Abstract: A prosthetic heart valve, comprising (a) a stent body including a generally tubular annulus region having a tubular wall and a proximal-to-distal axis, the stent body having a radially expanded condition when the stent body is implanted, (b) one or more prosthetic valve elements mounted to the stent body and operative to allow blood flow in a distal direction through the annulus region but to substantially block blood flow in a proximal direction through the annulus region, (c) a cuff coupled to the stent body, and (d) a water-absorbing polymer coupled to the cuff.

Abstract: A fishing lure system includes a link and link enclosure and a variety of attachments. The enclosure includes a channel dimensioned to snugly fit over the link and defined by walls of a rigid material such as to resist deformation of the link when the link is under stress (e.g., a pulling fish). The link may be attached to a spinnerbait frame that is constructed of a specially looped elongated component (e.g., wire) forming two legs at roughly 90 degrees to each other. The frame and loop are formed through a series of wire bends that support the 90 degree angle against deformation when the frame is under stress. The link may be attached to a swimbait body constructed with a cavity within which the lure’s hook is substantially concealed. The link or frame may be attached to a spinnerbait blade comprising an outer blade encapsulating and inner feature.

Abstract: The present invention provides constructs of the parainfluenza virus type-5 (PIV5) virus expressing the SARS-CoV-2 envelope spike (S) and nucleocapsid (N) proteins of SARS-CoV-2 variants for use as safe, stable, efficacious, and cost-effective vaccines against COVID-19.

Abstract: The present technology includes a system and method for monitoring a donor organ tissue using Raman spectroscopy. The technology enables real-time quantification of the mitochondrial redox state in the tissue sample taken from an organ intended for transplant using a compact device. The system is based on resonance Raman spectroscopy which can quantify a mitochondrial redox state in tissues using a Resonance Raman Reduced Mitochondrial Ratio. The mitochondrial redox state of the tissue sample acts as a marker of tissue function and may distinguish healthy versus damaged tissue. Moreover, these measures may correlate with transplantation outcomes.

Abstract: A data system is provided for analyzing and maintaining data obtained from one or more data sources on which the data system depends. The system includes a primary database including current values used by the system and a collection of executable algorithms used to generate the data maintained in the primary database. In response to receiving a notification regarding a change in one of the data sources, a dependency database is used to establish an execution order for algorithms of the algorithm collection that are directly or indirectly dependent on the changed data. The algorithms identified in the execution order are then executed in accordance with the execution order and the corresponding result is stored in the primary database. The system may include data harvesters adapted to recognize changes in the data sources and to generate and transmit corresponding change notifications when such changes occur.

Abstract: The present disclosure, in an embodiment, is a facility that includes a device configured to generate a beam having an energy range of 5 MeV to 500 MeV, a first radiation shielding wall surrounding the device, a second radiation shielding wall surrounding the first radiation shielding wall, radiation shielding fill material positioned between the first radiation shielding wall and the second radiation shielding wall forming a first barrier. In embodiments, the radiation shielding fill material includes at least fifty percent by weight of an element having an atomic number from 12 to 83, and a thickness of the first barrier is 0.5 meter to 6 meters.

Abstract: A computer-implemented method includes obtaining a multi-domain (MD) dataset and training a neural network model using the MD dataset with short-form data withheld (MD-SF). The neural network model includes a plurality of layer each having a plurality of parameters. The method also includes resetting each respective layer in the trained neural network one at a time. For each respective layer in the trained neural network model, and after resetting the respective layer, the method also includes determining a corresponding word error rate of the trained neural network model and identifying the respective layer as corresponding to an ambient layer when the corresponding word error rate satisfies a word error rate threshold. The method also includes transmitting an on-device neural network model to execute on one or more client devices for generating gradients based on the withheld domain (SF) of the MD dataset.

Abstract: This disclosure relates to the once weekly dosing regimen of a dual GLP-1R and GCGR agonist, formulations, and methods of using the same for treatment of chronic weight management, obesity and/or blood glucose control, including but not limited to dual agonist peptide product of SEQ ID NO. 1.

Abstract: An edge computing telecommunications network is provided for efficiently generating and updating computing models for use at distributed devices connected to different edge compute sites of the network. A network orchestration system may track devices connected to the network and the edge compute sites to which they are connected. The devices may comprise limited computing power and may include sensors or other data collection mechanisms. Raw data may be provided from connected devices to one or more edge compute sites. Edge compute sites may be instructed, e.g., by the network orchestration system, whether to replicate the raw data, modify the data to make it ready for consumption by a computing model, replicate the modified data, refine the computing model, replicate the refined computing model, and/or share some or all of the raw data, modified data, and/or refined computing model with other edge computing sites and/or connected devices.

