Abstract: The invention relates to compounds of formula (I): wherein R1 and R2 together form the following carbon-containing chain: wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom or an alkyl, aryl, heteroaryl, 3,4-dioxocyclobutenyl, alkylcarbonyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, benzoyl, arylsulphonyl or heteroarylsulphonyl group, each of those groups optionally being substituted, or R3 and R4 together with the nitrogen atom carrying them form a 5- to 8-membered ring, the ring thereby formed optionally being substituted. Medicinal products containing the same which are useful in treating conditions requiring a D3 receptor antagonist.
Type:
Grant
Filed:
July 20, 2010
Date of Patent:
August 21, 2012
Assignee:
Les Laboratoires Servier
Inventors:
Guillaume De Nanteuil, Bernard Cimetiere, Anne Dekeyne, Mark Millan
Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
Type:
Application
Filed:
February 14, 2012
Publication date:
August 16, 2012
Applicant:
LES LABORATOIRES SERVIER
Inventors:
Michel WIERZBICKI, Marie-Françoise BOUSSARD, Tony VERBEUREN, Patricia SANSILVESTRI-MOREL, Alain RUPIN, Jérôme PAYSANT, François LEFOULON
Abstract: Association comprising a selective and specific sinus node If current inhibitor, more especially ivabradine, and an agent that inhibits angiotension-converting enzyme. Medicinal products containing the same which are useful in treating arterial hypertension.
Type:
Application
Filed:
April 9, 2012
Publication date:
August 2, 2012
Applicant:
LES LABORATOIRES SERVIER
Inventors:
Vidal BENATAR, Guy LEREBOURS-PIGEONNIERE
Abstract: Association of a sinus node If current inhibitor and a ?-blocker and also pharmaceutical compositions containing it. Medicinal products containing the same which are useful in treating angina pectoris, ischaemia, and heart failure.
Type:
Grant
Filed:
February 11, 2009
Date of Patent:
July 10, 2012
Assignee:
Les Laboratoires Servier
Inventors:
Guy Lerebours-Pegeonniere, Jean-Henri Calvet
Abstract: Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
Type:
Application
Filed:
December 30, 2011
Publication date:
May 10, 2012
Applicants:
LES LABORATOIRES SERVIER, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, an in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to a compound useful for treatment of such conditions, and methods of using this compound for such treatment.
Type:
Grant
Filed:
December 28, 2007
Date of Patent:
May 8, 2012
Assignee:
Les Laboratoires Servier
Inventors:
Alexis Cordi, Gary Rogers, Rudolf Mueller
Abstract: The invention relates to a solid orodispersible pharmaceutical composition of perindopril, characterised in that it comprises perindopril or a pharmaceutically acceptable salt thereof and granules consisting of co-dried lactose and starch.
Type:
Application
Filed:
December 5, 2011
Publication date:
March 29, 2012
Applicant:
LES LABORATOIRES SERVIER
Inventors:
PATRICK WUTHRICH, Herve ROLLAND, Marc JULIEN
Abstract: Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing the same which are useful as modulators of the AMPA receptor.
Type:
Application
Filed:
September 15, 2011
Publication date:
March 22, 2012
Applicant:
LES LABORATOIRES SERVIER
Inventors:
Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
Type:
Grant
Filed:
March 30, 2009
Date of Patent:
March 20, 2012
Assignee:
Les Laboratoires Servier
Inventors:
Michel Wierzbicki, Marie-Françoise Boussard, Tony Verbeuren, Patricia Sansilvestri-Morel, Alain Rupin, Jérôme Paysant, François Lefoulon
Abstract: Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
March 13, 2012
Assignee:
Les Laboratoires Servier
Inventors:
Jean-Claude Ortuno, Alexis Cordi, Jean-Michel Lacoste, Vincent Lacoste, legal representative, Pauline Lacoste, legal representative, Imre Fejes, Michael Burbridge, John Hickman, Alain Pierre
Abstract: Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
Type:
Application
Filed:
November 2, 2011
Publication date:
February 23, 2012
Applicant:
LES LABORATOIRES SERVIER
Inventors:
Jean-Claude Ortuno, Alexis Cordi, Jean-Michel Lacoste, Vincent Lacoste, Pauline Lacoste, Imre Fejes
Abstract: Process for the preparation of compounds of formula (IV): wherein R1, R2, R3 and R4, which may be identical or different, each represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C1-C6)alkoxy group, a fluorine atom, a chlorine atom, a protected amine group, a protected hydroxyl group, an alkoxycarbonyl group in which the alkoxy group is linear or branched (C1-C6), or a CF3 group, or R1?R4?H and R2 and R3 together with the carbon atoms carrying them form a 1,3-dioxolane group, R5 represents a saturated or unsaturated, linear or branched (C1-C6)alkyl group, a linear or branched (C1-C6)hydroxyalkyl group in which the hydroxyl function is protected, or a CO2R7 group in which R7 is a linear or branched (C1-C6)alkyl group, R6 represents a cyano group or a CO2R8 group in which R8 is a linear or branched (C1-C6)-alkyl group. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
Type:
Grant
Filed:
July 15, 2009
Date of Patent:
February 7, 2012
Assignees:
Les Laboratoires Servier, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1