Patents Assigned to LTS Lohmann
  • Transdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis
    Patent number: 6264978
    Abstract: The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: July 24, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KG
    Inventors: Frank Becher, Thomas Kissel
  • Transdermal resorption of active substances from supercooled masses of levulic acid
    Patent number: 6264980
    Abstract: A pharmaceutical product for the release of medicinal agents to the skin having absorption-increasing auxiliary agents is characterized in that the auxiliary material forms subcooled melts.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: July 24, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventor: Thomas Hille
  • Transdermal therapeutic system, its use and production process
    Patent number: 6264977
    Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: July 24, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KG
    Inventor: Annegrete Hoffmann
  • Laminated tablet with pointed core
    Patent number: 6264985
    Abstract: A dry-coated tablet for controlled release of active substance, having an erodible core tablet (1) containing at least one active substance, and a substantially erosion-resistant shell consisting of a dry-coated layer (5), is characterized in that the dry-coated layer (5) has at least one opening (6), and one end of the core tablet (1) extends as far as the opening (6).
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: July 24, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventor: Karsten Cremer
  • Method for producing a therapeutic system in the form of plaster
    Patent number: 6254558
    Abstract: Process for the production, transport and storage of a therapeutic system which is in the form of a plaster and has an active layer supersaturated with active ingredient and containing the active ingredient in homogeneous dispersion or in solution, characterized in that it is carried out avoiding process parameters which favour or induce crystallization of active ingredient, and any type of pressure operating on the plaster and, in particular, on the active layer is avoided while it is carried out.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: July 3, 2001
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Reinhold Meconi, Tina Rademacher, Klaus Schumann, Frank Seibertz
  • Contour of a transdermal therapeutic system
    Patent number: 6238362
    Abstract: A transdermal therapeutic system (TTS) for the delivery of active compounds to or through the skin, having a layer adhering comparatively permanently to the skin, whose outer edges are defined by a contour, is characterized in that at least two sections which are concave relative to the surface are contained in the contour.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: May 29, 2001
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Stefan Bracht
  • Oral preparation containing at least one active pharmaceutical substance in a matrix capable of swelling in an aqueous medium
    Patent number: 6238698
    Abstract: An oral preparation, comprising at least one pharmaceutical active compound in a matrix which is swellable in aqueous medium, which is released from the matrix into the aqueous medium in a delayed manner on swelling thereof, while the matrix is largely resistant to disintegration during the release process, it is characterized in that it is a layered tablet with layers adhering to one another, of which at least one layer is the swellable matrix layer and at least another layer is an auxiliary and/or excipient layer, and in that the swellable matrix layer contains an amount of crosslinked amylose.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: May 29, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventor: Karsten Cremer
  • Transdermal compositions with enhanced skin penetration properties
    Patent number: 6238284
    Abstract: The invention relates to a transdermal therapeutic system for application to the skin and/or mucosa consisting of at least one active substance in the form of a solid dispersion in combination with at least one destructuring agent and/or at least one structuring agent in a common matrix.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: May 29, 2001
    Assignees: Jenapharm GmbH & Co. KG, LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Dittgen, Sabine Fricke, Christoph Völkel, Kathrin Ahrens, Hagen Gerecke, Kai Köpke
  • Sealing bag for a transdermal therapeutic system
    Patent number: 6224900
    Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: May 1, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KG
    Inventor: Annegrette Hoffmann
  • Surface-stabilized pharmaceutical preparation for application on the skin
    Patent number: 6207183
    Abstract: An active substance-containing transdermal pharmaceutical preparation with a given size of contact surface, comprising a tack-free backing layer which is permeable to active substances and an adhesive layer adhering to the skin is characterized by the fact that the backing layer comprises at least a third of the total active substance amount contained in the preparation.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: March 27, 2001
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Wolfgang Laux
  • Reservoir for controlled active substance delivery, and apparatus containing the same
    Patent number: 6207181
    Abstract: The invention relates to reservoirs with a delivery surface for the controlled delivery of active substances decreasing over the time of use to solid, liquid or gaseous acceptors and whereby at least at one point of the reservoir a cross-sectional surface of the reservoir is parallel to the delivery surface and smaller in area than the delivery surface. The invention also relates to an apparatus for the controlled delivery of active substances decreasing over the time of use, which has at least one reservoir. At least one active substance to be delivered is active in the technical, human and veterinary medical, cosmetic and pest control sectors.
