Abstract: The present disclosure provides conjugates which comprise an insulin molecule conjugated via a conjugate framework to one or more separate ligands that include a first saccharide, and wherein the conjugate framework also comprises a fatty chain (e.g., a C8-30 fatty chain). In certain embodiments, a conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic (PK) and/or pharmacodynamic (PD) property of the conjugate is sensitive to serum concentration of a second saccharide. In certain embodiments, a conjugate is also characterized by having a protracted PK profile. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.

Abstract: An apparatus and a method for controlling operation of a vehicle includes a controller having a processor and a tangible, non-transitory memory. The vehicle includes a park assembly with a park actuator motor having an actuator shaft. The vehicle has a park mode and an out-of-park mode. The controller is configured to determine if the park actuator motor has reached an out-of-park position when a shift command to the out-of-park mode is received. The controller is configured to obtain and store at least one dynamic parameter associated with the park actuator motor prior to the detent member reaching the out-of-park position. The method includes determining a load factor based on the dynamic parameter over time when at least one of a predefined time threshold and a predefined motor position threshold is reached. Operation of the vehicle is controlled based at least partially on the load factor.

Abstract: The disclosure relates to microphone and other sensor assemblies having a transduction element and an integrated circuit. The integrated circuit includes a switched-capacitor delta-sigma analog-to-digital converter (ADC) including a first integrator stage having a switched-capacitor circuit and a first plurality of parallel amplifiers. A logic circuit coupled to the integrator circuit is configured to selectably disable a subset of enabled amplifiers of the first integrator stage during a first phase of operation and to re-enable the subset of disabled amplifiers during a second phase.

Abstract: Method consists of placing a flexible container within a rigid frame and expanding the container by pneumatic or hydraulic pressure such that the walls of the container conform to the inside walls of the rigid frame thus forming a well-defined chamber. The system has the capability of reducing the volume of the chamber by adjusting the distance between the walls of the rigid container. The methods and systems so described are applicable to closed sterile systems that employ immunomagnetic isolation or purging of components from blood products. By providing a fixed volume and at least one surface upon which targeted entities can be magnetically deposited, target cells in the case of positive isolations can be magnetically held, flushed with wash buffers over them to remove entrapped cells and finally the recovery of product of very high purifies and at high yields.

Abstract: A method and system for determining if an individual is impaired. In one embodiment, physical and cognitive testing of the individual are conducted in the field or at the scene of an event. The test results are compared to previously stored baseline test results taken for the specific individual while the individual is known to be in an unimpaired state or condition. The current test results are electronically compared to the baseline test results and if the results differ or deviate beyond a predetermined level or amount the individual is considered to be impaired. If no baseline test results exist for the specific individual, the current test results can alternatively be compared to previously determined or known scientifically accepted or minimums for the specific tests given to the individual.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A plastic leaching chamber is provided and includes a chamber substrate constructed from a PET material and having opposing side base flanges which lie in a horizontal plane and extend lengthwise along the chamber substrate. The chamber substrate includes opposing sidewalls extending upwardly from each of the opposing side base flanges to a top of the chamber substrate and includes a lengthwise center plane which is perpendicular to the horizontal plane. The opposing sidewalls define a plurality of leaching openings having at least one tab slot opening located proximate thereto, and a plurality of louver articles constructed from at least one of a PE and a PP material. Each of the louver articles include a tab which is configured to engage a tab slot opening to securely associate the plurality of louver articles with the chamber substrate to cover the at least one leach opening.

Abstract: A bushing assembly includes a tube with an outer bearing surface, a metal part with an annular flange defining an opening and a plastic bushing with a bushing hub with an inner annular bushing contact surface and an axially extending metal part engagement surface. A friction torque setting connection is formed between the annular flange and the bushing hub and defines a rotational and axial connection between the annular flange and the bushing hub. The connection is configured to vary a radial force applied between the annular flange and the bushing hub with a deformation of bushing plastic material. This is to vary friction between the bushing contact surface and the tube outer bearing surface upon applying a torque to the plastic bushing, causing rotation and axial movement of the plastic bushing relative to the metal part, and causing the deformation of plastic material of the bushing hub.

Abstract: Data processing systems and methods, according to various embodiments, are adapted for performing a process of procuring a vendor and sub-processes associated therewith, such as performing vendor risk assessments and providing training specific to the procurement of that particular vendor. Training requirements for the user procuring the vendor and/or for the vendor itself are determined and any deficiencies in current, valid training requirements are identified. Training to address any identified deficiencies is provided as part of the vendor procurement process. Training may be customized based on trainee and/or organization attributes to improve the effectiveness of such training.

