Abstract: Solid dispersions of lurasidone or a pharmaceutically acceptable salt thereof are described, as well as pharmaceutical formulations thereof, and methods for making such formulations. Preferably, the solid dispersions are prepared by hot-melt extrusion or spray-drying, and comprise lurasidone with a pharmaceutically acceptable carrier (e.g., hydroxypropyl methyl cellulose acetate succinate (HPMC-AS), polyvinyl pyrrolidine vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), or mixtures thereof). The pharmaceutical composition may be orally administered to a patient in either the fed or fasted state, with a decrease or elimination of the food effect. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (e.g., Tmax, Cmax, AUC0-t and/or AUC0-infinity) of lurasidone, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.

Abstract: A method for managing collaborative playlists includes providing indication regarding one or more available collaborative guidance controls for a playlist created by a first user of a plurality of users of a content sharing platform, wherein the playlist comprises content items hosted by the content sharing platform. The method also includes receiving a user selection of the first user regarding one of the one or more collaborative guidance controls for the playlist, wherein the selected collaborative guidance control is to provide a theme for user suggestions for the playlist, and wherein a number of user suggestions from a particular user is limited based on a number of content items previously suggested by the particular user that have been added to the playlist.

Abstract: The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

Abstract: Systems and methods which facilitate automated querying of shipping services status information using a rules based engine are disclosed. A shipping status query engine of embodiments implements various rules for intelligently querying one or more shipping service provider systems for information regarding the status of shipped items. Using the intelligent determinations of a rules base shipping status query engine, embodiments enable large scale, automated status queries for a very large number of shipped items. Having such automated access to updated status information for the shipped items, additional functionality may also be supported, such as to provide alerts, reminders, notifications, etc., upon detecting certain events and/or failure to detect certain events. Moreover, embodiments may be adapted to utilize the updated status information to initiate actions with respect to particular shipments based upon detected events and/or failure to detect certain events.

Abstract: A system for sorting a mixture of sperm cells in a fluid flow path, including stained sperm cells from two distinguishable groups, namely X chromosome bearing sperm and Y chromosome bearing sperm. The system and method can include an electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the stained particles, a processor for classifying the stained particles; and a photo-damaging laser for damaging selected particles in the flow path.

Abstract: A bottom hole assembly is provided, having a housing having a housing lubricant channel; a motor having a rotor and a stator; a mandrel within the housing that rotates when drilling mud flows through the motor; a flex shaft within the housing that includes an internal fluid path for drilling mud to flow into the mandrel; a bushing between the housing and the mandrel having a spiral lubricant channel configured to pump lubricant while the mandrel rotates, such that lubricant in the housing lubricant channel returns to the spiral lubricant channel; first and second on-bottom thrust bearings; and a two stage rotor catch housing attached to the motor and having an internal shoulder, a rotor catch shaft, and a rotor catch nut attached to an upper end of the rotor catch shaft.

Abstract: A bypass plunger combines a unitary or one-piece hollow body-and-valve cage, retains a dart valve within the valve cage portion of the hollow body using a threaded retaining nut secured by crimple detents. A series of helical grooves surround the central portion of the outer surface of the hollow body of the plunger to control spin during descent. A canted-coil-spring disposed within the retaining nut functions as a clutch. The valve cage includes ports that may be configured to control flow through the plunger during ascent. Other embodiments include clutch assemblies using canted-coil springs with split bobbins, and valve stems surfaced to achieve specific functions. Combinations of these features provide enhanced performance, durability and reliability at reduced manufacturing cost, due primarily to the simplicity of its design.

Abstract: Methods and systems are provided for a pre-chamber. In one example, a pre-chamber comprises a plurality of slots fluidly coupling it to a primary combustion chamber. The plurality of slots comprising a plurality of corresponding flaps configured to direct gases through the plurality of slots.

Abstract: A computing device, including a processor configured to receive a first video including a plurality of frames. For each frame, the processor may determine that a target region of the frame includes a target object. The processor may determine a surrounding region within which the target region is located. The surrounding region may be smaller than the frame. The processor may identify one or more features located in the surrounding region. From the one or more features, the processor may generate one or more manipulated object identifiers. For each of a plurality of pairs of frames, the processor may determine a respective manipulated object movement between a first manipulated object identifier of the first frame and a second manipulated object identifier of the second frame. The processor may classify at least one action performed in the first video based on the plurality of manipulated object movements.

Abstract: In various examples there is an apparatus for detecting position and orientation of an object. The apparatus comprises a memory storing at least one frame of captured sensor data depicting the object. The apparatus also comprises a trained machine learning system configured to receive the frame of the sensor data and to compute a plurality of two dimensional positions in the frame. Each predicted two dimensional position is a position of sensor data in the frame depicting a keypoint, where a keypoint is a pre-specified 3D position relative to the object. At least one of the keypoints is a floating keypoint depicting a pre-specified position relative to the object, lying inside or outside the object's surface. The apparatus comprises a pose detector which computes the three dimensional position and orientation of the object using the predicted two dimensional positions and outputs the computed three dimensional position and orientation.