    Type: Grant
    Filed: August 31, 1995
    Date of Patent: March 27, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KG
    Inventor: Fritz Herrmann
  • Process for the isolation of galanthamine
    Patent number: 6194404
    Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: February 27, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Thomas Hille, Hans-Rainer Hoffmann, Mirko Kreh, Rudolf Matusch
  • Hydrophilic pressure sensitive hot-melt adhesives
    Patent number: 6190689
    Abstract: A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: February 20, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Hans-Rainer Hoffmann, Michael Roreger
  • Process and a device for the production of a flat administration form comprising a preparation which contains pharmaceutical active substances
    Patent number: 6187322
    Abstract: The present invention relates to a process and a device for the production of a flat administration form comprising a preparation that contains pharmaceutical active substances. The flowable preparation is conveyed to an applicator unit (12) by means of a metering pump, and flows through a distribution chamber (2) having a distribution plate (3) provided with passages (4). This application device (12) transfers the preparation onto a layer of the flat administration form (6,11) which is therefor contacted with the distribution plate (3) for a short time.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: February 13, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Thomas Hille, Ludwig Grader, Klaus Schumann
  • Water soluble film for oral administration with instant wettability
    Patent number: 6177096
    Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: January 23, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino
  • Transdermal therapeutic system with small application-area thickness and great flexibility, and production process
    Patent number: 6165499
    Abstract: A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2), a film layer (3) comprising the active substance, and a protective layer (4) provided with a nonstick finish, the separating layer (2) consisting of a material whose bond to the film layer (3) may be abolished. By means of printing methods, such systems having small application thickness and high flexibility can be manufactured, it being possible to provide a substrate that has been rendered adhesive as an alternative to the substrate/separating layer-complex. A printing method limiting the active substance-containing region to the application site reduces disposal problems.
    Type: Grant
    Filed: April 26, 1999
    Date of Patent: December 26, 2000
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Reinhard v. Kleinsorgen, Britta v. Kleinsorgen
  • Morphine and diamorphine salts of anionic non-narcotic analgesics of the substituted carboxylic acid type
    Patent number: 6156764
    Abstract: The present invention relates to morphine and diamorphine salts of anionic non-narcotic analgesics belonging to the type of substituted carboxylic acids, preferably the morphine and diamorphine salts of diclofenac (Formula 1); to processes for their production, the use of these salts in the treatment of diseases, as well as to pharmaceutical preparations comprising these salts.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: December 5, 2000
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Bodo Asmussen, Walter Muller, Walter Riess
  • Method for the low-waste manufacture of diskoid moulded bodies containing active ingredients, and transdermal therapeutic systems containing same
    Patent number: 6156336
    Abstract: Active ingredient-containing layered articles or discs which are suitable, in particular, as active ingredient reservoirs for transdermal therapeutic systems are obtained starting from an elongate article having an enveloping surface corresponding to the contour of the layered articles to be produced, and having a cross-sectional constitution corresponding to the internal structure of the layered articles, by layered detachment perpendicular to the axial direction of the elongate article. In the simplest case, this article consists of a uniform active ingredient-containing composition and forms a solid cylinder which is converted into single products perpendicular to the axis with identical spacing to result in circular one-compartment discs identical to one another.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: December 5, 2000
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventor: Stefan Bracht
  • Volume-expandable, sheet-like application form suitable as an active substance carrier, in particular for oral application
    Patent number: 6153222
    Abstract: A volume-expandable, sheet-like application form suitable as an active substance carrier, in particular for oral application, in the form of a film comprising a mixture of fillers, cleansers, cosmetics, or active substances, film formers, and softeners has portions of a highly absorbent hydrogel former which swells on contact with water and assumes several times its original volume.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: November 28, 2000
    Assignee: LTS Lohmann Therapie - Systeme GmbH
    Inventor: Frank Becher
  • Method for the application of an active substance patch for controlling or alleviating an addiction
    Patent number: 6143320
    Abstract: A method for the application of an active substance patch for controlling or alleviating an addiction such as drug addiction, addiction to pills or analgesia is characterized in that two or more active substance patches are applied simultaneously, sequentially or alternately within a given therapy plan under surveillance of the blood level of the active substance in a way that allows the achievement of an active substance blood level which is high enough for a successful suppression of the addiction and remains constantly effective throughout a useful period of administration.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: November 7, 2000
    Assignee: LTS Lohmann Therapie - Systeme GmbH
    Inventors: Frank Becher, Werner Wessling