Patents Assigned to Lexicon
  • Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use
    Patent number: 7998994
    Abstract: Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: August 16, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Suzanne Marie Buttar, Christopher Stephen Frampton
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20110191865
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: June 3, 2009
    Publication date: August 4, 2011
    Applicants: Genentech, Inc., Lexicon Genetics Incorporated
    Inventors: Joel A. Edwards, Wenhu Huang, Charles A. Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Westbrook
  • Methods of preparing imidazole-based bicyclic compounds
    Patent number: 7968726
    Abstract: Methods of preparing compounds of formula I are disclosed:
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Jason Guohua Chen, Weifeng Hu, Renmao Liu, Yuelie Lu, Wenxue Wu, Xiaogen Yang
  • 1-phenyl-1H-pyrazole-based compounds
    Patent number: 7968729
    Abstract: Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Hugh Alfred Burgoon, Jr., Shinya Iimura, Ramanaiah C. Kanamarlapudi, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang
  • Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
    Patent number: 7968559
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols
    Patent number: 7951941
    Abstract: Methods of preparing 5-alkyl-7H-pyrrolo[2,3-d]pyrimidin-4-ols are described, as are novel compounds useful in their preparation.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: May 31, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • Monoclonal antibodies against ANGPTL3
    Patent number: 7935796
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: May 3, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: E-Chiang Lee, Gregory Landes, Seokjoo Hong, Urvi Desai, David Powell, Xiao Feng
  • Novel Gene Disruptions, Compostitions and Methods Relating Thereto
    Publication number: 20110097330
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes.
    Type: Application
    Filed: February 27, 2006
    Publication date: April 28, 2011
    Applicants: Genentech, Inc., Lexicon Pharmaceuticals, Inc.
    Inventors: Allison Anne Byers Horner, Catherine Batac Clarke, Katherin E. Combs, Frederic J. de Sauvage, Joel Edwards, Paul Godowski, Deanna Grant Wilson, Wenhu Huang, Lorelei Diane Ketcherside, Erin Marie Massey, Charles Montgomery, Bobby Joe Payne, Andrew Peterson, Ni Nancy Qian, Jeffrey J. Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Colleen M. Viator, Peter Vogel, Weilan Ye, Jung-Hua Yeh, Zhiyong Ding
  • METHODS OF TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND DISORDERS
    Publication number: 20110082178
    Abstract: Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Application
    Filed: October 13, 2010
    Publication date: April 7, 2011
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Simon D.P. Baugh, Kenneth G. Carson, Theodore C. Jessop, James E. Tarver
  • Synthesis of piperazines, piperidines and related compounds
    Patent number: 7919618
    Abstract: Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 5, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Jr., Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • Process for the preparation of substituted phenylalanines
    Patent number: 7897763
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 1, 2011
  • Methods and compositions for treating pulmonary hypertension and related diseases and disorders
    Patent number: 7875622
    Abstract: Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also disclosed.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: January 25, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventor: Arthur T. Sands
  • MONOCLONAL ANTIBODIES AGAINST ANGPTL4
    Publication number: 20110008359
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 13, 2011
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: E-Chiang LEE, Gregory M. LANDES, Kyu CHUNG, Ling CHEN, Urvi DESAI, David Reed POWELL, Seokjoo HONG
  • Process for the preparation of substituted phenylalanines
    Patent number: 7855291
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 21, 2010
  • Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use
    Patent number: 7846945
    Abstract: Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: December 7, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
  • Compositions and methods for treating immunological and inflammatory diseases and disorders
    Patent number: 7825150
    Abstract: Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/or anti-inflammatory agent.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: November 2, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventor: Tamas Oravecz
  • Heterocyclic compounds, compositions comprising them and methods of their use
    Patent number: 7825142
    Abstract: Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: November 2, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Simon D. P. Baugh, Kenneth G. Carson, Theodore C. Jessop, James E. Tarver
  • Methods of preparing imidazole-based compounds
    Patent number: 7812174
    Abstract: Methods of preparing imidazole-based compounds are disclosed.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 12, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Wenxue Wu, Jie Yan, Haiming Zhang
  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND THE METHODS RELATING THERETO
    Publication number: 20100233153
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO1105, PRO1279 or PRO1783 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: October 1, 2007
    Publication date: September 16, 2010
    Applicants: GENENTECH, INC., LEXICON PHARMACEUTICALS, INC.
    Inventors: Mark Dominic Borromeo, Jaime-Jo Cunningham, Frederick Desauvage, Ellen Filvaroff, Mark Alan Klamer, Laurie Jeanette Minze, Bobby Joe Payne, Carolina Rangel, Zheng-Zheng Shi, Peter Vogel
  • Inhibitors of sodium glucose co-transporter 2 and methods of their use
    Patent number: 7781577
    Abstract: Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 24, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins, Nicole C Goodwin