Abstract: Described are light emitting diode (LED) devices comprising a plurality of mesas defining pixels, each of the mesas comprising semiconductor layers, an N-contact material in a space between each of the plurality of mesas, a dielectric material which insulates sidewalls of the P-type layer and the active region from the metal. A hard mask layer is above the semiconductor layers, the hard mask layer having a plurality of openings therein, each partially filled with a liner layer and partially filled with a P-metal material plug, the P-metal material plug having a width; and a passivation film is on the hard mask layer, the passivation film having a plurality of passivation film openings therein defining a width, the width of each passivation film opening being less than the width of a combination of the P-metal material plug and the liner layer.

Abstract: An exemplary embroidery accessory for a sewing machine includes a spool that is rotatable around a first vertical axis, a support rotatably attached to the sewing machine and to the spool, a sewing guide, and a mechanism for rotating the support around a second vertical axis of rotation. The spool receives and dispenses a length of embroidery material and is supported above a sewing bed of the sewing machine by the support. The sewing guide has a needle opening configured to receive a needle of the sewing machine and to guide the embroidery material toward the needle.

Abstract: This disclosure relates to apparatus and methods for molecular diagnostics. Certain embodiments include a piston cycled from a first position proximal to a first end of a housing, to a second position proximal to a second end of the housing, and back to the first position proximal to the first end of the housing. In some embodiments, the present disclosure relates to devices, methods, and systems for molecular diagnostics that do not comprise a piston.

Abstract: Embodiments include a hydraulic fracturing system for fracturing a subterranean formation. The system includes an electric pump, arranged on a first support structure, the electric pump coupled to a well associated with the subterranean formation and powered by at least one electric motor, and configured to pump fluid into a wellbore associated with the well at a high pressure so that the fluid passes from the wellbore into the subterranean formation and fractures the subterranean formation. The system also includes support equipment, arranged on a second support structure, electrically coupled to the electric pump, wherein the support equipment includes at least a transformer for distributing power to the electric pump, the power being received from at least one generator at a voltage higher than an operating voltage of the electric pump.

Abstract: A method that includes accelerating ions toward a lattice of carbon fibers and capturing the ions in the lattice of carbon fibers.

Abstract: An apparatus may control the power delivered from an AC power source to an electrical load, and may comprise a controllably conductive device. The apparatus may also comprise a controller that may be operatively coupled to a control input of the controllably conductive device. The apparatus may also include a first wireless communication circuit operable to communicate via a first protocol and to join a first wireless communication network operable to communicate via the first protocol. The first wireless communication circuit may be in communication with the controller. The controller may be operative to determine a first condition for communicating via the first protocol. The controller may also be operable to control the first wireless communication circuit to join the first wireless communication network upon the first condition being satisfied.

Abstract: In some embodiments, one or more user interfaces for facilitating personal payment transactions may be provided. In some embodiments, one or more first interfaces may be generated for a payer to effectuate a personal payment transaction. A location of a user device associated with the payer may be obtained. Based on the obtained location of the user device, one or more suggested payees for presentation on the first interfaces may be provided. An indication of a selected payee (from the suggested payees) may be obtained from the payer via the first interfaces. Options to fund a personal payment to the selected payee may be provided for presentation on the first interfaces. One or more options for routing the personal payment associated with the personal payment transaction may be provided to the payer via the first interfaces.

Abstract: Compositions comprising unseparated amnion/chorion derived from the placenta and methods of preparing and using those compositions are provided. Washing or preservation of placental tissue according to the methods of the disclosure may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, increased absorption potential, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the compositions of the invention to the wound.

Abstract: A computing apparatus includes a hardware platform comprising a processor and a memory; and instructions encoded within the memory to receive a user-generated comment related to a uniform resource locator (URL); analyze the comment with a trained machine learning (ML) model to determine a user sentiment for the comment; assign a predicted reputation to the URL according to the user sentiment; and use the predicted reputation as an input to an analysis of the URL.

Abstract: Electrical connectors for very high speed signals, including signals at frequencies at or above 112 GHz, with high density. Such connectors may be formed with fine features molded into portions of the connector housing to support closely spaced signal conductors. The signal conducts may nonetheless be accurately positioned, which leads to uniform impedance and other electrical characteristics that enable high frequency operation through the use of skeletal members that restrain bowing and twisting of housing components that position, directly or indirectly, the signal conductors. The skeletal members may be simply incorporated into the housing components by stamping a metal skeleton from a metal sheet in conjunction with one or more carrier strips. The housing component may be overmolded around the skeleton and then severed from the carrier strips.

Abstract: A method includes receiving an initial alignment for a candidate hypothesis generated by a transducer decoder model during a first pass. Here, the candidate hypothesis corresponds to a candidate transcription for an utterance and the initial alignment for the candidate hypothesis includes a sequence of output labels. Each output label corresponds to a blank symbol or a hypothesized sub-word unit. The method also include receiving a subsequent sequence of audio encodings characterizing the utterance. During an initial refinement step, the method also includes generating a new alignment for a rescored sequence of output labels using a non-autoregressive decoder. The non-autoregressive decoder is configured to receive the initial alignment for the candidate hypothesis and the subsequent sequence of audio encodings.