Abstract: A transdermal therapeutic system (TTS), in particular a patch, is described, comprising: a detectable protective layer a pressure-sensitive adhesive reservoir layer and a backing layer with or without a coating of pressure-sensitive adhesive and featuring a unintentionally, preferably longitudinally, elastic material having an elasticity of at least 20%. The TTS is particularly suitable for use as a multi-day plaster, for the treatment, for instance, of pain or of drug dependency.

Abstract: A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate is characterized in that the drying takes place in a first drying stage at between 30 and 50° C., in a second drying stage at between 35 and 80° C., and in third drying stage at between 25 and 50° C.

Abstract: The invention relates to a process for producing hot-seal packs, in particular for transdermal therapeutic systems, by welding to one another, at predetermined linear regions and at polymer layers facing towards one another, two laps of continuous pack material composed of two or more layers. To this end, one (or two) sealing tool(s) are used to bring the pack material into contact with pressure and heat. To improve the quality of the welded seams without altering the cycle rate, according to the invention the sealing time is doubled and the temperature of the sealing tool(s) (1, 2) is reduced so that there is a considerable reduction in the temperature reached within the pack material (3, 4), this temperature then being only slightly above the melting point of the polymer used. An example of a sealing tool (1, 2) is given (FIG. 1).

Abstract: The invention relates to a device for delaying the pylorus passage of orally administered medicament forms. Said device comprises a component which expands upon contact with the gastric juice and a polymer coat which is permeable to liquids but not to gases. The device can contain an active substance whose release into the gastric juice is mainly controlled by the medicament form into which it is incorporated. Unlike conventional medicament forms with delayed pylorus passage, the release of the active substance does not so much depend on the kind and structure of the polymer coat but is mainly determined by the incorporated medicament form. The inventive device can be easily rolled or folded and can be filled into capsules.

Abstract: The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally −5° C., thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents.

Abstract: The invention relates to a device and a method for increasing the transdermal permeation of medications. The invention is characterized in that a constituent which effects a local increase in temperature and/or an increase in blood flow or the skin is administered in a addition to the transdermally applied active substance.

Abstract: The invention relates to a composite laminate, especially a transdermal therapeutic system (TTS) that contains in at least one layer a component that is sensitive to moisture. Said system further comprises one layer that is spatially separate from said at least one moisture-sensitive layer and that is capable of absorbing moisture. The spatial separation can be achieved by means of a horizontal or vertical separation layer.

Abstract: A dermal or transdermal therapeutic system comprising a sheet-like substrate or reservoir containing readily volatile auxiliary agents or active agents, which substrate or reservoir is covered on one of its sides with a backing layer impermeable to the ingredients and on the opposite side with a detachable, likewise impermeable protective layer to prevent loss of ingredients during prolonged storage, is characterized in that both the backing layer and the protective layer are made of plastic film which is on both sides with vapour-deposited metal

Abstract: The invention relates to a device for the transfer of segregated flat-shaped products to a transport device transporting the products further, comprising a transfer device for the ordered feeding of the products to a transport device. It achieves the object of configuring the said device such that the products which have been transferred in an ordered arrangement are taken over in an ordered manner and transported further in an ordered manner. To this end, the said transport device (2) is coupled with a vacuum device (vacuum container 4) by which, in cooperation with the transport device (2), the products are taken over in an ordered manner and are fixed to said transport device (2) (FIG. 1).

Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

Abstract: In a process for the production of polysiloxane pressure-sensitive adhesive layers with reduced cold flow by means of coating and drying a one-component polysiloxane pressure-sensitive adhesive solution onto a suitable flat-shaped carrier, a complex of a metal ion of the group consisting of calcium, magnesium, zinc, aluminum, titanium, zirconium or hafnium with a low-molecular organic complex former is added to the organic adhesive solution to be coated, whereby the metal ion is only released from the bond to the complex former under the conditions of heating and/or drying of the adhesive solution.

