Abstract: The present invention is directed to pro drugs of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: An auto lock system for a manual treadmill, the auto lock system having a locking mechanism comprising a movable arm having a distal end facing one of the front axle or the rear axle, a locking device at the distal end of the movable arm configured to engage the one of the front axle or the rear axle to inhibit rotation of respective front wheels or rear wheels, and an actuator configured to move the movable arm. A controller is in communication with a sensor configured to detect a user on the tread. The controller is configured to, in response to the sensor detecting no user on the manual treadmill, actuate the actuator to move the movable arm such that the locking device engages the one of the front axle or the rear axle.

Abstract: Methods, systems, and devices to enhance fracturing fluid delivery to subsurface formations to enhance hydrocarbon production from the subsurface formations may include providing a manifold coupling having a manifold coupling passage with a manifold coupling axis. The manifold coupling may include a first inlet passage positioned to provide fluid flow between a first fracturing fluid output and the manifold coupling passage, and a second inlet passage positioned opposite the first inlet passage to provide fluid flow between a second fracturing fluid output and the manifold coupling passage. The first inlet passage may have a first inlet passage cross-section at least partially defining a first inlet axis extending transverse relative to the manifold coupling axis. The second inlet passage may have a second inlet passage cross-section at least partially defining a second inlet axis extending transverse relative to the manifold coupling axis and not being co-linear with the first inlet axis.

Abstract: VoC data, e.g., plurality of VoC communications, for a plurality of customers can be collected. A clustering algorithm may be utilized to generate a plurality of cluster each of which is assigned a group of customers that share similar metadata. An emotion profile may be generated for each cluster based on segment detected emotions for the VoC data corresponding to the customers that are assigned to the cluster. The emotion profile for a cluster may represent the normal or expected emotions experienced during VoC communications by customers assigned to the cluster. New VoC data corresponding to a new customer may be received. A cluster may be identified based on the metadata of the new customer, and the emotion attributes of the new VoC data may be compared to the emotion profile of the identified cluster. Based on the comparison, one or more deviation can be identified to trigger an action.

Abstract: Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.

Abstract: Computer-implemented systems and methods for rendering a visual effect on a graphical element, including: generating an initial visual effect based on the graphical element; computing a mask shape based on the graphical element; generating a mask based on the mask shape from the graphical element; masking the initial visual effect based on the mask to generate a masked visual effect; and combining the masked visual effect with the graphical element into a combined graphical element and visual effect.

Abstract: An authentication system comprises a browser extension and a password manager application. The browser extension can be configured for execution on a first user device. The browser extension can be configured to display a response code and receive a login credential from a server. The response code can comprise a unique session identifier identifying the browser extension and a user browsing session. The password manager application can be configured for execution on a second user device. The second user device can have a scanner configured to scan the response code. The password manager application can be configured to extract the unique session identifier, parse the unique session identifier into session identifier content, send a portion of the session identifier content to the server, receive an approval from a user of the second user device, and send a notification to the server.

Abstract: A system and method for optical assessment of a heliostat includes obtaining a point cloud data representing an image of the heliostat; isolating the data; filtering and fitting the filtered heliostat data to a bounding box; translating the heliostat data to a plane to aid in segmentation; segmenting a plurality of facets of the heliostat fitting each of the segmented facets to a respective plane; generating normal vectors characterizing each of the plurality of facets; and calculating a canting angle associated with each respective facet of the plurality of facets. A heliostat with mirrored facets and a scanner are provided. The scanner captures point cloud data representing the heliostat, which is segmented for each facet. Normal vectors characterize the facets and a canting angle is calculated for the respective facet.

Abstract: A device and method for transporting items, and more specifically a crate liner for use in delivering temperature-controlled items such as perishable food. The crate liner being insulated to maintain a temperature-controlled environment within the liner. The crate liner being collapsible to minimize the space required for storing the crate liner when not in use.

Abstract: For treating a fracture in a pars interarticularis, methods and apparatus provide for: (i) coupling a spinous process plate to a lateral side of a spinous process of a spine of a patient, the spinous process plate extending substantially parallel to a sagittal plane through the spine, the spinous process plate including a first fixation element configured to attach the spinous process plate to the lateral side; (ii) coupling a laminar plate to a laminar on the lateral side, the laminar plate extending transversely from the spinous process plate and transversely to both the sagittal plane and a coronal plane through the spine, the laminar plate including a second fixation element configured to attach the laminar plate to the laminar on the lateral side; (iii) engaging a sub-laminar hook to the laminar on the lateral side, the sub-laminar hook extending transversely from the laminar plate and substantially parallel to a transverse plane through the spine, the sub-laminar hook configured to extend and hook benea

Abstract: Various implementations of the invention develop executable code for an embedded system, including a microcontroller and a device. Some implementations of the invention comprise a microcontroller development tool configured to operate on a general purpose computer.

Abstract: Example embodiments of systems and methods for data transmission between a contactless card, a client device, and one or more servers are provided. The memory of the contactless card may include one or more applets and a counter. The client device may be in data communication with the contactless card and one or more servers, and the one or more servers may include an expected counter value. The client device may be configured to read the counter from the contactless card and transmit it to the one or more servers. The one or more servers may compare the counter to the expected counter value for synchronization. The contactless card and the one or more servers may resynchronize the counter, via one or more processes, based on one or more reads of the one or more applets. The one or more servers may authenticate the contactless card based on the resynchronization.

Abstract: The present disclosure provides for improving data retention reliability. During a programming operation associated with a memory cell, after the memory cell passes verification of a first verification voltage level, a second verification voltage level can be applied to the memory cell. Based on a comparison of the voltage in the memory cell with the second verification voltage level, a bit line voltage may be applied. Based on the applied bit line voltage, fast bits associated with the memory cell can be upshifted to an upper portion of a final voltage distribution associated with the programming operation. Upshifting the fast bits counteracts the downshifting effect in a final voltage distribution that may be caused by charge leakage or electron loss.

Abstract: A system for fault detection and control in an electric aircraft including an inertial measurement unit, the inertial measurement unit including at least a sensor configured to detect a torque datum associated with at least a propulsor. The system includes an observer, the observer configured to generate a torque prediction datum associated with the at least a propulsor, compare the torque prediction datum with the torque datum, and generate a residual datum as a function of the comparison. The system includes a mixer, the mixer comprising circuitry configured to generate, as a function of the residual datum, a torque priority command datum and transmit, to the at least a propulsor, the torque priority command datum.

Abstract: A parking pawl assembly having a housing, a parking pawl having a pin bore, a support sleeve fitted in the pin bore, and a pivot pin inserted through the support sleeve. The pivot pin is attached to the housing, thus pivotally attaching the parking pawl to the housing. The parking pawl includes a first end and a second end spaced from the first end. The first end defines the pin bore having an interior bore surface. The support sleeve includes an exterior surface fitted to the interior bore surface of the parking pawl. The exterior surface of the support sleeve may include outer diameter rolled threads or other locking features. The interior bore surface of the parking pawl may include inner diameter rolled threads operable to receive the outer diameter rolled threads of the support sleeve.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for indicating location status. A computing device can receive a query from a user device, a current time, and a location for the user device. The computing device identifies results responsive to the query, including one or more business results that are each associated with a business location and operating hours. The computing device can select a subset of the business results as open results based on the operating hours of the business results, the current time, and travel times from the device location to the respective business locations. Data can be provided for a search engine results page that designates the subset of the business results as open results.

Abstract: The presently disclosed subject matter includes an apparatus that receives a dataset with values associated with different digital resources captured from a group of compute devices. The apparatus includes a feature extractor, to generate a set of feature vectors, each feature vector from the set of feature vectors associated with a set of data included in the received dataset. The apparatus uses the set of feature vectors to validate multiple machine learning models trained to determine whether a digital resource is associated with a cyberattack. The apparatus selects at least one active machine learning model and sets the remaining trained machine learning models to operate in an inactive mode. The active machine learning model generates a signal to alert a security administrator, blocks a digital resource from loading at a compute device, or executes other remedial action, upon a determination that the digital resource is associated with a cyberattack.

Abstract: A method of fabricating a refractive optical element on a substrate may provide less expensive and more compact optics for an X-ray system. The method includes coating the substrate with a resin and providing radiation to a portion of the resin to cause two photon polymerization of the resin. The method further includes forming, by two photon polymerization, a first surface of a polymer refractive optical element from the resin. The first surface is disposed along an optical axis of the refractive optical element and the first surface has a roughness of less than 100 nanometers. Further, the method includes forming, by two photon polymerization, a second surface of the polymer refractive optical element. The second surface is disposed along the optical axis of the refractive optical element and the second surface has a roughness of less than 100 nanometers.

Abstract: A corrugated protective textile sleeve has a flexible, tubular wall of woven warp yarns, extending lengthwise along a longitudinal axis between opposite ends of the wall, and weft yarns, extending generally transversely to the warp yarns. At least some of the weft yarns are activatable weft yarn to shrink in length and at least some the weft yarns, adjacent the activatable weft yarn, are substantially non-activatable weft yarn. The substantially non-activatable weft yarn form crests, having a first diameter, spaced axially from one another and the activatable weft yarns, upon being activated and shrunken, form valleys, having a second diameter less than the first diameter, with at least some of the valleys extending between the crests to form the wall having a corrugated contour.

Abstract: The present disclosure provides method and apparatus for generating a response in a human-machine conversation. A first sound input may be received in the conversation. A first audio attribute may be extracted from the first sound input, wherein the first audio attribute indicates a first condition of a user. A second sound input may be received in the conversation. A second audio attribute may be extracted from the second sound input, wherein the second audio attribute indicates a second condition of a user. A difference between the second audio attribute and the first audio attribute is determined, wherein the difference indicates a condition change of the user from the first condition to the second condition. A response to the second sound input is generated based at least on the condition change.