Abstract: In an embodiment of the present invention, compounds of the present application or pharmaceutically acceptable salts thereof are capable of interacting with and activating the stimulator of interferon genes (STING) protein. In an embodiment of the present invention, pharmaceutical compositions and methods involving such compounds as STING modulators are additionally provided herein.

Abstract: Among other things, a determination is made that intervention in an operation of one or more autonomous driving capabilities of a vehicle is appropriate. Based on the determination, a person is enabled to provide information for an intervention. The intervention is caused in the operation of the one or more autonomous driving capabilities of the vehicle.

Abstract: The present disclosure pertains to branched surfactants for use in the formulation of detergents, foaming agents, emulsifiers, and degreasers. Some aspects of the invention include formulations suitable for cleaning and/or condition fabrics including upholstery. Some formulations are suitable for in home or commercial dry cleaning. Some of the formulations may be suitable for cleaning hard surfaces including plastic surfaces.

Abstract: An example luminaire includes a white light source (e.g. LEDs emitting white light in a region of the CIE color chart within three Macadam ellipses below the black body curve) and a violet light source emitting light in a wavelength range of approximately 380 nm to 450 nm (e.g. 405 nm LEDs) for deactivating bacteria, such as Methicillin-Resistant Staphylococcus aureus (MRSA) on a surface exposed to illumination from the luminaire. A controller coupled to the sources pulses the violet light source at an irregular rate and interval over a time period to apply a deactivation dosage of the violet light to bacteria within range of the emissions. When ON, the violet source emits light for deactivating bacteria at an intensity higher than the concurrent intensity of the white light.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to reassigning meeting rooms. In some embodiments, a system comprises a mobile device configured to receive user input to request a meeting room, determine a location of the mobile device, and transmit an indication of the request, the location of the mobile device, and the user, sensors associated with the meeting rooms configured to detect occupancy of the meeting rooms, a scheduling database configured to store scheduling information for the meeting rooms, the control circuit configured to receive the indication of the request, the location of the mobile device, and the user, determine that all meeting are booked, receive occupancy information for the meeting rooms, determine that one of the meeting rooms is unoccupied, reassign the one of the meeting rooms to the user, and cause transmission of a notification that the one of the meeting rooms has been reassigned.

Abstract: Techniques for remediating drift in real cloud infrastructure from desired cloud infrastructure. In one technique, a configuration graph is generated based on first infrastructure configuration code. A deployed state of a cloud infrastructure is generated based on a data schema and a current state of the cloud infrastructure. Resources indicated in the deployed state are matched to nodes in the configuration graph. Based on differences between the resources and the nodes, the configuration graph is updated to generate an updated configuration graph. Based on the updated configuration graph, second infrastructure configuration code is generated that is different than the first infrastructure configuration code.

Abstract: The disclosed method for implementing a digital assistant in a multi-application network includes: receiving an input command from a computing device; analyzing the input command; determining based on the analysis of the input command, a digital request data object associated with the input command; resolving the input command into a data string; determining, based on the digital request data object and the data string, intent data; and generating based on the intent data, a first set of operation recommendations comprising a first operation recommendation. The methods also include determining an application programming interface (API) associated with the first application; connecting the API to the first application; and executing the first operation recommendation to generate a computing operation result; and rendering the computing operation on a single graphical interface comprising a consolidation of a plurality of graphical interfaces associated with the first set of computing operation recommendations.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, L1, L2, L3, A1, A2, A3, A4, G1, G2, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: A cutting element for downhole drilling and related earth-boring tool for downhole drilling. The cutting element may include a substrate and a polycrystalline diamond material affixed to the substrate at an interface. The polycrystalline diamond material may include a raised cutting surface having at least two cutting edges, and first transition surfaces between the at least two cutting edges of the raised cutting surface and a side surface of the cutting element. The first transition surfaces may include multiple planar surfaces.

Abstract: A spinner assembly for an instrument having valves and/or slides. A clamp sub-assembly attaches to the instrument while a hand strap sub-assembly encircles a player's conjoined hand. A bearing rotatably connects the clamp sub-assembly to the hand strap sub-assembly about a drive axis (D) that is offset from the natural balance axis of the instrument (X). The clamp sub-assembly includes a mounting plate fashioned with three side-by-side cradles that nest against the horn valves. A lashing holds the cradles in position. The hand strap sub-assembly includes a generally rigid palm plate that fits in the player's palm. The palm plate has a hypothenar end, a web end and a distal edge. The distal edge has a ring finger relief adjacent the hypothenar end. A driver boss is affixed to the backside of the palm plate adjacent the web end. A flexible belt secures the player's hand to the palm plate.

