Patents Assigned to Massachusetts Institute of Technology
  • Substrate-immobilized optical nanosensors
    Patent number: 12105024
    Abstract: A sensor for detecting an analyte can include a photoluminescent nanostructure embedded in a sensor porous planar substrate. The sensor porous planar substrate can be supported by a substrate porous planar substrate.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: October 1, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Strano, Xun Gong, Daniel Salem
  • Cell atlas of the healthy and ulcerative colitis human colon
    Patent number: 12105089
    Abstract: The present invention provides for a human cell atlas of the colon from healthy and diseased subjects. The atlas was obtained by single sequencing of about 117,000 cells. The present invention discloses novel markers for cell types. Moreover, genes associated with disease are identified in the colon and colon specific cell types. The invention provides for diagnostic assays based on gene markers and cell composition, as well as target cell types that express genes associated with disease. Finally, disclosed are novel cell types and methods of quantitating, detecting and isolating the cell types.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 1, 2024
    Assignees: The Broad Institute, Inc., Massachusetts Institution of Technology, The General Hospital Corporation
    Inventors: Alexander K. Shalek, Christopher Smillie, Rebecca H. Herbst, Moshe Biton, Aviv Regev, Jose Ordovas-Montanes, Ramnik Xavier
  • LIPID NANOPARTICLES FOR DRUG DELIVERY TO MICROGLIA IN THE BRAIN
    Publication number: 20240316216
    Abstract: Provided herein are methods of selectively delivering an agent to a cell, comprising contacting the cell with a composition comprising an agent and lipids selected from: (a) an ionizable amino lipid, (b) a sterol, (c) a phospholipid, and (d) a PEG-lipid. The methods are selective for delivery to microglia over other neuroglia, such as astrocytes.
    Type: Application
    Filed: October 6, 2022
    Publication date: September 26, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, Li-Huei Tsai, Owen Shea Fenton, Joel Blanchard, Jason Andresen, Julia Bonner, William Ralvenius
  • PIEZOELECTRIC RESONATORS FOR POWER CONVERSION
    Publication number: 20240322789
    Abstract: Described are structures and techniques for providing high-efficiency. high-power-density piezoelectric resonators (PRs) for use in power converters. In some embodiments. a power converter can include a PR for energy transfer. where the PR substantially satisfies geometry conditions disclosed herein for achieving high-efficiency and high-power-density. The geometry conditions can be defined in terms of the converter's specified (e.g., rated) voltage and power level.
    Type: Application
    Filed: May 6, 2022
    Publication date: September 26, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: David J. Perreault, Jessica Boles, Jeffrey H. Lang, Joseph Bonavia
  • Drug delivery device
    Patent number: 12097021
    Abstract: A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: September 24, 2024
    Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.
    Inventors: Graham Arrick, Torben Sebastian Last, Declan Gwynne, Jacob Wainer, Carlo Giovanni Traverso, Drago Sticker, Cody Cleveland, Aghiad Ghazal, Adam Bohr, Jorrit Jeroen Water, Brian Mouridsen, Jacob Pyung Hwa Jepsen, Bozhidar Nikolaev Kozhuharov, Kim Frandsen, Robert Langer, Yi Lu, Niclas Roxhed, Siheng You
  • Modified alginates for anti-fibrotic materials and applications
    Patent number: 12097307
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: September 24, 2024
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Arturo Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
  • Mutant subgenomic promoter library and uses thereof
    Patent number: 12098366
    Abstract: Disclosed herein is a subgenomic promoter library derived from alphavirus. Also provided herein are methods of using the subgenomic promoters to produce antibodies and other molecules.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: September 24, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Jin Huh
  • ELECTROCHEMICAL TARGET SPECIES CAPTURE WITH A REDOX-ACTIVE AMINE
    Publication number: 20240307819
    Abstract: The present disclosure relates to electrochemical target species (e.g., carbon dioxide) capture and release with a redox-active amine. Associated systems and articles are also described.
    Type: Application
    Filed: June 24, 2022
    Publication date: September 19, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Trevor Alan Hatton, Hyowon Seo
  • SOFT HAND WITH ENDOSKELETON AND HIGH RESOLUTION SENSING
    Publication number: 20240308067
    Abstract: A robotic finger may include a first endoskeleton segment, a second endoskeleton segment, and a flexure connecting the first endoskeleton segment and the second endoskeleton segment, where the flexure is configured to elastically deform to allow the first endoskeleton segment to move relative to the second endoskeleton segment in a first degree of freedom. The robotic finger may include a transparent elastomeric pad disposed on the first endoskeleton segment and the second endoskeleton segment, at least one light source disposed on at least one of the first endoskeleton segment and the second endoskeleton segment, and at least one photosensitive detector disposed on at least one of the first endoskeleton segment and the second endoskeleton segment.
    Type: Application
    Filed: March 13, 2024
    Publication date: September 19, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward Adelson, Sandra Liu, Leonardo Zamora
  • CYBER-SECURE DYNAMIC MONITORING AND DECISION SYSTEMS
    Publication number: 20240314143
    Abstract: Systems and methods for detecting cyber attacks of subsystems include an interface of the subsystem that provides power exchange. A processor may be configured to calculate an interaction variable from a function of one or more internal states of the subsystem. A comparator circuit is coupled to receive the output signal and the interaction variable, to determine a difference between at least one characteristic of the power signal and at least one characteristic of the interaction variable. A cyber-attack identification module is configured to identify the presence of a cyber-attack targeting the system based on the difference between the at least one characteristic of the power signal and the at least one characteristic of the interaction variable.