Abstract: A method for facilitating integration of patient electronic healthcare record information from a community aggregator with electronic healthcare record information native to an electronic healthcare record (EHR) application includes, for each of a plurality of accessed community data items, comparing the community data item to native data items, and based on the comparison, identifying the community data item as a duplicate, a potential duplicate, or not a duplicate, and for each community data item which was not identified as a duplicate, comparing the community data item to entries in one or more native clinical dictionaries, and, based on the comparison, identifying the community data item as an exact match to a clinical dictionary entry, a potential match to one or more clinical dictionary entries, or not matched to any clinical dictionary entry.

Abstract: Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.

Abstract: A variable pressure regulator defining a distance between a proximal end of a piston and a floor of a piston seat is disclosed. Adjustment mechanisms for adjusting this distance to alter output pressure are disclosed.

Abstract: A plant growth lighting system (500) includes a plant support (503) and a light guide luminaire module (501), the plant support being configured to hold one or more plants (502). The light guide luminaire module includes at least one light-emitting element (LEE) (510), a light guide (511) arranged to receive light emitted by the at least one LEE at a first end of the light guide and guide the received light in a forward direction to a second end thereof, and an extractor (512) arranged to receive light from the second end of the light guide and configured to output light. The light guide luminaire module is disposed relative to the plant support such that at least a portion of the light output by the extractor impinges on the plants in predetermined directions.

Abstract: Systems and methods to practice putting are provided. In one embodiment, the system includes a framework, actuators mounted to the framework, a control system, a computing device, and an artificial green. The control system is coupled to the actuators and controls actuation of the actuators. The computing device includes a display for viewing mapped green profiles and is configured to communicate with the control system. The artificial green includes a putting surface with a cup defined therein, wherein the artificial green is positioned over the actuators. With this arrangement, a user can select a putting region, after which, the computing device can translate and transfer the mapped data of the putting region to the controllers to actuate the actuators to, therefore, adjust the putting surface of the artificial green to correspond to the mapped green profile of an actual green.

Abstract: In an example, a method comprises determining, based on a set of metadata items to be stored, a first sequence and a second sequence, wherein the first sequence and the second sequence each include a plurality of key-value pairs, each key-value pair including a metadata item from the set of metadata items and a keyword corresponding to the metadata item in the set. The method also comprises causing a first co-routine to utilize available computing resources to process the first sequence. The method further comprises in response to an amount of computing resources available for the first co-routine to process the first sequence being below a first threshold, causing a second co-routine to process the second sequence, wherein the second co-routine is different from the first co-routine. This method can increase the utilization rate of the processor and more rapidly stores the metadata into the external storage device.

Abstract: Embodiments are associated with a speaker-independent acoustic model capable of classifying senones based on input speech frames and on first parameters of the speaker-independent acoustic model, a speaker-dependent acoustic model capable of classifying senones based on input speech frames and on second parameters of the speaker-dependent acoustic model, and a discriminator capable of receiving data from the speaker-dependent acoustic model and data from the speaker-independent acoustic model and outputting a prediction of whether received data was generated by the speaker-dependent acoustic model based on third parameters.

Abstract: A digital assistant supported on devices such as smartphones, tablets, personal computers, game consoles, etc. includes an extensibility client that exposes an interface and service that enables third party applications to be integrated with the digital assistant so the application user experiences are rendered using the native voice of the digital assistant. Specific voice inputs associated with a given application may be registered by developers using a manifest that is loaded when the application is launched on the device so that voice inputs from the device user can be mapped by the digital assistant extensibility client to the appropriate application as input events for consumption. In typical implementations, the manifest is arranged as a declarative document that streamlines application development and provides a seamless user experience by enabling customization of third party applications to integrate the digital assistant's voice and behaviors within the user experience of the application's domain.

Abstract: Implementations described herein provide for a bone implant having a cylindrical member and an articulating member. The cylindrical member extends along an implant axis from a first end to an opposed second end thereof. The cylindrical member has a void disposed therein extending from the first end towards the second end. The cylindrical member has an interconnected open-pore structure for promoting bone tissue in-growth. The articulating member has an articulating portion and a core portion extending away from the articulating portion. The articulating member is coupled to the cylindrical member such that the core portion extends into the void disposed in the cylindrical member and the articulating portion is positioned adjacent the first surface of the cylindrical member and extends radially outward from the implant axis to cover the first surface of the cylindrical member.

Abstract: A thermal management system for an on-vehicle battery includes a battery, a first thermal element, a second thermal element, a battery mounting bracket, and a vehicle body structural element. The battery mounting bracket includes a first portion attached to the vehicle body structural element, and a second portion attached to the first thermal element. The first thermal element is attached to the first end portion of the battery, and the second thermal element is attached to at least one of the second end portion, the first and second side portions, the top portion or the bottom portion of the battery. The first thermal element is composed from a first phase-change material having a first phase-change temperature and the second thermal element is composed from a second phase-change material having a second phase-change temperature, wherein the first phase-change temperature is greater than the second phase-change temperature.