparatus encompasses a Dewar vessel (1) that is embodied with a neck. A chamber (5) for reception of at least one specimen is inserted in the neck (53). The chamber (5) is embodied with a heavy base (51) that is connected to a first thermal conduction rod (7). A platform (8) is provided at the end of the first thermal conduction rod (7) facing away from the base (51). An insulator (12) is provided above the platform (8) of the first thermal conduction rod (7).