Patents Assigned to Les Laboratoires Servier
  • INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20160152599
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: July 22, 2014
    Publication date: June 2, 2016
    Applicants: Les Laboratoires Servier, Vernails (R&D) Limited
    Inventors: Patrick CASARA, Thierry LE DIGUARHER, Jean-Michel HENLIN, Jéröme-Benoit STARCK, Arnaud LE TIRAN, Guillaume DE NANTEUIL, Olivier GENESTE, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Claire WALMSLEY, Christopher John GRAHAM, Stuart RAY, Daniel MADDOX, Simon BEDFORD
  • Methods for treating colorectal cancer
    Patent number: 9217032
    Abstract: The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: December 22, 2015
    Assignee: LES LABORATOIRES SERVIER
    Inventors: Julie Pannequin, Leïla Houhou, Bérénice Framery, Nejla Erkilic, Dominique Joubert, Frédéric Hollande
  • Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9120791
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: September 1, 2015
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Thierry Le Diguarher, Patrick Casara, Jérôme-Benoît Starck, Jean-Michel Henlin, James Edward Paul Davidson, James Brooke Murray, Christopher John Graham, I-Jen Chen, Olivier Geneste, John Hickman, Stéphane Depil, Arnaud Le Tiran, Miklos Nyerges, Guillaume De Nanteuil
  • Phosphate compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9115159
    Abstract: Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: August 25, 2015
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoit Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen
  • Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9108983
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: August 18, 2015
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, Janos Tatai, Miklos Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof
    Patent number: 9045788
    Abstract: Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: June 2, 2015
    Assignee: LES LABORATOIRES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon, Francisco Moris Varas, Javier Gonzalez Sabin
  • Association between 4-{3-[-hexahydrocyclopenta[]pyrrol-2(1)-yl]propoxy}benzamide and an acetylcholinesterase inhibitor, and pharmaceutical compositions containing it
    Patent number: 8940785
    Abstract: Association between 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, and an acetylcholinesterase inhibitor. Medicinal products containing the same which are useful in the treatment of cognitive disturbances associated with cerebral ageing and with neurodegenerative diseases.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: January 27, 2015
    Assignee: Les Laboratoires Servier
    Inventors: Caryn Trocme-Thibierge, Aurore Sors, Florence Keime-Guibert
  • Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
    Patent number: 8927708
    Abstract: Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: January 6, 2015
    Assignee: Les Laboratoires Servier
    Inventor: Alexandre Le Flohic
  • Combination of 4-{3-[-hexahydrocyclopenta[]pyrrol-2(1)-yl]propoxy}benzamide and a NMDA receptor antagonist and pharmaceutical compositions containing the same
    Patent number: 8921409
    Abstract: Combination between 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, and an NMDA glutamatergic receptor antagonist. Medicinal products containing the same which are useful in the treatment of cognitive disturbances associated with cerebral ageing and neurodegenerative diseases.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: December 30, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Aurore Sors, Caryn Trocme-Thibierge, Annette Merdes
  • Administration regime for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2- ylcarbonylamino]ethoxy}benzamide
    Patent number: 8883199
    Abstract: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterized in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: November 11, 2014
    Assignees: Les Laboratoires Servier, Pharmacyclics, Inc.
    Inventors: Ioana Kloos, Renata Robert, Anne Jacquet-Bescond, Stephane Depil, Marylore Chenel, Sylvain Fouliard, Sriram Balasubramanian
  • Process for the preparation of the L-arginine salt of perindopril
    Patent number: 8865915
    Abstract: Process for the preparation of the compound of formula (I):
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: October 21, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Julie Linol, Stéphane Laurent, Arnaud Grenier, Sébastien Mathieu
  • Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 8859763
    Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: October 14, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Lucile Vaysse-Ludot, Alexandre Le Flohic, Michel Vaultier, Mathieu Pucheault, Thomas Kaminski
  • Agents for treating disorders involving modulation of ryanodine receptors
    Patent number: 8853198
    Abstract: The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: October 7, 2014
    Assignees: Les Laboratoires Servier, ARMGO Pharma, Inc.
    Inventors: Jiaming Yan, Sandro Belvedere, Yael Webb, Marc Bertrand, Nicole Villeneuve
  • Process for the synthesis of agomelatine
    Patent number: 8853449
    Abstract: Process for the industrial synthesis of the compound of formula (I)
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Samir Zard, Béatrice Sire, Mehdi Boumediene
  • PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE
    Publication number: 20140296512
    Abstract: Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: March 24, 2014
    Publication date: October 2, 2014
    Applicant: LES LABORATOIRES SERVIER
    Inventor: Alexandre LE FLOHIC
  • Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and pharmaceutical compositions containing it
    Patent number: 8835652
    Abstract: Delta crystalline form of the compound of formula (I): characterised by its X-ray powder diffraction diagram. Medicinal products containing the same which are useful in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: September 16, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Julie Linol, Stephane Laurent, Arnaud Grenier, Sebastien Mathieu
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 8835627
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: September 16, 2014
    Assignee: Les Laboratoires Servier
    Inventors: Alexandre Le Flohic, Mathieu Grandjean
  • NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20140249215
    Abstract: Abexinostat tosylate of formula (II): and its crystalline form I characterised by its X-ray powder diffraction diagram, its Raman spectrum and its solid-state 13C CP/MAS NMR spectrum. Medicinal products containing the same which are useful in the treatment of cancer.
    Type: Application
    Filed: March 3, 2014
    Publication date: September 4, 2014
    Applicants: PHARMACYCLICS, LES LABORATOIRES SERVIER
    Inventors: Anne PIMONT-GARRO, Philippe LETELLIER
  • PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
    Publication number: 20140242644
    Abstract: Process for the enzymatic synthesis of the compound of formula (I): Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 28, 2014
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon
  • NOVEL IMAGING AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    Publication number: 20140241989
    Abstract: Compounds of formula (I) in which: >R is a linear or branched (C1-C6) alkyl, >L is a spacer group, >A is a diagnostic agent, and >m is equal to 1 or 2.
    Type: Application
    Filed: July 12, 2012
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), LES LABORATOIRES SERVIER
    Inventors: Alain Lepape, Stéphanie Lerondel, Guillaume Reveillon, Jean-Marie Delbos, Luc Demuynck, Hubert Grandon, François Lefoulon, Gordon Tucker