Abstract: A medical process comprising: identifying one or more symptoms, determining at least one measurement descriptive of the one or more symptoms, creating a model of the at least one measurement, obtaining the at least one measurement descriptive of the one or more symptoms from at least one symptomless subject, using the model to transform the at least one measurement from the at least one symptomless subject into a reference data, obtaining the at least one measurement descriptive of the one or more symptoms from at least one subject with the one or more symptoms, using the model to transform the at least one measurement from the at least one subject with the one or more symptoms into a patient data, and comparing the reference data to the patient data.

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

Abstract: The disclosure relates to portable staircases having a staircase assembly including an outer staircase and an inner staircase that can move in a telescoping relationship with respect to the outer staircase. Portable staircases of the disclosure are particularly useful for accessing an oil drilling rig as they are independently supported with respect to the drilling rig, thus providing numerous safety improvements and advantages. Methods of using the portable staircases of the disclosure are also disclosed.

Abstract: An aluminum alloy foil having a composition contains Si: 0.5 mass % or less, Fe: 0.2 mass % or more and 2.0 mass % or less, Mg: more than 1.5 mass % and 5.0 mass % or less, and Al balance containing inevitable impurities. In the aluminum alloy foil, Mn is desirably 0.1 mass % or less in the inevitable impurities, and preferably, the tensile strength is 180 MPa or more, the elongation is 15% or more, and the average crystal grain diameter is 25 ?m or less.

Abstract: This invention relates to alpha-4 binding antibodies, and fragments thereof.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: An aluminum alloy foil having a composition contains Si: 0.5 mass % or less, Fe: 0.2 mass % or more and 2.0 mass % or less, Mg: 0.1 mass % or more and 1.5 mass % or less, and Al balance containing inevitable impurities, and if desired, Mn is regulated to 0.1 mass % or less in the inevitable impurities, and preferably, the tensile strength is 110 MPa or more 180 MPa or less, the elongation is 10% or more, and the average crystal grain diameter is 25 ?m or less.

Abstract: An inner spiral grooved tube includes: a tube body; and grooves and fins aligned in an inner circumferential direction of the tube body, wherein the grooves and the fins are formed in a spiral along a longitudinal direction, an outer diameter is 3 mm or more and 10 mm or less, a number of the fins is 30 to 60, made of a metal, a cross sectional shape of each of the fins has a rectangular shape having an apex angle of 0±10°, a ratio h/f is 0.90 or more and 3.40 or less, h being a fin height and f being fin width, a ratio c/f is 0.50 or more and 3.80 or less, c being a fin spacing, and an average of the ratio h/f and the ratio c/f is 0.8 or more and 3.3 or less.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject.

Abstract: In a mixed composition coating material for brazing, when a total mass of a solid material, an organic solvent, and water is defined as 100 mass %, the solid material are contained in an amount of 30 mass % or greater and 80 mass % or less with respect to the whole coating material, the organic solvent and the water is contained in a total amount of 20 mass % or greater and 70 mass % or less with respect to the whole coating material, and the water is contained in an amount of 0.4 mass % or greater and 2.5 mass % or less with respect to the whole coating material.

Abstract: A pump cartridge for mounting on a drive rotor includes a roller assembly having first and second hubs maintained in a spaced apart relationship and defining an axis, and a plurality of planetary rollers arranged in a circumferentially spaced orientation about the axis, the rollers mounted to the hubs displacement radially outward. One or more compressible tubing lines are interposed between the rollers and an interior wall of the pump cartridge housing. The housing and the first and second hubs collectively define a passageway through which a spreader on the drive rotor extends and may be rotated relative to the roller assembly to displace the rollers radially outward to thereby compress the tubing lines against the interior wall. A coupling feature on the first hub engages a roller driving feature of the rotor, so that rotation of the rotor causes rotation of the roller assembly about the axis.

Abstract: A hairdryer includes a casing having a main body having a main through cavity containing an electric motor and a fan to generate an air flow with a settled speed; an inner diffuser inside the main through cavity at the front outlet opening of main body and includes a through cavity having a passage section decreasing towards the front outlet opening to increase the speed of the air flow; the main body includes at least one side opening at the front outlet opening to enable air from outside entering into the main through cavity to increase an air output flow rate from the front outlet opening; an outer outlet element is reversibly coupled to the front outlet opening and includes an outflow tubular portion and a coupling tubular portion inserted into the front outlet opening to close the side opening and prevent the air from entering the main through cavity.

Abstract: Methods of the disclosure may include obtaining a first set of medical images at a first time point and a second set of medical images at a second time point, each set including at least two medical images. First and second algorithms may be used to calculate, respectively, first and third brain volume (BV) values at the first time point based on two or more images from the first set of medical images and second and fourth BV values at the second time point based on two or more images from the second set of medical images. A mathematical weight may be applied to at least one of the first, second, third, or fourth BV values. The first and third BV values may be averaged, and the second and fourth BV values may be averaged to determine overall BV values at the first and second time points, respectively.

Abstract: Methods of activating GDF11 proteins in vitro as well as formulations of mature GDF11 polypeptides with enhanced solubility at neutral pH are provided.

Abstract: Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.

Abstract: A sandwich wrap including a flexible, edible sheet that is adapted to enfold an edible filling whereby the resulting enclosing tube has both ends open and an auxiliary support situated under the lowermost open end when the wrap is held vertically for consumption, thus restraining filling from exiting. A method using an assembly frame positions the auxiliary support. Filling is stocked in a capped filling storage tube including at least two components that can be disassembled from inside the edible enclosing tube to give the edible enclosed filling. The food product may include a set of separately enclosed different fillings and each edible enclosing tube may be shaped around the filling storage tube to give a cross-sectional form of a circle sector so that the set forms a right circular cylinder. A seepage container assists assembly in advance of an order to avoid impairment by moisture seeping out of fillings.

Abstract: Featured are biomarkers for, e.g., diagnosis and prognosis of spinal muscular atrophy (SMA) as well as identification of responders to treatment of SMA. Also provided are methods of treating subjects with SMA.

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.

Abstract: The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of sing thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.