Abstract: An air filtration apparatus includes an airflow powerhead assembly including a fan assembly and a vane assembly, a filter assembly, and a separator chamber housing inside of which the filter assembly is disposed. The separator chamber housing has a chamber inlet at a first axial side and a clean air outlet at a second axial side of the separator chamber housing opposite the first axial side. The filter assembly has a first axial end adjacent the chamber inlet and a second axial end adjacent the clean air outlet. The separator chamber housing includes at least one debris ejection slot extension configured to eject debris from an inner space of the separator chamber housing. The filter assembly includes a debris catch tray disposed at the second axial end, the debris catch tray having a debris ejection slot aligned with the at least one debris ejection slot extension.

Abstract: In some implementations, a monitoring device may obtain information related to one or more extract, transform, and load (ETL) jobs scheduled in an ETL system. The monitoring device may generate ETL job metrics that include status information, timing information, and data volume information associated with one or more constituent tasks associated with the one or more ETL jobs, wherein the ETL job metrics include metrics related to extracting data records from a data source, transforming the data records into a target format, and/or loading the data records in the target format into a data sink. The monitoring device may enable capabilities to create or interact with one or more dashboards to visualize the ETL job metrics via a workspace accessible to one or more client devices. The monitoring device may invoke a messaging service to publish one or more notifications associated with the ETL job metrics via the workspace.

Abstract: Systems and methods are described for improving content classifications and metadata for a plurality of content items. The content items may comprise various forms of media content. A content recommendation processing system may automatically annotate and/or classify content items with a plurality of metadata tag information describing content items. The disclosed system and methods may also determine and/or assign applicability scores indicating a level or degree of suitability for annotating a content item with particular metadata tag information, and may utilize applicability scores to provide content to calibrate metadata information for a plurality of content items, and further to provide content recommendations to users.

Abstract: Embodiments include systems and methods for offloading media service operation to one or graphical processing unit (GPUs). In some embodiments, a computer system, includes a first computer device to provide a media service that involves implementing media service operations and transmit a first media service request for a first media service operation of the media service operations. In addition, the computer system includes a second computer device that includes one or more GPUs. The second computer device is to implement the first media service operation with the one or more GPUs in response to the first computer device transmitting the first media service request for the first media service operation.

Abstract: A hydraulic fracturing plan executable by a hydraulic fracturing system to hydraulically fracture at least first and second wells. In one or more embodiments, executing the hydraulic fracturing plan includes opening a first valve while hydraulic fracturing fluid is communicated to the second well via a second valve and a manifold, the first valve being associated with both the first well and the manifold, and the second valve being associated with both the second well and the manifold. In one or more embodiments, executing the hydraulic fracturing plan further includes closing the second valve, wherein the second valve is closed after opening the first valve, and while hydraulic fracturing fluid is communicated to the first well via the first valve and the manifold.

Abstract: Designing garments that include brassiere cups can be challenging due to the natural fluctuation of a woman's breast size, as well as a possible disconnect between the size of her breasts and the size of the rest of her body. The high range of size variability places pressure on stores to stock inventories that include great ranges of sizes. This places an inventory risk to the store, since rarer sizes may never sell. The disclosed garment addresses these issues by including a fit-adjustable brassiere portion. The cups of the fit-adjustable brassiere portion include fit-modifying panels that increase their flexibility and elasticity. The rear side of the fit-adjustable brassiere portion includes a back adjuster with highly elastic regions that enables the brassiere portion to fit a broader range of chest sizes. Each of these features give the garment a more universal fit and enable stores to carry fewer sizes.

Abstract: Methods and systems for customizing wearable equipment such as athletic equipment, including ice skates. For example, an ice skate may comprise a skate boot and blade holder. The skate boot may be customized, e.g., may be manufactured using a custom last. A method of operating a computing device to customize the skate boot last may comprise: carrying out a 3D modeling application; obtaining a scan of a foot from an image acquisition device; creating a model of the foot; obtaining a model of a customized last based on the model of the foot; creating metadata and associating the metadata with the 3D model data; and generating a production specification for the customized last based on the model of the customized last and the metadata.

Abstract: A firmware is configured with a firmware management protocol (“FMP”) capable of updating a firmware logo image and a firmware logo image volume is defined within a firmware for storing a firmware logo image. A firmware logo image updater executing on a computing device receives a UEFI capsule that contains a firmware logo image. The firmware logo image updater stores the UEFI capsule in a UEFI system partition on a computer-readable storage medium accessible to the computing device. Upon a reboot of the computing device, the FMP is executed. The FMP retrieves the UEFI capsule from the UEFI system partition. The FMP then updates the firmware logo image volume with the firmware logo image stored in the UEFI capsule.