Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2 having the formula I: Also provided are methods of inhibiting ROCK1 and/or ROCK2 useful for the treatment of disease.

Abstract: A cast film inducing a bimodal ethylene-based polymer having a high density fraction (HDF) from 3.0% to 10.0%, an I10/I2 ratio from 5.5 to 7.0, a short chain branching distribution (SCBD) less than or equal to 10° C., a density from 0.910 g/cc to 0.920 g/cc, and a melt index (I2) from 1.0 g/10 mins to 8.0 g/10 mins.

Abstract: This disclosure describes systems and methods for protecting commercial off-the-shelf software program code from piracy. A software program may include an executable file having code and data. A platform may modify the executable file such that the data may be placed at a location in memory that is an arbitrary distance from the code. The platform may modify the executable file to include a separation header. The separation header may indicate that the data can be placed at an arbitrary distance in the memory from the code. The separation header may indicate that the code should be loaded into a hardware enclave and that the data should be loaded outside of the hardware enclave. The platform may encrypt the code and provide it to a computing device. The computing device may load the encrypted code into the hardware enclave but load the data into memory outside the hardware enclave.

Abstract: Examples of detecting whether a device meets an enrollment level are disclosed. In one case, a method for providing access to an application on a client device includes receiving a request to access an application from the client device, determining an enrollment level associated with the application, and determining that multi-factor authentication is required for access to the application on the client device based on the enrollment level associated with the application. The method can also include initiating multi-factor authentication on the client device before access to the application is permitted. The method can also include determining that multi-factor authentication is successful on the client device, transmitting a management component to the client device, and installing the management component on the client device for enrollment as a managed device with a management service.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: A protective packaging web is disclosed. The web includes a first film web having a plurality of extended portions including a base perimeter enclosing an open base region and an extended surface protruding in one direction from a plane defined by the first film web. The extended surface has a larger surface area than the open base region. The web also includes a second film web sealed to the first film web around a portion of the open base region to form sub-chambers on a side of the first film web opposite the protruding direction. The first film web and the second film web remain unsealed across the open base region defining regions within the sub-chambers suitable to contain a fluid volume. The plurality of sub-chambers are interconnected via one or more intra-chamber channels, allowing each of the sub-chambers to receive and release fluid in response to external pressures.

Abstract: The technology relates to assisting large self-driving vehicles, such as cargo vehicles, as they maneuver towards and/or park at a destination facility. This may include a given vehicle transitioning between different autonomous driving modes. Such a vehicles may be permitted to drive in a fully autonomous mode on certain roadways for the majority of a trip, but may need to change to a partially autonomous mode on other roadways or when entering or leaving a destination facility such as a warehouse, depot or service center. Large vehicles such as cargo truck may have limited room to maneuver in and park at the destination, which may also prevent operation in a fully autonomous mode. Here, information from the destination facility and/or a remote assistance service can be employed to aid in real-time semi-autonomous maneuvering.

Abstract: Techniques for generating distributed representations of computing processes and events are provided. According to one set of embodiments, a computer system can receive occurrence data pertaining to a plurality of computing processes and a plurality of events associated with the plurality of computing processes. The computer system can then generate, based on the occurrence data, (1) a set of distributed process representations that includes, for each computing process, a representation that encodes a sequence of events associated with the computing process in the occurrence data, and (2) a set of distributed event representations that includes, for each event, a representation that encodes one or more event properties associated with the event and one or more events that occur within a window of the event in the occurrence data.

Abstract: In some variations, an interferometric frequency-reference apparatus comprises: an atom source configured to supply neutral atoms; a collimator configured to form a collimated beam of the neutral atoms; one or more probe lasers; and a Doppler laser configured to determine a ground-state population of the neutral atoms. Other variations provide a method of creating a stable frequency reference, comprising: forming a collimated beam of neutral atoms; illuminating the neutral atoms with first and second probe lasers; adjusting the frequencies of the first probe laser and second probe laser using Ramsey spectroscopy to an S?D transition of the neutral atoms; and determining a ground-state population of the neutral atoms with another laser. The interferometric frequency-reference apparatus may provide an optical frequency reference or a microwave frequency reference.

Abstract: Packaging media for optimizing immersive media distribution of a media steam performed by at least one processor, is provided, including: receiving immersive media data for an immersive presentation; acquiring asset information associated with media assets corresponding to a set of scenes included in the immersive media data for the immersive presentation; analyzing characteristics of the media assets based on the asset information, the characteristics comprising an asset type associated with a respective media asset and a frequency that indicates a number of times the respective media asset is used among the set of scenes included in the immersive presentation; ordering the media assets in a sequence based on the asset type and the frequency associated with each of the media assets; and streaming the immersive media data for the immersive presentation based on the ordered sequence of the media assets.

Abstract: A thermally reflective membrane apparatus comprises a housing structure, and a thermally reflective membrane contained within the housing structure. The thermally reflective membrane comprises a semipermeable structure, and a porous, thermally reflective structure physically contacting the semipermeable structure. The porous, thermally reflective structure comprises discrete thermally reflective particles, and a binder material coupling the discrete thermally reflective particles to one another and the semipermeable structure. A fluid treatment system and method of treating a fluid are also described.

Abstract: The present invention relates to methods and apparatuses for determining the ratio of oxidized and reduced forms of a redox couple in solution, each method comprising: contacting first and second stationary working electrodes and first and second counter electrode to the solution; applying a first potential at the first stationary working electrode and a second potential at the second stationary working electrode relative to the respective counter electrodes and measuring first and second constant currents for the first and second stationary working electrodes, respectively; wherein the first and second constant currents have opposite signs and the ratio of the absolute values of the first and second constant currents reflects the ratio of the oxidized and reduced forms of the redox couple in solution. When used in the context of monitoring/controlling electrochemical cells, additional embodiments include those further comprising oxidizing or reducing the solution.

Abstract: Technologies for enhancing credit transactions include a point of sale computing system. The point of sale computing system receives payment vehicle data for a credit transaction associated with a purchase event. The point of sale computing system determines whether the credit transaction is an alternate routing candidate. The point of sale computing system routes an authorization request message to an issuer computing system via a payment card network in response to a determination that the credit transaction is not an alternate routing candidate. Alternatively, the point of sale computing system routes the authorization request message directly to the issuer computing system via a PIN debit network in response to a determination that the credit transaction is an alternate routing candidate. A corresponding authorization response message is received by the point of sale computing system via the payment card network or the PIN debit network. Other embodiments are described and claimed.

Abstract: A brine-based viscosified pill including (1) a viscosified brine, (2) a surfactant-solvent blend containing about 5 wt. % to about 40 wt. % of at least one nonionic surfactant; about 5 wt. % to about 20 wt. % of at least one polyglycerol ester, about 20 wt. % to about 60 wt. % of at least one co-solvent; about 20 wt. % to about 25 wt. % water; and optionally about 1 wt. % to about 15 wt. % of at least one hydrophobic solvent, and (3) no solid weighting agent, may be introduced to a wellbore in an effective amount to clean the wellbore or displace fluid in the wellbore at a wide range of temperatures.