Abstract: The present disclosure relates to an oral eliglustat transmucosal delivery system. More specifically, the present disclosure is related to an oral transmucosal dosage form comprising a non-disintegrating solid mass comprising (a) a hydrophilic viscosity modifying agent selected from a natural or a synthetic gum with a molecular weight of 10,000 Daltons or greater, (b) a low molecular weight water soluble component with a molecular weight of less than 10,000 Daltons and (c) not more than 70 mg eliglustat, wherein the dosage form is 500 mg or less and provides an oral cavity residence time of at least about 5 minutes, and wherein the dosage form generates a microenvironment inside the oral cavity exhibiting a thixotropic behavior with viscosities of at least 50 poises at 1/sec shear rate and at least 10 poises at 10/sec share rate. The dosage forms of as described herein have at least 30% dose reduction as compared to commercially available eliglustat capsules.
Type:
Grant
Filed:
June 7, 2019
Date of Patent:
August 16, 2022
Assignee:
ABON PHARMACEUTICALS LLC
Inventors:
Salah U. Ahmed, Yanming Zu, Tahseen A. Chowdhury, Saad Muntazim, Mohammed Irfan Syed
Abstract: Disclosed are methods and systems for causing display of alternative content. The alternative content may be determined by a computing device. The computing device may cause output of the alternative content.
Abstract: A method of predicting behavior or a degradable device of a borehole tool when deployed downhole including introducing a test mass of material identical to the material of the degradable device to the same general location and at a time near to when the degradable device is deployed, removing the test mass from downhole, determining characteristics related to degradation of the test mass, and predicting degradation behavior of the degradable device based on the determined characteristics.
Type:
Grant
Filed:
May 1, 2020
Date of Patent:
August 16, 2022
Assignee:
BAKER HUGHES OILFIELD OPERATIONS LLC
Inventors:
Aaron Edward Young, Ricardo Arturo Barker Gomez
Abstract: A method of ultrasonic inspection includes generating, by a phased array ultrasonic probe, a first ultrasonic beam propagating in a fluid and incident at a first angle to a target surface in response to receipt of first instructions. Ultrasonic echoes from first beam reflection by the target are measured and corresponding ultrasonic measurement signals are output. At least one environmental sensor measures at least one fluid property and outputs corresponding environmental signals. One or more processors determine a current speed of sound within the fluid from the ultrasonic measurement signals and environmental signals. Second instructions including a second angle are generated by the processors, based on the current speed of sound, when the current speed of sound differs from a predetermined speed of sound by more than a speed threshold. The ultrasonic probe generates a second ultrasonic beam at the second angle in response to receipt of the second instructions.
Abstract: A locking system securing an image scanning device to a container includes a first and second compressible material. A first securing plate is disposed between the first and second compressible materials, while a second securing plate is adjacent to the second compressible material on a surface opposite a surface of the second compressible material that is adjacent to the first securing plate. A ball is disposed within curved edges of the first and second securing plates, where the curved edges each curve away from the second compressible material. A shaft extends from the ball to the image scanning device. A fastener is secured through the first and second securing plates, and into the securing surface to lock the ball, and subsequently the shaft and image scanning device, in place. The locking system can be secured to a pitched surface to naturally position the image scanning device perpendicular to level ground.
Type:
Grant
Filed:
January 21, 2022
Date of Patent:
August 16, 2022
Assignee:
AGI SURETRACK LLC
Inventors:
Luke Kelly, Corey Barkhurst, Cole Fincham
Abstract: A kit may include at least one frame lifting mechanism configured to be mounted within the support frame. The lifting mechanism may include a movable element configured to be movably mounted to the frame and an extendible member configured to extend between the movable element and a static member mounted on the frame. The movable element includes at least one support portion extending from a lower surface of the movable element when the movable element is mounted to the frame. The extendible member is configured to be movable between a compressed state and an extended state. The movable element is configured to be mounted to the frame such that on extension of the extendible member the movable element is pushed downwards and the at least one support portion moves below a base of the frame and provides a lifting force to the frame.