Abstract: A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Abstract: This invention provides for, inter alia, a transdermal therapeutic system comprising at least one therapeutically active substance, which is oxidizable by hydroperoxides, wherein the amount of oxidative degradation of said active substances(s) and the corresponding formation of oxidative degradation products is reduced, which comprises one or more constituents of said transdermal therapeutic system being in contact with said active substance(s), wherein the sum of the peroxide number(s) (PON) of each of said constituents related to their percentage of the whole amount of said constituents as expressed by the formula ∑ i = 1 n ⁢   ⁢ ( N i · PON / 100 ) where N is the percentage content of the whole amount of said constituents in the TTS, n is the number of said constituents i

Abstract: A blister cardboard pack for sensitive goods to be packaged comprising readily volatile and/or moisture-sensitive components, in a configuration preventing the entrance of moisture and/or the escape of volatile components, comprising a blister card (1), which in a manner known per se is configured either as one piece or, e.g. as a folding card (1, 1′), in two pieces, as a carrier for a blister cap (2) of transparent material containing the goods to be packaged, which blister card (1) and blister cap (2) are connected to each other by at least one sealing lacquer film (3, 3′), characterized in that between the blister card (1) and the blister cap (2) there is arranged a barrier layer (4) which is impermeable to water vapour and/or volatile components and which is connected in a media-tight manner, on the one hand, to the blister card (1) and, on the other hand, to the blister cap (2) by means of at least one sealing lacquer pressure-sensitive adhesive film (3, 3′).

Abstract: A transdermal therapeutic system embodied as a matrix or reservoir system is characterized by a content of at least one basic- or neutral-reacting pharmaceutical active agent a content of a pressure-sensitive adhesive polymer which possesses as part of its chain acrylic acid or methacrylic acid units, the content of the carboxyl groups, relative to the mean polymer mass, being 0.5 to 10.0% (w/w) and the carboxyl groups being present stoichiometrically at 5 to 100 %, preferably 10 to 50%, in form of alkali salts or alkaline earth salts. Water-binding additives may also be present, for reducing the sensitivity to moisture.

Abstract: Individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w) of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.

Abstract: A topical patch having non-steroid antirheumatic agent as active substance, consisting of a backing layer inert to the active substance, a self-adhesive, active substance-containing matrix layer based on a polyacrylate adhesive, and a protective film to be removed prior to use, is characterized in that a. the non-steroid antirheumatic agent has a free carboxyl group, b. the active substance-containing matrix of the patch consists of a polyacrylate adhesive cross-linked with multivalent metal ions and having free carboxyl groups, and is free of hydroxyl groups, c. the matrix contains a fatty acid as plasticizer and permeation enhancer, and d. the backing layer consists of a material that is elastic in at least one direction.

Abstract: A device for transferring segregated flat-shaped products includes a transfer device and a transport device by which the products transferred from the transfer device are further transported along a transport path. The transport device includes a moveable transport surface having suction openings communicative with a vacuum container. The transfer device includes a roll arranged transverse to the transport path and having suction orifices arranged about a circumference thereof. The roll has internal channels having openings in opposed axial end faces of said roll which are communicative with the suction orifices. Vacuum chamber members are disposed axially at the opposed end faces of the roll which is rotatable relative to the vacuum chamber members. Each of the vacuum chamber members has a concentric grove and a ventilation channel which correspond to the openings of the internal channels.

Abstract: A device and a process for drying thin layers or films which are manufactured by applying a coating mass, which is produced on an aqueous basis, to a support, the said layer or film being transported through a drying device having at least one drying zone, is characterized in that in at least one drying zone, designated as moisture-compensation zone, air is supplied which has a moisture content corresponding to the constant moisture content of the film to be prepared or the layer to be prepared.

Abstract: A primary packaging unit for film-like or wafer-like administration forms for oral application with an off-cut of an upper web of packaging material and of an lower web of packaging material is characterized in that a plurality of dosage units of a film-like or wafer-like administration form, individually sealed in flat compartments formed without cold or hot forming of the packaging material and spaced at a distance to one another, are present in a primary packaging unit, and there are perforations between the compartments which enable the separation of individual compartments, if necessary.