Abstract: A computing device that provides access to digital media items receives a command from an entity to share a digital media item that was uploaded by another entity. The computing device invokes an interface for trimming the digital media item in response to receiving the command. The computing device receives input for a trim operation to be performed on the digital media item. The computing device then provides a link or embed code for the digital media item for posting on a web site, wherein accessing the link or embed code causes the output of the trim operation to be presented to a user.

Abstract: Methods, systems, and media for presenting recommended content based on social cues are provided. In accordance with some embodiments, a method for presenting recommended content is provided comprising: receiving a query associated with a user; generating a list of relevant media content items based on the query; selecting items for presentation to the user based on social relevance scores based on social connections of the user that have consumed a relevant item and contextual relevance scores for each item; causing the selected items to be presented to the user; and indicating that a particular item was consumed by a particular social connection.

Abstract: A system and method are described for an online game service. One method includes receiving a request from a client device interacting with a game application. The request is received by a server of the online game service. Then, receiving a control signal from the client device in response to an input made when interacting with the game application. The control signal is transmitted over a communication channel between the client device and the server. Executing a game associated with the game application by the server to generate a video stream comprising a sequence of images. Compressing the sequence of images of the application in accordance with a compression process to generate a compressed sequence of images using a compression resource used by said server and at least one other server of said online game service.

Abstract: Automated uploading of user and system data from one or more source computing systems to one or more destination storage repositories is provided. A data uploader module is installed on each computing system or is accessible by each computing system from which user and/or system data may need to be exported to a destination repository. Upon command, a data uploader module reads desired user data or system data from the computing system. The read data is transformed, if required, and the data is then exported to a destination storage repository. The exported data may be stored and analyzed at the destination storage repository from which it may be subsequently exported to other destinations, including back to the source computing system from which it was originally extracted.

Abstract: A wireless device may receive system information comprising a parameter indicating a number of paging sub-groups. The wireless device may determine that the wireless device is associated with a first paging sub-group based on the number and a wireless device identifier. The wireless device may receive a DCI indicating first paging sub-group(s) for a paging occasion. The wireless device may monitor a control channel in the paging occasion in response to the first paging sub-group(s) comprising the first paging sub-group. The wireless device may receive paging information.

Abstract: A railroad switch circuit controller assembly includes a switch frame configured to be mounted to a stock rail, and a switch controller held by the switch frame. The switch controller includes at least one switching mechanism. The switch controller includes a point detection rod operatively connected to the at least one switching mechanism. The point detection rod extends a length from a proximate end portion to a distal end portion. The proximate end portion of the point detection rod is located closer to the stock rail as compared to the distal end portion when the switch frame is mounted to the stock rail. The railroad switch circuit controller assembly also includes a switch foot configured to be mounted to a switch rail, and an external rod operatively connected between the switch foot and the point detection rod of the switch controller such that the external rod is configured to translate linear movement of the switch foot toward and away from the stock rail to the point detection rod.

Abstract: A transfer belt assembly includes a plurality of transfer belts. The transfer belt assembly is structured to move any of an increased number of shells, a very increased number of shells, or an extremely increased number of shells through said conversion press.

Abstract: A kyphoplasty system includes various instruments which can be selectively used in a surgical theater (e.g., during a surgical operation on a patient) or a surgical training environment. The kyphoplasty system can include one or more of a kyphoplasty apparatus, a prone table mat, a connector system, a bone introducer needle, and a biopsy device. The kyphoplasty system may also include a training system for use in the training environment.

Abstract: An articulating composite surface covering mat and process of forming the mat which has multiple units having a regular, natural or irregular appearance, and each unit a flexible geogrid extending therethrough. A method of forming the mat includes forming the mat upside-down on a bottom surface of a bottom mold, placing the top mold over the bottom mold to form the mold assembly, locating a geogrid in the mold assembly, latching the mold assembly together with magnets, and adding the filler to the mold assembly.

Abstract: A system and method for identifying a person's location at a school, hotel, office, business, restaurant or other venue and tracking the movements of that person during their visit to the venue. One or more wireless virtual beacons communicate with the person's electronic device. The virtual beacons provide the system with real-time data about the person's whereabouts, allowing for the confirmation and tracking of the person at the location. A first non-limiting example of use, include a company that provides food and beverage allowing the person to place an order for food and beverages on their electronic device and having the order delivered to the person at their current location as determined by the system. Another non-limiting example includes a company performing analytics on the time and movement of it's employees and customers.