Abstract: The present invention provides perorally administrable drug release systems and processes for producing perorally administrable systems having a drug-containing core and a sheath which surrounds the core and comprises a swellable shell and an elastic coating which surrounds at least the shell, the sheath having at least one orifice.

Abstract: A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm.

Abstract: Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided.

Abstract: Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.

Abstract: A film-shaped therapeutic system comprising at least two layers connected with each other, for transmucosal administration of active substances. The system has a layer which is mucoadhesive in an aqueous environment and a mono-layered or multi-layered backing layer. At least one of these layers contains an active substance. The mucoadhesive layer is capable of swelling in an aqueous media, but is insoluble or only poorly soluble in an aqueous media.

Abstract: In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, and at least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

Abstract: Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided.

Abstract: An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

Abstract: The end face of a cylinder-piston unit has a press-in area, engaging around the mouth, and a press-on area, surrounding the press-in area. The press-in area comprises an inner web, delimiting the mouth, and an outer web. The webs delimit a recess, which surrounds the inner web and of which the depth measured parallel to the center axis of the cylinder-piston unit is at least a quarter of its width in a plane oriented normal thereto. The press-on area, at least during an injection, is offset counter to the injection direction relative to the end face of the press-in area. Moreover, the surface of the press-on area projected into a plane normal to the center axis is at least as large as the surface of the press-in area projected into the same plane.

Abstract: The invention relates to a single-use injector (4) and a dual-chamber system (99), wherein at least one first chamber (105) is part of a cylinder-piston unit (100) that can be received in the single-use injector, and wherein the second chamber (255) is part of a container (250) that can be at least temporarily closed by means of a stopper (257) and that is inserted in a container adapter (200) releaseably supported on the single-use injector. To this end, the plug comprises a plug hole. The container adapter comprises a transfer tube that is closed at first. When the container is inserted in the container adapter, the transfer tube (242) connects the interior of the cylinder-piston unit to the interior of the container.

Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.

Abstract: A method for preparing a solution from a solvent and an active substance in and on a disposable injector with a housing, with an at least intermittently fillable cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of the cylinder/piston unit, wherein the container adapter supports a container which can be filled at least temporarily with active substance and which is closable by an openable stopper.

Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.

Abstract: The invention relates to a web-form packaging material which comprises at least one layer, comprising a packaging material surface, of a sealable material, to a packaging unit with a transdermal therapeutic system and with a packaging material of this kind, and also to a process for producing a packaging unit. For this purpose, at least the abovementioned surface of the packaging material has a multiplicity of recesses and/or a multiplicity of non-recessed regions. The distance between two adjacent recesses and/or the distance between two adjacent non-recessed regions is less than five times the packaging material thickness. Moreover, the depth of the recesses is not less than 1.2 nanometers and not more than 95% of the packaging material thickness. With the present invention, the sticking of an adhesive on the inner face of the packaging material is effectively prevented.

Abstract: Strip-shaped forms of administration for administering an active ingredient via the mucous membrane of the gums.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least one cylinder/piston unit (100), at least one piston-actuating ram, and at least one trigger unit. For this purpose, the housing has at least one inverted draw hook, which has at least one support surface respectively in the region of its free end. The spring-loaded piston-actuating plunger rests on the support surface, whereby the contact zone placed between the draw hook and the piston-actuating plunger represents a variable-speed gear pair thrusting the draw hook radially outwards. The locking position of the draw hook is secured by an actuating element positioned in a locked position. The actuating element has a triggering position which effects radially outwards aligned retreat of the draw hook when the piston-actuating plunger is released.

Abstract: A dispenser for a volatile substance, which contains a reservoir and two control elements. The first control element exerts a control function that is dependent on the substance characteristics of the volatile substance and the material characteristics of the constituents of said first control element. However, the second control element exerts a control function that is independent of the substance characteristics of the volatile substance and the material characteristics of the constituents of said first control element. The first control element is located between the reservoir and the second control element and is permeable to at least one volatile substance. The second control element consists of a material that is impermeable to the volatile substance and contains defined material cavities. Perfumes, crop protection agents, pheromones and repellents, which can be released in a controlled manner, constitute the volatile substances.

Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.

Abstract: A disposable injector with a cylinder/piston unit that can be filled at least temporarily with active substance, with a housing in which a pretensioned and releasable mechanical spring energy reservoir is arranged, and with at least one piston-actuating ram positioned between the spring energy reservoir and the piston of the cylinder/piston unit. The piston-actuating ram has two draw hooks that engage around the housing in some areas. In addition, the piston-actuating ram is separable from the housing by means of the relaxing spring energy reservoir.