Abstract: In an example, a semiconductor device includes an active trench region and an intersecting trench. The active region includes an active shield electrode and the intersecting trench includes an intersecting shield electrode. A coupling trench region connects the active trench region to the intersecting trench region. The coupling trench region includes a coupling shield electrode. The coupling shield electrode and the intersecting shield electrode are provided proximate to a termination mesa region. One or more of the coupling shield electrode or the intersecting shield electrode is thinner than the active shield electrode. The thinner shield electrode reduces depletion in the termination mesa region to improve, among other things, breakdown voltage performance.

Abstract: Methods and systems are disclosed herein for cryptographically secured transfer of an item. In some embodiments, the system may cause generation of multiple key shares of a private key from which a blockchain address on a blockchain is derived. The system may generate a cryptographic representation of a physical item to be transferred from the first user to the second user, the physical item corresponding to the first item. The system may cause a first amount of the first item to be transferred to the blockchain address. The system may obtain a candidate cryptographic representation from the second user. The system may generate, based on the candidate hash matching the hash of the feature vector representing the physical item, a signed message using a partial signature of the second user and another partial signature derived from the third key share.

Abstract: An optical-fiber-based optical switch arrangement configured to redirect light from axial propagation to off-axis propagation due to axial repositioning of the optical fiber within the optical termination element and internally reflecting light in an annular fashion off the axis in one state of the switch arrangement and not in the other.

Abstract: A method for forming and abrading an implant void in a sacroiliac joint (“SI Joint”) without the use of a rotary cutting instrument. The method incorporates a multimodal abrading device having abrading surfaces on opposing sides, an open tip having a leading edge defining an enclosed oblong perimeter, and a cutting edge disposed at the leading edge of the open tip. The method includes the step of using the abrading head to cut bone tissue from the SI Joint at an insertion point while simultaneously using the abrading surfaces to decorticate the cortical bone at the insertion point.

Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable transgene marker. The methods and compositions employ a guide polynucleotide/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed, without incorporating a selectable transgene marker. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a guide polynucleotide/Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell, without incorporating a selectable transgene marker.

Abstract: A semiconductor device package may include a substrate having an insulating layer with a patterned conductive layer formed thereon, the patterned conductive layer including at least a first pattern portion and a second pattern portion. The semiconductor device package may include a leadframe having a lead that is soldered to the substrate with solder provided in an opening between the first pattern portion and the second pattern portion and with the lead inserted into the opening.

Abstract: Systems and methods include a wing tool configured to be operable from work vessel(s), the wing tool including thrusters capable of fluidizing sediments from a first seabed location and moving it to a second seabed location, the second seabed location including a trench or differently shaped collection sump previously made by the wing tool and/or an extraction pump. The extraction pump operates from a second work vessel having sufficient capacity to pump fluidized sediments from the trench. Certain systems include a separation unit that separates sand from silts and clays and water from collected sediment. Systems and methods for reclamation of reservoirs, moving sand waves, for pre-trenching and/or recovering marine pipelines and cables, for removing cover from marine archaeological sites and for disposing of contaminated bottom materials in an environmentally acceptable manner.

Abstract: Apparatus and methods relate to a pneumatic compression therapy device configured to suggest content to the patient based on a determined disease state, the content pertaining to suggested changes in lifestyle based on a standard of care. In an illustrative embodiment, the suggested changes may include modifications to treatment location, treatment time, diet, eating habits, or sleeping schedule. Various examples may further sample the patient's health and automatically adjust a treatment parameter within a predetermined parameter range based on a history of measured parameters, such as limb volume, for example. In coordination with the therapeutic treatment, the therapy device may deliver suggested content to guide the patient to make more healthful lifestyle choices to reduce recovery time and improve patient health outcomes.

Abstract: The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (DoI) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances. More particularly, the disclosed method employs relatively high physiologic concentrations of one or more antioxidants that are normally present in tears. In a variation, much higher concentrations of one or more antioxidants may provide protection against in vivo exposure to ocular irritants.

Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.

Abstract: A soft and stretchable microelectrode array (sMEA) including a first circuit board having a first though hole; a second circuit board having a second through hole; a microelectrode array including a plurality of microelectrodes embedded in an elastomeric substrate, wherein the microelectrode array is disposed between the first and second printed circuit boards, and includes an exposed portion corresponding the first and second through holes; a plurality of contact pads formed on a top or bottom surface of the first printed circuit board and electrically connected to the plurality of microelectrodes; and a culture well mounted on the first printed circuit board and encompassing the first through hole. Further, the exposed portion of the microelectrode array includes a 3D pocket lined with stretched microelectrodes for electrically stimulating and recording signals from an organoid placed in the 3D pocket.

