Abstract: A control system is configured to facilitate transfer of a package between a room in a building and a delivery service outside the room associated with a shipment order. The system controls a shiftable panel of the building to selectively provide a path into and out of the room. The system includes a location sensor and a system processor. The location sensor is configured to sense package location data associated with the location of the package relative to the panel.
Type:
Grant
Filed:
July 31, 2020
Date of Patent:
May 23, 2023
Assignee:
DVW Holdings, LLC
Inventors:
Daniel A. Spurgeon, Vernon Hugh McGee, II
Abstract: In its many embodiments, the present invention provides certain substituted aryl and heteroaryl ether compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
Type:
Grant
Filed:
October 9, 2017
Date of Patent:
May 23, 2023
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Michael T. Rudd, Zhaoyang Meng, Jenny Wai, David Jonathan Bennett, Edward J. Brnardic, Nigel J. Liverton, Shawn J. Stachel, Yongxin Han, Paul Tempest, Jiuxiang Zhu, Xuewang Xu, Bin Zhu
Abstract: The disclosure relates to a chewable medicated composition comprising sennosides as the active ingredient and at least one excipient, wherein the bitter taste of sennosides is masked and the composition is substantially free of sugar.
Abstract: Disclosed herein are compositions and methods for treating cancer in a subject. In some embodiments, the methods involve generating an immune response in an individual by inducing the expression of neoantigens on the surface of abnormal (such as proliferative) cells. In one embodiment, a method of treating cancer in a subject includes administering amlexanox in combination with immune modulators, such as checkpoint inhibitors, immune co-stimulatory molecules, TLR agonists, and TNFR superfamily agonists. In one embodiment, the checkpoint inhibitors are selected from antibodies against PD-1, PD-L1, and CTLA-4.
Abstract: A deployable hanger assembly for a vehicle is provided. The hanger assembly includes a housing having a front side, a back side having one or more ribs, and an aperture extending in from the front side, and a deployable hanger that pivots relative to the housing between a flush retracted stored position within the aperture and an outward extending deployed use position. The deployable hanger assembly also includes a backer plate having one or more slots configured to receive the one or more ribs on the back side of the housing, wherein the backer plate is configured to engage a backside of a trim component of the vehicle and the housing is configured to engage a front side of the trim component, and wherein the one or more ribs extend through an opening in the trim component.
Abstract: A flow control assembly including a subassembly including an annular safety valve, a shroud, a bushing connecting the shroud to the subassembly at one of two opposing ends of the shroud, and another bushing connecting the shroud to the subassembly at the other of the two opposing ends of the shroud. The method for operating a hydrogen storage and production system including pumping hydrogen into the salt cavern for storage through a borehole and producing hydrogen from the salt cavern through the same borehole.
Type:
Grant
Filed:
September 23, 2021
Date of Patent:
May 23, 2023
Assignee:
BAKER HUGHES OILFIELD OPERATIONS LLC
Inventors:
Oscar Hilhorst, Beau Wright, Antonio Di Campli
Abstract: A razor blade having a substrate with a cutting edge being defined by a sharpened tip. The substrate has a thickness of greater than about 2.30 micrometers measured at a distance of four micrometers from the blade tip, a thickness of greater than about 4.26 micrometers measured at a distance of eight micrometers from the blade tip, and greater than about 7.93 micrometers measured at a distance of sixteen micrometers from the blade tip. A hard coating joined to the substrate has a thickness of 700 Angstroms to about 3500 Angstroms. An outer layer joined to a coated substrate is discontinuous. The outer layer may be produced from a dispersion comprising about 0.03 g/L or less of telomer or from about 0.5 % solids or less of telomer by weight of composition. The novel razor blade cuts at less than 100 % cutting efficiency using a single fiber cutting efficiency measure.
Type:
Grant
Filed:
August 8, 2017
Date of Patent:
May 23, 2023
Assignee:
The Gillette Company LLC
Inventors:
John Joseph Nisby, Matthew Robert Stone, Yongqing Ju, Ronald Richard Duff, Jr.
Abstract: A compound dowel for positioning a first component defining a first aperture relative to a second component defining a second aperture in a motor vehicle body structure in response to a determined misalignment between the first and second components includes a compensation pin. The compensation pin is selected in response to the determined misalignment and configured to be inserted into the second aperture. The compensation pin has a center axis and an indexing feature configured to orient and fix the compensation pin to the first component. The compound dowel also includes a nominal pin arranged parallel to the center axis and offset therefrom by a distance. The nominal pin is configured to be inserted through the first aperture, such that position of the first component is set relative to the second component. A method of positioning components in a vehicle body structure using a compound dowel is also considered.