Abstract: A system is configured to discriminate amongst different environments based in part on characteristics of ambient light. Ambient light intensity is measured using a light-sensitive element configured to generate an output signal indicative of an intensity of light incident on the light-sensitive element. A controller is configured to obtain a set of ambient light measurements using the light-sensitive element, and determine that the measurements correspond to a particular ambient light profile. The particular ambient light profile can be one of multiple ambient light profiles that each correspond to a different environment and/or context.

Abstract: One example insect sensing system includes a light emitter configured to emit light; a structured light generator positioned to receive the emitted light and configured to generate structured light from the emitted light; a plurality of light sensors arranged in a line, each of the light sensors oriented to receive at least a portion of the structured light and output a sensor signal indicating an amount of light received by the respective light sensor; a processing device configured to: obtain the sensor signals from each of the light sensors, and determine a presence of an insect based a received sensor signal from at least one light sensor, the sensor signal indicating a reduced amount of received light by the at least one light sensor. Another example insect sensing system includes a camera comprising an image sensor and a lens having an aperture of f/2.8 or wider; and a processor configured to obtain an image from the camera and detect an insect in the image.

Abstract: Systems and methods for detecting a color of a color changing indicator in the presence of ambient light. A system includes a light source, a photodetector, and a processor. The processor obtains a first measurement of ambient light received from the photodetector while the light source is off. The processor causes the light source to transmit light. The processor obtains a second measurement from the photodetector during the transmission, the second measurement including the ambient light and the pulsed light reflected from an object. The processor determines a color of the color changing indicator by removing an ambient light signal from the second measurement based on the first measurement and therefrom determines a volume of bodily exudate present.

Abstract: Image guided surgery includes capturing a primary modality image of a surgical field of a patient with a camera system, obtaining a secondary modality image of the surgical field registered to the primary image, generating a surgical guidance image based at least in part upon the secondary modality image, and projecting the surgical guidance image onto the patient. The surgical guidance image presents visual augmentations on or over the patient to inform a medical practitioner during a surgical procedure.

Abstract: Example implementations may relate to a haptic hand-holdable controller configured with throttle functionality. An example device may take the form of a haptic controller, which senses tactile information and provides force feedback. The haptic hand-holdable controller may implement a throttle where a motor varies feedback to the hand-holdable controller to simulate a throttle.

Abstract: Provided herein are methods, systems, kits and compositions for identifying nucleic acids of interest from individual cells. The methods include isolating single cells on electrodes and identifying nucleic acids of interest from the isolated cells by sequencing.

Abstract: Disclosed herein are methods and systems for adjusting the power level of an external reader of an electronic device. The external reader transmits power to the electronic device with a radio frequency electromagnetic signal. The electronic device may rectify the radio frequency electromagnetic signal and create a rectified voltage. The rectified voltage may be positively correlated to the power level transmitted by the external device. The rectified power can be used to power a component of the electronic device, such as a component configured to measure either a voltage or power associated with the rectified voltage. The electronic device may communicate the measured voltage or power back to the external reader. Based on the communicated voltage or power, the external reader may adjust its power level of the transmitted power.

Abstract: The combination of a repellent agent or an attractant agent with a wavelength-specific visual cue agent has been found to produce an unexpected and synergistic effect of increased repellency or attraction in dichromatic animals who are not maximally sensitive to the wavelength of the repellent or attractant agent. The method of the invention may be used to repel dichromatic-animal pests; or to prevent or minimize monetary damage, particularly to agricultural products, natural resources or private property. The method of the invention may also be used to attract dichromatic animals for the purpose of agricultural production, recreational opportunities (e.g., wild-rodent feeders), or the effective administration of target-animal pharmaceuticals or mitigation techniques.

Abstract: Body-mountable devices comprising a dyed polymer layer that covers a portion of an electronic structure embedded in a transparent polymer are described. An example method for fabricating a body-mountable device includes providing a dyed polymer material on an electronic structure. The electronic structure comprises at least one antenna, a sensor, and an electronic device. The example method also includes molding the dyed polymer material to provide a dyed polymer layer that covers a portion of the electronic structure.