Type:
Grant
Filed:
March 20, 2020
Date of Patent:
August 16, 2022
Assignee:
Edwards Vacuum LLC
Inventors:
Ian Patrick Kirkland, Brian James McDowell, Gregory Ryan Le Mon, Jacob Henry Goeke
Abstract: A system or method may be used to perform image processing. An example method may include extracting a plurality of sub-images corresponding to a plurality of regions of an image. A rating classification may be generated, using a machine learning trained model, for each of the plurality of sub-images, for example including a no-rating classification for at least one sub-image of the plurality of sub-images. The method may include creating, using the rating classification for each of the plurality of sub-images, a color map overlay of a grayscale image corresponding to the image. The color map overlay may include colors corresponding to respective rating classifications for the plurality of regions or a region without a color corresponding to the at least one sub-image having the no-rating classification. The method may include outputting the color map overlaid on the grayscale image.
Abstract: A computer-implemented method is provided to authenticate a user. The computer-implemented method includes obtaining, at an authentication server, a current location and an associated time from a client device of the user over a communications network; determining, by a hardware processor, a location score based on a correlation between the current location and the associated time and a historical location and a historical time that are associated with the client device of the user; determining, by the hardware processor, a risk assessment score based on the location score; and providing, over the communications network, an authentication verification for the user to perform one or more actions with an online resource based on the risk assessment score.
Abstract: Analyzing or debugging applications is provided. The system identifies an action for an application provided by a developer. The system determines a first classification score based on historical execution of the action. The system generates a machine generated action for the application based on metadata associated with the application. The system determines a second classification score based on a comparison of the action with the machine generated action. The system selects, via a matching program, a second application that matches the application. The system determines a third classification score based on a comparison of an action approved for the second application with the action provided by the application developer. The system updates a delivery control parameter based on the first classification score, the second classification score and the third classification score. The system controls delivery of the application based on the delivery control parameter.
Abstract: Implementations relate to various techniques for resource efficient interactions with data corresponding to a physical parcel (already created or yet to be created) that is to be delivered to a recipient by a courier entity. Some of those implementations relate to techniques to enable access, by the recipient, of interior content data of the physical parcel. Some additional or alternative implementations relate to techniques to enable resource efficient storage and/or access to data related to a physical parcel, while enabling interaction(s) with the physical parcel by various disparate entities to be tracked and while maintaining appropriate access control to such data.
Type:
Grant
Filed:
December 30, 2021
Date of Patent:
August 16, 2022
Assignee:
POSTAL PARTNERS, LLC
Inventors:
Stacy B. Griggs, Richard M. Teachout, III, Christopher W. Porter, T. Calvin Wells, Jr.
Abstract: A backlight device includes a first surface and a second surface that is opposite to the first surface. The backlight device is configured to emit light in a first optical band through the second surface toward a display panel of a head-mounted display (HMD). The display panel is configured to convert the light from the backlight device to image light. The backlight device is transparent to light in a second optical band that is different than the first optical band. An eye tracking system illuminates an eyebox with light in the second optical band. A camera assembly positioned adjacent to the first surface of the backlight device. The camera assembly is configured to capture images of the eye in the second optical band through the backlight device, the display panel. The eye tracking system determines eye tracking information based at least in part on the captured images.
Type:
Grant
Filed:
April 1, 2021
Date of Patent:
August 16, 2022
Assignee:
Meta Platforms Technologies, LLC
Inventors:
Andrew John Ouderkirk, Jacques Gollier, Robin Sharma, Yusufu Njoni Bamaxam Sulai, Brian Wheelwright, Ying Geng, Alexander Sohn, Abbas Mehdi Kazmi
Abstract: Methods, systems, and apparatus, including computer programs stored on a computer-readable storage medium, for transliteration for speech recognition training and scoring. In some implementations, language examples are accessed, some of which include words in a first script and words in one or more other scripts. At least portions of some of the language examples are transliterated to the first script to generate a training data set. A language model is generated based on occurrences of the different sequences of words in the training data set in the first script. The language model is used to perform speech recognition for an utterance.
Type:
Grant
Filed:
December 12, 2019
Date of Patent:
August 16, 2022
Assignee:
Google LLC
Inventors:
Bhuvana Ramabhadran, Min Ma, Pedro J. Moreno Mengibar, Jesse Emond, Brian E. Roark
Abstract: A new and distinct cultivar of Rose plant named ‘ESM R432’, characterized by its upright and strong flowering stems; vigorous growth habit; dark green-colored leaves; dark pink-colored flowers; and excellent postproduction longevity.