Patents Assigned to Lexicon
  • Methods of treating ulcerative colitis
    Patent number: 8404732
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: March 26, 2013
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • METHODS OF TREATING ULCERATIVE COLITIS
    Publication number: 20130005775
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Application
    Filed: January 4, 2012
    Publication date: January 3, 2013
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Modulators of G protein-coupled receptor 88
    Patent number: 8304577
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: November 6, 2012
    Assignees: Bristol-Myers Squibb Company, Lexicon Pharmaceuticals, Inc.
    Inventors: Carolyn Diane Dzierba, Richard A. Hartz, Yingzhi Bi, Vijay T. Ahuja, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Michael Green, David Kimball, S. Roy Kimura, Soojin Kwon, John E. Macor, Yulian Zhang, Greg Zipp
  • Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
    Patent number: 8293878
    Abstract: Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: October 23, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Nicole Cathleen Goodwin, Bryce Alden Harrison, Shinya Iimura, Ross Mabon, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang, Matthew Mangzhu Zhao
  • Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions
    Patent number: 8227661
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: July 24, 2012
    Assignee: Lexicon Genetics, Inc.
    Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox
  • Solid forms of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol and methods of their use
    Patent number: 8217156
    Abstract: Solid forms of anhydrous (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol are disclosed, in addition to methods of their use in the treatment of various diseases and disorders.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: July 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Susan Margaret De Paul, Anett Perlberg, Matthew Mangzhu Zhao
  • Monoclonal Antibodies Against ANGPTL4
    Publication number: 20120171217
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Application
    Filed: December 8, 2011
    Publication date: July 5, 2012
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: E-Chiang Lee, Gregory M. Landes, Kyu Chung, Ling Chen, Urvi Desai, David Reed Powell, Seokjoo Hong
  • Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1- (4-chloro-2-(3-methyl-1H-pyrazol-1-YL)phenyl)2,2,2-trifluoroethoxy)-pyrimidin-4-YL)phenyl)propanoate and methods of their use
    Patent number: 8193204
    Abstract: Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: June 5, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Susan De Paul, Ramanaiah C. Kanamarlapudi, Anett Perlberg, Haiming Zhang
  • LIMK2 inhibitors, compositions comprising them, and methods of their use
    Patent number: 8193202
    Abstract: Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 5, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Nicole Cathleen Goodwin, Bryce Alden Harrison, Jason Patrick Healy, Ying Liu, Ross Mabon, Brett Marinelli, David Brent Rawlins, Dennis Stewart Rice, Norris Andrew Whitlock
  • Aryl pyridines and methods of their use
    Patent number: 8153804
    Abstract: Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: April 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, James E. Tarver, Jr., Qinghong Fu, Michael Victor Voronkov, Doan Hackley, Michael E. Mertzman, Marianne Carlsen
  • Methods of treating rheumatoid arthritis
    Patent number: 8093267
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Methods of preparing imidazole-based compounds
    Patent number: 8093280
    Abstract: Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Wenxue Wu, Jie Yan, Haiming Zhang
  • 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use
    Patent number: 8093245
    Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Alexander Heim-Riether, Theodore C. Jessop, James E. Tarver, Jerry A. Taylor
  • O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
    Patent number: 8093246
    Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Jason P. Healy, Alexander Heim-Riether, Theodore C. Jessop, Philip E. Keyes, Min Shen, James E. Tarver, Jerry A. Taylor, Xiaolian Xu
  • Methods of using and compositions comprising tryptophan hydroxylase inhibitors
    Patent number: 8093291
    Abstract: Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Philip Manton Brown, Qingyun Liu
  • Monoclonal antibodies against ANGPTL4
    Patent number: 8092796
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: E-Chiang Lee, Gregory M. Landes, Kyu Chung, Ling Chen, Urvi Desai, David Reed Powell, Seokjoo Hong
  • Multicyclic amino acid derivatives and methods of their use
    Patent number: 8063057
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 22, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Brett Marinelli, Lakshama Samala, Zhi Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Monoclonal Antibodies Against ANGPTL3
    Publication number: 20110243948
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Application
    Filed: March 28, 2011
    Publication date: October 6, 2011
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: E-Chiang Lee, Gregory Landes, Seokjoo Hong, Urvi Desai, David Powell, Xiao Feng
  • Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
    Patent number: 8026347
    Abstract: Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: September 27, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Nicole Cathleen Goodwin, Bryce Alden Harrison, Shinya Iimura, Ross Mabon, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang, Matthew Mangzhu Zhao
  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20110200579
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO57290 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as cardiovascular, endothelial or angiogenic disorders; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; or developmental abnormalities.
    Type: Application
    Filed: January 22, 2008
    Publication date: August 18, 2011
    Applicants: Genentech, Inc., Lexicon Pharmaceuticals, Inc
    Inventors: Jaime-Jo Cunningham, Peter Vogel