Abstract: A method for profiling extracellular vesicles (EV) is provided.

Abstract: Methods and systems are disclosed for image process biological samples to infer biomarker values. An image of a biological sample can be accessed. The image can be segmented into a set of patches. Edge detection performed on each patch can be used to identify one or more biological features represented by the patch. An indication of the one or more features of each patch may be used to generate one or more image level metrics. A value of a biomarker may be inferred using the one or more image level metrics. The value of the biomarker can then be output.

Abstract: Systems and methods for fluorescent microscopy are disclosed where fluorophores can be excited over an excitation band to emit light in a wide emission band. Simultaneous acquisition of multiple planes in the sample can be achieved using a modified form of confocal microscopy. In one implementation, an objective employs a lens having optics exhibiting a large degree of axial chromatic aberration, such that emissions from different axially spaced focal planes are encoded by wavelength. Advantageously, simultaneous acquisition of multiple focal planes encoded by color can be processed to obtain efficient and rapid three-dimensional imaging of a sample.

Abstract: Introduced here are diabetes management platforms able to make annotations to physiological data of a subject whose glycemic health state is being monitored. These annotations can be used to classify excursions detected in the physiological data to facilitate the identification of a therapeutic behavior change intended to improve the glycemic health state of the subject. For example, a health coach may review the annotation(s) associated with the subject before generating a recommendation for improving the glycemic health state. As another example, the diabetes management platform can automatically identify an appropriate recommendation based on the annotation(s).

Abstract: A robotic surgical system includes a surgical instrument configured to cut biological tissues and an imaging system configured to image the biological tissues. Based on one or more images of the biological tissue generated by the imager, the robotic surgical system operates the surgical instrument to cut the biological tissue according to a desired dissection of the tissue. The robotic surgical system operates the surgical instrument to partially or wholly automatically perform one or more cuts into the biological tissue to achieve the desired dissection.

Abstract: An example ophthalmic device for impedance-based measurements of hydration of the ophthalmic device includes an enclosure having a shape to be worn on an eye, an insert disposed within the enclosure control electronics disposed on the insert, the control electronics coupled to control operation of the ophthalmic device, and a plurality of electrodes disposed within the enclosure and electrically coupled to the control electronics, where the plurality of electrodes are arranged outside of a central optical area of the ophthalmic device, and where each of the plurality of electrodes is electrically coupled to receive a respective voltage from the control electronics to measure an impedance of the enclosure proximate the plurality of electrodes, the measured impedance indicative of a hydration level of the enclosure proximate to the plurality of electrodes.

Abstract: Introduced here is an attachable unit that connects to a base unit through a snap-fitting mechanism. The attachable unit can include a top housing structure and a bottom housing structure that are ultrasonically welded together. The top housing structure can include the toe portion that is integral with remaining portions of the top housing structure, where the toe portion is configured to provide the snap-fit with the base unit.

Abstract: Insect storage and dispensing system are described. An example system may include a dispensing container including at least one wall defining an interior volume for retaining a plurality of adult insects. The system may also include a piston that extends through a first opening of the dispensing container so as to expose a top face of the piston to the interior volume. Longitudinal movement of the piston toward a second opening of the dispensing container may dispense a portion of the plurality of insects from the dispensing container when the plurality of insects is retained in the dispensing container.

Abstract: Disclosed herein are systems and methods capable of identifying, tracking, and sorting particles flowing in a channel, for example, a microfluidic channel having a fluid medium. The channel and the fluid medium can have a similar refractive index such that they appear translucent or transparent when illuminated by electromagnetic radiation. The particles can have a refractive index substantially different from that of the channel and the medium, such that the particles interfere with the electromagnetic radiation. A sensor can be disposed adjacent to the channel to record the electromagnetic radiation. The sensor can be used for identifying, tracking, and sorting the particles.

Abstract: Provided herein are compositions and methods for identifying one or more targeted nanoparticles suitable for delivery to one or more organs or tissues of a subject.

Abstract: The disclosure provides a simple and efficient method for producing a compound of Formula I.