Abstract: The invention of the present disclosure may be a pressure sensitive locking mechanism comprising a first tine, a second tine, and a third tine. The locking mechanism may further comprise a tab disposed on the second tine, where the tab may be orthogonal to the second tine. In an embodiment, the second tine is configurable in a locked state and an unlocked state, where the second tine comprises a second tine bell disposed on the lower portion of the second tine, and where the second tine bell is tapered from the tab to an upper portion of the second tine. The tab may be configured to receive a pressure, application of the pressure may be configured to convert the second tine from the locked state to the unlocked state, and withdrawal of the pressure may be configured to convert the second tine from the unlocked state to the locked state.

Abstract: A system for monitoring a battery module having a plurality of cells includes a sensor adapted to obtain respective cell voltages of the plurality of cells. The controller is adapted to receive data from the sensor, the controller having a processor and tangible, non-transitory memory on which instructions are recorded. The controller is configured to sort the respective cell voltages to create a voltage ranking. The voltage ranking is repeated with at least one new set of cell voltage readings obtained at a predefined checking frequency. Differences in the voltage ranking of the plurality of cells are analyzed. The controller is adapted to control operation of the battery module based in part on differences in the voltage ranking. The controller may be adapted to predict likelihood of a thermal runway event based in part on the differences in the voltage ranking.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for allocating computing resources. In one aspect, a method includes receiving intent data specifying one or more computing services to be hosted by a computing network, requested characteristics of computing resources for use in hosting the computing service, and a priority value for each requested characteristic. A budget constraint is identified for each computing service. Available resources data is identified that specifies a set of available computing resources. A resource allocation problem for allocating computing resources for the one or more computing resources is generated based on the intent data, each budget constraint, and the available resources data. At least a portion of the set of computing resources is allocated for the one or more computing services based on results of evaluating the resource allocation problem to meet a particular resource allocation objective.

Abstract: A method for modifying engine files, the method performed by at least one processor in one or more servers at a cloud based location, the method comprising receiving, by the one or more servers at the cloud based location from at least one host device, a derived data cache (DDC) generated by the at least one host device; distributing the DDC from the one or more servers at the cloud based location to one or more client locations, the one or more client locations performing at least one modification to the DDC; and receiving the modified DDC, by the one or more servers at the cloud based location from the one or more client locations.

Abstract: A method of encoding includes receiving a polygon mesh comprising a plurality of original vertices. The method further includes deriving an initial base mesh from the polygon mesh, the initial base mesh including a first set of base mesh vertices. The method further includes performing a symmetrize process on the initial base mesh to generate a symmetrical base mesh that includes a first side having the first set of base mesh vertices and a second side having a second set of base mesh vertices, each base mesh vertex in the first set of base mesh vertices having a corresponding symmetric vertex in the second set of base mesh vertices. The method further includes determining a first displacement between each original vertex in the polygon mesh located on the second side of the symmetrical base mesh and a nearest vertex included in the second set of base mesh vertices.

Abstract: The present disclosure relates to generating and adjusting translated audio from a video-based source. The method includes receiving video data and corresponding audio data in a first language; generating a translated preliminary transcript in a second language; aligning timing windows of portions of the translated preliminary transcript with corresponding segments of the audio data; determining portions of the translated aligned transcript in the second language that exceed a timing window range of the corresponding segments of the audio data in the first language to generate flagged transcript portions; transmitting the original transcript, the translated aligned transcript, and the first speech dub to a first device, the generated flagged transcript portions included in the original transcript and the translated aligned transcript; receiving, from the first device, a modified original transcript; and generating, based on the modified original transcript, a second speech dub in the second language.

Abstract: The invention relates to generating cryptographic tokens based on received records. The system may receive a blockchain operation request comprising a plurality of records, encrypt a plurality of records into an encrypted payload, generate a cryptographic token based on the encrypted payload, and cause the cryptographic token to be committed to a blockchain.

Abstract: A multi-factor authentication request of a user is received. For example, the multi-factor authentication request may include a valid username/password and a valid fingerprint scan. A first authentication factor of the multi-factor authentication request is an access authentication factor (e.g., the valid username/password) and a second authentication factor (e.g., the valid fingerprint scan) of the multi-factor authentication request is one of: a time-only authentication factor; a multi-session authentication factor; and a location-only authentication factor. The user is authenticated based on the first authentication factor and the second authentication factor. Access is granted to one or more resources according to one or more rules associated with the first authentication factor and second authentication factor.

Abstract: A modular cam system for an archery bow or crossbow includes swappable cams that change the maximum draw weight of the archery bow or crossbow. Moreover, the modular cams can be affixed to a rotatable member in a number of orientations to set the desired draw length without changing the limbs, tightening or loosening limb bolts, or disassembling the bow. Further, the maximum draw weight of the bow remains substantially similar throughout a large portion of the draw length adjustment for a specified cam module.