Abstract: The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. Regions of the genome are differentially methylated or mutated in different cell types, including cancerous cell types. The TSP50 gene is thereby identified and found to be differentially expressed in breast cancer cells. The present invention provides methods and compositions for identifying aberrant expression of the TSP50 gene and of tsp50 protein. Antibodies of the present invention can be used for diagnosis and treatment of diseases characterized by aberrant tsp50 expression.

Abstract: A mechanism for determining whether the sun is visible at a diurnal solar event and for mechanically triggering actions based upon the sun being visible during the diurnal solar event is disclosed. The mechanisms of the invention can perform these operations without intervention or supervision for long periods of time. Certain embodiments have been applied to provide a diurnal solar event trigger based upon sidereal noon for a clock providing accurate timing for 10,000 years without intervention or supervision.

Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.

Abstract: The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction.

Abstract: A nanocrystal cerium zirconium composite oxide and its preparation and application are disclosed. The nanocrystal cerium zirconium composite oxide of the present invention comprises 4-98% by weight of CeO2 and 1-95% by weight of ZrO2, the crystalline particle size thereof is 100 nm or less, and the ignition loss thereof after igniting at 900° C. for one hour is smaller than 5%.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including, septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

Abstract: Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Abstract: The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

Abstract: A heat dissipater structure has a heat sink base with peripheral sides thereof folded upwards from the bottom plate and cut into a plurality of lateral plates at proper angles to form wind channels for current conduction and to define a receiving slot at the center for holding a fan. A convex block is disposed on two opposite lateral plates for easily hooking and assembling a cover body so as to allow the air current inducted by the fan to rapidly dissipate the heat absorbed by the bottom plate outwardly through the wind channels formed by the interference of the lateral plates.

Abstract: A structure for assembling a heat sink assembly uses at least an interlocking device to assemble at lease a heat sink fin. The improvement in the interlocking devices comprises a female slot, a protruding hook, and an opening hole. Said protruding hook of each first heat sink fin wedges into said female slot of an adjacent first heat sink fin by the shape of said protruding hook corresponding to said female slot, and said protruding hook of each first heat sink fin having a barb portion for hooking into said opening hole of said adjacent first heat sink fin for interlocking completely in the vertical direction. Besides, the protruding hook further includes a protruding portion, said protruding portion having a T-shaped cross-section configuration is correspondingly equal to said female slot for interlocking completely in the horizontal direction. Therefore, the heat sink assembly provided by the present invention may be interlocked in both horizontal and vertical direction.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

Abstract: A combination paging and gaming system and apparatus enabling a user to utilize a pager to play an electronic game while waiting for a page. May be used as an on-premises paging system in a restaurant. A centralized control station includes a page transmitter and a plurality of buttons which may be pressed individually to send a page to one of an associated plurality of game pagers. The control station also includes a game transmitter and a text generator. A game input device inputs game questions and game answers to the control station. The game questions are sent to the text generator and to a television screen or scrolling display for display to all users. The game answers ate transmitted by the game transmitter to the game pagers. Alternatively, game questions may also be transmitted to the game pagers for display on an LED display. Each user enters an answer on a keypad on the game pager, and the pager then indicates whether the entered answer was right or wrong.

Abstract: An aquarium thermostat comprises a ventilation box and a transforming mechanism disposed in the ventilation box such that the transforming mechanism is regulated by a microcomputer control mechanism to effect the generation of heating or cooling energy by which the aquarium water flowing into the aquarium thermostat is heated or cooled to a present level. The heated or cooled water is then sent back to the interior of the aquarium via a pipe.

Abstract: The invention provides device for affixing a lens of a safety helmet. A helmet housing has a base located on each of both sides. The base has a C-like protruding ring. The protruding ring has an upward opening gap, wherein an inner side surface has a C-like groove. A protruding body is located under the protruding ring, wherein a bottom of the protruding body has a concave clicking opening. A side front portion of the protruding ring has clicking protruding body having a top with a slant surface. A windshield lens of safety helmet has a base plate at each of both sides, which base plate can be affixed onto the base of the helmet housing. An inner side of the base has two L-like clicking protruding bodies, which can be inserted to the C-like groove. A clicking gear is formed on the base plate at a bottom rim corresponding to the protruding body of the base.

Abstract: Switchable mosquito expelling/killing device including a box body having a clip body for hanging the box body on a user's body. The box body is disposed with a pushing block, an electric mosquito incense mat insertion hole, gas releasing slots, DC socket and a switch. An oscillating circuit and a heater fixing seat, an electric heater and a cell for supplying power are disposed in the box body. The box body can be co-used with a transformer socket to be used indoors. By means of switching the switch outside the box body, the mosquito expelling/killing device can be switched between a mosquito expeller using the oscillating circuit to-generate a sound wave simulating the sound wave of male mosquitoes for expelling fertilized female mosquitoes and an electric mosquito incense device using the electric heater to heat electric mosquito incense mat for releasing mosquito-killing incense to kill the mosquitoes.

Abstract: A system and method of selectively paging an individual through one of a plurality of paging mechanisms. An indication of a paging mechanism for each individual to be paged is stored in a memory device. When an input is received from a user to page the individual, a control processor retrieves the indication of a paging mechanism for the individual to be paged and determines which of the plurality of paging mechanisms is to be utilized to page the individual. The individual may be selectively paged through an on-premises paging system, a wide area paging system, or a cellular telephone.

Abstract: Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Abstract: A heat exchanger includes an extruded base member having a planar central portion and spaced-apart cooling fins extending from one side of the planar central portion. A cross-over member is located on the other side of the planar central portion and includes a plurality of spaced-apart flow channels that communicate with inlet and outlet manifolds formed in the base member or the cross-over member, or partially in both the base member and the cross-over member.

Abstract: A plate and fin type heat exchanger is disclosed which can be made in any convenient size with minimum tooling required. The heat exchanger is made from a plurality of stacked plate pairs having raised peripheral edge portions to define flow channels inside the plate pairs. The plates of the plate pairs are formed with offset, diverging end flanges that space the plate pairs apart. A U-shaped channel envelops the plate end flanges to form part of a manifold at each end of the plate pairs. End caps or plates close the open ends of the U-shaped channels to complete the manifolds, and inlet and outlet openings are formed in the manifolds as desired to complete the heat exchanger.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.