Patents Assigned to Les Laboratoires Servier
  • Crystal structure of the CCZ-LZ domain of NEMO
    Patent number: 8440790
    Abstract: The invention relates to a crystal of the CC2-LZ domain of the NEMO protein, in which the three-dimensional structure has been determined by X-ray diffraction at a resolution of about 3.25 A. The invention also relates to methods for the crystallization of the CC2-LZ domain. The CC2-LZ crystals and the information derived from the crystalline structures thereof are used for identifying and designing compounds interacting with CC2-LZ.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: May 14, 2013
    Assignees: Les Laboratoires Servier, Institut Pasteur
    Inventors: Fabrice Agou, Jeanne Chiaravalli, Stéphane Duquerroy, Elisabeth Fontan, Olivera Grubisha, Monika Dorota Kaminska, Michel Veron, Florence Cordier
  • Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
    Patent number: 8436206
    Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: May 7, 2013
    Assignee: Les Laboratoires Servier
    Inventors: Thierry DuBuffet, Jean-Pierre Lecouve, Jean-Paul Hermet
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 8415468
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: April 9, 2013
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Louis Peglion, Aimee Dessinges, Bernard Serkiz, Jean-Michel Lerestif, Jean-Pierre Lecouve
  • ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE
    Publication number: 20130064880
    Abstract: N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterised in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 14, 2013
    Applicants: LES LABORATOIRES SERVIER
    Inventors: Ioana Kloos, Renata Robert, Anne Jacquet-Bescond, Stéphane Depil, Marylore Chenel, Sylvain Fouliard, Sriram Balasubramanian
  • SOLID PHARMACEUTICAL COMPOSITION FOR BUCCAL ADMINISTRATION OF AGOMELATINE
    Publication number: 20130041040
    Abstract: The invention relates to a solid buccal pharmaceutical composition comprising agomelatine intended for systemic action.
    Type: Application
    Filed: August 9, 2012
    Publication date: February 14, 2013
    Applicant: LES LABORATOIRES SERVIER
    Inventors: François THARRAULT, Cécile POIRIER, Gilles FONKNECHTEN, Jean-Manuel PEAN
  • AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF
    Publication number: 20130012592
    Abstract: The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.
    Type: Application
    Filed: March 17, 2011
    Publication date: January 10, 2013
    Applicant: Les Laboratoires Servier
    Inventors: Hanbin Shan, Zhedong Yuan, Xueyan Zhu, Peng Zhang, Hongjuan Pan, Xiong Yu
  • AGOMELATINE HYDROCHLORIDE HYDRATE AND PREPARATION THEREOF
    Publication number: 20130005820
    Abstract: The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.
    Type: Application
    Filed: March 17, 2011
    Publication date: January 3, 2013
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Hanbin Shan, Zhedong Yuan, Xueyan Zhu, Peng Zhang, Hongjuan Pan, Xiong Yu
  • PROCESS FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL) ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE
    Publication number: 20120330062
    Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.
    Type: Application
    Filed: July 30, 2012
    Publication date: December 27, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve, Jean-Paul Hermet
  • SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
    Publication number: 20120316214
    Abstract: Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.
    Type: Application
    Filed: June 6, 2012
    Publication date: December 13, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Nicolas ROBERT, Jean-Michel LERESTIF, Jean-Pierre LECOUVE, Marina GAILLARD, Loïc MEUNIER, Philippe LETELLIER, Mathieu BOIRET, Julie Meunier
  • CO-CRYSTALS OF AGOMELATINE, A PROCESS FOR THERE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20120316245
    Abstract: New co-crystal of agomelatine composed of: agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide of formula (I) and an organic acid. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 13, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Philippe Letellier, Michael Lynch, Jean-Manuel Pean
  • Process for the synthesis of agomelatine
    Patent number: 8329947
    Abstract: Process for the industrial synthesis of the compound of formula (I)
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: December 11, 2012
    Assignee: Les Laboratoires Servier
    Inventors: Pascal Bontempelli, Xavier Jalenques, Jerome-Benoit Starck, Jean-Pierre Sery
  • USE OF AGOMELATINE IN OBTAINING MEDICAMENTS INTENDED FOR THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (OCD)
    Publication number: 20120309838
    Abstract: The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in obtaining medicaments intended for the treatment of Obsessive-Compulsive Disorder (OCD).
    Type: Application
    Filed: February 10, 2011
    Publication date: December 6, 2012
    Applicant: Les Laboratoires Servier
    Inventors: Laurence Laigle, Elisabeth Mocaer, Mark Millan
  • ASSOCIATION BETWEEN 4-BENZAMIDE AND AN ACETYLCHOLINESTERASE INHIBITOR, AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
    Publication number: 20120283244
    Abstract: Association between 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, and an acetylcholinesterase inhibitor. Medicinal products containing the same which are useful in the treatment of cognitive disturbances associated with cerebral ageing and with neurodegenerative diseases.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 8, 2012
    Applicant: Les Laboratoires Servier
    Inventors: Caryn TROCME-THIBIERGE, Aurore Sors, Florence Keime-Guibert
  • AZABICYCLO[3.1.0]HEX-2-YL COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20120283245
    Abstract: Compounds of formula: wherein: ALK represents an alkylene chain, W represents a group wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in treating cognitive disorders associated with cerebral aging or with neurodegenerative diseases.
    Type: Application
    Filed: December 8, 2010
    Publication date: November 8, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Jean-Michel Henlin, Pierre Lestage, Fany Panayi
  • Diazeniumdiolate compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 8288433
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a —COOR group, R2 represents a group G or a linear or branched (C1-C6)alkyl group substituted by a group G, wherein G represents a —(CH2)n-A-(CH2)m—B—(CR4R5)p—(CH2)o—R6 group as defined in the description, R3 represents a hydrogen atom, an alkyl group or an NO2 group. Medicinal products containing the same which are useful in treating hypertension and cardiovascular pathologies.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: October 16, 2012
    Assignee: Les Laboratoires Servier
    Inventors: Alexis Cordi, Laure Haberkorn, Tony Verbeuren, Christine Courchay, Serge Simonet
  • Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 8288581
    Abstract: Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 16, 2012
    Assignees: Les Laboratoires Servier, Centre National de la Recherche Scientifique
    Inventors: Jean-Louis Peglion, Olivier Baudoin, Nicolas Audic, Manon Chaumontet, Riccardo Piccardi
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 8278440
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: October 2, 2012
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Louis Peglion, Pascal Caignard
  • PROCESS FOR THE SYNTHESIS OF AGOMELATINE
    Publication number: 20120245363
    Abstract: Process for the industrial synthesis of the compound of formula (I)
    Type: Application
    Filed: June 1, 2012
    Publication date: September 27, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Christophe HARDOUIN, Jean-Pierre LECOUVE, Nicolas BRAGNIER
  • DIHYDRO-OXAZOLOBENZODIAZEPINONE COMPOUNDS, A PROCESS FOR THERE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20120232065
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group; R3 represents an aryl or heteroaryl group. Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterised by cognitive deficits.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 13, 2012
    Applicants: EGIS GYOGYSZERGYAR NYRT, LES LABORATOIRES SERVIER
    Inventors: István LING, József BARKÓCZY, Ferenc ANTONI, István GACSÁLYI, György LÉVAY, Michael SPEDDING, László HÁRSING
  • Process for the synthesis of (methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
    Patent number: 8252951
    Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: August 28, 2012
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve, Jean-Paul Hermet