    Type: Application
    Filed: July 26, 2022
    Publication date: September 19, 2024
    Applicant: Massachusetts Institute of Technology
    Inventor: Marija Ilic
  • Method for design and manufacture of compliant prosthetic foot
    Patent number: 12090067
    Abstract: A compliant prosthetic foot is designed and fabricated by combining a compliant mechanism optimization technique with a calculation of low leg trajectory error under a reference loading condition. The compliant mechanism optimization technique includes a set of determinants for the compliant prosthetic foot. An optimized set of determinants of the compliant prosthetic foot is formed that minimizes the lower leg trajectory error relative to a target kinematic data set. The compliant prosthetic foot is then fabricated in conformance with the optimized set of determinants.
    Type: Grant
    Filed: April 21, 2023
    Date of Patent: September 17, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Amos Greene Winter, V, Kathryn Michelle Olesnavage
  • Crispr enzymes and systems
    Patent number: 12091709
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Grant
    Filed: August 17, 2023
    Date of Patent: September 17, 2024
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh, Ian Slaymaker
  • FANZORS ARE RNA-GUIDED NUCLEASES ENCODED IN EUKARYOTIC GENOMES
    Publication number: 20240301373
    Abstract: The invention relates to compositions and methods for targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, programmable RNA-guided DNA endonucleases termed Fanzors, can be harnessed for genome editing.
    Type: Application
    Filed: January 5, 2024
    Publication date: September 12, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Omar Abudayyeh, Jonathan Gootenberg, Justin Lim, Kaiyi Jiang
  • RADIO-FREQUENCY POWER GENERATOR AND CONTROL METHOD
    Publication number: 20240305254
    Abstract: A power generator includes a plurality of amplifier blocks and a combiner. Each of the amplifier blocks include one or more amplifiers, and the combiner combines modulated power signals output from the amplifier blocks to generate an RF power signal of a load. The amplifier blocks are controlled to outphase the modulated power signals based on a phase angle. Ones of the amplifier blocks may perform discrete modulation to generate a respective one of the modulated power signals. The discrete modulation includes selecting different combinations of the amplifiers in one or more of the amplifier blocks to change the RF power signal in discrete steps. In embodiments, the amplifiers may be radio frequency power amplifiers.
    Type: Application
    Filed: May 17, 2024
    Publication date: September 12, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Haoquan Zhang, Anas Al Bastami, David J. Perreault
  • Hydration-based shape memory adhesive materials and methods of making
    Patent number: 12084604
    Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: September 10, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Xuanhe Zhao, Hyunwoo Yuk, Heejung Roh
  • Separators comprising elongated nanostructures and associated devices and methods, including devices and methods for energy storage and/or use
    Patent number: 12087506
    Abstract: The use of elongated nanostructures in separators and associated devices and methods, including devices and methods for energy storage and/or use, are generally described. According to certain embodiments, the elongated nanostructures can extend from a first solid substrate to a second solid substrate. In some embodiments, the nanostructures penetrate a surface of the first solid substrate (e.g., a first electrode) and/or a surface of the second solid substrate (e.g., a second electrode). The elongated nanostructures can, according to certain embodiments, provide structural reinforcement between two substrates (e.g., between two electrodes) while maintaining electronic insulation between the two substrates.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: September 10, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian L. Wardle, Luiz Acauan, Yue Zhou
  • Coatings to improve the selectivity of atomically thin membranes
    Patent number: 12083483
    Abstract: Disclosed embodiments are related to mitigating leaks in membranes and/or improving the selectivity of membranes.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: September 10, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohit N. Karnik, Doojoon Jang
  • Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent
    Patent number: 12084415
    Abstract: The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: September 10, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Peyton Shieh, Wencong Wang, Bin Liu, Valerie Lensch, Landon Kilgallon, Yutong Dai, Samantha Lynn Kristufek
  • Method and apparatus for contactless voltage and current estimation through measurements of electric and magnetic fields with redundant sensor arrays
    Patent number: 12085591
    Abstract: A multi-sensor, real-time, in-process current and voltage estimation system is disclosed including sensors, affiliated hardware, and data processing algorithms that allow accurate estimation of currents and voltages from magnetic and electric field measurements, respectively. Aspects of the system may be embodied in a detector that is readily attachable to conductors of an energized system for contactless current and/or voltage sensing of the conductors without requiring the conductors to be disconnected from the energized system.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: September 10, 2024
    Assignees: HARTING Electric Stiftung & Co. KG, The Massachusetts Institute of Technology
    Inventors: Vivek R. Dave, Felix Loske, Enger Knop, Lutz Tröger, Alan E. Casallas, Jeffrey H. Lang
  • Lipid Formulations for Delivery of Messenger RNA
    Publication number: 20240293319
    Abstract: The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 19, 2023
    Publication date: September 5, 2024
    Applicants: Translate Bio, Inc., Massachusetts Institute of Technology
    Inventors: Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa