Abstract: Provided herein are recombinant antibodies, antigen-binding fragments, and fusion proteins thereof useful for binding to and inhibiting programmed death 1 (PD-1), nucleic acid molecules encoding the same and therapeutic compositions thereof, as well as methods of using such antibodies, including the methods for enhancing T cell and NK cell function to increase cell and cytokine mediated immunity and methods of treatment of various immune dysfunction related disorders including cancer and infectious diseases.

Abstract: Disclosed herein are system, method, and computer program product aspects for testing reuse across protolane families. For example, the method includes comparing a first protolane level flowchart to a second protolane level flowchart to determine a common graph corresponding to a portion of the first protolane level flowchart and a portion of the second protolane level flowchart. A first protolane corresponding to the first protolane level flowchart and a second protolane corresponding to the second protolane level flowchart within a protolane family are grouped based on the common graph, wherein a test directed to conditions of the common graph is applicable to the portion of the first protolane level flowchart and the portion of the second protolane level flowchart.

Abstract: Methods and systems are presented for generating real-time dynamic conversational responses during conversational interactions using machine learning models based on historic intents for a plurality of users and user-specific interactions. The machine learning models comprise a neural network trained to select a first intent from a plurality of intents based on historic data accumulated prior to the conversational interaction and a neural network trained to select a first interaction-specific intent from a plurality of interaction-specific intents based on interaction-specific data for a user.

Abstract: A rectocele device having a rectocele handle with a first static paddle removably affixed to a rectocele paddle connector at a paddle connector end. A second static paddle is configured to replace the first static paddle after the first static paddle is removed from the rectocele paddle connector. The first static paddle is configured and sized to fit within a human vagina wherein the first static paddle is only removable from the handle distal end when the first static paddle is not deployed in the human vagina. The first static paddle is shaped differently from the second static paddle. The first or second static paddle is inserted in a human vagina (by a woman using the rectocele device) wherein the first or second static paddle can be leveraged against a rectocele via the rectocele handle thereby pushing the rectocele bulge back into the colon so that the woman can evacuate a bowel more efficiently.

Abstract: Provided is a monolithically integrated red green blue (RGB) light emitting diode (LED) array manufactured with a reduced number of mesa etching steps and contact terminals. The LED array may have two or three p-n-junctions grown sequentially on a wafer. One of the p-n junctions has the opposite order of deposition of the n- and p-layers. A light-emitting active region is embedded between the n- and p-layers of each of the p-n junctions. Each active region emits light of different wavelength. The wafer is etched into multi-level mesas, creating two separate voltage terminals and a ground contact to control the bias between particular semiconductor layers. All of the p-n junctions share a common ground contact.

Abstract: A battery pack includes battery cells arranged a distance above a battery tray such that an exhaust passage is defined between the battery cells and the battery tray. Each respective one of the battery cells includes a casing defining a cell cavity therein and having an end surface disposed proximate the battery tray, an anode and a cathode disposed within the cell cavity, and a sacrificial vent cap. The sacrificial vent cap is constructed at least partially of a polymeric material and connected to the end surface of the casing. The sacrificial vent cap is configured to melt or fracture at a predetermined temperature or pressure, respectively, to thereby connect the cell cavity to the exhaust passage.

Abstract: A wireless device transmits, to a base station, a radio resource control (RRC) request message comprising an indication of priority access of the wireless device to a network slice. The wireless device receives, from the base station, based on the indication of priority access, an RRC response message indicating an acceptance associated with the RRC request message.

Abstract: A seat adapter removably mounts a child seat to a wagon having two opposing walls and an interposed connecting wall, and includes two latch components that mount to the wagon's opposing walls. In some embodiments, the seat adapter includes a cross-member extending between the latch components so that the cross-member provides structural integrity to the wagon if the connecting wall is displaced from its upright use position. In some embodiments, the seat adapter and the child seat can be mounted to the wagon for use with the connecting wall in its upright use position, and in some embodiments the seat adapter and the child seat can be mounted to the wagon for use whether the connecting wall is in its upright use position or its displaced position, with no mechanical interference between any part of the wagon and any part of the adapter or the child seat mounted to it.

Abstract: The invention provides methods and compositions for improved production of large quantities of unencapsidated double strand RNA (dsRNA) in vivo. The disclosed methods and compositions, comprising co-expression of genes encoding orotate phosporibosyl transferase, bacteriophage coat protein and dsRNA produce a significant improvement over current in vivo methods of producing unencapsidated dsRNA.

Abstract: Provided is an LED comprised of a first and a second p-n junction deposited sequentially on the same wafer. The first and second junctions have opposite orders of deposition of the n- and p-layers. One light-emitting active region is embedded between the n- and p-layers of the first junction and another light-emitting active region is embedded between the n- and p-layers of the second junction. Contacts are processed such that forward current can be passed in parallel through both of the junctions using a single voltage source. For a given forward current, the LED operates at lower voltage with higher optical flux and efficiency.

Abstract: Particular embodiments described herein provide for a system and method for supplementing a vehicle's sensor data, the system and method can include identifying a personal sensor on a user device, communicating a library of object recognition profiles for the personal sensor to the user device, capturing personal sensor data related to an environment, using the library of object recognition profiles for the personal sensor to use the captured personal sensor data to identify objects and/or features in the environment, and using the identified objects and/or features in the environment to supplement data collected by the autonomous vehicle's sensors.

Abstract: A wireless vehicle light washing system that is activated by a remote controller to enable washer fluid spray nozzles to spray/wash external lights of a semitrailer or other commercial vehicle from within a cab of the semitruck or other commercial vehicle. The wireless vehicle light washing system can be wirelessly activated to independently control the washer fluid spray nozzles fixed to the semitrailer or other commercial vehicle as desired.

Abstract: A charging heating device for charging and temperature maintenance of an energy storage device having a core with an electrolyte, with one input having characteristics of a frequency-dependent resistor and inductor series coupled to a voltage source, the device including: a coupling coupled to the one input; an exciter coupled to the coupling, the exciter provides a positive and negative input current at the one input, the exciter operates a heating mode where a current frequency is set at or close to a maximum heating rate to internally heat the electrolyte, and an ionic-excitation mode where the current frequency is set above the maximum heating rate to generate ionic-excitation of the electrolyte ions; an input coupled to a charger; a switch coupling the device input and the coupling; and a controller controlling the exciter and switching of the modes.

Abstract: Results of an authentication process are received. The authentication process allows for a graded level of authentication using a plurality of authentication types (e.g., a username/password and a fingerprint scan). Encrypted data is then accessed. The encrypted data has been encrypted using a plurality of encryption levels. The data is unencrypted based on the graded level of authentication. In a second embodiment, a system and method are provided that establish a communication session (e.g., a voice or email communication session). The communication session is between a plurality of users. During the communication session, an indication is received to change an encryption level for the communication session. In response to receiving the indication to change the encryption level for the communication session, an encryption level of the first communication session is dynamically changed from a first level of encryption to a second level of encryption.

Abstract: Systems and methods are provided for facilitating a cryptographic digital asset transaction via natural language commands using a conversation or chat interface associated with a digital wallet application. The digital wallet owner may exchange commands with an assistant user. The assistant user may comprise an automated software agent. The digital wallet owner may perform transactions with digital assets comprising fungible token (NFT) which are governed by a smart contract on a blockchain and are configured to represent first user's guaranteed mortgage preapproval. The NFT stores borrower information, property information, and seller information. The transaction may cause the smart contract associated with the NFT being updating on the blockchain in accordance with the borrowers' instructions.

Abstract: In some examples, systems and methods for formatting ink are provided. Ink stroke data may be received, letters may be identified from the ink stroke data, and spacing may be identified between the letters. A user command and semantic context may be received. An action may be determined based on the user command, the semantic context, and the spacing between the letters. Further, the action may be performed.

Abstract: A wax-extender emulsion including a plurality of wax-extender complex particles suspended in water is described. A wax-extender complex includes a wax component, an organic extender component and a surfactant that stabilizes the wax component and the organic extender component collectively to form the wax-extender complex. The wax-extender emulsion comprises from 2 wt % to 30 wt % organic extender. During manufacturing, the organic extender and wax component are emulsified and homogenized together to produce the wax-extender emulsion. The wax-extender emulsion can be co-applied as a mixture with adhesive resin during wood-based composite manufacturing.

Abstract: Systems and methods auto-reporting public music performances. The method includes generating an instance of a data structure for a music setlist that will be performed during a public performance. The method also includes adding, to the instance of the data structure, a performance date for the music setlist. The method further includes receiving, from a user, a master audio recording of a song to add to the music setlist. The method also includes adding, to the instance of the data structure, a master identifier indicating a first entity that owns the master audio recording. The method further includes adding, to the instance of the data structure, a publishing identifier indicating a second entity that owns publishing rights to the song. The method also includes automatically reporting the music setlist after a predetermined period of time following the performance date.

Abstract: Disclosed herein are system, method, and computer program product aspects for testing autonomous vehicle intent using protolanes. For example, the method includes selecting a first lane segment of a roadway within a geonet, wherein the geonet comprises a plurality of lane segments. It is determined that the first lane segment corresponds to a protolane of a set of protolanes, wherein the protolane is associated with one or more additional lane segments of the plurality of lane segments. The protolane is associated with the first lane segment based on the determination that the first lane segment corresponds to the protolane.

Abstract: A method including: transmitting, by a control device, a first portion of content comprising a first portion of a signal corresponding to a multimedia presentation characteristic of a peripheral device; receiving, when an adjustment of the signal is below an adjustment threshold, a first instance of an input indicating a request to change the multimedia presentation characteristic; in response to receiving the first instance of the input, adjusting a second portion of the signal and transmitting a second portion of the content comprising the adjusted second portion of the signal; receiving, when the adjustment of the signal is at or above the adjustment threshold, a second instance of the input; and transmitting, in response to receiving the second instance of the input, a communication signal to the peripheral device to adjust a peripheral device control of an output of the multimedia presentation characteristic.