Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

Abstract: Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are limited. Here, Applicants developed Nuc-seq, Div-Seq, and Dronc-Seq. Div-seq combines Nuc-Seq, a scalable single nucleus RNA-Seq method, with EdU-mediated labeling of proliferating cells. Nuc-Seq can sensitively identify closely related cell types within the adult hippocampus. Div-Seq can track transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead. Finally, Applicants found rare adult newborn GABAergic neurons in the spinal cord, a non-canonical neurogenic region.

Abstract: The present invention relates to a bicycle lock for blocking of a wheel of a bicycle in a locked state. The bicycle includes a tube assembly including a frame with mutually fixed tube elements and movable tube elements, such as a front stay. The bicycle includes a housing, a bolt for providing a blocking action in a blocking state with which the wheel is blockable, a channel for arranging therein of the bolt, and a latch for, in a latching state of the lock, keeping the latest in the blocking state. The latch in the blocking state is in cooperation with receiving means defining a state of cooperation in which the bolt and the receiving means block the wheel of the bicycle.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: The invention relates to anti-VLA-4 antibodies and binding fragments thereof. The invention further includes polynucleotides encoding said antibodies and binding fragments thereof and methods of manufacturing said antibodies and binding fragments thereof. The invention further includes methods of treating patients suffering from multiple sclerosis and/or epilepsy by administration of said antibodies and binding fragments thereof. The invention further includes methods of reducing the susceptibility to scrambling of a recombinant anti-alpha 4 antibody or a binding fragment thereof.

Abstract: An aluminum alloy foil having a composition including, Fe of 1.0% by mass or more and 1.8% by mass or less, Si of 0.01% by mass or more and 0.08% by mass or less, Cu of 0.005% by mass or more and 0.05% by mass or less, Mn of 0.01% by mass or less, and Al. In a crystal orientation analysis per unit area by electron backscatter diffraction (EBSD), a ratio (HAGBs/LAGBs) of a length of high angle grain boundaries (HAGBs) having an orientation difference of 15° or more to a length of low angle grain boundaries (LAGBs) having an orientation difference of 2° or more and less than 15° is more than 2.0, and a Cu orientation density is 40 or less and an R orientation density is 30 or less as a texture.

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

Abstract: A multi-stage process for the production of an ISO 8217 Table 2 residual marine fuel Product Heavy Marine Fuel Oil from a Feedstock Heavy Marine Fuel Oil that is ISO 8217:2017 Table 2 compliant except for the Environmental Contaminants involves a Reaction System composed of one or more reactor vessels selected from a group reactor wherein said one or more reactor vessels contains one or more reaction sections configured to promote the transformation of the Feedstock Heavy Marine Fuel Oil to the Product Heavy Marine Fuel Oil. The Product Heavy Marine Fuel Oil has an Environmental Contaminant level less than 0.5 wt % and preferably a maximum sulfur content (ISO 14596 or ISO 8754) between the range of 0.05 mass % to 0.5 mass %. A process plant for conducting the process for conducting the process is also disclosed.

Abstract: An apparatus for loading and unloading slices of bacon includes a loading portion including: a motor-driven conveying arrangement arranged to convey the slices of fresh bacon; a first motor-driven conveyor arranged to convey the seasoning hooks; a second motor-driven conveyor arranged to receive the seasoning hooks loaded with the slices of fresh bacon, and to move away the seasoning hooks from the loading zone; and a manipulator device configured to load onto the seasoning hooks the slices of fresh bacon. The apparatus further includes: an unloading portion including a motor-driven conveying arrangement, arranged to convey the seasoning hooks, loaded with the slices of seasoned bacon; and a manipulator device cooperating with the conveying arrangement to unload/extract one hook after another of the seasoning hooks from the slices of seasoned bacon.

Abstract: The present invention relates to improved methods in the separation recombinant polypeptides with post-translational modifications from complex mixtures through the use of a cation exchange medium.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. Also provided are kits for detecting the amount of SMN protein in a sample of cerebrospinal fluid.

Abstract: An aluminum alloy foil having a composition, including Fe: 1.2% by mass or more and 1.8% by mass or less, Si: 0.05% by mass or more and 0.15% by mass or less, Cu: 0.005% by mass or more and 0.10% by mass or less, and Mn: 0.01% by mass or less, with a remainder being Al and inevitable impurities. An average crystal grain size of the aluminum alloy foil is 20 to 30 ?m, a maximum crystal grain size/the average crystal grain size is ?3.0, a Cube orientation density is 5 or more, a Cu orientation density is 20 or less, and an R orientation density is 15 or less.

Abstract: Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R1, R2, R3, R4 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

Abstract: The present invention relates to a bicycle with light system. The bicycle includes a tube assembly including a frame with mutually fixed tube elements with a tube wall and movable tube elements, such as a steering pin and a handlebar, a light generation subsystem including at least one independently controllable light source for generation of light, a light control for controlling the light generation subsystem for providing at least one light effect, and a light guiding subsystem for guiding light over a part of the path between the at least one light source and the surroundings of the bicycle. The at least one light source is arranged in at least one of the at least one tube element. The bicycle includes the at least one opening in at least one tube element for passing the light through the tube wall. The light guiding subsystem provides a guiding from the inside of the respective at least one tube element to the outside of the at least one tube element of the frame.

Abstract: In some instances, the application provides methods of culturing host cells comprising a gene encoding a recombinant N protein in a cell culture medium, wherein the cell culture medium comprises: (i) iron at a concentration of less than 1200 ?M; and (ii) citrate at a concentration of less than 2400 ?M. In some instances, the methods comprise culturing host cells expressing a recombinant protein in a cell culture medium at a first temperature; and decreasing the first temperature to a second temperature. In some instances, the methods comprise purifying the recombinant protein by a carbon depth filtration.

Abstract: Methods, apparatus, and systems for multi-resolution processing for video classification. A plurality of video frames of a video are obtained and a resolution for classifying each video frame of the plurality of video frames is determined by analyzing each video frame using a policy network. Based on the determined resolution, each video frame having a determined resolution is rescaled and each rescaled video frame is routed to a classifier of a backbone network that corresponds to the determined resolution. Each rescaled video frame is classified using the corresponding classifier of the backbone network to obtain a plurality of classifications and the classifications are averaged to determine an action classification of the video.

Abstract: This invention relates to alpha-4 binding antibodies, and fragments thereof.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.