Abstract: The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation.

Abstract: This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.

Abstract: A heat exchanger having a plurality of stacked plate pairs consisting of face-to-face mating plates with each plate having a peripheral flange and annular inner and outer primary bosses. Each boss has a portion thereof located in a common first plane with the peripheral flange. An annular secondary boss has a portion thereof located in a second plane spaced from the first plane. Intermediate areas between the inner and outer primary bosses have spaced-apart portions to form inner flow passages. Both the primary and secondary bosses have openings formed therein for the passage of heat exchanging fluids. In back-to-back plate pairs, the secondary bosses are joined and the openings therein communicate to define a manifold for a second of these fluids. The inner and outer primary bosses include radially extending ribs formed about the circumference of each boss and extending substantially across the boss.

Abstract: A method of charting a race course comprises the steps of applying an adhesive fastener (116-118) on the strip (110) for adhesively interconnecting the first (112) and second (114) ends and disposing a column of marker indicia (120) extending along the strip (110) between the ends thereof with each marker indicia (120) signifying a mile marker along a course. The method includes the steps of forming the station indicia (122) to portray the availability of first aid, a toilet, and/or a prominent landmark along the course. A topographical outline (129) is formed to extend along the strip (110) parallel to the column of marker indicia (120) for indicating variances in elevation above sea level along the course. The back of the strip is formed with a legend and advertising indicia.

Abstract: Compositions for female sexual arousal stimulating vaginal lubrication, vaginal and clitorial engorgement; said compositions contain aphrodisiacs, spermicidal and fungicidal components, may be applied intravaginally, extravaginally, and transdermally, and as a condom lubricant; and said compositions are contained in a water miscible cream base.

Abstract: A rotary-plug wall lamp, which comprises a socket body having a seat hole to be mounted with a ring-shaped copper piece and a contact copper piece riveted in place; the outer ends of the two contact copper pieces are in contact with the power copper pins of the rotary disk respectively; the inner edge thereof is in contact with the contact points of the circuit board; the rotary disk and the socket body are connected electrically through a shaft contact point therein and a ring-shaped contact point so as to supply power for the wall lamp, which can be turned freely within an angle of 270 degrees.

Abstract: A retaining clamp for cooling fins comprises a L-shaped retaining lever, a resilient component, and a detachable lever. The L-shaped retaining lever is an elongated lever provides a fixing component at the bottom thereof. An end of the L-shaped retaining lever extends a vertical bent part with a locking hook, and the other end thereof is a narrow hanging part. The resilient component is disposed beneath the L-shaped retaining lever and fixed by the fixing component. The detachable lever has an end thereof extend a handle, and has the other end thereof provide a hook. A hanging groove is on the detachable lever between two ends thereof for being passed through by the hanging part on the L-shaped retaining lever. No flexibility is necessary for the L-shaped retaining lever so that no heat treatment is required and it does not result in deformation. The resilient component can have a changeable height to accommodate cooling fins indifferent sizes.

Abstract: There is disclosed a class of pharmaceutical compositions useful for the treatment of cancer, particularly solid tumors, and having a mechanism of action as spermine antagonists. The present pharmaceutical compositions are able to inhibit the inhibitory effect of spermine upon macrophage function, and thus prevent spermine-induced immunosuppression.

Abstract: A flexible storage rack including a pair of base bars, multiple frames, a pair of stand braces, several adjustable stretchers and supporting boards to make it more sturdy. The large area base bars also make the rack more stable. The flexible storage rack has different assembly methods for different applications; multiple variations offer more flexibility.

Abstract: A movable rack for storing and organizing in-line skates. The rack comprises a frame to support at least one platform containing elongated slots. The frame includes four horizontal support members to support the platform extending between four vertical members. The elongated slots contained within the platform have a suitable width to allow only a wheeled portion of the in-line skate therethrough, thus supporting the in-line skate in a substantially upright position.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

Abstract: A rotary-plug wall lamp, which comprises a socket body having a seat hole to be mounted with a ring-shaped copper piece and a contact copper piece riveted in place; the outer ends of the two contact copper pieces are in contact with the power copper pins of the rotary disk respectively; the inner edge thereof is in contact with the contact points of the circuit board; the rotary disk and the socket body are connected electrically through a shaft contact point therein and a ring-shaped contact point so as to supply power for the wall lamp, which can be turned freely within an angle of 270 degrees.

Abstract: A fishing lure is disclosed having a body with two sections that move relative to one another. An aft section is connected via a shaft to a fore section and is slidable toward and away from the aft section along the shaft as the lure is pulled through the water. A contact post mounted on a rear end of the fore section or a fore end of the rear section impacts the other section as the lure is pulled through the water producing a clicking or popping sound which attracts fish.

Abstract: The invention relates to the molecular cloning and expression of a gibberellin (GA) 20-oxidase gene and its use, for example in transgenic plants. Aspects of the invention include recombinant DNA which encodes a polypeptide exhibiting GA 20-oxidase activity, a recombinant polypeptide exhibiting GA 20-oxidase activity, and transgenic plants which express a GA 20-oxidase gene or reverse GA 20-oxidase sequences.

Abstract: The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. The methods of the present invention are particularly useful for detecting and isolating genomic DNA fragments which are near coding and regulatory regions of genes and which are differentially mutated or methylated relative to the corresponding DNA from normal cells. Genes are frequently not methylated in the cells where they are expressed but are methylated in cell types where they are not expressed. Moreover, tumor cell DNA is frequently methylated to a different extent and in different regions than is the DNA of normal cells. The present invention is used for identifying which regions of the genome are methylated or mutated in different cell types, including cancerous cell types.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

Abstract: A heat exchanger and method of transferring heat between fluids is disclosed using a plurality of stacked plate pairs consisting of face-to-face, mating, ringlike plates, each plate having an outer peripheral flange, an annular inner boss located in a common plane with the peripheral flange, and an offset intermediate area located between the peripheral flange and the inner boss. The peripheral flanges and inner bosses in the mating plates are joined together. The intermediate areas have outwardly disposed joined intermediate bosses having aligned inlet and outlet openings forming manifolds for the flow of a first heat exchange fluid circumferentially through the plate pairs from the inlet manifold to the outlet manifold. The heat exchanger also has a header enclosing either the inner bosses or the outer peripheral flanges to cause all of a second heat exchange fluid to pass between the plate pairs transversely relative to the flow of the first heat exchange fluid.

Abstract: This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.

Abstract: There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.